The Bähler laboratory studies global gene expression programs in fission yeast (S. pombe). We apply a wide range of integrated approaches to analyse regulatory networks during cell proliferation, differentiation and quiescence including genetic and environmental perturbations. We are also interested in genetic diversity, genome evolution, and the complex interactions between genotypes, phenotypes, and the environment. The relative simplicity of the yeast cell promises a deeply satisfying, systems-level understanding of its inner workings within our life time.
We are at University College London in the Department of Genetics, Evolution and Environment and associated with the UCL Cancer Institute and the Department of Structural and Molecular Biology. Our research is mainly funded by Cancer Research UK and the EC FP7 PhenOxiGEn project.p>