•phenotype | •cell phenotype | •cell population phenotype | •cell viability |
•abnormal cell morphology | •abnormal mitotic DNA damage checkpoint | •abnormal S-phase DNA damage checkpoint | •abnormal meiotic recombination |
•abnormal cell adhesion during vegetative growth | •abolished cell-substrate adhesion | •abnormal cell cycle | •mitotic G2/M phase transition delay |
•T-shaped vegetative cell | •tapered cell | •branched vegetative cell | •curved vegetative cell |
•elongated cell | •pear-shaped cell | •spheroid vegetative cell | •shmoo with long tip |
•small cell | •stubby vegetative cell | •swollen cell | •abnormal vegetative cell polarity |
•abnormal cell wall during vegetative growth | •abnormal chromosome segregation | •abnormal mitotic chromosome congression | •abnormal mating |
•abnormal cytokinesis | •abnormal actomyosin contractile ring localization | •abnormal endocytosis during vegetative growth | •growth auxotrophic for arginine |
•growth auxotrophic for cysteine | •growth auxotrophic for lysine | •growth auxotrophic for methionine | •abnormal negative regulation of transcription by glucose |
•abnormal cell population growth | •decreased cell population growth | •normal cell population growth | •inviable cell |
•abnormal kinetochore morphology during vegetative growth | •abnormal meiosis | •abnormal meiotic cell cycle | •abnormal microtubule cytoskeleton organization |
•long microtubules | •mitochondria fused | •abnormal mitotic cell cycle | •mononucleate vegetative cell |
•multinucleate vegetative cell | •abnormal nuclear morphology during vegetative growth | •abnormal DNA recombination | •resistance to 2-deoxyglucose |
•resistance to brefeldin A | •resistance to K-252a | •resistance to thiabendazole | •resistance to amphotericin B |
•resistance to benomyl | •resistance to caffeine | •resistance to lovastatin | •resistance to nystatin |
•abnormal cellular respiration | •sensitive to caspofungin | •decreased cell population growth at low temperature | •sensitive to high osmolarity |
•decreased cell population growth at high temperature | •sensitive to 6-azauracil | •sensitive to camptothecin | •sensitive to tacrolimus |
•sensitive to hydrogen peroxide | •sensitive to hydroxyurea | •sensitive to methyl methanesulfonate | •sensitive to thiabendazole |
•sensitive to arsenic | •sensitive to benomyl | •sensitive to bleomycin | •sensitive to cadmium |
•sensitive to caffeine during vegetative growth | •sensitive to calcium | •sensitive to canavanine | •sensitive to chlorpropham |
•sensitive to cisplatin | •sensitive to copper | •sensitive to cycloheximide | •sensitive to cyclosporin A |
•sensitive to hygromycin B | •sensitive to latrunculin A | •sensitive to menadione | •sensitive to papulacandin B |
•sensitive to pravastatin | •sensitive to rapamycin | •sensitive to sorbitol | •sensitive to staurosporine |
•cellular process phenotype | •sensitive to valproic acid | •sensitive to zinc | •abnormal septum assembly |
•multiseptate vegetative cell | •abnormal spindle assembly | •abnormal spindle | •abnormal sporulation |
•abnormal telomere maintenance | •large vacuoles during vegetative growth | •viable cell | •resistance to amiloride |
•increased resistance to chemical during vegetative growth | •increased sensitivity to chemical during vegetative growth | •auxotrophy | •spherical vegetative cell |
•short spindle | •abnormal mitotic spindle elongation | •abnormal septum disassembly | •elongated multinucleate vegetative cell |
•branched, elongated, multiseptate cell | •abnormal plasma membrane sterol distribution | •cellular physical quality phenotype | •mitotic cell cycle checkpoint phenotype |
•localization phenotype | •cell population growth phenotype | •cellular metabolism phenotype | •abnormal mitotic sister chromatid segregation |
•gene expression phenotype | •transcription regulation phenotype | •abnormal chromatin silencing | •regulation phenotype |
•abnormal chromatin silencing at centromere | •abnormal activation of bipolar cell growth | •abnormal regulation of mitotic cell cycle | •transport phenotype |
•abnormal colony morphology | •abnormal meiotic chromosome segregation | •abnormal cellular response to nitrogen starvation | •increased flocculation |
•abnormal chromatin silencing at silent mating-type cassette | •abnormal response to DNA damage stimulus during vegetative growth | •DNA content increased during vegetative growth | •abnormal chromosome condensation |
•fragmented DNA | •abnormal actomyosin contractile ring assembly | •abnormal cellular response to stress | •abnormal macroautophagy |
•abnormal cell separation after cytokinesis | •abnormal regulation of mating | •abnormal regulation of G2/M transition of mitotic cell cycle | •increased DNA recombination at mitotic DNA replication fork barriers |
•abnormal mitotic spindle assembly checkpoint | •abnormal chromatin silencing at telomere | •abnormal late endosome to vacuole transport | •abnormal meiotic telomere clustering |
•abnormal mitotic cell cycle DNA replication checkpoint | •abnormal cell wall biogenesis | •abnormal ascospore wall assembly | •abnormal DNA replication initiation |
•abnormal mitotic spindle assembly | •abnormal cellular response to oxidative stress | •abolished crossover | •abnormal cell wall organization during vegetative growth |
•abnormal poly(A)+ mRNA export from nucleus | •decreased gene conversion during vegetative growth | •abnormal cell division | •abnormal chromatin silencing by small RNA |
•abnormal DNA repair during vegetative growth | •abnormal mRNA splicing, via spliceosome | •abnormal actin cortical patch localization during vegetative growth | •abnormal regulation of establishment or maintenance of cell polarity |
•abnormal cellular response to hydrogen peroxide | •abnormal prospore formation | •abnormal horsetail movement | •increased long tract gene conversion |
•abnormal regulation of mitotic metaphase/anaphase transition | •abnormal mRNA export from nucleus | •abnormal chromatin silencing at rDNA | •abnormal attachment of spindle microtubules to kinetochore during meiosis I |
•abnormal cellular response to heat | •abnormal vesicle-mediated transport during vegetative growth | •abnormal mitotic chromosome condensation | •abnormal intracellular protein transport during vegetative growth |
•abnormal negative regulation of mitotic DNA replication initiation | •abnormal DNA replication | •decreased Mre11 complex assembly | •increased protein oxidation during vegetative growth |
•increased centromeric outer repeat transcript level | •elongated multiseptate vegetative cell | •lemon-shaped cell | •snowman-shaped spore |
•chromosome loss during mitotic chromosome segregation | •lagging mitotic chromosomes | •cut | •abnormal actomyosin contractile ring actin filament organization |
•split actomyosin contractile ring | •long cytoplasmic microtubules | •abnormal cytoplasmic interphase microtubule nucleation | •inviable cell upon G0 to G1 transition |
•increased transcription from MCB promoter | •abnormal filament morphology | •normal growth on ammonia nitrogen source | •normal growth on proline nitrogen source |
•loss of viability upon nutrient depletion | •loss of viability in stationary phase | •growth auxotrophic for antioxidant | •decreased cell population growth on ammonia nitrogen source |
•decreased cell population growth on proline nitrogen source | •decreased cell population growth on galactose carbon source | •increased spontaneous diploidization | •increased HMG-CoA reductase activity |
•increased nuclear protein level during vegetative growth | •mutator | •normal phenotype | •sensitive to DNA damage |
•sensitive to DNA damaging agents | •sensitive to ionizing radiation during vegetative growth | •sensitive to UV during vegetative growth | •sensitive to osmotic stress |
•sensitive to salt stress | •abolished septum assembly | •centromeric outer repeat transcripts absent | •increased duration of mitotic M phase |
•monopolar mitotic spindle | •decreased cell population growth following spore germination | •sterile | •small vacuoles present in increased numbers during vegetative growth |
•mitotic chromosome fragmentation upon segregation | •large and small daughter nuclei, with unequal mitotic sister chromatid segregation | •abnormal subcellular component | •gene expression regulation phenotype |
•translation regulation phenotype | •transcription phenotype during vegetative growth | •translation phenotype | •nucleic acid metabolism phenotype |
•DNA metabolism phenotype | •RNA metabolism phenotype | •cytoskeleton organization phenotype | •actin cytoskeleton organization phenotype |
•microtubule cytoskeleton organization phenotype | •cellular response phenotype | •biological process phenotype | •mating phenotype |
•abnormal response to pheromone | •decreased mating frequency | •sensitive to stress during vegetative growth | •abnormal spore germination |
•inviable small spore | •inviable spore with abnormal morphology | •inviable after spore germination, without cell division, with normal germ tube morphology | •inviable after spore germination with normal, unseptated germ tube morphology |
•inviable after spore germination, without cell division, with abnormal germ tube morphology | •inviable after spore germination with elongated germ tube | •inviable after spore germination, without cell division, with elongated, septated germ tube | •inviable after spore germination |
•inviable after spore germination, single cell division, normal cell morphology | •mitotic metaphase/anaphase transition delay | •abnormal attachment of spindle microtubules to kinetochore | •abnormal mitotic sister chromatid biorientation |
•resistance to trichostatin A | •abnormal protein metabolic process during vegetative growth | •abnormal protein modification during vegetative growth | •abnormal histone modification during vegetative growth |
•decreased histone acetylation during vegetative growth | •increased histone acetylation during vegetative growth | •mitotic G1/S phase transition delay | •cellular component organization phenotype |
•abnormal cellular component organization | •abnormal cellular component assembly | •abnormal mitosis | •abnormal mitotic spindle |
•mislocalized septum during vegetative growth | •decreased cellular respiration | •increased hydrogen sulfide biosynthesis | •enlarged nucleus during vegetative growth |
•abnormal protein export from nucleus during vegetative growth | •small spores | •swollen spore | •abnormal spore morphology |
•abnormal Golgi morphology | •abnormal actin cytoskeleton morphology during vegetative growth | •abnormal cell wall morphology during vegetative growth | •abnormal cytoskeleton morphology during vegetative growth |
•abnormal endomembrane system morphology | •abnormal endoplasmic reticulum morphology | •abnormal shmoo morphology | •abnormal mitochondrial morphology |
•abnormal RNA localization during vegetative growth | •abnormal nucleolar morphology | •abnormal plasma membrane morphology | •abnormal vacuolar morphology during vegetative growth |
•abnormal RNA modification | •abolished RNA modification | •decreased RNA modification | •increased frequency of apoptosis |
•normal apoptosis | •abolished macroautophagy | •decreased macroautophagy | •delayed onset of macroautophagy |
•normal macroautophagy | •abnormal mitotic G1/S phase transition | •premature mitotic G1/S phase transition | •abnormal mitotic G2/M phase transition |
•cell cycle arrest at mitotic G2/M phase transition | •abnormally arrested cell cycle progression | •increased duration of cell cycle phase | •delayed cell cycle phase transition |
•decreased duration of cell cycle phase | •normal mitotic cell cycle | •abnormal cell fusion during mating | •abolished cell fusion during mating |
•decreased cell fusion during mating | •premature mitotic sister chromatid separation | •abolished cytokinesis | •decreased rate of cytokinesis |
•delayed onset of cytokinesis | •abolished endocytosis during vegetative growth | •decreased endocytosis during vegetative growth | •decreased rate of endocytosis during vegetative growth |
•normal endocytosis | •abnormal G1 to G0 transition | •normal fermentation | •sensitive to antimycin A |
•resistance to antimycin A | •decreased cell population growth on glycerol/ethanol carbon source | •abnormal protein localization during vegetative growth | •abnormal mitotic cell cycle arrest with replicated DNA |
•cell cycle arrest in mitotic G1 phase | •cell cycle arrest in mitotic G2 phase | •abnormal protein complex assembly | •abnormal MCM complex assembly |
•abnormal protein localization to centromere during vegetative growth | •decreased protein localization to centromere during vegetative growth | •increased protein localization to centromere during vegetative growth | •abnormal protein localization to chromatin during vegetative growth |
•DNA content decreased during vegetative growth | •increased number of double-strand break sites during vegetative growth | •abnormal histone acetylation during vegetative growth | •abnormal histone methylation during vegetative growth |
•abnormal histone H3-K9 methylation during vegetative growth | •abnormal mitotic centromeric sister chromatid cohesion | •decreased mitotic centromeric sister chromatid cohesion | •decreased intracellular transport |
•abnormal mating type switching | •abolished mating type switching | •decreased mating type switching | •normal mating type switching |
•increased mitotic recombination | •abolished meiosis | •abnormally arrested meiosis | •decreased frequency of meiosis |
•delayed onset of meiosis | •normal meiosis | •premature meiosis | •abnormal mitotic recombination |
•decreased mitotic recombination | •abolished meiotic recombination | •decreased meiotic recombination | •increased meiotic recombination |
•normal meiotic recombination | •abnormal mitochondrial distribution | •abnormally arrested mitotic cell cycle progression | •normal mitotic recombination |
•abnormal nuclear export | •abolished nuclear export | •decreased nuclear export | •normal nuclear export |
•abnormal nuclear fusion during mating | •abolished nuclear fusion during mating | •decreased nuclear fusion during mating | •decreased nuclear import |
•normal nuclear import | •abnormal nucleus localization | •abnormal nuclear transport during vegetative growth | •abnormal mitotic cell cycle arrest in response to pheromone |
•abolished mitotic cell cycle arrest in response to pheromone | •decreased mitotic cell cycle arrest in response to pheromone | •abnormal mitotic spindle pole body localization | •abnormal protein secretion during vegetative growth |
•abolished protein secretion during vegetative growth | •decreased protein secretion during vegetative growth | •increased protein secretion during vegetative growth | •abnormal protein transport during vegetative growth |
•decreased protein transport during vegetative growth | •abolished protein modification during vegetative growth | •decreased protein modification during vegetative growth | •delayed onset of protein modification during vegetative growth |
•increased protein modification during vegetative growth | •increased duration of protein modification during vegetative growth | •normal protein modification during vegetative growth | •abnormal pseudohyphal growth |
•pseudohyphal growth abolished | •decreased pseudohyphal growth | •abnormal re-entry into mitotic cell cycle after pheromone arrest | •abolished cellular respiration |
•abnormal mitotic G2 phase progression | •decreased rate of cellular respiration | •increased cellular respiration | •abnormal shmoo formation |
•abolished shmoo formation | •increased rate of shmoo formation | •normal shmoo formation | •abnormal gene silencing |
•decreased gene silencing | •increased gene silencing | •normal gene silencing | •normal spore germination |
•abnormal ascospore wall biogenesis | •decreased spore germination frequency | •decreased rate of spore germination | •abolished sporulation |
•decreased sporulation frequency | •abolished ascospore wall biogenesis | •delayed onset of sporulation | •increased sporulation frequency |
•normal sporulation | •abnormal transposition | •decreased transposition | •increased transposition |
•normal transposition | •abnormal vacuolar transport during vegetative growth | •decreased vacuolar transport | •normal vacuolar transport |
•abnormal mitotic G1 phase progression | •decreased duration of mitotic G1 phase | •abnormal mitotic M phase progression | •abnormal cell cycle arrest in mitotic M phase |
•abnormal mitotic S phase progression | •abnormal cell cycle arrest in mitotic S phase | •increased duration of mitotic S phase | •abnormal mitotic anaphase progression |
•increased duration of mitotic anaphase | •abnormal cell cycle arrest in mitotic anaphase | •abnormal cell cycle arrest in mitotic metaphase | •abnormal positive regulation of transcription |
•abnormal negative regulation of transcription during vegetative growth | •abnormal premeiotic DNA replication | •normal cellular process | •abnormal cellular process |
•cell cycle phenotype | •mitochondrial translation phenotype | •sensitive to G418 | •abolished protein localization to centromere during vegetative growth |
•growth auxotrophic for leucine | •increased cell population growth rate | •increased cell population growth rate on glucose carbon source | •delayed onset of septum assembly |
•abnormal transcriptional repression at centromere central core | •abnormal chromosome organization | •abnormal chromatin organization | •abnormal mitotic DNA integrity checkpoint |
•normal protein localization during vegetative growth | •small vegetative cell | •swollen vegetative cell | •vegetative cell lysis |
•viable small vegetative cell | •increased septation index | •increased duration of septum assembly | •molecular function phenotype |
•DNA binding phenotype | •catalytic activity phenotype | •normal DNA binding | •abnormal DNA binding |
•increased DNA binding | •decreased DNA binding | •abolished DNA binding | •normal catalytic activity |
•abnormal catalytic activity | •increased catalytic activity | •decreased catalytic activity | •abolished catalytic activity |
•normal peptidase activity | •abnormal peptidase activity | •increased peptidase activity | •decreased peptidase activity |
•abolished peptidase activity | •abnormal mitotic sister chromatid separation | •abnormal rDNA separation | •normal cell morphology |
•normal septum assembly | •normal cell population growth at high temperature | •abnormal protein targeting during vegetative growth | •abnormal protein targeting to vacuole |
•abnormal protein localization to prospore membrane | •unequal homologous chromosome segregation | •developmental process phenotype | •abnormal ascus development |
•abnormal sporulation resulting in formation of two-spore ascus | •abnormal regulation of molecular function | •constitutive catalytic activity | •decreased cell population growth on glycerol carbon source |
•abnormal oxidoreductase activity | •decreased oxidoreductase activity | •protein-protein interaction phenotype | •normal protein-protein interaction |
•abnormal protein-protein interaction | •abolished protein-protein interaction | •normal molecular function | •abnormal molecular function |
•decreased mating efficiency | •decreased cell population growth during nitrogen starvation | •abnormal mitotic cell cycle arrest in response to nitrogen starvation | •decreased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation |
•delayed onset of cell cycle arrest in mitotic G1 phase in response to nitrogen starvation | •abnormal cellular response to starvation | •sensitive to leptomycin B | •sensitive to K-252a |
•sensitive to actinomycin D | •sensitive to acidity | •sensitive to alkalinity | •resistance to methyl methanesulfonate |
•sensitive to oxidative stress | •abnormal actin filament organization during vegetative growth | •abnormal actin cortical patch assembly | •delayed onset of actomyosin contractile ring assembly |
•long spindle | •abnormal protein localization to medial cortex during vegetative growth | •short mitotic spindle | •long mitotic spindle |
•abnormal meiotic spindle | •long meiotic spindle | •abnormal meiotic spindle assembly | •cellular pigment accumulation phenotype |
•increased cellular pigment accumulation | •abnormal protein localization to actin cortical patch | •abnormal actin cortical patch internalization | •normal protein localization to actin cortical patch |
•delayed onset of actin cortical patch internalization | •growth auxotrophic for adenine | •sensitive to mercury | •sensitive to nickel |
•sensitive to nigericin | •normal mating | •increased mating frequency | •resistance to cadmium |
•resistance to cycloheximide | •resistance to leptomycin B | •resistance to staurosporine | •resistance to valinomycin |
•abnormal nuclear envelope morphology during vegetative growth | •normal nuclear pore distribution | •perforated nuclear envelope | •abnormal pre-replicative complex assembly |
•abnormal protein phosphorylation during vegetative growth | •normal protein phosphorylation during vegetative growth | •abnormal double-strand break repair during vegetative growth | •delayed onset of double-strand break repair |
•inviable elongated vegetative cell with central constriction | •increased transcription during vegetative growth | •decreased transcription during vegetative growth | •mislocalized protein during vegetative growth |
•protein mislocalized to cytoplasm during vegetative growth | •protein mislocalized to nucleus during vegetative growth | •sensitive to formamide | •increased plasmid loss |
•abnormal histone H3-K9 trimethylation during vegetative growth | •abnormal histone H3-K14 acetylation during vegetative growth | •abnormal actin cortical patch organization | •abnormal actin cortical patch morphology |
•normal glycerol dehydrogenase activity | •abnormal glycerol dehydrogenase activity | •decreased glycerol dehydrogenase activity | •increased glycerol dehydrogenase activity |
•sensitive to tert-butyl hydroperoxide | •sensitive to anisomycin | •sensitive to diamide | •increased concentration of substance in growth medium |
•abnormal actin cytoskeleton organization during vegetative growth | •abnormal cytoskeleton organization | •abnormal endomembrane system organization | •abnormal endoplasmic reticulum organization |
•abnormal Golgi organization | •abnormal kinetochore organization | •abnormal lipid droplet organization | •abnormal mitochondrion organization |
•abnormal nucleus organization | •abnormal vacuole organization during vegetative growth | •abnormal plasma membrane organization | •abnormal nucleolus organization |
•abnormal nuclear envelope organization | •decreased concentration of substance in growth medium | •increased concentration of pheromone in growth medium | •decreased concentration of pheromone in growth medium |
•decreased concentration of M-factor in growth medium | •decreased concentration of P-factor in growth medium | •altered RNA level | •increased RNA level during vegetative growth |
•decreased RNA level | •premature cell cycle phase transition | •premature mitotic G1 phase entry | •resistance to cisplatin |
•resistance to vanadate | •resistance to actinomycin D | •elongated nucleus during vegetative growth | •normal protein level during vegetative growth |
•altered protein level | •decreased protein level | •increased protein level | •cell cycle arrest in mitotic interphase |
•normal protein localization to nucleus during vegetative growth | •inviable elongated mononucleate aseptate cell | •normal RNA level | •sensitive to sodium dodecyl sulfate |
•sensitive to ethanol during vegetative growth | •sensitive to dithiothreitol | •abnormal protein degradation during vegetative growth | •decreased protein degradation during vegetative growth |
•increased protein degradation during vegetative growth | •abnormal chromosome morphology during vegetative growth | •increased cytoplasmic protein level during vegetative growth | •resistance to stress during vegetative growth |
•resistance to osmotic stress | •resistance to salt stress | •abnormal nucleosome positioning | •abnormal nucleosome positioning in euchromatin |
•abnormal nucleosome positioning in heterochromatin | •normal nucleosome positioning | •normal nucleosome positioning in euchromatin | •normal metabolic process during vegetative growth |
•abnormal metabolic process | •normal histone methylation during vegetative growth | •normal histone H3-K9 dimethylation at centromere during vegetative growth | •normal histone H3-K9 dimethylation at centromere inner repeat during vegetative growth |
•abnormal histone H3-K9 trimethylation at centromere during vegetative growth | •abnormal histone H3-K9 trimethylation at centromere inner repeat during vegetative growth | •abnormal histone H3-K9 dimethylation during vegetative growth | •abnormal histone H3-K9 dimethylation at centromere during vegetative growth |
•abnormal histone H3-K9 dimethylation at centromere inner repeat during vegetative growth | •increased histone methylation during vegetative growth | •decreased histone methylation during vegetative growth | •increased histone H3-K9 methylation during vegetative growth |
•decreased histone H3-K9 methylation during vegetative growth | •increased histone H3-K9 dimethylation during vegetative growth | •increased histone H3-K9 dimethylation at centromere during vegetative growth | •increased histone H3-K9 dimethylation at centromere inner repeat during vegetative growth |
•decreased histone H3-K9 dimethylation during vegetative growth | •decreased histone H3-K9 dimethylation at centromere during vegetative growth | •decreased histone H3-K9 dimethylation at centromere inner repeat during vegetative growth | •increased histone H3-K9 trimethylation during vegetative growth |
•decreased histone H3-K9 trimethylation during vegetative growth | •decreased histone H3-K9 trimethylation at centromere during vegetative growth | •abnormal histone H3-K9 trimethylation at centromere outer repeat during vegetative growth | •abnormal histone H3-K9 dimethylation at centromere outer repeat during vegetative growth |
•increased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth | •decreased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth | •decreased histone H3-K9 trimethylation at centromere outer repeat during vegetative growth | •abnormal histone H3-K9 acetylation during vegetative growth |
•increased histone H3-K9 acetylation during vegetative growth | •increased histone H3-K9 acetylation at centromere during vegetative growth | •abnormal intracellular mitochondrion distribution | •mitochondrial aggregation |
•normal microtubule cytoskeleton organization during vegetative growth | •abnormal microtubule polymerization or depolymerization during vegetative growth | •abnormal microtubule depolymerization during vegetative growth | •decreased rate of microtubule depolymerization during vegetative growth |
•decreased microtubule polymerization or depolymerization | •abnormal protein ubiquitination during vegetative growth | •abnormal protein localization to linear element | •increased nuclear RNA level during vegetative growth |
•abolished protein ubiquitination during vegetative growth | •abnormal sporulation resulting in formation of ascus containing non-uniform spores | •abnormal aconitate hydratase activity | •increased aconitate hydratase activity |
•unequal meiotic chromosome segregation | •normal volume vegetative cell | •abolished horsetail movement | •abnormal protein localization to cell cortex during vegetative growth |
•decreased protein localization to cell cortex during vegetative growth | •abolished protein localization to cell cortex during vegetative growth | •abnormal protein localization to microtubule cytoskeleton during vegetative growth | •increased protein localization to microtubule cytoskeleton during vegetative growth |
•decreased protein localization to microtubule cytoskeleton during vegetative growth | •abolished protein localization to microtubule cytoskeleton during vegetative growth | •abnormal protein localization to cortical microtubule cytoskeleton during vegetative growth | •decreased protein localization to cortical microtubule cytoskeleton during vegetative growth |
•abnormal protein localization to mitotic spindle pole body | •decreased protein localization to mitotic spindle pole body | •abolished protein localization to mitotic spindle pole body | •normal spore morphology |
•swollen spheroid vegetative cell | •normal volume spheroid vegetative cell | •aseptate | •elongated aseptate vegetative cell |
•inviable small vegetative cell | •vacuoles present in increased numbers during vegetative growth | •normal cellular response to chemical stimulus | •normal growth on nickel cation |
•normal growth on lead ion | •normal growth on methyl methanesulfonate | •normal growth on sodium dodecyl sulfate | •normal growth on ethanol |
•normal growth on sorbitol | •normal growth on hydrogen peroxide | •normal growth on hydroxyurea | •normal growth on thiabendazole |
•abnormal histone H3-K14 acetylation at centromere outer repeat during vegetative growth | •increased histone H3-K14 acetylation at centromere outer repeat during vegetative growth | •normal cellular response to stress during vegetative growth | •normal growth during cellular response to UV |
•sensitive to mitomycin C | •increased number of Rad52 foci during vegetative growth | •normal growth on miconazole | •normal growth on amphotericin B |
•normal glutamate dehydrogenase (NAD+) activity | •abnormal glutamate dehydrogenase (NADP+) activity | •decreased glutamate dehydrogenase (NADP+) activity | •abnormal transcriptional response to pheromone |
•normal cellular response to arsenic | •altered level of substance in cell | •increased level of substance in cell | •decreased level of substance in cell |
•abnormal cell morphology during nitrogen starvation | •pear-shaped cell during nitrogen starvation | •elongated cell during nitrogen starvation | •enlarged nucleus during nitrogen starvation |
•normal cell cycle arrest in mitotic G1 phase during nitrogen starvation | •abnormal cell cycle arrest in mitotic G2 phase during nitrogen starvation | •abolished cell division prior to G0 entry | •small vacuoles present in increased numbers during nitrogen starvation |
•fragmented DNA during nitrogen starvation | •inviable elongated multinucleate vegetative cell with central constriction | •normal mitosis | •actomyosin contractile ring absent |
•abolished actomyosin contractile ring assembly | •abolished actin filament organization | •filamentous actin absent | •growth auxotrophic for uracil |
•abnormal membrane organization | •altered cellular phosphatidylinositol-4-phosphate level | •normal growth on actinomycin D | •premature activation of bipolar cell growth |
•abolished activation of bipolar cell growth | •monopolar actin cortical patch localization during vegetative growth | •normal growth on calcium | •normal growth during cellular response to osmotic stress |
•normal growth during cellular response to high osmolarity | •normal growth on cisplatin | •cell cycle arrest phenotype | •normally arrested mitotic cell cycle progression |
•abnormal occurrence of normal mitotic cell cycle arrest | •abnormal cell cycle arrest in mitotic interphase | •resistance to canavanine | •normal growth on dithiothreitol |
•resistance to camptothecin | •normal double-strand break repair | •resistance to tunicamycin | •increased cell wall thickness during vegetative growth |
•normal growth during cellular response to salt stress | •increased protein phosphorylation during vegetative growth | •inviable after spore germination, single or double cell division | •increased mating efficiency |
•abnormal acid phosphatase activity | •decreased acid phosphatase activity | •premature mitosis | •mitotic catastrophe |
•mitotic catastrophe, small cell | •mitotic catastrophe, elongated cell | •mitotic catastrophe with cut, elongated cell | •cut following normal mitotic chromosome condensation |
•abnormal amino acid import | •decreased amino acid import | •abnormal glutamate import during vegetative growth | •decreased glutamate import during vegetative growth |
•abnormal tyrosine import | •decreased tyrosine import | •increased duration of mitotic cell cycle phase | •decreased duration of mitotic cell cycle phase |
•normal transport | •normal growth on papulacandin B | •normal level of substance in cell | •normal polysaccharide level |
•normal beta-glucan level | •normal galactomannan level | •decreased polysaccharide level | •decreased cell wall alpha-glucan level |
•decreased cell wall beta-glucan level | •increased polysaccharide level | •increased cell wall alpha-glucan level | •altered polysaccharide level |
•normal glucosyltransferase activity | •abnormal glucosyltransferase activity | •decreased glucosyltransferase activity | •increased glucosyltransferase activity |
•resistance to heat shock during vegetative growth | •normal cellular response to heat shock | •binding phenotype | •abolished chromatin binding |
•normal DNA replication origin binding | •abolished DNA replication origin binding | •normal RNA level during nitrogen starvation | •sensitive to amitrole |
•sensitive to 4-nitroquinoline N-oxide | •decreased protein level during cellular response to hydrogen peroxide | •increased protein level during cellular response to hydrogen peroxide | •resistance to hydrogen peroxide |
•abnormal catalase activity | •abnormal glutathione-disulfide reductase activity | •resistance to menadione | •inviable after spore germination, multiple cell divisions, normal morphology |
•increased cellular glutathione disulfide level | •premature cell cycle arrest in mitotic G1 phase in response to nitrogen starvation | •decreased RNA level during cellular response to hydrogen peroxide | •decreased RNA level during vegetative growth |
•abnormal vegetative cell morphology | •tapered vegetative cell | •pear-shaped vegetative cell | •vegetative cell, abnormal cell shape, normal cell size |
•elongated vegetative cell | •elongated spore | •normal vegetative cell size | •normal vegetative cell shape |
•abnormal cell shape | •abnormal cell size | •decreased septation index | •abnormal protein localization to nucleus during vegetative growth |
•increased protein localization to nucleus during vegetative growth | •abnormal protein localization to heterochromatin during vegetative growth | •abolished protein localization to heterochromatin during vegetative growth | •normal DNA replication |
•normal mature 18S rRNA level | •increased 35S rRNA precursor level | •increased 27S rRNA precursor level | •decreased mature 25S rRNA level |
•decreased mature 5.8S rRNA level | •abnormal leucine import | •decreased leucine import | •abolished transcriptional response to pheromone |
•normal Man8GlcNAc level | •normal Man9GlcNAc level | •increased Man9GlcNAc level | •decreased misfolded glycoprotein degradation during vegetative growth |
•normal mating efficiency | •cell cycle arrest in mitotic G2 phase during starvation | •decreased RNA level during nitrogen starvation | •altered effect on growth medium |
•decreased pH of growth medium | •increased cell population growth rate at high pH | •normal cellular pH | •normal growth on glucose carbon source |
•normal growth on fructose carbon source | •abnormal ATPase activity | •decreased ATPase activity | •normal proton transport |
•normal growth on sucrose carbon source | •normal growth on maltose carbon source | •decreased cell population growth on sucrose carbon source | •loss of viability upon nitrogen starvation |
•abolished protein localization during vegetative growth | •decreased cell density in stationary phase | •sensitive to Calcofluor White | •sensitive to cilofungin |
•sensitive to cell wall-degrading enzymes | •normal growth on cell wall-degrading enzymes | •increased beta-glucan level | •decreased galactomannan level |
•normal alpha-glucan level | •decreased cellular calcium level | •increased cellular calcium level | •normal cellular calcium level |
•sensitive to calcium ion starvation | •mistimed mitosis | •sensitive to raffinose | •substance absent from cell during vegetative growth |
•polysaccharide absent from cell | •increased Man8GlcNAc level | •sensitive to potassium chloride | •normal protein complex assembly during vegetative growth |
•abnormal nuclear import | •increased protein level during cellular response to nitrogen starvation | •increased protein level during cellular response to pheromone | •normal nucleus:cytoplasm ratio |
•binucleate vegetative cell | •binucleate multiseptate vegetative cell | •monoseptate | •inviable mononucleate vegetative cell with mislocalized septum |
•protein mislocalized to cytoplasm during cellular response to hydrogen peroxide | •increased nuclear protein level during cellular response to hydrogen peroxide | •normal subcellular component | •slow vegetative cell population growth |
•decreased extent of cell population growth | •normal growth on cycloheximide | •normal growth on cadmium | •normal growth on staurosporine |
•normal growth on tert-butyl hydroperoxide | •normal growth on diamide | •normal growth on anisomycin | •increased RNA level during cellular response to adenine starvation |
•decreased RNA level during cellular response to thiamine starvation | •sensitive to cobalt | •normal RNA level during cellular response to hydrogen peroxide | •abnormal regulation of mitotic DNA replication initiation |
•increased origin firing efficiency | •decreased origin firing efficiency | •multinucleate multiseptate vegetative cell | •elongated multinucleate multiseptate vegetative cell, single septa between nuclei |
•multinucleate multiseptate vegetative cell, septa grouped | •increased protein level during cellular response to oxygen | •normal protein level during cellular response to oxygen | •normal protein level during cellular response to hypoxia |
•decreased RNA level during cellular response to hypoxia | •normal protein phosphorylation during cellular response to salt stress | •abnormal protein localization to kinetochore during vegetative growth | •abolished protein localization to kinetochore during vegetative growth |
•complete but unequal mitotic sister chromatid segregation | •incomplete, unequal mitotic sister chromatid segregation | •incomplete, unequal mitotic sister chromatid segregation, with smeared DNA | •mitotic spindle elongation with incomplete, unequal mitotic sister chromatid segregation and unseparated DNA |
•decreased protein level during cellular response to hypoxia | •decreased MCM complex assembly | •abolished MCM complex assembly | •normal MCM complex assembly |
•increased RNA level during cellular response to oxidative stress | •decreased RNA level during cellular response to oxidative stress | •normal protein phosphorylation during cellular response to hydrogen peroxide | •decreased protein level during cellular response to nitrogen starvation |
•increased cellular phosphoinositide level | •altered phospholipid level | •increased phospholipid level | •decreased phospholipid level |
•altered cellular phosphoinositide level | •normal cell wall biogenesis | •normal actin cortical patch localization | •abnormal myristoyl-CoA ligase activity |
•decreased myristoyl-CoA ligase activity | •abnormal long-chain fatty acid-CoA ligase activity | •decreased long-chain fatty acid-CoA ligase activity | •increased viability in stationary phase |
•normal viability in stationary phase | •decreased plasmid loss | •normal vegetative phenotype | •normal subcellular component during vegetative growth |
•normal vegetative cell morphology | •normal level of substance in cell during vegetative growth | •normal RNA level during vegetative growth | •normal cellular response to chemical stimulus during vegetative growth |
•normal cellular process during vegetative growth | •vegetative cell phenotype | •cellular physical quality phenotype during vegetative growth | •abnormal subcellular component during vegetative growth |
•altered level of substance in cell during vegetative growth | •decreased protein level during vegetative growth | •altered protein level during vegetative growth | •altered RNA level during vegetative growth |
•increased protein level during vegetative growth | •abnormal cytoskeleton organization during vegetative growth | •decreased level of substance in cell during vegetative growth | •increased level of substance in cell during vegetative growth |
•cellular process phenotype during vegetative growth | •gene expression regulation phenotype during vegetative growth | •regulation phenotype during vegetative growth | •transcription regulation phenotype during vegetative growth |
•transport phenotype during vegetative growth | •localization phenotype during vegetative growth | •abnormal nucleus localization during vegetative growth | •abnormal cellular response to oxidative stress during vegetative growth |
•abnormal cellular response to stress during vegetative growth | •cellular response phenotype during vegetative growth | •abnormal mitotic DNA replication | •abnormal mitotic DNA replication initiation |
•abnormal DNA recombination during vegetative growth | •DNA metabolism phenotype during vegetative growth | •nucleic acid metabolism phenotype during vegetative growth | •cellular metabolism phenotype during vegetative growth |
•abnormal microtubule cytoskeleton organization during vegetative growth | •abnormal membrane organization during vegetative growth | •abnormal chromatin organization during vegetative growth | •abnormal cellular component organization during vegetative growth |
•abnormal cellular component assembly during vegetative growth | •decreased vegetative cell population growth | •abnormal vegetative cell population growth | •normal vegetative cell population growth |
•vegetative cell population growth phenotype | •decreased amino acid import during vegetative growth | •abnormal amino acid import during vegetative growth | •abnormal cellular process during vegetative growth |
•abnormal metabolic process during vegetative growth | •abnormal actomyosin contractile ring contraction | •decreased rate of actomyosin contractile ring contraction | •normal actin cytoskeleton organization |
•normal cytokinesis | •normal actomyosin contractile ring assembly | •mislocalized actomyosin contractile ring | •abnormal protein localization |
•abolished protein localization to medial cortex | •abnormal protein localization to medial cortex | •abolished protein localization | •resistance to tacrolimus |
•normal nuclear morphology during vegetative growth | •abnormal protein kinase activity | •decreased protein kinase activity | •normal DNA content |
•abolished protein kinase activity | •inviable after spore germination, without cell division, cell cycle arrest with replicated DNA | •increased haploidization | •loss of viability at high temperature |
•decreased protein level in germinating spore | •normal nucleus localization | •misoriented septum during vegetative growth | •mislocalized septum, near new end |
•abnormal regulation of cell growth | •abnormal activation of monopolar cell growth | •activation of monopolar cell growth at either end | •normal activation of monopolar cell growth |
•normal activation of bipolar cell growth | •monopolar actin cortical patch localization to old end | •normal mitotic spindle | •normal interphase microtubules |
•abnormal protein localization to cell division site | •normal protein localization to cell cortex during vegetative growth | •irregular colony morphology | •increased septum thickness |
•decreased cell population growth on glucose carbon source | •sensitive to heat shock | •normal growth on glycerol carbon source | •altered cellular sulfide level |
•increased cellular sulfide level | •abnormal microtubule cytoskeleton morphology during vegetative growth | •normal cell population growth rate | •normal vegetative cell population growth rate |
•abnormal protein processing during vegetative growth | •decreased protein processing during vegetative growth | •normal protein targeting to vacuole | •abolished protein localization to nucleus during vegetative growth |
•abnormal negative regulation of mitotic DNA replication initiation resulting in complete rereplication | •swollen elongated cell | •abnormal mitotic cell cycle arrest with unreplicated DNA | •normal growth on antimycin A |
•abnormal protein complex localization | •decreased histone H3-K9 acetylation during vegetative growth | •abolished transcription during vegetative growth | •increased cellular trehalose level during vegetative growth |
•increased cellular trehalose level during heat shock | •altered cellular trehalose level | •decreased cellular trehalose level | •normal cellular trehalose level |
•resistance to water deprivation | •resistance to ethanol | •normal growth during cellular response to freezing | •increased RNA level during cellular response to endoplasmic reticulum stress |
•sensitive to tunicamycin | •decreased histone H3-K14 acetylation during vegetative growth | •increased transcription from CDRE promoter in response to calcium ion | •altered cellular calcium level |
•normal growth on tacrolimus | •resistance to tacrolimus during salt stress | •abnormal mitotic spindle pole body morphology | •fragmented mitotic spindle pole body |
•abnormal alpha,alpha-trehalase activity | •normal alpha,alpha-trehalase activity | •alpha,alpha-trehalase activity increase abolished during cellular response to nutrient | •alpha,alpha-trehalase activity increase abolished during cellular response to heat |
•abnormal cellular response to nutrient | •normal cellular response to oxidative stress | •normal RNA level during cellular response to salt stress | •normal RNA level during cellular response to heat |
•inviable vegetative cell | •inviable elongated vegetative cell | •viable vegetative cell | •viable elongated vegetative cell |
•inviable elongated multinucleate vegetative cell | •inviable elongated multiseptate vegetative cell | •viable elongated multinucleate vegetative cell | •viable elongated multiseptate vegetative cell |
•inviable elongated vegetative cell with mitotic cell cycle arrest in interphase | •sensitive to cytochalasin B | •resistance to cytochalasin B | •sensitive to brefeldin A |
•increased cellular phosphatidylserine level | •normal cellular phosphatidylcholine level | •normal cellular phosphatidylinositol level | •abolished protein localization to chromatin during vegetative growth |
•normal protein localization to chromatin during vegetative growth | •viable vegetative cell, abnormal cell shape, normal cell size | •inviable vegetative cell, abnormal cell shape, normal cell size | •branched, elongated cell |
•normal mitotic sister chromatid segregation | •decreased protein localization to nucleus during vegetative growth | •abnormal telomere tethering at nuclear periphery during vegetative growth | •resistance to mercury |
•resistance to aluminium | •increased cellular glutathione level during vegetative growth | •normal growth on caffeine | •normal growth on leptomycin B |
•resistance to L-thialysine | •sensitive to L-thialysine | •normal GTP binding | •abnormal GTP binding |
•decreased GTP binding | •abnormal GTPase activity | •decreased GTPase activity | •normal duration of mitotic S phase |
•decreased cellular zinc level | •normal cellular zinc level | •normal cellular copper level | •normal cellular iron level |
•normal cellular potassium level | •normal cellular magnesium level | •normal cellular manganese level | •normal cellular molybdenum level |
•normal cellular nickel level | •normal cellular phosphorus level | •normal cellular sulfur level | •normal growth on L-canavanine |
•decreased RNA level during cellular response to zinc ion | •increased RNA level during cellular response to zinc ion starvation | •altered protein level during cellular response to hydrogen peroxide | •altered protein level during cellular response to hypoxia |
•altered protein level during cellular response to zinc ion | •increased cellular zinc level | •abnormal RNA processing | •abnormal tRNA processing |
•formation of abnormal tRNA processing intermediates | •excess nuclear envelope present | •resistance to ethionine | •decreased cellular threonine level |
•decreased cellular citrulline level | •decreased cellular histidine level | •increased cellular glutamate level | •decreased cellular glutathione level during vegetative growth |
•increased protein-protein interaction | •increased RNA level during cellular response to rapamycin | •abnormal bipolar mitotic spindle | •abolished vegetative cell population growth |
•abolished cell population growth on dipeptide nitrogen source | •abolished cell population growth on tetrapeptide nitrogen source | •normal growth on dipeptide nitrogen source | •normal growth on tetrapeptide nitrogen source |
•vacuolated | •resistance to lithium | •abnormal protein localization to cell tip during vegetative growth | •abolished protein localization to cell tip during vegetative growth |
•decreased protein localization to cell tip during vegetative growth | •normal protein localization to cell tip during vegetative growth | •decreased lysine import during vegetative growth | •decreased arginine import |
•normal amino acid import | •altered level of substance in vacuole | •decreased level of substance in vacuole | •normal level of substance in vacuole |
•altered level of substance in cytosol | •decreased level of substance in cytosol | •normal level of substance in cytosol | •decreased vacuolar lysine level |
•decreased vacuolar histidine level | •decreased vacuolar arginine level | •decreased cellular valine level | •decreased cellular isoleucine level |
•decreased cellular lysine level | •decreased cellular arginine level | •normal vacuolar threonine level | •normal vacuolar serine level |
•normal vacuolar asparagine level | •normal vacuolar glycine level | •normal vacuolar alanine level | •normal vacuolar valine level |
•normal vacuolar methionine level | •normal vacuolar isoleucine level | •normal vacuolar leucine level | •normal vacuolar phenylalanine level |
•normal vacuolar tryptophan level | •normal cellular serine level | •normal cellular glycine level | •normal cellular alanine level |
•normal cellular methionine level | •normal cellular leucine level | •normal cellular tyrosine level | •normal cellular phenylalanine level |
•normal cellular tryptophan level | •decreased protein-protein interaction | •abnormal glutamate import | •decreased glutamate import |
•decreased lysine import | •abnormal lysine import | •abnormal lysine import during vegetative growth | •abnormal arginine import |
•altered cellular cAMP level | •decreased cellular cAMP level | •increased cellular cAMP level | •increased cellular cAMP level during cellular response to glucose stimulus |
•decreased cellular cAMP level during cellular response to glucose stimulus | •normal cAMP level | •normal protein processing during vegetative growth | •abolished protein processing during vegetative growth |
•normal GTPase activity | •normal nuclear morphology | •abnormal L-aminoadipate-semialdehyde dehydrogenase activity | •increased protein localization to medial cortex during vegetative growth |
•abolished protein localization to chromatin | •abnormal protein localization to chromatin | •normal alpha,alpha-trehalase activity increase during cellular response to salt stress | •abolished mitotic spindle assembly |
•decreased RNA level during cellular response to purvalanol A | •normal growth on carbendazim | •normal growth on benomyl | •normal growth on brefeldin A |
•normal growth on 4-nitroquinoline N-oxide | •normal growth on camptothecin | •normal growth on paraquat | •sensitive to purvalanol A |
•sensitive to protease inhibitor | •sensitive to bortezomib | •normal mitotic cell cycle checkpoint | •abnormal mitotic cell cycle checkpoint |
•normal mitotic DNA damage checkpoint | •normal mitotic DNA damage checkpoint during cellular response to ionizing radiation | •increased mitotic DNA damage checkpoint activation | •abnormal iron-sulfur cluster binding |
•coenzyme Q10 absent from cell | •sensitive to lithium | •abnormal transport | •increased GTP binding |
•normal cellular aspartate level | •decreased cellular glutamine level | •increased cellular serine level | •increased level of substance in vacuole |
•abnormal mitotic spindle pole body separation | •abolished mitotic spindle pole body separation | •abnormal iron-sulfur cluster transfer | •decreased iron-sulfur cluster transfer |
•increased gross chromosomal rearrangement | •increased chromosomal translocation | •increased isochromosome formation | •abnormal homocitrate synthase activity |
•decreased homocitrate synthase activity | •normal anaerobic cell population growth | •abnormal protein phosphatase activity | •decreased protein phosphatase activity |
•increased protein phosphatase activity | •normal protein phosphatase activity | •normal mitotic G1/S phase transition | •normal tRNA modification |
•normal tRNA methylation | •normal tRNA-Asp C48, C49, C60, C61 and C62 methylation | •abnormal tRNA modification | •abnormal tRNA methylation |
•abolished tRNA-Asp C38 methylation | •increased tRNA-Asp C38 methylation | •normal tRNA methyltransferase activity | •abnormal tRNA methyltransferase activity |
•decreased tRNA methyltransferase activity | •abolished tRNA methyltransferase activity | •abnormal centromere localization | •abnormal centromere clustering at nuclear periphery |
•constricted nucleus | •elongated, constricted nucleus | •excess endoplasmic reticulum membrane present | •normal protein localization to cytoplasm |
•normal protein localization to nucleus during cellular response to oxidative stress | •normal plasmid loss | •abnormal mitotic spindle pole body duplication | •abolished mitotic spindle pole body duplication |
•normal RNA level during cellular response to purvalanol A | •normal growth on purvalanol A | •abnormal translation | •decreased translation |
•cell cycle arrest in mitotic G2 phase during response to DNA damage | •abolished protein localization to cell tip, with protein distributed in plasma membrane or cortex | •altered 5-phosphoribosyl diphosphate level | •increased 5-phosphoribosyl diphosphate level |
•normal cell population growth during iron starvation | •increased level of Okazaki fragments | •normal growth on lithium | •increased number of heterothallic h+ cells |
•mating cassette duplication | •sensitive to chlorpromazine | •sensitive to trifluoperazine | •abnormal glucose import |
•normal growth on gluconate carbon source | •decreased cell population growth on gluconate carbon source | •normal protein localization to spindle pole body | •increased duration of protein localization to mitotic spindle pole body |
•decreased protein phosphorylation during vegetative growth | •normal minichromosome loss | •increased minichromosome loss during vegetative growth | •abnormal adenylyl cyclase activity |
•increased adenylyl cyclase activity | •normal kinetochore organization | •increased duration of mitotic anaphase A | •abnormal ferric-chelate reductase activity |
•decreased transcription during iron starvation | •increased transcription during cellular response to iron | •normal transcription during vegetative growth | •normal transcription during cellular response to iron |
•increased minichromosome loss | •increased minichromosome loss during meiotic cell cycle | •increased minichromosome loss upon segregation during vegetative growth | •mating without glucose starvation |
•normal negative regulation of transcription by glucose | •normal centromere clustering at nuclear periphery | •increased agglutination | •abnormal cell adhesion |
•shmoo formation in absence of opposite mating type | •abnormal asymmetric protein localization to old or new mitotic spindle pole body | •decreased asymmetric protein localization to old or new mitotic spindle pole body | •decreased asymmetric protein localization to old or new mitotic spindle pole body during anaphase, with protein symmetrically localized to both spindle pole bodies |
•viable thin vegetative cell | •viable thin, elongated vegetative cell | •thin cell | •abolished protein localization to cell division site |
•resistance to cell wall-degrading enzymes | •normal growth on caspofungin | •resistance to Calcofluor White | •decreased protein phosphorylation during salt stress |
•meiosis and sporulation in haploid | •substance absent from cell | •RNA absent from cell | •increased RNA level |
•abnormal sporulation resulting in formation of azygotic ascus with more or fewer than four spores | •abnormal sporulation resulting in formation of ascus with more or fewer than four spores | •P-bodies present in increased numbers | •enlarged P-bodies |
•normal septation index | •premature actomyosin contractile ring disassembly | •normal mitotic spindle microtubules | •growth auxotrophic for thiamine |
•increased pre-mRNA level | •normal protein glycosylation during vegetative growth | •abnormal protein glycosylation during vegetative growth | •decreased protein glycosylation during vegetative growth |
•abnormal ubiquitin ligase activity | •abolished ubiquitin ligase activity | •abnormal prospore membrane formation | •abolished prospore membrane formation |
•elongated mononucleate vegetative cell | •inviable elongated mononucleate monoseptate vegetative cell | •fragmented nucleus during vegetative growth | •abolished protein export from nucleus |
•normal protein dephosphorylation during vegetative growth | •inviable after spore germination, without cell division, cell cycle arrest | •normal cellular response to gamma radiation | •normal cellular response to hydroxyurea |
•normal cell cycle regulation during cellular response to ionizing radiation | •normal regulation of mitotic cell cycle | •normal cell cycle regulation during cellular response to hydroxyurea | •abnormal cellular response to gamma radiation |
•abnormal mitotic cell cycle regulation during cellular response to gamma radiation | •abnormal cellular response to hydroxyurea | •abnormal mitotic cell cycle regulation during cellular response to hydroxyurea | •abolished cell population growth on glycerol carbon source |
•abnormal proton-transporting ATP synthase activity, rotational mechanism | •decreased proton-transporting ATP synthase activity, rotational mechanism | •abnormal cytochrome-c oxidase activity | •decreased cytochrome-c oxidase activity |
•abnormal ubiquinol-cytochrome-c reductase activity | •decreased ubiquinol-cytochrome-c reductase activity | •increased duration of lag phase | •abnormal microtubule binding |
•abolished microtubule binding | •normal protein secretion | •abolished mitotic sister chromatid separation | •increased level of substance in cytosol |
•increased cytosolic calcium level | •abnormal calcium import | •decreased calcium import | •spheroid cell |
•spherical cell | •abolished protein phosphatase activity | •sensitive to aculeacin A | •abnormal 1,3-beta-D-glucan synthase activity |
•increased 1,3-beta-D-glucan synthase activity | •abnormal cell separation after cytokinesis resulting in chained cells | •abnormal cell separation after cytokinesis resulting in septated cell | •increased number of cells with 1C DNA content |
•normal cytoplasmic microtubules | •bent mitotic spindle | •normal RNA processing | •decreased rate of DNA replication |
•decreased rate of DNA replication during vegetative growth | •protein absent from cell | •protein absent from cell during vegetative growth | •abnormal phenotype |
•resistance to 5-fluorouracil | •sensitive to high pH | •normal cell population growth at high pH | •sensitive to low pH |
•normal cell population growth at low pH | •inviable after spore germination, without cell division | •RNA absent from cell during nitrogen starvation | •inviable septated mononucleate vegetative cell |
•multiseptate vegetative cell, septa grouped | •abolished RNA polymerase II proximal promoter sequence-specific DNA binding | •microtubules absent from cell | •increased cellular iron level |
•decreased aconitate hydratase activity | •decreased oxygen consumption during vegetative growth | •increased level of iron ion starvation-induced proteins | •normal protein oxidation during vegetative growth |
•increased RNA level during cellular response to iron ion starvation | •sensitive to iron ion starvation | •sensitive to oxygen | •mitotic spindle absent from cell |
•elongated telomeres during vegetative growth | •increased RNA level during nitrogen starvation | •dispersed actin cortical patch localization during vegetative growth | •normal actin cortical patch morphology |
•abnormal septum morphology during vegetative growth | •inviable elongated multinucleate aseptate vegetative cell | •inviable elongated multinucleate vegetative cell with abnormal septum morphology | •actomyosin contractile ring displaced from midpoint |
•angled actomyosin contractile ring | •abnormal cell division, large and small daughter cells | •abnormal actin cable organization | •abnormal actin cable morphology |
•abolished protein phosphorylation during vegetative growth | •abnormal endodeoxyribonuclease activity | •decreased endodeoxyribonuclease activity | •abnormal deadenylation-independent decapping of nuclear-transcribed mRNA |
•decreased deadenylation-independent decapping of nuclear-transcribed mRNA | •abolished deadenylation-independent decapping of nuclear-transcribed mRNA | •decreased RNA level during cellular response to iron ion starvation | •normal premeiotic DNA replication |
•abolished premeiotic DNA replication | •resistance to heat shock | •resistance to stress | •resistance to heat shock during nitrogen starvation |
•normal cell morphology during nitrogen starvation | •elongated multinucleate aseptate vegetative cell | •branched elongated multinucleate aseptate vegetative cell | •swollen elongated multinucleate aseptate vegetative cell |
•normal sporulation frequency | •normal DNA topoisomerase II activity | •cut during cellular response to hydroxyurea | •decreased mitochondrial translation |
•cell population viability | •viable cell population | •inviable cell population | •viable vegetative cell population |
•inviable vegetative cell population | •normal cell growth | •abnormal 3'-5'-exoribonuclease activity | •abolished 3'-5'-exoribonuclease activity |
•inviable elongated aseptate cell | •slow cell population growth during recovery from stationary phase | •growth auxotrophic for histidine | •mislocalized nucleus |
•normal nucleus location | •mislocalized nucleus during vegetative growth | •protein mislocalized to nucleus during cellular response to copper ion | •sensitive to low osmolarity |
•sensitive to TPCK | •normal growth on TPCK | •increased protein ubiquitination during vegetative growth | •inviable swollen elongated cell with enlarged nucleus |
•normal vegetative cell growth | •exocytic vesicles present in increased numbers | •exocytic vesicles present in increased numbers at cell tip during mitotic interphase | •exocytic vesicles present in increased numbers at septum during septum assembly |
•abnormal exocytosis | •lagging chromosomes | •lagging meiotic chromosomes | •abnormal meiotic sister chromatid cohesion |
•decreased meiotic sister chromatid cohesion | •normal meiotic sister chromatid cohesion | •increased protein phosphorylation during cellular response to hydroxyurea | •decreased protein kinase activity during cellular response to hydroxyurea |
•decreased protein phosphorylation during cellular response to hydroxyurea | •normal protein phosphorylation during cellular response to hydroxyurea | •normal mitotic DNA damage checkpoint during cellular response to UV | •inviable swollen mononucleate monoseptate vegetative cell |
•viable vegetative cell with normal cell shape | •viable stubby vegetative cell | •inviable stubby vegetative cell | •viable tapered cell |
•inviable tapered cell | •viable tapered vegetative cell | •inviable tapered vegetative cell | •viable curved vegetative cell |
•inviable curved vegetative cell | •transporter activity phenotype | •normal transporter activity | •abnormal transporter activity |
•abolished transporter activity | •decreased transporter activity | •pyruvylated galactose absent from cell | •abnormal protein localization to plasma membrane during vegetative growth |
•abolished protein localization to plasma membrane during vegetative growth | •increased protein localization to plasma membrane during vegetative growth | •abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm, during vegetative growth | •increased protein phosphorylation during cellular response to heat |
•abolished protein phosphorylation during cellular response to heat | •RNA binding phenotype | •abnormal RNA binding | •abolished RNA binding |
•decreased RNA binding | •increased RNA binding | •abnormal RNA catabolic process during vegetative growth | •decreased RNA catabolic process during vegetative growth |
•increased RNA catabolic process during vegetative growth | •normal cell population growth at low temperature | •altered cellular reactive oxygen species level | •decreased cellular reactive oxygen species level in stationary phase |
•inviable after spore germination, multiple cell divisions, abnormal morphology | •inviable spore population | •inviable spore | •normal telomere structure during vegetative growth |
•normal 1,3-beta-D-glucan synthase activity | •decreased 1,3-beta-D-glucan synthase activity | •normal growth on Calcofluor White | •decreased cell wall thickness during vegetative growth |
•normal growth during cellular response to gamma radiation | •inviable after spore germination, multiple cell divisions, branched, elongated cell | •increased level of nitrogen starvation gene mRNA during vegetative growth | •increased level of meiosis gene mRNA during vegetative growth |
•decreased degradation of DSR-containing RNA | •viable vegetative cell with normal cell size | •viable vegetative cell with normal cell morphology | •inviable normal volume spheroid vegetative cell |
•inviable swollen spheroid vegetative cell | •inviable swollen septated spheroid vegetative cell | •inviable normal volume septated spheroid vegetative cell | •abnormal vegetative cell shape |
•viable vegetative cell with abnormal cell shape | •inviable vegetative cell with normal cell morphology | •inviable stubby septated vegetative cell | •inviable swollen spore |
•inviable after spore germination, without cell division, with elongated, curved germ tube | •viable curved elongated vegetative cell | •normal chromosome disjunction at meiosis I | •increased duration of meiotic cell cycle phase |
•increased duration of meiotic anaphase II | •long meiosis II spindle | •abnormal cell cycle arrest in meiosis II | •abnormally arrested meiotic cell cycle |
•increased cellular triglyceride level | •normal cellular phosphatidylethanolamine level | •normal cellular ergosterol level | •normal cellular sterol ester level |
•sensitive to cerulenin | •shortened telomeres during vegetative growth | •swollen septated spheroid vegetative cell | •inviable elongated tapered vegetative cell |
•increased acid phosphatase activity | •abolished acid phosphatase activity | •abnormal monosaccharide binding | •inviable swollen elongated vegetative cell |
•normal septum location | •abnormal telomere morphology during vegetative growth | •enlarged nucleus | •abnormal nuclear morphology |
•abnormal vacuolar morphology | •small vacuoles present in increased numbers | •normal leucine import | •inviable after spore germination, multiple cell divisions, elongated cell |
•inviable after spore germination, without cell division, cell cycle arrest, elongated cell | •decreased cell wall galactomannan level | •decreased cell wall polysaccharide level | •abnormal glutamate-ammonia ligase activity |
•increased glutamate-ammonia ligase activity | •inviable vegetative cell with abnormal cell morphology | •abnormal protein metabolic process | •abnormal protein degradation |
•increased protein degradation | •inviable after spore germination, single cell division | •inviable after spore germination with abnormal germ tube morphology | •inviable curved septated vegetative cell |
•decreased RNA level during cellular response to osmotic stress | •decreased RNA level during cellular response to heat | •abolished protein phosphorylation during cellular response to osmotic stress | •normal protein phosphorylation during cellular response to osmotic stress |
•inviable after spore germination with elongated germ tube and cell lysis | •dispersed actin cortical patch localization during mitotic interphase | •inviable after spore germination, multiple cell divisions, spheroid cell | •inviable mononucleate monoseptate vegetative cell |
•decreased RNA level during cellular response to salt stress | •decreased RNA level during cellular response to non-ionic osmotic stress | •resistance to ionizing radiation during vegetative growth | •ergosterol absent from cell |
•normal cellular squalene level | •increased cellular ergosterol level | •decreased cellular ergosterol level | •decreased cellular GGPP level |
•decreased cellular lanosterol level | •altered cellular sterol level | •decreased cellular sterol level | •increased cellular sterol level |
•sensitive to terbinafine | •normal growth on pravastatin | •abnormal histone H3-K4 methylation during vegetative growth | •increased histone H3-K4 dimethylation at centromere outer repeat during vegetative growth |
•normal protein localization to Golgi apparatus | •protein localization phenotype | •normal chromatin silencing | •normal chromatin silencing at silent mating-type cassette |
•inviable elongated mononucleate vegetative cell with mislocalized nucleus | •abnormal protein localization to nuclear periphery | •decreased protein localization to nuclear periphery | •decreased DNA recombination during vegetative growth |
•increased duration of mitotic DNA damage checkpoint | •septated vegetative cell | •normal growth on terbinafine | •sensitive to phleomycin |
•sensitive to oxaliplatin | •abnormal chromatin silencing at centromere outer repeat | •abnormal stress granule assembly | •normal stress granule assembly |
•abnormal stress granule disassembly | •delayed onset of stress granule disassembly | •decreased chromatin silencing | •increased level of heterochromatin-encoded proteins |
•decreased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth | •normal RNA binding | •normal histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth | •normal histone H3-K9 dimethylation at telomere during vegetative growth |
•normal chromatin silencing at centromere | •abnormal histone H3 acetylation during vegetative growth | •decreased histone H3 acetylation during vegetative growth | •increased histone H3 acetylation during vegetative growth |
•abnormal histone H4 acetylation during vegetative growth | •increased histone H4 acetylation during vegetative growth | •decreased histone H3-K4 methylation during vegetative growth | •decreased histone H3-K4 dimethylation during vegetative growth |
•decreased histone H3-K4 trimethylation during vegetative growth | •increased histone H3-K56 acetylation at centromere outer repeat during vegetative growth | •abnormal actin cortical patch localization during mitosis | •decreased protein phosphorylation during cellular response to osmotic stress |
•viable swollen vegetative cell | •inviable after spore germination, without cell division, with elongated germ tube | •viable spheroid vegetative cell | •increased histone H3 acetylation at centromere outer repeat during vegetative growth |
•increased histone H3-K9 and H3-K14 acetylation at centromere outer repeat during vegetative growth | •increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere outer repeat during vegetative growth | •decreased protein localization to heterochromatin during vegetative growth | •decreased protein localization to heterochromatin at centromere outer repeat |
•decreased protein localization to subtelomeric heterochromatin during vegetative growth | •normal protein localization to heterochromatin at centromere outer repeat | •normal mitotic sister chromatid cohesion | •decreased protein localization to rDNA |
•abnormal protein acetylation during vegetative growth | •abolished protein acetylation during vegetative growth | •decreased protein acetylation during vegetative growth | •decreased maintenance of protein localization to heterochromatin at centromere outer repeat |
•abnormal cytoskeleton | •abnormal actin cytoskeleton during vegetative growth | •abnormal microtubule cytoskeleton | •single microtubule bundle |
•microtubule bundles present in increased numbers | •viable swollen vegetative cell with abnormal cell shape | •abnormal nucleus | •abnormal endomembrane system |
•viable curved stubby vegetative cell | •inviable after spore germination, single cell division, with elongated germ tube | •inviable vacuolated vegetative cell, abnormal cell shape, normal cell size | •inviable curved elongated vegetative cell |
•inviable swollen vegetative cell | •inviable swollen vegetative cell with abnormal cell shape | •inviable after spore germination, single cell division, abnormal cell shape | •inviable after spore germination, single or double cell division, abnormal cell shape |
•inviable after spore germination, without cell division, septated cells with abnormal cell shape | •normal actin cortical patch localization during mitotic interphase | •abnormal actin cable organization during mitosis | •inviable spore with abnormal shape |
•inviable after spore germination, multiple cell divisions, abnormal cell shape, normal cell size | •inviable after spore germination, multiple cell divisions | •short actin cables | •abnormal actin cables |
•misoriented actin cables | •thick actin cables | •short, misoriented actin cables | •abnormal actin cable distribution |
•decreased rate of actin cable retrograde transport | •normal protein localization to cell division site | •loss of punctate cytoplasmic protein localization | •protein mislocalized to actin cortical patch |
•decreased protein phosphorylation during cellular response to hydrogen peroxide | •abnormal protein N-linked glycosylation during vegetative growth | •normal Dsc complex assembly | •inviable after spore germination, multiple cell divisions, septated cell with abnormal morphology |
•inviable vegetative cell with abnormal cell shape | •inviable septated vegetative cell with abnormal cell morphology | •abnormal septum during vegetative growth | •viable curved vegetative cell with abnormal septum |
•viable branched, elongated vegetative cell | •viable branched, curved, elongated vegetative cell | •inviable branched, elongated vegetative cell | •inviable branched, curved, elongated vegetative cell |
•abnormal spore shape | •decreased protein phosphorylation during cellular response to ionizing radiation | •abolished protein phosphorylation during cellular response to ionizing radiation | •abnormal protein localization to double-strand break site |
•decreased protein localization to double-strand break site | •increased protein localization to double-strand break site | •viable vacuolated vegetative cell, abnormal cell shape, normal cell size | •viable swollen elongated vegetative cell |
•viable after spore germination with elongated germ tube | •inviable spheroid vegetative cell | •increased intergenic meiotic recombination | •decreased intergenic meiotic recombination |
•normal actin cable morphology | •cell lysis | •spore lysis | •inviable after spore germination, multiple cell divisions, swollen cell |
•abnormal DNA 5'-adenosine monophosphate hydrolase activity | •abolished DNA 5'-adenosine monophosphate hydrolase activity | •abnormal protein modification | •normal protein modification |
•normal metabolic process | •abolished protein modification | •decreased protein modification | •increased protein modification |
•normal protein palmitoylation | •normal protein palmitoylation during meiosis | •normal protein palmitoylation during vegetative growth | •abnormal protein palmitoylation |
•abolished protein palmitoylation | •abnormal protein palmitoylation during vegetative growth | •abolished protein palmitoylation during vegetative growth | •abolished protein palmitoylation during meiosis |
•abnormal protein palmitoylation during meiosis | •inviable after spore germination, without cell division, with branched, elongated germ tube | •premature mitotic G2/M phase transition | •abnormal response to mitotic cell cycle checkpoint signaling |
•abolished response to mitotic cell cycle checkpoint signaling | •abolished response to mitotic G2/M transition checkpoint signaling | •decreased frequency of mating with h- cells | •decreased poly(A)+ mRNA export from nucleus |
•sensitive to latrunculin B | •increased duration of protein localization to cell division site | •decreased duration of protein localization to cell division site | •abnormal protein localization to nucleoplasm |
•decreased protein localization to nucleoplasm | •abolished protein localization to nucleoplasm | •delayed onset of protein localization to nucleoplasm | •abnormal protein localization to nucleoplasm during cellular response to hydrogen peroxide |
•decreased protein localization to nucleoplasm during cellular response to hydrogen peroxide | •delayed onset of protein localization to nucleoplasm during cellular response to hydrogen peroxide | •abnormal protein localization to nucleoplasm during cellular response to hydroxyurea | •abolished protein localization to nucleoplasm during cellular response to hydroxyurea |
•increased protein localization to nucleoplasm | •sensitive to trichostatin A | •sensitive to nicotinamide | •sensitive to stress |
•sensitive to UV | •lipid droplets present in decreased numbers | •abnormal double-strand break processing | •normal protein localization to double-strand break site |
•abolished protein localization to medial cortex during vegetative growth | •decreased protein localization to medial cortex during vegetative growth, with protein distributed in cell cortex near non-growing end | •decreased protein localization to medial cortex during vegetative growth | •normal protein localization to medial cortex during vegetative growth |
•normal protein localization to actomyosin contractile ring | •abnormal protein localization to actomyosin contractile ring | •abolished protein localization to actomyosin contractile ring | •delayed onset of protein localization to actomyosin contractile ring |
•normal protein localization to nuclear periphery | •abolished histone methylation during vegetative growth | •abolished histone H3-K9 methylation during vegetative growth | •normal centromeric outer repeat transcript level |
•abolished protein localization to nuclear periphery | •decreased cellular dGTP level | •decreased cellular dTTP level | •increased number of Ssb1 foci |
•normal protein localization to centromere | •abnormal chromatin binding | •decreased chromatin binding | •resistance to hydroxyurea |
•altered mature tRNA level during vegetative growth | •normal mature tRNA level | •decreased mature tRNA level during vegetative growth | •increased level of mitochondrial polycistronic RNA precursors |
•abnormal histone phosphorylation during vegetative growth | •abolished histone phosphorylation during vegetative growth | •decreased histone phosphorylation during vegetative growth | •increased histone phosphorylation during vegetative growth |
•normal histone phosphorylation during vegetative growth | •increased histone H2A phosphorylation during vegetative growth | •abolished histone H2A phosphorylation during vegetative growth | •decreased histone H2A phosphorylation during vegetative growth |
•abnormal histone H2A phosphorylation during vegetative growth | •normal histone modification during vegetative growth | •normal histone H2A phosphorylation during vegetative growth | •abolished histone H2A phosphorylation at mating type locus during mitotic S phase |
•increased histone H2A phosphorylation at rDNA during vegetative growth | •decreased histone H2A phosphorylation at subtelomeric heterochromatin during mitotic S phase | •normal histone H2A phosphorylation at mating type locus during vegetative growth | •abnormal protein localization to pre-autophagosomal structure |
•decreased protein localization to pre-autophagosomal structure | •increased protein localization to pre-autophagosomal structure | •sensitive to sodium butyrate | •normal growth on valproic acid |
•normal growth on sodium butyrate | •normal growth on trichostatin A | •decreased RNA level during cellular response to glucose stimulus | •decreased punctate nuclear protein localization |
•resistance to heat | •altered level of substance in cell wall | •decreased level of substance in cell wall | •irregular cell wall during vegetative growth |
•resistance to cobalt | •normal protein ubiquitination during vegetative growth | •delayed onset of mitotic spindle elongation | •normal growth on hygromycin B |
•increased activation of mitotic cell cycle spindle assembly checkpoint | •increased interkinetochore distance before mitotic anaphase | •sensitive to clotrimazole | •sensitive to micafungin |
•sensitive to amphotericin B | •normal growth on clotrimazole | •elongated kinetochore during mitosis | •split kinetochore during vegetative growth |
•merotelic kinetochore attachment | •excess intracellular endomembrane system present | •decreased vacuolar import | •decreased actin filament binding |
•normal occurrence of activation of bipolar cell growth | •increased cellular trehalose 6-phosphate level | •decreased cellular trehalose level during heat shock | •alpha,alpha-trehalase activity increase abolished during cellular response to hydrogen peroxide |
•increased level of stress responsive gene mRNA during vegetative growth | •abnormal peptide-serine-N-acetyltransferase activity | •decreased peptide-serine-N-acetyltransferase activity | •normal growth on rapamycin |
•normal growth on torin1 | •normal protein localization to plasma membrane | •abnormal protein phosphorylation | •abolished protein phosphorylation |
•decreased protein phosphorylation | •increased protein phosphorylation | •increased protein phosphorylation during nitrogen starvation | •increased resistance to chemical |
•increased sensitivity to chemical | •increased cellular trehalose level | •normal telomere length during vegetative growth | •mitotic spindle collapse without elongation during prophase |
•sensitive to cumene hydroperoxide | •normal growth on menadione | •sensitive to paraquat | •resistance to diamide |
•abnormal methylenetetrahydrofolate reductase (NADPH) activity | •decreased methylenetetrahydrofolate reductase (NADPH) activity | •increased methylenetetrahydrofolate reductase (NADPH) activity | •decreased protein localization to actomyosin contractile ring |
•increased protein kinase activity | •sensitive to torin1 | •circularized chromosome | •sensitive to methionine |
•resistance to cordycepin | •abolished prospore formation | •abnormal nuclear separation after meiosis | •decreased DNA recombination |
•protein mislocalized to Golgi apparatus | •normal vacuole fusion during vegetative growth | •normal vacuole fusion during cellular hypotonic response | •abnormal protein localization to septum |
•decreased protein localization to septum | •sensitive to beta-glucanase | •resistance to alpha-glucanase | •phytochelatin absent from cell |
•increased cellular pigment accumulation during cellular response to cadmium ion | •inviable after spore germination, single or double cell division, elongated cell | •decreased L-aminoadipate-semialdehyde dehydrogenase activity | •inviable swollen elongated cell with enlarged nucleus upon entry into stationary phase |
•DNA content increased | •mononucleate | •inviable after spore germination, multiple cell divisions, elongated tapered cell | •abnormal cell cycle process |
•abnormal cell cycle phase | •abnormal mitotic cell cycle phase | •abnormal mitotic cell cycle process | •abnormal meiotic cell cycle phase |
•abnormal meiotic cell cycle process | •normal mitotic cell cycle phase | •normal mitotic cell cycle process | •increased level of iron transport gene mRNA during vegetative growth |
•increased level of amino acid metabolism gene mRNA during vegetative growth | •normal cellular proline level | •normal cellular valine level | •normal cellular lysine level |
•decreased cellular alanine level | •decreased cellular asparagine level | •abolished cell population growth on sulfate sulfur source | •abnormal cysteine synthase activity |
•decreased cysteine synthase activity | •short cytoplasmic microtubules | •abnormal microtubule bundle formation | •resistance to clotrimazole |
•resistance to terbinafine | •decreased protein ubiquitination during vegetative growth | •abnormal protein localization to spindle pole body | •decreased protein localization to spindle pole body |
•abnormal protein localization to meiotic spindle pole body | •decreased protein localization to meiotic spindle pole body | •third meiotic division | •increased level of ubiquitinated protein in cell during vegetative growth |
•decreased level of sumoylated protein in cell | •normal level of sumoylated protein in cell | •abnormal protein sumoylation during vegetative growth | •decreased protein sumoylation during vegetative growth |
•abolished protein localization to nucleus, with protein mislocalized to cytoplasm, during vegetative growth | •decreased cellular reactive oxygen species level during vegetative growth | •small vacuoles | •small vacuoles during vegetative growth |
•vacuoles present in increased numbers | •small vacuoles present in increased numbers during cellular hypotonic response | •vacuoles present in decreased numbers during vegetative growth | •abnormal vacuole |
•large vacuoles present in decreased numbers during vegetative growth | •abnormal protein degradation during nitrogen starvation | •decreased protein degradation | •decreased protein degradation during nitrogen starvation |
•normal protein degradation | •normal protein degradation during vegetative growth | •normal protein degradation during nitrogen starvation | •nucleus mislocalized to cell cortex during nitrogen starvation |
•abnormal vacuole organization | •sensitive to arsenate | •normal growth on arsenate | •sensitive to non-ionic osmotic stress |
•decreased cellular glycerol level | •decreased cellular glycerol level during cellular response to salt stress | •abnormal protein localization to cell surface | •inviable after spore germination, without cell division, multinucleate cell with elongated germ tube |
•abnormally arrested meiosis I | •microtubule bundles present in decreased numbers | •abolished histone H3-K9 methylation at telomere during vegetative growth | •decreased protein localization to mitotic spindle pole body during mitosis |
•abnormal protein localization to mitotic spindle | •decreased protein localization to mitotic spindle | •normal gamma-tubulin complex assembly | •decreased chromatin silencing at silent mating-type cassette |
•decreased cellular phytochelatin level | •delayed onset of protein phosphorylation during vegetative growth | •decreased chromatin silencing at centromere | •centromeric outer repeat transcript-derived siRNA absent |
•increased centromeric outer repeat transcript-derived siRNA level | •normal centromeric outer repeat transcript-derived siRNA level | •abnormal protein localization to chromosome during vegetative growth | •decreased protein localization to chromosome during vegetative growth |
•increased protein localization to chromosome during vegetative growth | •abolished protein localization to chromosome during vegetative growth | •decreased protein localization to centromere outer repeat | •inviable swollen elongated septated vegetative cell |
•T-shaped cell during recovery from stationary phase | •curved cell during recovery from stationary phase | •increased protein localization to cell tip during vegetative growth | •abnormal glutamate-cysteine ligase activity |
•increased (1->3)-beta-D-glucan level at cell tip | •abolished protein localization to non-growing cell tip | •abnormal cell growth | •resistance to 5-fluoroorotic acid |
•sensitive to polypeptone | •decreased protein localization to cell division site | •increased protein localization to non-growing cell tip | •decreased protein localization to growing cell tip |
•abnormal endoplasmic reticulum localization | •normal septum orientation | •premature protein localization to medial cortex during vegetative growth | •increased transcription |
•decreased transcription | •abolished transcription | •increased transcription during glucose starvation | •normal transcription |
•normal transcription during glucose starvation | •normal protein localization to telomere during vegetative growth | •mitotic cell cycle arrest before cell separation | •inviable elongated vegetative cell with abnormal septum |
•abnormal horsetail nucleus morphology | •normal chromatin organization during vegetative growth | •normal heterochromatin organization during vegetative growth | •decreased transcription during cellular response to calcium ion |
•increased transcription during cellular response to calcium ion | •normal transcription during cellular response to calcium ion | •decreased protein phosphorylation during cellular response to DNA damage | •abolished protein phosphorylation during cellular response to DNA damage |
•normal protein phosphorylation during cellular response to DNA damage | •abnormal mitotic DNA damage checkpoint during cellular response to UV | •normal protein localization to kinetochore during vegetative growth | •decreased protein localization to kinetochore during vegetative growth |
•viable pear-shaped vegetative cell | •inviable pear-shaped vegetative cell | •normal telomere maintenance | •increased transcription at telomere |
•decreased protein localization to chromatin during vegetative growth | •inviable after spore germination, without cell division, with swollen elongated germ tube | •inviable after spore germination, without cell division, elongated multinucleate cell | •increased antisense RNA transcription |
•abnormal RNA splicing | •increased RNA splicing | •abolished histone H3-K4 methylation during vegetative growth | •abnormal histone H3-K36 methylation during vegetative growth |
•abolished histone H3-K36 methylation during vegetative growth | •normal histone H3-K36 methylation during vegetative growth | •abnormal histone ubiquitination during vegetative growth | •abolished histone H2B-K119 ubiquitination during vegetative growth |
•decreased cell population growth on maltose carbon source | •decreased protein localization to chromosome at CRE promoter | •abolished poly(A) RNA binding | •decreased poly(A) RNA binding |
•normal poly(A) tail length | •abnormal poly(A) tail length | •increased poly(A) tail length | •decreased mature snoRNA level |
•increased mature snoRNA level | •decreased pre-mRNA level | •normal nuclear mRNA catabolic process | •normal growth on micafungin |
•swollen spheroid cell | •increased RNA level during G0 | •abnormal cell wall | •abnormal cell wall morphology |
•delaminated cell wall | •increased level of substance in cell during G0 | •increased L-ergothioneine level during G0 | •abnormal G0 to G1 transition |
•abnormal protein localization to nucleus | •abnormal protein localization to nucleus during meiosis | •abnormal protein localization to Mei2 nuclear dot | •decreased RNA level during meiosis |
•increased level of DSR-containing meiosis gene mRNA during vegetative growth | •abolished protein localization to Mei2 nuclear dot | •abnormal protein localization to Mmi1 focus | •normal protein localization to nucleolus |
•normal protein localization to mitotic spindle | •normal protein localization to mitotic spindle pole body | •increased protein localization to mitotic spindle pole body | •increased protein localization to mitotic spindle pole body during metaphase |
•increased ubiquitin ligase activity | •decreased RNA level during cellular response to hydroxyurea | •decreased protein localization to chromatin at MCB promoters during cellular response to hydroxyurea | •increased protein localization to chromatin during cellular response to methyl methanesulfonate |
•increased chromatin binding | •normal RNA level during cellular response to methyl methanesulfonate | •increased RNA level during cellular response to methyl methanesulfonate | •inviable after spore germination, without cell division, swollen binucleate cell with central constriction |
•sensitive to ammonium | •increased level of transmembrane transport gene mRNA during vegetative growth | •decreased protein phosphorylation during cellular response to methyl methanesulfonate | •normal regulation of DNA replication |
•abolished actomyosin contractile ring assembly, clumped medial cortical nodes | •normal protein localization to medial cortical node | •abolished actin filament polymerization | •actin filaments present in increased numbers |
•decreased protein localization to centromere during mitotic metaphase | •increased protein localization to kinetochore during vegetative growth | •increased cellular reactive oxygen species level during vegetative growth | •inviable after spore germination, without cell division, with swollen, branched, elongated germ tube |
•increased protein localization to centromere outer repeat | •increased protein localization to subtelomeric heterochromatin during vegetative growth | •increased protein localization to chromatin | •mitosis with unreplicated DNA |
•abnormal actomyosin contractile ring disassembly | •decreased rate of actomyosin contractile ring disassembly | •cell lysis during cellular response to salt stress | •abnormal protein autophosphorylation during vegetative growth |
•abolished protein autophosphorylation during vegetative growth | •abnormal homologous chromosome pairing | •decreased homologous chromosome pairing | •normal poly(A)+ mRNA export from nucleus |
•normal actin cortical patch localization during mitosis | •decreased mRNA splicing, via spliceosome | •mating without nitrogen starvation | •decreased RNA level during glucose starvation |
•increased RNA level during glucose starvation | •decreased RNA level during cellular response to UV | •normal RNA level during cellular response to UV | •normal transcription during cellular response to UV |
•abnormal cell phenotype | •abnormal RNA stability | •decreased RNA stability during cellular response to UV | •decreased RNA splicing |
•decreased snRNA splicing | •abolished protein localization to Mmi1 focus | •abnormal heterochromatin assembly | •heterochromatin assembly beyond boundary element IRC1R |
•abnormal transcript length | •increased transcriptional readthrough | •normal homologous chromosome pairing | •normal homologous chromosome pairing at cis-acting homologous chromosome pairing region |
•abnormal homologous chromosome pairing at cis-acting homologous chromosome pairing region | •Mei2 nuclear dot absent from cell | •abnormal RNA localization | •normal RNA localization |
•twin haploid meiosis | •abnormal nuclear migration during mating | •abnormal cytoskeleton morphology | •abnormal microtubule cytoskeleton morphology |
•abnormal sporulation resulting in formation of ascus with fewer than four spores | •abnormal replication fork reversal | •decreased protein localization to chromatin at replication forks during cellular response to hydroxyurea | •normal protein localization to chromatin at replication forks during cellular response to hydroxyurea |
•abnormal primary amine oxidase activity | •decreased primary amine oxidase activity | •abolished protein localization to nuclear centromeric heterochromatin | •normal protein kinase activity |
•normal protein autophosphorylation during vegetative growth | •increased protein autophosphorylation during vegetative growth | •abnormal genetic imprinting at mating-type locus | •abolished genetic imprinting at mating-type locus |
•decreased genetic imprinting at mating-type locus | •normal genetic imprinting at mating-type locus | •abnormal replication fork arrest at mating-type locus | •abolished replication fork arrest at mating-type locus |
•decreased replication fork arrest at mating-type locus | •normal chromatin binding | •normal chromatin binding at mating-type region replication fork barrier | •abnormal replication fork arrest |
•abnormal replication fork arrest at rDNA repeats | •decreased replication fork arrest at rDNA repeats | •decreased chromatin binding at mating-type region replication fork barrier | •decreased centromeric outer repeat transcript level |
•viable elongated vegetative cell, with progressive elongation | •decreased histone H3-K9 methylation at centromere outer repeat during vegetative growth | •abolished histone H3-K9 methylation at centromere outer repeat during vegetative growth | •abnormal heterochromatin assembly at centromere outer repeat during vegetative growth |
•decreased heterochromatin assembly at protein coding gene | •increased histone H3-K9 methylation at protein coding gene during vegetative growth | •decreased mRNA-derived small RNA level | •increased transposable element-derived small RNA level |
•stable shortened telomeres during vegetative growth | •progressively shortening telomeres during vegetative growth | •abnormal protein localization to telomere during vegetative growth | •abolished protein localization to telomere during vegetative growth |
•abnormal ubiquitinyl hydrolase activity | •increased ubiquitinyl hydrolase activity | •resistance to sodium nitroprusside | •normal cellular reactive oxygen species level during vegetative growth |
•increased nuclear polyadenylated mRNA level during vegetative growth | •decreased transcription during glucose starvation | •normal rate of homologous chromosome pairing at cis-acting homologous chromosome pairing region | •abolished protein localization to nuclear periphery during cellular response to heat |
•abnormal cytoplasmic translation | •decreased cytoplasmic translational initiation | •post-anaphase array absent from cell | •decreased cellular nitric oxide level during vegetative growth |
•inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic M phase | •loss of punctate nuclear protein localization during cellular response to ionizing radiation | •premature mitotic G1 phase entry during cellular response to ionizing radiation | •normal protein phosphorylation during cellular response to ionizing radiation |
•normal punctate nuclear localization during cellular response to ionizing radiation | •normal agglutination | •excess plasma membrane present | •abnormal ascospore wall morphology |
•abnormal sporulation resulting in formation of ascus containing anucleate spores | •decreased RNA level during cellular response to methyl methanesulfonate | •decreased protein level during cellular response to methyl methanesulfonate | •normal protein level during cellular response to methyl methanesulfonate |
•decreased activation of bipolar cell growth | •decreased protein level during cellular response to heat | •increased protein level during cellular response to heat | •abnormal vegetative cell growth |
•intermittent monopolar cell growth | •abnormal maintenance of protein location at growing cell tip | •elongated cell during stationary phase | •RNA absent from cell during vegetative growth |
•RNA absent from cell during cellular response to salt stress | •abnormal nuclease activity | •abolished nuclease activity | •cut with abnormal chromosome segregation |
•monoseptate vegetative cell with binucleate and anucleate compartments | •increased amino acid import during vegetative growth | •increased arginine import | •binucleate monoseptate cell with mitotic cell cycle arrest before cell separation |
•normal meiotic chromosome segregation | •abnormal meiotic homologous chromosome biorientation | •normal meiotic sister chromatid segregation | •decreased intragenic meiotic recombination |
•abolished meiotic DNA double-strand break formation | •unequal meiotic sister chromatid segregation | •normal growth on phleomycin | •normal protein localization to cytoskeleton during vegetative growth |
•normal protein localization to microtubule cytoskeleton during mitotic interphase | •abolished protein localization to mitotic spindle | •protein mislocalized to astral microtubule during mitosis | •abnormal protein import into nucleus during vegetative growth |
•decreased protein import into nucleus | •decreased rate of cytoplasmic microtubule depolymerization | •abolished protein localization to nucleus during mitosis | •normal rate of microtubule depolymerization |
•increased rate of microtubule depolymerization during vegetative growth | •altered RNA level during cellular response to phosphate starvation | •altered RNA level during cellular response to iron ion starvation | •altered RNA level during cellular response to copper ion starvation during vegetative growth |
•altered RNA level during cellular response to osmotic stress | •decreased rate of primary cell septum biogenesis | •actomyosin contractile ring contraction uncoupled from septum assembly | •curved septum |
•decreased primary cell septum thickness | •decreased protein-protein interaction during cellular response to salt stress | •decreased protein-protein interaction during cellular response to hydrogen peroxide | •decreased protein localization to cell tip, with protein distributed in plasma membrane or cortex |
•abolished protein localization to cell tip, with protein mislocalized to cytoplasm | •mislocalized, misoriented septum | •abnormal secondary cell septum biogenesis | •kinked septum |
•normal protein phosphorylation during cellular response to glucose starvation | •normal protein-protein interaction during cellular response to hydrogen peroxide | •decreased chromatin silencing at rDNA | •decreased transcriptional repression at centromere central core |
•abolished tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis | •normal histone acetylation during vegetative growth | •normal histone H3-K9 acetylation during vegetative growth | •normal histone H3-K14 acetylation during vegetative growth |
•normal rate of microtubule polymerization | •delayed onset of protein localization to mitotic spindle | •interphase microtubules present during mitosis | •abolished protein oxidation during cellular response to hydrogen peroxide |
•decreased histone H3-K9 methylation at heterochromatin island during vegetative growth | •decreased histone H3-K9 methylation at heterochromatin domain during vegetative growth | •normal histone H3-K9 methylation during vegetative growth | •normal histone H3-K9 methylation at heterochromatin island during vegetative growth |
•normal histone H3-K9 methylation at centromere outer repeat during vegetative growth | •increased RNA splicing at cryptic splice sites | •decreased anaerobic cell population growth | •unequal mitotic sister chromatid segregation |
•decreased splicing of mRNA introns with low A/U content | •intron-specific abnormal mRNA splicing, via spliceosome | •telophase nuclear clustering | •normal mitotic S phase progression |
•abolished histone H3 binding | •increased level of histone H3 at centromere inner repeat | •decreased level of histone H3 at dh repeat | •premature septum assembly |
•decreased transcription from SRE promoter | •abnormal proline import | •decreased proline import | •abnormal sporulation resulting in formation of ascus with more than four spores |
•overlapping meiosis I spindles | •normal alpha,alpha-trehalase activity increase during cellular response to heat stress | •normal acid phosphatase activity | •decreased rate of mitotic spindle elongation |
•abolished protein localization to microtubule during vegetative growth | •growth auxotrophic for glutathione | •normal growth on sodium hypochlorite | •normal growth on nitrite |
•normal growth on GSNO | •abolished protein localization to microtubule during mitosis | •abnormal plasma membrane | •excess Golgi cisternae present |
•decreased RNA level during cellular response to copper ion starvation during vegetative growth | •abnormal superoxide dismutase activity | •decreased superoxide dismutase activity | •abnormal copper import |
•decreased copper import | •decreased mitotic chromosome condensation | •abnormal protein localization to medial cortical node | •abnormal glycoprotein glycan structure |
•normal growth on amitrole | •abolished ribosome binding | •decreased protein autophosphorylation during vegetative growth | •decreased protein degradation via N-end rule pathway during vegetative growth |
•nucleus mislocalized towards cell tip during mitotic interphase | •mislocalized post-anaphase array | •abnormal mitotic spindle midzone assembly | •separate mitotic half spindles present |
•decreased mitotic index | •increased mitotic index | •normal protein localization to mitotic spindle pole body during interphase | •inviable after spore germination, without cell division, mononucleate cell with elongated germ tube |
•activation of monopolar cell growth at new end | •actin cables absent from cell | •normal protein localization to growing cell tip | •decreased protein localization to growing cell tip, with protein distributed in plasma membrane or cortex |
•abolished galactose-specific flocculation | •abnormal succinate dehydrogenase (ubiquinone) activity | •normal interphase microtubule nucleation | •curved interphase microtubules |
•misoriented interphase microtubules | •abolished protein localization to cell tip during mitotic interphase | •normal protein localization to new mitotic spindle pole body | •decreased protein kinase activity during mitotic interphase |
•normal protein kinase activity during mitotic interphase | •inviable lemon-shaped cell | •normal protein localization to septin ring | •increased galactose-specific flocculation |
•increased protein localization to septum | •abnormal actomyosin contractile ring morphology | •decreased rate of actomyosin contractile ring assembly | •decreased re-entry into mitotic cell cycle during recovery from stationary phase |
•multinucleate | •elongated multinucleate cell | •elongated multinucleate multiseptate cell, single septa between nuclei | •elongated multinucleate multiseptate cell, single septa between nuclei, during stationary phase |
•abolished cell cycle arrest in mitotic G1 phase in response to nitrogen starvation | •abnormal meiotic recombination at silent mating-type cassette | •altered substrate specificity | •normal protein localization to mitotic spindle midzone during anaphase B |
•abolished protein localization to mitotic spindle midzone during anaphase B | •increased duration of protein localization to kinetochore during vegetative growth | •decreased DNA double-strand break formation at mating-type locus | •normal DNA double-strand break formation at mating-type locus |
•decreased galactose level in glycoprotein glycan | •growth auxotrophic for sulfur-containing amino acid | •sensitive to filipin | •sensitive to miconazole |
•sensitive to myriocin during vegetative growth | •abolished superoxide dismutase activity | •normal protein acetylation during vegetative growth | •abolished cytogamy |
•abolished protein localization to actomyosin contractile ring, with protein mislocalized to cytoplasm | •RNA absent from cell during meiosis | •abnormal cell cycle arrest in mitotic G2 phase | •normal cellular coenzyme Q10 level |
•resistance to nitrogen starvation | •abolished meiosis I | •abolished meiosis II | •decreased frequency of meiosis I |
•resistance to tert-butyl hydroperoxide | •sensitive to chromium | •increased superoxide dismutase activity | •decreased catalase activity |
•viable elongated vegetative cell with swollen medial region | •resistance to ricinoleic acid | •resistance to methylglyoxal | •resistance to glyoxal |
•sensitive to methylglyoxal | •abnormal CENP-A containing nucleosome assembly | •increased spatial extent of CENP-A containing nucleosome assembly | •decreased chromatin silencing at centromere inner repeat |
•decreased chromatin silencing at centromere outer repeat | •inviable branched, elongated, multiseptate vegetative cell | •normal protein localization to septum | •increased histone H4 acetylation at centromere central core during vegetative growth |
•cytoplasmic vesicles present in increased numbers | •increased microtubule dwell time at cell tip | •inviable after spore germination, multiple cell divisions, elongated multiseptate tapered cell | •decreased mitochondrial RNA level |
•increased mitochondrial RNA level | •abolished protein-protein interaction during cellular response to rapamycin | •decreased RNA level during cellular response to pheromone | •decreased queuosine level in tRNA |
•short interphase microtubules present in decreased numbers | •microtubules present in decreased numbers | •abnormal ornithine carbamoyltransferase activity | •decreased ornithine carbamoyltransferase activity |
•decreased protein kinase activity during mitotic G2 phase | •abolished protein kinase activity during mitotic G1 phase | •mitotic G1/S phase transition delay following nitrogen starvation-induced G1 phase arrest | •branched septum |
•cell lysis during cytokinesis | •normal protein localization to actin cytoskeleton | •abolished protein localization to actin cable | •abnormal medial cortical node condensation |
•increased duration of mitotic DNA damage checkpoint during cellular response to UV | •decreased level of glycosylated protein in cell | •abnormal cell cycle arrest at mitotic G1/S phase transition | •abolished protein localization to nucleus |
•abolished protein localization to nucleus during meiotic anaphase II | •mislocalized protein | •protein mislocalized to nucleus | •alpha,alpha-trehalase activity increase abolished during cellular response to salt stress |
•normal cellular trehalose level during cellular response to salt stress | •normal cellular trehalose level during cellular response to oxidative stress | •altered splice site specificity | •normal RNA splicing |
•increased mRNA splicing, via spliceosome | •abnormal arsenate reductase activity | •decreased arsenate reductase activity | •queuosine absent from tRNA |
•viable elongated vegetative cell, elongated upon mitotic entry | •increased punctate cytoplasmic protein localization | •decreased punctate nuclear protein localization during cellular response to ionizing radiation | •abolished protein localization to mitotic spindle midzone |
•abolished protein localization to double-strand break site | •cut during cellular response to ionizing radiation | •abnormal mitotic cell cycle regulation during cellular response to ionizing radiation | •increased duration of mitotic DNA damage checkpoint during cellular response to ionizing radiation |
•sensitive to UV during mitotic G1 phase | •resistance to beta-glucanase | •sensitive to L-azetidine-2-carboxylic acid | •premature mitotic DNA replication initiation |
•viable branched, elongated, multiseptate vegetative cell | •inviable aseptate mononucleate vegetative cell, normal cell length | •normal vegetative cell length | •normal growth on copper |
•normal growth on zinc | •normal growth on mercury | •increased cellular L-ergothioneine level during vegetative growth | •increased cellular hercynine level during vegetative growth |
•increased cellular hercynylcysteine sulfoxide level during vegetative growth | •decreased cellular L-ergothioneine level | •increased cellular hercynylcysteine sulfoxide level | •protein mislocalized to cell tip |
•inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells | •normal S-phase DNA damage checkpoint | •increased monopolar index | •increased bipolar index |
•decreased bipolar index | •increased septation index in stationary phase | •decreased rate of premeiotic DNA replication | •premature meiosis I |
•decreased regional homologous chromosome pairing | •normal protein localization to meiotic spindle pole body | •abolished protein localization to meiotic spindle pole body | •increased number of double-strand break sites |
•increased number of double-strand break sites during meiotic cell cycle | •increased duration of mitotic cell cycle DNA replication checkpoint | •increased DNA damage | •increased DNA damage during vegetative growth |
•abolished mitotic G1/S phase transition following nitrogen starvation-induced G1 phase arrest | •abnormal protein localization during meiosis | •decreased protein level during meiosis | •abnormal RNA catabolic process |
•decreased RNA catabolic process | •increased RNA catabolic process | •normal chromatin silencing at telomere | •abnormal transcription termination |
•increased antisense RNA level | •increased repeat element RNA level | •sensitive to doxorubicin | •abnormal spindle pole body organization |
•abnormal prospore-specific spindle pole body remodeling | •normal horsetail nucleus morphology | •normal meiosis I | •abnormal meiotic DNA double-strand break formation |
•increased protein phosphorylation during meiosis I | •delayed onset of mitotic spindle pole body separation | •abnormal establishment of mitotic spindle pole body localization to nuclear envelope | •spindle pole body unanchored to nuclear envelope |
•abnormal establishment of mitotic spindle pole body localization to nuclear envelope, with spindle pole body in cytoplasm | •normal attachment of spindle microtubules to kinetochore | •decreased histone H3-K9 methylation at silent mating-type cassette during vegetative growth | •decreased histone H3-K9 methylation at subtelomeric heterochromatin during vegetative growth |
•decreased protein localization to heterochromatin at silent mating-type cassette | •normal histone H3-K14 acetylation at centromere outer repeat during vegetative growth | •normal histone H3-K9 acetylation at centromere outer repeat during vegetative growth | •normal protein localization to subtelomeric heterochromatin |
•abolished plasma membrane to vacuole transport after nitrogen starvation | •abnormal vacuolar transport | •normal RNA level during meiosis | •increased number of Sad1 foci during response to DNA damage |
•increased double-strand break repair via nonhomologous end joining | •decreased anaphase-promoting complex-dependent protein catabolic process | •abnormal replication fork processing | •loss of gross chromosomal rearrangement during replication fork processing |
•decreased replication slippage during replication fork processing | •abnormal protein complex binding | •abolished anaphase-promoting complex-dependent protein catabolic process | •normal anaphase-promoting complex-dependent protein catabolic process |
•S-shaped cell | •abnormal snRNA 3'-end processing | •increased rRNA precursor level | •decreased rRNA precursor level |
•abolished mRNA splicing, via spliceosome | •abnormal meiosis I | •sister chromatid separation during meiosis I | •decreased duration of meiotic prophase I |
•abnormal spindle morphology | •increased protein level during meiosis | •viable spore population | •normal meiotic sister chromatid cohesion during meiotic prophase I |
•decreased meiotic DNA double-strand break formation | •normal mRNA splicing, via spliceosome | •normal pre-mRNA level | •abnormal microtubule cytoskeleton morphology during mitotic interphase |
•normal protein localization to shmoo tip | •normal protein localization | •abnormal ribonucleoprotein complex assembly | •abolished U2-type prespliceosome assembly |
•abnormal ribonucleoprotein complex binding | •abolished cell wall biogenesis | •abnormal urease activity | •decreased protein level during cellular response to glucose starvation |
•sensitive to vanadate | •protein mislocalized to endoplasmic reticulum during vegetative growth | •normal protein localization to Golgi membrane | •abnormal mating type switching resulting in duplication or deletion in mating-type region |
•decreased double-strand break repair during vegetative growth | •abnormal double-strand break repair via nonhomologous end joining | •abnormal crossover junction endodeoxyribonuclease activity | •abolished crossover junction endodeoxyribonuclease activity |
•resistance to caffeine during cellular response to hydroxyurea | •exon skipping | •sensitive to mycophenolic acid | •abnormal ATP binding |
•abolished ATP binding | •abolished ATPase activity | •increased mature 5.8SL rRNA level | •increased cellular doxorubicin level |
•sensitive to epirubicin | •decreased protein level at centromere outer repeat | •inviable after spore germination, without cell division, elongated multinucleate aseptate cell | •altered level of macromolecular complex |
•abnormal protein localization to nucleolus | •abolished protein localization to nucleolus | •abolished cell population growth on glycerol/ethanol carbon source | •increased protein phosphorylation during cellular response to oxidative stress |
•decreased mature 18S rRNA level | •abnormal dense body present in nucleolus | •snoRNA guided rRNA pseudouridine synthesis abolished at specific site | •increased snoRNA primary transcript level |
•poly(A)+ RNA-containing focus present in nucleus | •normal microtubule cytoskeleton morphology during vegetative growth | •normal growth on K-252a | •swollen pear-shaped vegetative cell |
•lateral cortical nodes absent from cell | •abolished protein localization to lateral cortical node | •abolished protein localization to lateral cortical node, with protein distributed in plasma membrane or cortex | •normal actin cytoskeleton morphology during vegetative growth |
•sensitive to tributyltin | •normal growth on tributyltin | •normal growth on G418 | •abolished cell population growth on galactose carbon source |
•normal growth on galactose carbon source | •abnormal alcohol dehydrogenase activity | •decreased alcohol dehydrogenase activity | •normal mitotic index |
•abnormal mitotic cell cycle arrest with condensed chromosomes | •decreased CENP-A containing nucleosome assembly | •inviable after spore germination, multiple cell divisions, unequal chromosome segregation | •decreased cell population growth during glucose starvation |
•abolished protein localization to centromeric chromatin during vegetative growth | •increased histone H3-K9 methylation at heterochromatin island during vegetative growth | •normal level of DSR-containing meiosis gene mRNA during vegetative growth | •abnormal protein localization to nuclear body |
•normal nuclear envelope morphology | •increased total nuclear polyadenylated mRNA level during vegetative growth | •abnormal vegetative cell phenotype | •incomplete mitotic sister chromatid segregation |
•mitotic spindle elongation without chromosome separation | •inviable after spore germination, single or double cell division, arrest with single nucleus | •inviable after spore germination, single or double cell division, arrest with cut | •normal mitotic spindle assembly checkpoint |
•inviable aseptate mononucleate vegetative cell | •normal protein localization to mitochondrion | •decreased cellular mtDNA level | •decreased transcriptional response to pheromone |
•decreased protein localization to plasma membrane of cell tip during vegetative growth | •increased pseudohyphal growth | •abnormal protein localization to endoplasmic reticulum during vegetative growth | •decreased protein localization to endoplasmic reticulum tubular network |
•abnormal nuclear envelope morphology during mitosis | •abnormal nuclear pore distribution during mitosis | •inviable after spore germination, single or double cell division, arrest with septated mononucleate cell | •aseptate mononucleate vegetative cell |
•abolished protein localization to centromere central core during vegetative growth | •long mitotic spindle microtubules protruding beyond spindle pole body | •nuclear envelope protrusion present during mitosis | •decreased frequency of meiosis II |
•normal protein localization during meiosis | •increased meiotic recombination at silent mating-type cassette | •normal RNA level during cellular response to osmotic stress | •normal cellular glycerol level during cellular response to osmotic stress |
•normal cell wall alpha-glucan level | •abolished transcription from RNA polymerase II promoter | •normal mating frequency | •normal meiosis II |
•normal chromatin binding at replication origin | •decreased protein localization to telomere | •branched mitochondria | •normal growth on latrunculin A |
•small mitochondria present in increased numbers, with normal total mitochondrial volume | •asymmetric mitochondrial aggregation | •abnormal nucleosome positioning at stress response genes | •abolished response to S-phase DNA damage checkpoint signaling |
•decreased response to S-phase DNA damage checkpoint signaling | •mitochondria present in decreased numbers during vegetative growth | •abnormal ribonuclease activity | •decreased ribonuclease activity |
•septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyurea | •resistance to caffeine and rapamycin | •inviable binucleate aseptate cell with cell cycle arrest in mitotic G2 phase before cell separation | •decreased ribosomal S6 protein phosphorylation during vegetative growth |
•normal ribosomal S6 protein phosphorylation during vegetative growth | •abolished mitotic spindle elongation | •abnormal cytokinesis checkpoint | •normal cell cycle |
•normal cell cycle phase | •normal horsetail movement | •decreased RNA polymerase II carboxy-terminal domain kinase activity | •abolished actomyosin contractile ring contraction |
•sensitive to carbendazim | •decreased protein localization to mitotic spindle midzone | •inviable following spore germination, single cell division, abolished mitotic sister chromatid separation | •abolished mitotic chromosome condensation |
•normal protein localization to prospore membrane | •spores sensitive to acetone | •h- specific sterility | •normal growth on fluconazole |
•normal growth on oligomycin | •normal growth on MTT | •normal growth on FR901464 | •sensitive to fluconazole |
•sensitive to etoposide | •sensitive to wortmannin | •resistance to miconazole | •normal acidification of growth medium in stationary phase |
•increased protein oxidation in stationary phase | •increased protein oxidation | •decreased level of substance in cell during G0 | •decreased protein level during G0 |
•abnormal chromatin organization during G0 | •increased glutathione level during G0 | •inviable elongated cell with mitotic G2/M transition delay and cell cycle arrest in M phase | •normal cytokinesis checkpoint |
•single cell division prior to G0 entry | •decreased chromatin silencing at telomere | •abnormal endocytosis | •decreased cell wall thickness at old end during vegetative growth |
•abnormal primary cell septum biogenesis | •normal intragenic meiotic recombination | •abnormal error-prone translesion synthesis | •sensitive to rotenone |
•normal mitochondrial morphology | •resistance to etoposide | •loss of viability at low temperature | •normal meiotic spindle pole body morphology during meiosis II |
•normal growth on bleomycin | •sensitive to okadaic acid | •UGA suppression | •decreased double-strand break repair via homologous recombination |
•decreased minichromosome loss during vegetative growth | •increased protein level in stationary phase | •decreased mitochondrial protein level | •abnormal nonsense-mediated decay |
•decreased nonsense-mediated decay | •abolished protein localization to medial cortical node | •decreased rate of mitotic DNA replication elongation | •decreased population viability in presence of persistent double-strand breaks |
•altered double-strand break repair junction in presence of persistent double-strand breaks | •spores sensitive to ionizing radiation | •decreased protein level during cellular response to salt stress | •inviable aseptate vegetative cell |
•abolished nuclear mRNA catabolic process | •decreased protein localization to Golgi apparatus, with protein mislocalized to endoplasmic reticulum | •abnormal protein localization to Golgi apparatus | •increased cell population growth |
•abnormal m7G(5')pppN diphosphatase activity | •decreased m7G(5')pppN diphosphatase activity | •delayed onset of protein localization to cell division site | •normal nonsense-mediated decay |
•abnormal sulfite reductase activity | •decreased sulfite reductase activity | •decreased protein localization to chromatin at replication origin | •increased triglyceride biosynthetic process |
•abnormal diacylglycerol O-acyltransferase activity | •abnormal glutathione disulfide oxidoreductase activity | •decreased glutathione disulfide oxidoreductase activity | •increased glutathione disulfide oxidoreductase activity |
•mislocalized mitotic spindle | •incomplete mitotic sister chromatid segregation, with chromatin bridge | •abnormal exit from mitosis | •abnormal nuclear pore distribution |
•abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell with 1C DNA content per nucleus | •abnormal glutathione transferase activity | •increased glutathione transferase activity | •abnormal disulfide oxidoreductase activity |
•increased disulfide oxidoreductase activity | •altered cellular amino acid level during vegetative growth | •decreased cellular amino acid level | •increased cellular amino acid level |
•abnormal actin cortical patch | •mislocalized actin cortical patches during vegetative growth | •inviable stubby mononucleate vegetative cell | •increased RNA level in stationary phase |
•normal RNA level during cellular response to menadione | •decreased RNA level during cellular response to menadione | •normal cellular glutathione level | •delayed onset of replication fork processing |
•decreased protein level during cellular response to menadione | •normal cell surface pyruvylated galactose level | •decreased cell surface pyruvylated galactose level | •normal mitotic cell cycle regulation during cellular response to UV |
•normal cellular mtDNA level | •long polar microtubules | •increased duration of protein localization to mitotic spindle | •resistance to carbendazim |
•loss of template switch-mediated chromosomal rearrangement during replication fork processing | •normal 5' deoxyribonuclease (pyrimidine dimer) activity | •abnormal 5' deoxyribonuclease (pyrimidine dimer) activity | •decreased UV-damage excision repair |
•increased protein localization to chromatin at rDNA | •increased protein localization to chromatin at tRNA genes | •decreased glutathione transferase activity | •delayed onset of increase in RNA level during cellular response to hydrogen peroxide |
•abolished primary amine oxidase activity | •mitotic cell cycle arrest phenotype | •normal primary amine oxidase activity | •fragmented septum |
•tetranucleate vegetative cell | •elongated tetranucleate vegetative cell | •elongated tetranucleate vegetative cell with fragmented septum | •tetranucleate vegetative cell with fragmented septum |
•decreased glutathione transferase activity during stationary phase | •RNA absent from cell during cellular response to hydrogen peroxide | •cut during cellular response to UV | •abolished protein localization to nucleus during cellular response to salt stress |
•decreased protein localization to nucleus, with protein mislocalized to cytoplasm | •increased intragenic meiotic recombination | •decreased meiotic recombination at CRE promoter | •normal meiotic recombination at CRE promoter |
•increased duration of protein phosphorylation during cellular response to salt stress | •abnormal transcription during vegetative growth | •abnormal transcription elongation from RNA polymerase II promoter | •decreased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during vegetative growth |
•decreased phosphorylation of RNA polymerase II C-terminal domain serine 5 residues during vegetative growth | •abolished phosphorylation of RNA polymerase II C-terminal domain serine 2 residues | •decreased cell growth | •inviable after spore germination, single or double cell division, elongated multiseptate cell |
•abnormal sporulation resulting in formation of ascus with single large spore | •normal histone H3-S10 phosphorylation during vegetative growth | •decreased protein localization to chromatin at tRNA genes | •normal protein phosphorylation during mitosis |
•normal protein level | •normal protein level during nitrogen starvation | •decreased vegetative cell growth | •abnormal meiotic centromere clustering |
•abnormal cytoplasmic microtubules | •decreased meiotic recombination during zygotic meiosis | •abnormal protein localization to microtubule cytoskeleton | •abolished protein localization to microtubule cytoskeleton |
•normal meiotic telomere clustering | •abnormal protein localization during meiotic cell cycle | •normal protein localization during meiotic cell cycle | •normal protein localization to cytoskeleton |
•normal actomyosin contractile ring contraction | •incomplete mitotic sister chromatid segregation, with phi-shaped DNA mass | •normal mitotic chromosome condensation | •lagging mitotic chromosomes, with complete sister chromatid separation |
•decreased protein polyubiquitination during vegetative growth | •viable spherical vegetative cell | •inviable spherical vegetative cell | •abolished polar cell growth |
•inviable multinucleate aseptate vegetative cell | •normal protein level during mitotic G2 phase | •increased protein level during mitotic G1 phase | •decreased protein phosphorylation during mitotic G2 phase |
•increased protein phosphorylation during mitotic G2 phase | •inviable after spore germination, without cell division, small cell | •inviable after spore germination, without cell division, abnormal septum morphology | •inviable after spore germination, multiple cell divisions, normal septum morphology |
•normal protein import into nucleus during vegetative growth | •cut during cellular response to thiabendazole | •abolished histone H3-K4 trimethylation during vegetative growth | •abnormal cysteine-type peptidase activity |
•increased cysteine-type peptidase activity | •decreased succinate dehydrogenase (ubiquinone) activity | •increased succinate dehydrogenase (ubiquinone) activity | •abolished histone H3-K9 dimethylation at telomere during vegetative growth |
•decreased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth | •altered level of substance in cell during nitrogen starvation | •decreased RNA polymerase II proximal promoter sequence-specific DNA binding | •increased flocculation in stationary phase |
•normal protein phosphorylation during cellular response to heat | •increased protein level during mitosis | •abnormal homologous chromosome segregation | •normal meiotic spindle |
•decreased protein localization to chromatin at RNA polymerase II-transcribed genes during vegetative growth | •loss of viability upon glucose starvation | •increased cellular reactive oxygen species level in stationary phase | •normal glucose consumption |
•increased oxygen consumption during vegetative growth | •increased cell population growth on glycerol carbon source | •normal viability in stationary phase during glucose starvation | •decreased RNA level in stationary phase |
•abolished histone H3-K9 dimethylation at centromere during vegetative growth | •normal RNA level during glucose starvation | •decreased protein kinase activity during cellular response to heat | •decreased protein phosphorylation during cellular response to heat |
•h+ specific sterility | •increased cellular protein aggregate level | •normal protein localization to cell-cell contact point during mating | •normal vegetative growth on myriocin |
•abolished protein localization to nucleus during cellular response to hydroxyurea | •increased protein level during cellular response to hydroxyurea | •decreased protein level during mitotic S phase | •decreased protein level during cellular response to hydroxyurea |
•normal protein localization to telomere during meiosis | •inviable elongated vegetative cell with fragmented nucleus and mitotic cell cycle arrest in interphase | •decreased protein degradation during mitosis | •decreased centromeric outer repeat transcript-derived siRNA level |
•decreased mature snRNA level | •decreased siRNA level | •increased siRNA level | •decreased protein localization to kinetochore during meiosis I |
•abnormal attachment of mitotic spindle microtubules to kinetochore | •normal protein localization to kinetochore during meiosis I | •abnormal histone H4-K20 methylation during vegetative growth | •abolished histone H4-K20 monomethylation during vegetative growth |
•abolished histone H4-K20 dimethylation during vegetative growth | •abolished histone H4-K20 trimethylation during vegetative growth | •decreased protein phosphorylation during cellular response to UV | •normal growth during cellular response to ionizing radiation |
•normal protein phosphorylation during cellular response to UV | •abnormal methylated histone binding | •abolished methylated histone binding | •decreased and delayed cell cycle arrest in mitotic G1 phase in response to nitrogen starvation |
•normal RNA level oscillation during mitotic cell cycle | •thin mitotic spindle midzone | •increased protein localization to heterochromatin at centromere outer repeat | •increased histone H3-K4 acetylation during vegetative growth |
•decreased histone H3-K56 acetylation during vegetative growth | •decreased protein kinase activity during mitotic S phase | •decreased protein kinase activity during cellular response to DNA damage | •decreased protein kinase activity during mitotic S phase during cellular response to DNA damage |
•normal protein kinase activity during mitotic S phase during cellular response to DNA damage | •normal vacuolar morphology during vegetative growth | •normal protein localization to vacuolar membrane | •abnormal protein localization to vacuolar membrane |
•abolished protein localization to vacuolar membrane | •increased DNA resection during replication fork processing | •normal regulation of DNA replication during replication fork arrest | •decreased nuclease activity |
•abnormal mitotic cell cycle regulation during cellular response to UV | •inviable elongated mononucleate vegetative cell | •viable lemon-shaped cell | •swollen multinucleate vegetative cell |
•abolished mitotic G2 DNA damage checkpoint | •increased duration of protein localization to double-strand break site | •decreased protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation | •abolished protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation |
•normal viability in stationary phase during nitrogen limitation | •abnormal protein localization to cortical microtubule cytoskeleton | •abolished protein localization to cortical microtubule cytoskeleton | •decreased septum disassembly |
•abnormal cell septum edging catabolic process | •decreased cell septum edging catabolic process | •abnormal ascospore release from ascus | •normal growth on mitomycin C |
•normal double-strand break repair via nonhomologous end joining | •decreased double-strand break repair via nonhomologous end joining | •decreased GT repeat stability | •abnormal septum |
•mislocalized septum | •mislocalized septum in stationary phase | •multiseptate cell | •septated cell |
•normal ATPase activity | •normal mitotic sister chromatid separation | •abnormal phosphatase activity | •abolished phosphatase activity |
•decreased phosphatase activity | •long mitotic spindle during metaphase | •abnormal CENP-A containing chromatin organization | •normal duration of mitotic M phase |
•abnormal protein localization to CENP-A containing chromatin | •abolished protein localization to CENP-A containing chromatin | •decreased protein localization to CENP-A containing chromatin | •normal protein localization to CENP-A containing chromatin |
•abnormal microtubule cytoskeleton during vegetative growth | •abnormal post-anaphase array | •abnormal post-anaphase array morphology | •abolished mitotic spindle assembly checkpoint |
•increased cyclin-dependent protein kinase activity | •altered DNA level | •altered DNA level during vegetative growth | •decreased spatial extent of CENP-A containing nucleosome assembly |
•increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere central core during vegetative growth | •increased histone H4-K16 acetylation at centromere central core during vegetative growth | •sensitive to 5-fluorouracil | •normal protein phosphorylation during cellular response to sorbitol |
•normal protein localization during mitosis | •normal mitotic telomeric DNA separation | •normal transcriptional repression at centromere central core | •delayed onset of protein degradation during mitosis |
•increased protein phosphorylation during cellular response to hydrogen peroxide | •abnormal protein localization to mitochondrion | •abolished protein localization to mitochondrion | •decreased protein localization to nucleus during cellular response to hydrogen peroxide |
•abnormal mitochondrial fission | •increased LTR-derived RNA level | •increased wtf-derived RNA level | •increased viability upon nitrogen starvation |
•decreased protein localization to chromatin at long terminal repeat | •decreased protein localization to chromatin at ncRNA genes | •increased histone H3-K9 acetylation at protein coding gene during vegetative growth | •increased protein phosphorylation during mitotic S phase |
•increased protein phosphorylation during mitosis | •increased protein localization to nucleolus | •decreased protein phosphorylation during mitosis | •decreased duration of mitotic cell cycle DNA replication checkpoint |
•meiosis and sporulation in haploid during nitrogen starvation | •altered level of stress responsive gene mRNA during vegetative growth | •normal mitotic spindle assembly | •normal growth on arsenic |
•decreased vacuolar phytochelatin level | •decreased duration of S-phase DNA damage checkpoint | •decreased response to mitotic G2 DNA damage checkpoint signaling | •abnormal mitotic G2 DNA damage checkpoint |
•increased chromatin silencing at silent mating-type cassette | •increased protein localization to heterochromatin at silent mating-type cassette | •normal protein localization to heterochromatin at silent mating-type cassette | •merotelic kinetochore attachment during mitosis |
•meroterically attached lagging mitotic chromosomes | •premature protein localization to mitotic spindle | •normal single-stranded DNA binding | •decreased single-stranded DNA binding |
•decreased positive regulation of DNA-directed DNA polymerase activity | •increased level of amino acid catabolism gene mRNA during vegetative growth | •abolished cell population growth on uracil nitrogen source | •abolished positive regulation of DNA-directed DNA polymerase activity |
•lagging chromosomes during meiosis I | •lagging chromosomes during meiosis II | •short mitotic spindle during metaphase | •normal mitotic spindle elongation |
•normal protein export from nucleus during vegetative growth | •sensitive to JM216 | •normal growth on JM216 | •sensitive to JM335 |
•normal growth on JM335 | •sensitive to triplatin tetranitrate | •normal growth on triplatin tetranitrate | •sensitive to tetraplatin |
•normal growth on tetraplatin | •normal growth on oxaliplatin | •abolished protein localization to mitotic spindle midzone during anaphase | •decreased phosphatase activity during cellular response to phosphate starvation |
•increased phosphatase activity during cellular response to phosphate starvation | •increased phosphatase activity | •decreased RNA level during cellular response to phosphate starvation | •normal RNA level during cellular response to phosphate starvation |
•cut cell with decreased poly(A)+ mRNA export from nucleus | •abolished protein localization to cytoplasm with increased protein localization to nucleus | •normal protein phosphorylation | •normal protein threonine phosphorylation |
•abnormal protein dephosphorylation | •increased rate of cytokinesis | •normal rate of mitotic spindle elongation | •premature actomyosin contractile ring contraction |
•sensitive to 2-bromo-2-(((4-methylphenyl)sulfonyl)methyl)-1-indanone | •sensitive to 2-bromo-1-(4-methoxyphenyl)-3-((4-methylphenyl)sulfonyl)-1-propanone | •sensitive to viridicatumtoxin | •sensitive to 4-amino-1-methyl-1H-imidazole-5-carboselenoamide |
•sensitive to tingenone | •normal mitotic recombination frequency | •long mitotic spindle during anaphase | •long curved mitotic spindle during anaphase |
•normal cytosolic calcium level | •decreased protein localization to prospore membrane | •decreased protein localization to prospore membrane during meiosis II | •decreased protein localization to prospore membrane during meiosis II with protein mislocalized to plasma membrane |
•decreased endocytosis during meiotic cell cycle | •decreased protein phosphorylation during mitotic metaphase | •normal protein phosphorylation during cellular response to calcium ion | •decreased protein level during cellular response to calcium ion |
•resistance to calcium | •decreased protein localization to nucleus | •increased protein localization to nucleus | •decreased protein localization to nucleus during nitrogen starvation |
•decreased level of regulation of sexual differentiation gene mRNA during nitrogen starvation | •abolished protein localization to nucleus during nitrogen starvation | •decreased protein phosphorylation during cellular response to camptothecin | •increased number of Rad52 foci during cellular response to camptothecin |
•normal protein localization to cell tip during cellular response to salt stress | •normal phosphatase activity | •decreased protein localization to actomyosin contractile ring during mitotic anaphase | •abolished protein localization to cytoplasm with protein mislocalized to nucleolus during cellular response to latrunculin B |
•inviable after spore germination, without cell division, cell cycle arrest with unreplicated DNA | •normal mitotic cell cycle DNA replication checkpoint | •decreased RNA level during cellular response to calcium ion | •decreased transcription from CDRE promoter in response to salt stress |
•decreased transcription from CDRE promoter in response to micafungin | •abolished cell population growth at high temperature | •abnormal vacuole fusion during vegetative growth | •abnormal vacuole fusion during cellular hypotonic response |
•abnormal protein deacetylation during vegetative growth | •increased protein acetylation during vegetative growth | •abolished protein lysine methylation during vegetative growth | •increased level of amino acid biosynthesis gene mRNA during vegetative growth |
•increased level of transport gene mRNA during vegetative growth | •decreased nucleosome occupancy | •inviable branched, swollen, elongated vegetative cell | •increased cellular HMW ubiquitin conjugate level |
•abnormal nucleolar chromatin organization | •abnormal nucleolar chromatin organization resulting in peripheral chromatin distribution | •long curved interphase microtubules | •sensitive to EGTA |
•resistance to latrunculin A | •abnormal chromosome morphology, indistinct DNA | •decreased number of Rad52 foci during vegetative growth | •abnormal DNA-directed DNA polymerase activity |
•decreased DNA-directed DNA polymerase processivity | •inviable after spore germination, single or double cell division, branched, elongated cell | •inviable after spore germination, single or double cell division, branched, curved, elongated cell | •inviable after spore germination, single or double cell division, curved, elongated cell |
•decreased number of Rad54 foci during cellular response to doxorubicin | •abnormal regulation of transcription | •abnormal regulation of transcription during vegetative growth | •abnormal mitochondrial translation |
•normal mitochondrial translation | •abolished mitochondrial translation | •normal cell wall beta-glucan level | •inviable small spore with abnormal shape |
•abnormal response to mitotic cell cycle spindle assembly checkpoint signaling | •mitotic spindle assembly checkpoint override | •microtubules present in increased numbers | •short interphase microtubules present in increased numbers |
•increased chromatin silencing | •abnormal heterochromatin organization during vegetative growth | •decreased proteasomal ubiquitin-dependent protein degradation | •cut during cellular response to methyl methanesulfonate |
•normal protein kinase activity during cellular response to hydroxyurea | •abolished protein phosphorylation during cellular response to hydroxyurea | •growth auxotrophic for choline | •increased vegetative cell population growth |
•viable swollen spheroid vegetative cell | •sensitive to BE49385A | •binucleate aseptate vegetative cell | •increased transcription of pheromone response gene mRNA during vegetative growth |
•normal spindle | •normal spindle during meiosis I | •increased RNA level during cellular response to hydrogen peroxide | •decreased exocytosis |
•increased telomeric transcript level | •increased subtelomere-derived RNA level | •increased histone H3-K9 acetylation at subtelomere during vegetative growth | •decreased level of histone H3 in cell |
•normal transposable element-derived small RNA level | •increased transcriptional response to pheromone | •increased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation | •abnormal linear element morphology |
•sensitive to caffeine and hydroxyurea | •abolished cell population growth on urea nitrogen source | •abnormal mitosis following normal mitosis | •abnormal gamma-tubulin complex localization to mitotic spindle pole body |
•abnormal vegetative cell phenotype following normal mitosis | •branched, elongated, septated cell | •abnormal negative regulation of DNA replication initiation during mitotic G2 phase resulting in complete rereplication | •increased protein localization to chromatin during mitotic G2 phase |
•normal transcriptional response to pheromone | •normal S-phase DNA damage checkpoint during cellular response to hydroxyurea | •normal linear element morphology | •inviable after spore germination, without cell division, elongated cell |
•decreased chromatin silencing at subtelomere | •decreased horsetail movement | •normal protein level during meiotic cell cycle | •abnormal spindle pole body morphology |
•abnormal spindle pole body morphology during meiosis II | •spindle pole bodies present in increased numbers during meiosis | •increased duration of meiotic prophase I | •long interphase microtubules |
•abolished microtubule attachment to spindle pole body | •abnormal microtubule polymerization | •abnormal spindle disassembly | •abnormal mitotic spindle disassembly |
•abolished mitotic spindle disassembly | •inviable curved elongated mononucleate vegetative cell | •delayed onset of premeiotic DNA replication | •normal mitotic DNA replication |
•decreased RNA level during meiotic cell cycle | •abnormal cellular physical quality phenotype | •abnormal cellular physical quality phenotype during vegetative growth | •normal duration of mitotic anaphase |
•delayed onset of mitotic spindle assembly | •abolished protein localization to mitotic spindle pole body during metaphase | •decreased mitotic spindle microtubule depolymerization | •normal actomyosin contractile ring morphology |
•delayed onset of actomyosin contractile ring contraction | •increased protein localization to cell division site | •increased protein localization to telomere during vegetative growth | •inviable mononucleate multiseptate vegetative cell |
•normal viability following cellular response to UV | •linear elements absent from cell | •decreased meiotic sister chromatid cohesion along chromosome arms | •normal meiotic sister chromatid cohesion at centromere |
•premature homologous chromosome segregation | •sensitive to ferrozine | •abnormal macroautophagy during nitrogen starvation | •abolished protein localization to vacuole during nitrogen starvation |
•inviable elongated vegetative cell with fragmented DNA | •sensitive to dimethyl sulfoxide | •unequal nucleolus inheritance | •decreased cytosolic large ribosomal subunit level |
•increased cenH-derived RNA level | •normal protein localization to mitotic spindle midzone | •decreased heme binding | •bent vegetative cell |
•cytoplasmic microtubules absent from cell | •viable curved, elongated, swollen vegetative cell | •delayed onset of mitotic sister chromatid separation | •increased number of Rad52 foci |
•decreased level of translation gene mRNA during vegetative growth | •abnormal protein localization to heterochromatin | •abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell | •normal viability following cellular response to heat shock |
•protein mislocalized to lateral cell cortex | •normal protein localization to interphase microtubule plus-end | •abolished protein localization to medial cortical node, with protein mislocalized to cytoplasm | •abnormal actomyosin contractile ring |
•abnormal actomyosin contractile ring organization | •normal actin cytoskeleton during vegetative growth | •normal actomyosin contractile ring | •normal chromatin silencing at centromere outer repeat |
•normal histone H3-K9 dimethylation at centromere outer repeat during vegetative growth | •abolished histone H3-K9 dimethylation at centromere outer repeat during vegetative growth | •actin cortical patches present in increased numbers at cell tip during early mitosis | •increased spatial extent of subtelomeric heterochromatin assembly |
•elongated septated vegetative cell | •abolished protein localization to nucleus during mitotic interphase | •abolished protein localization to mitotic spindle during mitosis | •abnormal protein localization to microtubule minus-end |
•abnormal regulation of DNA replication initiation | •abnormal negative regulation of DNA replication initiation | •abnormal protein localization to kinetochore during meiosis | •abolished protein localization to kinetochore during meiosis I |
•normal protein localization to meiotic spindle pole body during meiosis I | •normal cell population growth during glucose starvation | •abolished cytoplasmic interphase microtubule nucleation | •decreased protein localization to plasma membrane, with protein mislocalized to cytoplasm, during vegetative growth |
•abnormal histone methyltransferase activity | •decreased histone methyltransferase activity | •decreased protein localization to Golgi apparatus | •abnormal telomere-nuclear envelope distance during vegetative growth |
•increased telomere-nuclear envelope distance during mitotic G2 phase | •normal zygotic meiosis | •abnormal protein localization to shmoo tip | •abnormal actin cytoskeleton organization |
•abnormal cell wall organization | •incomplete cell wall disassembly at cell fusion site | •narrow cell fusion site following mating | •abnormal termination of RNA polymerase II transcription |
•abnormal rDNA copy number | •normal rDNA copy number | •normal protein localization to nucleus during mitosis | •decreased phosphatase activity during cellular response to adenine starvation |
•arrested mitotic spindle elongation during anaphase B | •decreased protein localization to mitotic spindle midzone during anaphase | •decreased protein localization to mitotic spindle midzone during anaphase B | •increased phosphatase activity during cellular response to adenine starvation |
•abolished protein localization to nucleus during cellular response to hydrogen peroxide | •abolished cell population growth during glucose starvation | •abnormal protein localization to plasma membrane | •abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm, during glucose starvation |
•abnormal high-affinity glucose import | •protein mislocalized to cytoplasm | •abnormal mitotic DNA replication lagging strand elongation | •transcription phenotype |
•normal protein transport during vegetative growth | •normal protein metabolic process | •normal RNA metabolic process | •abnormal RNA metabolic process |
•RNA transport phenotype | •RNA localization phenotype | •increased protein localization to actomyosin contractile ring | •abnormal endo-1,6-beta-glucosidase activity |
•increased endo-1,6-beta-glucosidase activity | •normal growth on Congo Red | •increased cell wall polysaccharide level | •increased cell wall beta-glucan level |
•curved microtubules | •long curved microtubules | •decreased histone H2A phosphorylation during cellular response to ionizing radiation | •sensitive to ionizing radiation during mitotic G1 phase |
•decreased number of Crb2 foci during cellular response to ionizing radiation | •normal chromatin binding at centromere central core | •decreased level of lipid metabolism gene mRNA during vegetative growth | •abnormal protein localization to mitotic spindle midzone |
•abnormal protein localization to nuclear envelope during vegetative growth | •abolished protein localization to nuclear envelope during vegetative growth | •normal protein localization to nuclear envelope during vegetative growth | •abnormal protein localization to telomere |
•normal growth on echinocandin | •normal 1,3-beta-D-glucan synthase activity during vegetative growth | •normal rate of actomyosin contractile ring contraction | •decreased level of cell separation after cytokinesis gene mRNA during vegetative growth |
•decreased protein localization to centromere central core during vegetative growth | •decreased level of histone gene mRNA during vegetative growth | •decreased chromatin binding at histone promoter | •abolished L-aminoadipate-semialdehyde dehydrogenase activity |
•loss of punctate nuclear protein localization, with protein distributed in nucleus | •normal punctate nuclear protein localization | •normal telomeric repeat sequence | •abnormal regulation of catalytic activity |
•abolished positive regulation of protein kinase activity | •normal regulation of molecular function | •normal regulation of catalytic activity | •normal positive regulation of protein kinase activity |
•inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic G2 phase | •normal telomere tethering at nuclear periphery | •irregular ascospore wall | •fragmented DNA during vegetative growth |
•normal RNA level during sporulation | •abolished DNA binding at PCB | •decreased protein level during meiosis I | •abnormal mitochondrion |
•decreased mitochondrial membrane potential | •increased spatial extent of centromeric heterochromatin assembly | •increased protein phosphorylation during cellular response to rapamycin | •elongated vegetative cell with elongated oscillating nucleus |
•incomplete prospore membrane closure | •abnormal prospore membrane | •excess prospore membrane present | •abnormal mitochondrial RNA 3'-end processing |
•altered level of substance in mitochondrion | •altered RNA level in mitochondrion | •normal level of substance in mitochondrion | •normal mitochondrial RNA level |
•increased protein localization to chromatin at replication origin | •normal protein localization to chromatin at replication origin | •normal plasma membrane sterol distribution | •actin cortical patches present in decreased numbers |
•inviable swollen pear-shaped vegetative cell | •increased duration of horsetail movement | •increased vegetative cell population growth during phosphate starvation | •normal vegetative cell population growth during phosphate starvation |
•actin cortical patches present in increased numbers | •normal telomere localization | •increased protein localization to new cell tip | •elongated monoseptate vegetative cell |
•normal cellular histone level | •increased centromeric transcript level | •sensitive to vorinostat | •abnormal RNA level oscillation during mitotic cell cycle |
•decreased protein level during meiotic cell cycle | •normal spore germination frequency | •delayed onset of meiosis I | •abnormal protein localization to chromosome |
•normal protein localization to chromosome | •elongated vegetative cell with oscillating nucleus | •abnormal protein complex composition | •decreased protein level in anaphase-promoting complex |
•increased level of hexose transport gene mRNA during vegetative growth | •decreased histone H4 acetylation during vegetative growth | •decreased histone H4-K5 acetylation during vegetative growth | •decreased histone H4-K12 acetylation during vegetative growth |
•abnormal ribosome biogenesis | •decreased double-stranded DNA binding | •normal duration of actomyosin contractile ring contraction | •inviable elongated septated mononucleate vegetative cell |
•decreased H4-K20 dimethylation during vegetative growth | •decreased gamma-tubulin complex localization to mitotic spindle pole body | •normal mutation rate | •abnormal protein phosphorylation during nitrogen starvation |
•decreased protein phosphorylation during nitrogen starvation | •normal protein phosphorylation during nitrogen starvation | •decreased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during nitrogen starvation | •normal phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during nitrogen starvation |
•increased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during vegetative growth | •normal protein localization to kinetochore | •abnormal regulation of translation in response to UV | •translation regulation phenotype during vegetative growth |
•abnormal mitotic sister chromatid segregation with lagging chromosomes, complete sister chromatid separation, and decreased rate of mitotic spindle elongation | •decreased protein localization to chromatin at RNA polymerase II promoter during vegetative growth | •increased protein localization to chromatin at RNA polymerase II promoter during vegetative growth | •decreased protein localization to chromatin at RNA polymerase II-regulated genes during nitrogen starvation |
•binucleate multiseptate cell, septa grouped | •abolished meiotic DNA double-strand break clipping | •decreased meiotic DNA double-strand break clipping | •normal phosphorylation of RNA polymerase II C-terminal domain serine 5 residues during vegetative growth |
•increased histone H3-K4 methylation at telomere during vegetative growth | •increased histone H3-K4 methylation at mating type locus during vegetative growth | •increased histone H3-K9 methylation at telomere during vegetative growth | •increased histone H3-K9 methylation at mating type locus during vegetative growth |
•increased histone H3-K9 methylation at centromere during vegetative growth | •unequal mitotic sister chromatid segregation following normal mitosis | •cut with abolished mitotic sister chromatid separation, with mononucleate and anucleate compartment formation | •increased chromatin silencing at centromere |
•normal protein localization to centromeric chromatin | •normal protein localization to chromatin at centromere central core | •normal protein localization to chromatin at centromere inner repeat | •normal protein localization to chromatin at ncRNA gene |
•normal protein localization to chromatin at tRNA gene | •decreased level of cytokinesis gene mRNA during vegetative growth | •normal DNA binding at PCB | •decreased duration of protein phosphorylation during cellular response to hydroxyurea |
•decreased duration of S-phase DNA damage checkpoint during cellular response to hydroxyurea | •abolished protein localization to chromatin at replication origin | •increased duration of protein localization to mitotic spindle pole body during anaphase | •abnormal cell cycle arrest in mitotic G1 phase |
•decreased poly(U) RNA binding | •decreased protein level at silent mating-type cassette | •curved elongated vegetative cell | •normal regulation of mitotic DNA replication initiation |
•normal rate of mitotic DNA replication elongation | •normal sodium export | •abnormal ubiquitin-specific protease activity | •decreased ubiquitin-specific protease activity |
•normal protein localization to endosome | •elongated vegetative cell with central constriction | •increased punctate nuclear protein localization | •decreased transcription during nitrogen starvation |
•altered protein binding specificity | •increased RNA level during meiotic cell cycle | •increased level of middle meiotic gene mRNA during vegetative growth | •spores sensitive to cell wall-degrading enzymes |
•decreased protein phosphorylation during cellular response to micafungin | •normal protein localization to linear element | •normal meiotic DNA double-strand break formation | •normal meiotic recombination double-strand break repair |
•abnormal meiotic recombination double-strand break repair | •abolished meiotic recombination double-strand break repair | •abolished proteasome localization to nuclear periphery | •septated spheroid vegetative cell |
•abnormal ascus morphology | •decreased cell wall (1->6)-beta-D-glucan level | •decreased DNA synthesis involved in mitotic DNA replication | •abnormal spatio-temporal regulation of replication fork localization |
•decreased protein localization to chromatin at centromere inner repeat | •normal protein level during cellular response to salt stress | •abnormal uracil import | •increased uracil import |
•increased protein localization to cell surface | •abolished tRNA wobble position uridine thiolation | •abnormal mitotic cell cycle regulation during cellular response to UV during mitotic G1 phase | •normal mitotic cell cycle regulation during cellular response to UV during mitotic G1 phase |
•normal protein degradation during cellular response to UV | •decreased protein degradation during cellular response to UV | •abolished protein polyubiquitination during cellular response to UV | •decreased level of transport gene mRNA during vegetative growth |
•abnormal re-entry into mitotic cell cycle after arrest in response to hydroxyurea | •normal cellular response to stress | •resistance to torin1 | •decreased protein degradation during mitotic S phase |
•normal protein degradation during mitotic S phase | •increased protein phosphorylation during glucose starvation | •abnormal mitotic cell cycle regulation during cellular response to heat stress | •abnormal mitotic cell cycle regulation upon nitrogen source shift |
•normal mitotic cell cycle regulation upon nitrogen source shift | •abolished protein localization during meiotic cell cycle | •abnormal protein localization to kinetochore | •abolished protein localization to kinetochore during mitotic metaphase |
•normal protein localization to kinetochore during mitotic prometaphase | •normal regulation of translation in response to stress during vegetative growth | •normal regulation of translation in response to osmotic stress | •decreased protein localization to kinetochore during mitosis |
•normal protein localization to mitotic spindle pole body during metaphase | •decreased transcript length | •abnormal protein oligomerization | •normal protein oligomerization |
•decreased histone H3 localization to chromatin at protein coding gene | •increased histone H3-K4 dimethylation during vegetative growth | •decreased level of ubiquitinated protein in cell | •normal level of ubiquitinated protein in cell |
•normal growth on doxorubicin | •decreased transcription from RNA polymerase II promoter during vegetative growth | •normal regulation of translation in response to UV | •loss of viability in stationary phase upon glucose starvation |
•normal protein complex binding | •normal protein localization to chromatin at stalled replication fork | •increased cellular proline level | •sensitive to tamoxifen |
•resistance to tamoxifen | •abnormal carboxypeptidase activity | •decreased carboxypeptidase activity | •abnormal mitotic cell cycle regulation during cellular response to methyl methanesulfonate |
•abnormal cell cycle phase transition | •abnormal meiotic cell cycle phase transition | •abnormal mitotic cell cycle phase transition | •multinucleate multiseptate cell |
•increased level of glucose-repressed gene mRNA during vegetative growth | •increased viability upon inositol starvation | •cut during cellular response to bleomycin | •decreased cysteine-type endopeptidase activity |
•heterochromatin assembly beyond boundary element IRC1L | •decreased negative regulation of transcription by glucose | •actomyosin contractile ring sliding | •increased chromatin binding during cellular response to hydroxyurea |
•decreased RNA catabolic process during nitrogen starvation | •increased number of Rad52 foci during mitotic S phase | •normal mitotic G2 DNA damage checkpoint during cellular response to UV | •decreased protein localization to kinetochore during mitotic spindle assembly checkpoint signaling |
•increased level of cell cycle regulated gene mRNA during vegetative growth | •abnormal protein localization to centromeric chromatin during vegetative growth | •decreased phospholipid binding | •increased histone H3-K14 acetylation during vegetative growth |
•decreased protein localization to chromatin at MCB promoters during vegetative growth | •increased transcriptional repression at centromere central core | •increased histone H4-K12 acetylation at subtelomere during vegetative growth | •decreased transcription from MCB promoter |
•abnormal error-free translesion synthesis | •decreased error-free translesion synthesis of cyclobutane pyrimidine dimers | •normal error-free translesion synthesis | •abolished error-free translesion synthesis of cyclobutane pyrimidine dimers |
•normal error-free translesion synthesis of cyclobutane pyrimidine dimers | •normal error-free translesion synthesis of pyrimidine-pyrimidone 6-4 photoproducts | •decreased error-free translesion synthesis of pyrimidine-pyrimidone 6-4 photoproducts | •decreased error-prone translesion synthesis of pyrimidine-pyrimidone 6-4 photoproducts |
•abolished error-prone translesion synthesis of pyrimidine-pyrimidone 6-4 photoproducts | •increased protein level during cellular response to methyl methanesulfonate | •normal level of histone H3 in cell | •increased histone H3-K9K14 acetylation during vegetative growth |
•decreased protein localization to nucleus during cellular response to hydroxyurea | •normal rate of mitotic spindle elongation during anaphase B | •decreased rate of mitotic spindle elongation during anaphase B | •abolished mitotic spindle midzone assembly |
•abnormal maintenance of spindle pole body localization | •abnormal chromatin organization resulting in peripheral chromatin distribution | •increased guanyl-nucleotide exchange factor activity | •normal replication fork arrest at mating-type locus |
•abnormal site-specific DNA replication termination at RTS1 barrier | •abolished site-specific DNA replication termination at RTS1 barrier | •decreased site-specific DNA replication termination at RTS1 barrier | •normal termination of RNA polymerase II transcription at RTS1 barrier |
•increased level of large-Y replication intermediates | •abnormal mitotic metaphase chromosome recapture | •abolished protein phosphorylation during mitosis | •inviable mononucleate aseptate vegetative cell with cell cycle arrest in mitotic G2 phase |
•decreased level of iron ion starvation-induced proteins | •abolished cell population growth at low temperature | •decreased fidelity of double-strand break repair via nonhomologous end joining | •increased linear minichromosome loss during vegetative growth |
•normal mitotic cell cycle regulation during cellular response to methyl methanesulfonate | •abnormal proteolysis | •abolished proteolysis during vegetative growth | •normal spindle pole body organization |
•normal spindle pole body | •normal mitotic spindle pole body duplication | •delayed exit from meiosis | •normal duration of meiosis I |
•meiosis I metaphase/anaphase transition delay | •decreased protein localization to chromatin at chromosome arms | •decreased number of Rad51 foci during cellular response to ionizing radiation | •increased number of Rqh1 foci during cellular response to ionizing radiation |
•increased DNA recombination during cellular response to ionizing radiation | •progressively decreasing vegetative cell population growth rate | •normal protein phosphorylation during cellular response to methyl methanesulfonate | •abolished protein localization to subtelomeric heterochromatin |
•normal intracellular protein transport during vegetative growth | •increased telomeric 3' overhang length during vegetative growth | •telomeric regions absent from linear chromosomes | •increased number of unattached kinetochores |
•delayed onset of meiosis II | •increased protein level during meiosis II | •increased protein level during meiotic anaphase II | •increased level of iron assimilation gene mRNA during vegetative growth |
•decreased mitotic spindle microtubule depolymerization during anaphase A | •aggregated actin cortical patches during vegetative growth | •decreased mitotic recombination at hotspot | •globally decreased mitotic recombination |
•decreased meiotic recombination at hotspot | •abolished double-strand break repair | •abnormal DNA/DNA annealing activity | •swollen elongated cell with enlarged nucleus |
•abolished protein localization to microtubule during mitotic interphase | •decreased proteolysis during vegetative growth | •abolished molecular function | •abnormal biological process |
•abolished biological process | •abolished cellular process | •decreased break-induced loss of heterozygosity | •increased break-induced loss of heterozygosity |
•abolished break-induced loss of heterozygosity via chromosomal translocation | •abnormal telomere assembly | •telomere assembly at double-strand break site | •decreased cellular glycerol level during cellular response to osmotic stress |
•decreased cellular glycerol level during cellular response to non-ionic osmotic stress | •abolished protein localization to chromatin at MCB promoters | •abnormal microtubule-based movement during vegetative growth | •decreased microtubule-based movement during vegetative growth |
•abnormal maintenance of protein location at cell tip during vegetative growth | •protein mislocalized to non-growing cell tip | •decreased protein localization to actomyosin contractile ring during mitosis | •inviable after spore germination, without cell division, lysed cell |
•abnormal glutamate synthase (NADH) activity | •abolished glutamate synthase (NADH) activity | •abolished glutamate dehydrogenase (NADP+) activity | •normal glutamate dehydrogenase (NADP+) activity |
•swollen vegetative cell with normal cell length | •decreased filamentous actin level | •normal protein phosphorylation during cellular response to arsenite ion | •abnormal inositol phosphate phosphatase activity |
•abolished inositol phosphate phosphatase activity | •decreased iron-sulfur cluster binding | •sensitive to arsenite | •abnormal protein localization to vacuole |
•decreased transcription from CRE promoter | •abolished protein localization to cell cortex, with protein mislocalized to cytoplasm, during vegetative growth | •abnormal transcription | •abnormally monopolar protein localization to cell tip |
•increased level of cell surface glycoprotein gene mRNA during vegetative growth | •increased level of mitochondrial transport gene mRNA during vegetative growth | •increased mature rRNA level | •abnormal meiotic sister chromatid segregation |
•meiotic cell cycle checkpoint phenotype | •increased activation of meiosis I spindle assembly checkpoint | •protein mislocalized to vacuole | •abolished protein localization to cell cortex, with protein mislocalized to vacuole, during vegetative growth |
•normal growth on 6-azauracil | •increased histone H3-K14 acetylation at protein coding gene during vegetative growth | •abnormal nucleosome organization | •increased forward centromeric outer repeat transcript level |
•normal subtelomeric chromatin knob formation | •decreased protein localization to chromatin at boundary element IRC1L | •abnormal histone H4-K16 acetylation during vegetative growth | •decreased histone H4-K16 acetylation at boundary element IRC1L during vegetative growth |
•normal telomere-telomerase complex assembly | •increased duration of actomyosin contractile ring contraction | •abnormal protein localization to plasma membrane at cell division site during vegetative growth | •normal viability upon nitrogen starvation |
•decreased protein localization to cleavage furrow | •decreased protein localization to cleavage furrow rim | •abolished histone H3-K9 dimethylation at centromere inner repeat during vegetative growth | •decreased mitotic cohesin loading |
•abolished mitotic cohesin loading | •decreased mitotic cohesin unloading | •abnormal microtubule bundle | •abnormal microtubule bundle during G0 to G1 transition |
•T-shaped cell | •T-shaped cell during G0 to G1 transition | •abnormal cell polarity | •abnormal protein localization to cell periphery during vegetative growth |
•abolished protein localization to cell periphery during vegetative growth | •normal protein localization to cell periphery | •abnormal nuclear transport | •decreased protein localization to chromatin during meiotic cell cycle |
•decreased protein phosphorylation during meiotic cell cycle | •normal intergenic meiotic recombination | •decreased meiotic sister chromatid cohesion at centromere | •decreased level of lipid metabolism gene mRNA during cellular response to hypoxia |
•decreased cellular triglyceride level | •decreased cellular phosphoinositide level | •normal cellular cardiolipin level | •increased protein localization to chromatin at rDNA replication fork barrier |
•abnormal protein localization to centromere | •increased duration of meiosis I | •abnormal chromosome morphology | •abnormal chromosome morphology during meiotic cell cycle |
•normal subtelomere-derived RNA level | •abnormal histone H2B-K119 ubiquitination during vegetative growth | •normal protein localization to nuclear envelope | •normal protein phosphorylation during cellular response to bleomycin |
•abnormal protein phosphorylation during cellular response to bleomycin | •decreased protein phosphorylation during cellular response to bleomycin | •increased duration of meiotic recombination double-strand break repair | •increased level of sumoylated protein in cell |
•increased SUMO chain length | •normal topoisomerase-DNA adduct level | •sensitive to UV during late mitotic G2 phase | •sensitive to UV during mitotic S phase |
•normal viability following cellular response to UV during mitotic S phase | •normal mitotic G2 DNA damage checkpoint during cellular response to UV during mitotic S phase | •increased duration of mitotic DNA damage checkpoint during cellular response to UV during mitotic S phase | •decreased rate of cell separation after cytokinesis |
•increased cellular HMW SUMO conjugate level | •decreased cellular HMW SUMO conjugate level | •decreased rate of protein degradation during vegetative growth | •premature sister kinetochore separation and normal chromosome division in meiosis I, and unequal sister chromatid segregation in meiosis II |
•equational sister chromatid separation during meiosis I | •normal RNA level during cellular response to iron ion starvation | •resistance to Cutin-1 | •abnormal kinetochore morphology |
•split kinetochore | •sister kinetochore separation during meiosis I | •increased duration of protein localization to telomere | •normal onset of premeiotic DNA replication |
•abnormal nuclear morphology during meiosis I | •abnormal spindle morphology during meiosis I | •decreased level of iron assimilation gene mRNA during vegetative growth | •abolished iron ion binding |
•normal frequency of meiotic crossover associated with gene conversion | •abnormal frequency of meiotic crossover associated with gene conversion | •decreased frequency of meiotic crossover associated with gene conversion | •increased transcription during nitrogen starvation |
•viable elongated cell during nitrogen starvation | •abnormal actin cytoskeleton | •cut with abnormal chromosome segregation during cellular response to hydroxyurea | •decreased protein localization to nucleus during mitosis |
•increased level of ubiquitinated protein in cell during cellular response to methyl methanesulfonate | •normal protein deubiquitination following cellular response to methyl methanesulfonate during vegetative growth | •decreased number of Rad52 foci during mitotic S phase | •ubiquitinated protein absent from cell during vegetative growth |
•normal number of Rad52 foci during mitotic S phase | •decreased microtubule polymerization | •decreased microtubule depolymerization during vegetative growth | •increased duration of mitotic prometaphase |
•decreased RNA level during cellular response to cadmium ion | •microtubule bundles present in decreased numbers during mitotic interphase | •normal astral microtubules | •inviable binucleate aseptate cell with mitotic cell cycle arrest before cell separation |
•abnormal eMTOC assembly | •decreased spindle pole body-led chromosome movement during mitotic interphase | •abnormal microtubule nucleation | •abolished cytoplasmic microtubule nucleation |
•decreased interphase microtubule nucleation | •normal interphase microtubule nucleation from spindle pole body | •abnormal protein localization to microtubule organizing center | •loss of viability following cellular response to hydroxyurea |
•loss of viability following cellular response to UV | •increased duration of mitotic anaphase B | •normal protein localization to eMTOC | •normal protein localization to mitotic spindle pole body during mitosis |
•abnormal negative regulation of DNA replication initiation resulting in complete rereplication, with mitotic cell cycle arrest | •decreased cyclin B1-CDK1 complex level | •normal protein kinase activity during mitosis | •mitotic spindle collapse during anaphase B elongation |
•abnormal protein methyltransferase activity | •decreased protein methyltransferase activity | •abolished deactivation of mitotic spindle assembly checkpoint | •increased cellular ferrichrome level |
•increased protein localization to kinetochore during mitosis | •decreased prospore membrane formation | •complete but unequal mitotic sister chromatid segregation with unseparated chromosomes | •abnormal invertase activity |
•decreased invertase activity during glucose starvation | •normal invertase activity during glucose starvation | •abnormal protein transport | •abnormal protein export from nucleus |
•decreased protein export from nucleus during glucose starvation | •normal protein transport | •normal protein export from nucleus during glucose starvation | •decreased protein phosphorylation during glucose starvation |
•sensitive to Zeocin | •normal growth on Zeocin | •increased cellular dNTP level | •normal cellular dNTP level |
•abolished protein localization to membrane during vegetative growth | •abnormal regulation of mitotic DNA replication initiation from late origin | •increased protein localization to chromatin at late replication origin | •increased cell-cell adhesion |
•elongated mononucleate aseptate vegetative cell | •sensitive to acetaldehyde | •normal growth on acetaldehyde | •increased number of Rad52 foci during cellular response to acetaldehyde |
•normal protein localization to kinetochore during mitosis | •decreased duration of mitotic spindle assembly checkpoint | •normal mitotic checkpoint complex assembly | •decreased duration of protein-protein interaction |
•decreased spatial extent of double-strand break processing | •increased gene conversion during vegetative growth | •abnormal shmoo directionality | •bent cell |
•short microtubule bundle | •decreased protein localization to cell cortex of cell tip during vegetative growth | •decreased microtubule dwell time at cell tip | •abnormal protein movement within plasma membrane during vegetative growth |
•decreased rate of protein movement within plasma membrane at cell tip | •decreased rate of protein movement within plasma membrane at cell side | •normal protein movement within plasma membrane during vegetative growth | •normal rate of protein movement within plasma membrane at cell tip |
•normal rate of protein movement within plasma membrane at cell side | •normal protein movement within plasma membrane | •T-shaped cell during recovery from quiescence | •normal protein localization to microtubule end during mitotic interphase |
•abolished protein localization to microtubule plus-end | •normal microtubule-based movement | •normal protein neddylation | •increased phosphatidylserine externalization |
•increased plasma membrane permeability | •sensitive to iron | •normal protein transport along microtubule during vegetative growth | •symmetric mitochondrial aggregation |
•normal protein localization to interphase microtubule | •abolished histone H3-K9 trimethylation at centromere outer repeat during vegetative growth | •decreased histone H3-K9 trimethylation at silent mating-type cassette during vegetative growth | •abnormal histone methyltransferase activity (H3-K9 specific) activity |
•decreased histone methyltransferase activity (H3-K9 specific) activity | •abolished protein localization to heterochromatin at centromere outer repeat | •altered antisense RNA level during vegetative growth | •altered level of translation gene mRNA during vegetative growth |
•loss of punctate nuclear protein localization | •normal histone H3-K9 methylation at subtelomeric heterochromatin during vegetative growth | •normal histone H3-K9 methylation at silent mating-type cassette during vegetative growth | •increased mitotic recombination at rDNA |
•incomplete septum | •thin, incomplete primary cell septum | •increased secondary cell septum thickness | •growth auxotrophic for proline |
•growth auxotrophic for tryptophan | •long interphase microtubules curved around cell end | •ophthalmic acid absent from cell | •abolished anaerobic cell population growth |
•normal growth on myxothiazol | •sensitive to myxothiazol | •ectopic CENP-A containing nucleosome assembly | •sensitive to sodium chloride |
•normal rate of actin filament-based movement | •abnormal actin filament-based movement | •incomplete actomyosin contractile ring contraction | •normal onset of actomyosin contractile ring assembly |
•normal onset of actomyosin contractile ring contraction | •decreased level of stress responsive gene mRNA during vegetative growth | •abnormal RNA 3'-end processing during cellular response to endoplasmic reticulum stress | •normal meiosis-specific chromatin remodeling |
•abnormal meiosis-specific chromatin remodeling | •increased transcription at subtelomeric heterochromatin | •decreased protein localization to subtelomeric heterochromatin | •sensitive to TOP-53 |
•abolished protein polyubiquitination during vegetative growth | •decreased nucleosome occupancy at silent mating-type cassette | •abolished protein sumoylation during vegetative growth | •normal intragenic meiotic recombination frequency |
•decreased protein localization to chromatin at late replication origin | •decreased replicative lifespan | •normal intergenic meiotic recombination frequency | •normal frequency of break-induced loss of heterozygosity |
•decreased level of cell cycle regulated gene mRNA during vegetative growth | •normal growth on potassium chloride | •decreased protein localization to chromatin at highly transcribed RNA polymerase II genes during vegetative growth | •normal protein localization to chromatin at highly transcribed RNA polymerase II genes during vegetative growth |
•increased nucleosome occupancy at highly transcribed RNA polymerase II genes | •increased duration of mitotic cell cycle | •abnormal protein dephosphorylation during vegetative growth | •decreased protein dephosphorylation during vegetative growth |
•multipolar spindle | •multipolar mitotic spindle | •resistance to sodium chloride | •resistance to magnesium chloride |
•abnormal transport during vegetative growth | •increased rate of mitotic spindle elongation during anaphase B | •increased spliced cen-dg RNA level | •abnormal actin filament bundle organization |
•linear elements present in decreased numbers | •abnormal protein localization to cell tip | •abolished microtubule anchoring at cell cortex of cell tip during meiotic cell cycle | •abnormal protein localization during mating |
•abnormal maintenance of protein location in cell cortex of cell tip during karyogamy | •decreased protein localization to P-bodies | •normal cytoplasmic translation | •increased lncRNA level |
•altered rRNA or precursor level | •altered snRNA or precursor level | •altered snoRNA or precursor level | •altered tRNA or precursor level |
•normal rRNA or precursor level | •normal cellular component organization | •normal interphase microtubule organization | •normal actomyosin contractile ring localization |
•normal onset of protein localization to cell division site | •abolished shmoo contact with partner cell | •shmoo formation at cell side | •elongated cell with abolished shmoo formation |
•large ascus | •promiscuous mating | •multiseptate cell with shmoo | •sensitive to urea |
•abnormal protein distribution along RNA polymerase II-transcribed genes | •elongated multinucleate multiseptate vegetative cell, irregular septum position | •normal actin filament binding | •abolished actin filament bundle assembly |
•actin cables present in increased numbers | •decreased actin filament depolymerization | •actin cortical patches absent from cell | •delayed onset of mitotic DNA replication initiation |
•decreased protein localization to chromatin during mitotic DNA replication | •normal protein localization to chromatin during mitotic DNA replication | •normal mitochondrion | •increased cytosolic monomeric ribosome level |
•decreased cytosolic half-mer polysome level | •incomplete mitotic metaphase chromosome recapture | •decreased rate of mitotic metaphase chromosome recapture | •unstable mitotic spindle |
•fluctuating mitotic spindle length | •decreased lipid droplet localization to prospore membrane leading edge | •lipid droplets present in spore cytoplasm in decreased numbers, mislocalized to ascus epiplasm | •normal protein localization to meiotic spindle pole body during meiosis II |
•abnormal vacuole fusion | •abnormal protein localization to septin ring | •abolished protein localization to septin ring | •abnormal septin ring assembly during vegetative growth |
•ectopic septin ring assembly during vegetative growth | •decreased small RNA degradation | •siRNA absent from cell | •increased protein localization to actin cortical patch |
•abnormal sporulation resulting in formation of ascus with four spores | •sensitive to cold shock | •abolished DNA resection during replication fork processing | •abnormal glutathione hydrolase activity |
•increased glutathione hydrolase activity | •abnormal actin filament bundle assembly | •abnormal protein localization to actin cable | •increased protein localization to actin cable |
•abnormal protein localization to cytoplasm | •abnormal interphase microtubules | •interphase microtubules absent from cell | •short interphase microtubules |
•abnormal actin fusion focus assembly | •increased subtelomeric transcript-derived siRNA level | •abolished protein localization to actin cortical patch | •decreased protein localization to actin cortical patch |
•abnormal protein methylation during vegetative growth | •normal asymmetric protein arginine dimethylation during vegetative growth | •normal duration of meiosis II | •increased cellular gluconate level |
•sensitive to idarubicin | •normal growth on etoposide | •abolished DNA binding at STREP motif | •normal RNA level during mitotic S phase |
•increased protein localization to linear element | •decreased number of Rad51 foci during meiotic prophase I | •abolished protein localization to chromatin during meiosis I | •normal protein localization to chromatin during meiosis I |
•normal protein localization to chromatin | •mitotic spindle collapse without elongation during anaphase B | •abolished mitotic spindle elongation during prophase | •abolished mitotic spindle elongation during anaphase B |
•abnormal protein localization to centromere during mitotic metaphase | •decreased rate of actin cortical patch localization | •increased microtubule polymerization | •decreased protein localization to interphase microtubule |
•abnormal protein localization to nucleus during meiotic prophase I | •normal rate of actomyosin contractile ring assembly | •decreased number of elongated microtubule bundles curved around cell end | •sensitive to phosphate starvation |
•abnormal regulation of adenine biosynthetic process | •decreased rate of actin filament depolymerization | •altered RNA level during cellular response to copper ion starvation | •decreased RNA level during cellular response to copper ion starvation |
•inviable after spore germination, before germ tube formation | •inviable after spore germination, before germ tube formation, during copper ion starvation | •normal septum morphology | •actin cables present in decreased numbers |
•normal cell population growth during potassium ion starvation | •abolished protein localization to septum | •decreased phosphatidylinositol phosphate level in plasma membrane | •sensitive to tetramethylammonium |
•decreased cytoplasmic translational initiation during cellular response to oxidative stress | •decreased cytoplasmic translational initiation during cellular response to osmotic stress | •abolished protein phosphorylation during cellular response to hydrogen peroxide | •decreased protein localization to vacuolar membrane |
•increased cell population growth on gluconate carbon source | •normal level of macromolecular complex | •normal cytosolic monomeric ribosome level | •normal cytosolic half-mer polysome level |
•decreased protein localization to centromere | •increased protein localization to centromere | •abnormal tRNA aminoacylation | •decreased tRNA aminoacylation |
•normal duration of mitotic prophase | •abolished subtelomeric chromatin knob formation | •increased histone H3-K36 trimethylation during vegetative growth | •normal vacuole size during vegetative growth |
•increased telomere clustering and tethering at nuclear periphery during mitotic metaphase | •increased histone H3-K9 dimethylation at protein coding gene during vegetative growth | •decreased histone H3-K9 dimethylation at protein coding gene during vegetative growth | •premature mitotic DNA replication initiation from late origin |
•abolished protein localization via NVT pathway | •normal termination of RNA polymerase II transcription | •increased mitotic recombination with crossover formation at centromere | •decreased mitotic recombination at centromere |
•decreased mitotic recombination at chromosome arms | •normal cyclin B1-CDK1 complex level | •normal protein localization via NVT pathway | •normal macroautophagy during nitrogen starvation |
•abolished macroautophagy during nitrogen starvation | •increased chromatin silencing at centromere outer repeat | •increased protein localization to chromatin at centromere inner repeat | •abolished ribonuclease activity |
•abolished intra-arm chromosome contact change during mitosis | •abnormal actin filament-based process | •abolished meiotic G2/MI transition | •abolished homologous chromosome segregation |
•normal extent of DNA resection during replication fork processing | •increased protein localization to chromatin at stalled replication fork | •loss of viability following replication fork stalling | •normal septin ring morphology |
•decreased protein localization to medial cortical node | •abnormal organelle localization | •decreased endoplasmic reticulum-plasma membrane tethering | •decreased RNA level during cellular response to zinc ion starvation |
•decreased microtubule nucleation | •decreased mitotic microtubule nucleation | •mononucleate vegetative cell with mislocalized nucleus | •abolished equatorial endocytosis during mitosis |
•increased duration of protein phosphorylation during nitrogen starvation | •abolished protein localization to chromatin at promoter | •increased centromere central core transcript level | •abnormal transcription during glucose starvation |
•delayed onset of transcription during glucose starvation | •abnormal chromatin remodeling | •decreased chromatin remodeling during glucose starvation | •decreased protein exchange at pericentric heterochromatin |
•increased protein exchange at pericentric heterochromatin | •increased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth | •abolished meiotic telomere clustering | •increased chromatin silencing at subtelomere |
•normal spatial extent of centromeric heterochromatin assembly | •increased histone H3-K9 dimethylation at heterochromatin domain during vegetative growth | •incomplete meiotic chromosome segregation, with chromosomal bridge | •abnormal protein processing |
•decreased protein processing during nitrogen starvation | •abnormal protein localization to endoplasmic reticulum | •normal protein localization to cell tip during nitrogen starvation | •protein abnormally dispersed at shmoo tip |
•abnormal meiotic spindle pole body organization during meiosis I | •multiple meiotic spindles | •localization phenotype during meiotic cell cycle | •abolished protein phosphorylation during cellular response to leucine starvation |
•abnormal septin ring morphology | •decreased cellular dNTP level | •fragmented spindle pole body | •abnormal spindle pole body morphology during meiotic cell cycle |
•altered cellular nitric oxide level | •increased level of histone gene mRNA during vegetative growth | •increased level of histone gene mRNA during mitotic interphase | •increased duration of Rad51 focus presence during meiotic cell cycle |
•decreased meiotic sister chromatid cohesion at centromere during meiosis I | •abolished meiotic sister chromatid cohesion at centromere during meiosis I | •inviable mononucleate vegetative cell | •abnormal S-phase DNA damage checkpoint during cellular response to methyl methanesulfonate |
•normal mitotic DNA damage checkpoint during cellular response to methyl methanesulfonate | •alkylation damage repair intermediates absent | •abolished protein kinase activity during cellular response to hydroxyurea | •increased mitochondrial pre-mRNA level |
•abolished protein localization to cleavage furrow during vegetative growth | •decreased rate of histone H3 acetylation during vegetative growth | •decreased histone H3 acetyltransferase processivity | •abnormal histone acetyltransferase activity |
•abnormal protein localization to meiotic spindle | •abolished protein localization to meiotic spindle during meiosis I | •abolished protein localization to meiotic spindle during meiosis II | •abnormal histone modification |
•abnormal protein modification during meiotic cell cycle | •abnormal telomere length during vegetative growth | •altered mature ncRNA level during vegetative growth | •decreased mature ncRNA level |
•increased mature ncRNA level | •altered mature rRNA level during vegetative growth | •normal mature ncRNA level | •decreased mature rRNA level |
•mitotic spindle collapse | •abnormal mitotic metaphase/anaphase transition | •abnormal cohesin loading | •decreased mitotic cohesin ssDNA (lagging strand) loading |
•decreased rDNA copy number during vegetative growth | •abnormal plasma membrane phosphatidylserine distribution | •abnormal cell wall disassembly at cell fusion site | •premature cell wall disassembly at cell fusion site |
•premature actin fusion focus assembly | •abolished protein localization to cell cortex of cell tip during vegetative growth | •abnormal protein localization to actin fusion focus | •multiple shmoo formation |
•abolished protein localization to shmoo tip | •normal RNA level during mitotic G1 phase | •abnormal telomere morphology | •abnormal telomere length |
•abnormal telomere structure | •normal telomere morphology | •normal telomere morphology during vegetative growth | •normal telomere structure |
•normal telomere length | •loss of viability in G0 | •increased cytoplasmic translation | •abnormal mitotic sister chromatid cohesion |
•abnormal meiosis II | •decreased proteolysis | •abnormal protein localization to centromere during meiotic cell cycle | •abolished protein localization to centromere during meiotic prophase II |
•normal protein localization to centromere during meiotic prophase II | •abnormal protein localization to cell periphery | •abolished protein localization to cell periphery during nitrogen starvation | •increased protein localization to cell periphery during vegetative growth |
•loss of viability following cellular response to pheromone | •abnormal actin cytoskeleton organization during cellular response to pheromone | •decreased protein level during mating | •increased protein level during mitotic metaphase |
•abnormal membrane lipid distribution | •normal membrane lipid distribution | •abnormal plasma membrane phosphatidylserine distribution resulting in decreased concentration at cell tip | •increased gene expression |
•decreased gene expression | •decreased gene expression during nitrogen starvation | •abnormal gene expression | •increased protein localization to cytoplasm |
•normal protein localization to nucleus | •normal protein localization to nucleus during nitrogen starvation | •abnormal multiple protein binding to DNA | •inviable elongated tetranucleate triseptate vegetative cell, single septa between nuclei |
•abolished septum disassembly | •abolished MBF complex assembly during mitotic G1 phase | •normal viability upon sulfur starvation | •abnormal DNA repair |
•abnormal meiotic mismatch repair | •normal DNA repair | •increased cyclin-dependent protein kinase activity during cellular response to pheromone | •normal mitotic G2 DNA damage checkpoint |
•sensitive to manganese | •resistance to amiodarone | •abnormal protein localization to shmoo tip membrane | •abolished protein localization to shmoo tip membrane, with protein mislocalized to endoplasmic reticulum |
•decreased protein localization to shmoo tip membrane | •decreased protein localization to shmoo tip membrane, with protein distributed in plasma membrane | •protein mislocalized to endoplasmic reticulum | •increased level of flocculin gene mRNA during vegetative growth |
•increased level of cell wall organization gene mRNA during vegetative growth | •decreased histone H3-T3 phosphorylation during vegetative growth | •decreased protein localization to centromeric chromatin during vegetative growth | •decreased protein localization to centromeric chromatin during mitotic metaphase |
•abnormal dynamic protein localization pattern | •abnormal intermittent protein localization to Cdr2 medial cortical node complex | •intermittent protein localization to Cdr2 medial cortical node complex decoupled from cell size | •decreased protein localization to chromatin at transcription termination site |
•increased cell diameter | •viable vegetative cell with increased cell diameter | •viable elongated vegetative cell with increased cell diameter | •decreased phosphatidylinositol-4,5-bisphosphate level in plasma membrane |
•decreased phosphatidylinositol-4-phosphate level in plasma membrane | •decreased protein localization to chromatin | •increased cell length | •mislocalized protein distributed in cell cortex |
•decreased protein localization to cell cortex of cell tip, with protein distributed in cortex | •decreased protein localization to medial cortex during vegetative growth, with protein distributed in cell cortex | •normal protein localization to kinetochore during mitotic metaphase | •decreased protein localization to nucleus during mitotic interphase |
•loss of viability upon G0 to G1 transition | •fragmented nucleus | •fragmented nucleus during G0 | •elongated nucleus |
•elongated nucleus during G0 | •abnormal nuclear morphology during G0 | •abnormal mating between three cells | •meiosis in haploid nucleus |
•transient cell fusion followed by meiosis and sporulation in haploid | •decreased DNA binding at double-strand break | •increased number of Rad52 foci during cellular response to chromium | •normal growth on chromium |
•sensitive to bisphenol A | •increased histone H3-K9 acetylation at centromere inner repeat during vegetative growth | •increased protein localization to chromatin at centromere outer repeat | •normal histone H3-K9 methylation at centromere inner repeat during vegetative growth |
•decreased centromeric transcript binding | •decreased DNA double-strand break processing | •decreased DNA double-strand break processing during double-strand break repair via homologous recombination | •increased insertion/deletion frequency |
•mitotic catastrophe with abnormal chromosome segregation | •decreased cellular S-adenosyl-L-homocysteine level during vegetative growth | •decreased cellular CDP level | •decreased cellular pentose phosphate level |
•decreased cellular acetyl-CoA level | •increased cellular malonyl-CoA level | •increased cellular free fatty acid level | •large and small daughter nuclei |
•increased duration of protein phosphorylation during cellular response to osmotic stress | •abolished mitotic DNA replication initiation | •abnormal mitotic DNA replication elongation | •delayed onset of protein localization to chromatin at replication origin |
•stationary phase viability unaffected by tschimganine | •normal protein localization to chromatin at MCB promoters during vegetative growth | •increased protein localization to chromatin at MCB promoters during vegetative growth | •increased nucleosome occupancy at MCB promoters |
•normal transcription from MCB promoter | •decreased protein localization to nucleus during cellular response to osmotic stress | •abnormal cell wall thickness during vegetative growth | •decreased cell wall thickness at cell tip during vegetative growth |
•decreased pre-tRNA level during vegetative growth | •decreased promoter-enhancer looping during glucose starvation | •decreased chromatin binding at promoter element during glucose starvation | •protein absent from cell during mitotic G1 phase |
•abnormal meiotic chromosome organization | •abnormal protein phosphorylation during meiotic cell cycle | •mislocalized actin cortical patches | •dispersed actin cortical patch localization during mating |
•abolished protein localization to prospore septin ring | •decreased cellular phosphatidylinositol-4-phosphate level | •prospore membrane formation excluding nucleus | •resistance to spermidine |
•tubular vacuole morphology during vegetative growth | •normal growth on cobalt | •normal growth on manganese | •lipid droplets present in normal numbers |
•altered meiotic drive suppression specificity | •inviable branched, swollen vegetative cell | •delayed onset of cell separation after cytokinesis | •decreased centromere clustering at nuclear periphery during mitosis |
•abnormal galactosyltransferase activity | •decreased galactosyltransferase activity | •decreased galactose level in cell surface glycoprotein glycan | •abnormal deadenylation-dependent decay |
•decreased nuclear-transcribed mRNA poly(A) tail shortening | •normal gross chromosomal rearrangement frequency | •increased histone H3-K9 acetylation at centromere outer repeat during vegetative growth | •decreased protein localization to chromatin at centromere outer repeat |
•normal vegetative cell growth rate | •abnormal cell growth rate | •slow vegetative cell growth | •viable small vegetative cell with normal cell growth rate |
•premature protein localization to mitotic spindle pole body | •abolished protein localization to mitotic spindle pole body during mitosis | •increased cytosolic zinc level | •delayed onset of primary cell septum biogenesis |
•premature primary cell septum biogenesis | •sensitive to magnesium chloride | •normal protein complex assembly | •increased histone H3 localization to chromatin |
•decreased duration of meiotic cell cycle phase | •normal growth on EGTA | •abnormal histone H3-K37 methylation | •decreased histone H3-K37 methylation |
•mislocalized RNA during vegetative growth | •RNA mislocalized to cytoplasm during vegetative growth | •cut during cellular response to streptonigrin | •abnormal protein localization to cell cortex |
•decreased protein localization to cell cortex during meiotic prophase I | •abolished histone H3-K36 methylation | •abnormal histone methylation | •abnormal protein localization to cell cortex of cell tip during vegetative growth |
•normal protein localization to cell cortex of cell tip | •decreased protein level at mitotic spindle | •decreased protein localization to cell tip during meiosis | •decreased mitochondrion localization to cell tip during meiosis |
•decreased septum thickness | •mitotic G1/S phase transition at small cell size | •normal cell cycle process | •normal cell cycle phase transition |
•normal onset of mitotic metaphase/anaphase transition | •decreased DNA recombination at mitotic DNA replication fork barriers | •decreased gene conversion at mitotic DNA replication fork barriers | •increased nucleus:cytoplasm ratio |
•decreased nucleus:cytoplasm ratio | •sensitive to butylated hydroxyanisole | •sensitive to butylated hydroxytoluene | •resistance to butylated hydroxyanisole |
•resistance to butylated hydroxytoluene | •abolished protein localization to plasma membrane at cell division site during vegetative growth | •abolished lipid binding | •asymmetric actomyosin contractile ring contraction |
•increased duration of protein localization to actin cortical patch | •decreased ribosomal protein level | •inviable swollen elongated multiseptate vegetative cell | •increased cellular asparagine level |
•increased cellular glutamine level | •RNA absent from cell during meiotic cell cycle | •normal RNA level during meiotic cell cycle | •abnormal protein ubiquitination |
•decreased cellular coenzyme Q10 level | •increased cellular coenzyme Q10 level | •normal cell wall morphology during vegetative growth | •abnormal termination of RNA polymerase III transcription |
•increased transcriptional readthrough at RNA polymerase III-transcribed genes | •heterochromatin assembly beyond boundary element IRL | •normal spatial extent of heterochromatin assembly to boundary element IRL | •normal spatial extent of heterochromatin assembly at protein coding gene |
•normal chromatin silencing at centromere otr1R | •decreased chromatin silencing at centromere otr1R | •increased chromatin silencing at centromere otr1L | •normal chromatin silencing at centromere inner repeat |
•normal dynamic protein localization pattern | •decreased DNA recombination downstream of mitotic DNA replication fork barriers | •increased DNA recombination downstream of mitotic DNA replication fork barriers | •normal DNA recombination frequency downstream of mitotic DNA replication fork barriers |
•decreased chromatin silencing by small RNA | •increased protein localization to chromatin at ncRNA genes | •normal mature 28S rRNA level | •normal mature 5S rRNA level |
•normal tRNA pseudouridylation | •normal tRNA guanosine 2'-O-methylation | •abolished tRNA cytosine 2'-O-methylation | •increased tRNA guanosine 1-methylation |
•decreased tRNA guanosine 7-methylation | •decreased tRNA guanosine N2-methylation | •decreased tRNA wybutosine biosynthesis | •abolished protein localization to medial cortex, with protein mislocalized to cytoplasm, during vegetative growth |
•resistance to fluconazole | •resistance to phenylglyoxal | •normal growth on 5-fluorouracil | •abnormal alkaline phosphatase activity |
•decreased alkaline phosphatase activity | •decreased alkaline phosphatase activity during stress response to zinc ion | •decreased alkaline phosphatase activity during cellular response to zinc ion starvation | •normal alkaline phosphatase activity |
•normal alkaline phosphatase activity during stress response to zinc ion | •decreased RNA level during stress response to zinc ion | •altered protein level during stress response to zinc ion | •abnormal post-Golgi vesicle-mediated transport |
•normal protein localization to vacuole | •decreased actin filament depolymerization involved in actomyosin contractile ring assembly | •increased origin firing efficiency in subtelomeric heterochromatin | •increased rate of mitotic spindle elongation during anaphase A |
•decreased duration of mitotic anaphase B | •normal meiotic cell cycle process | •increased duration of cell fusion during mating | •increased protein localization to actin fusion focus |
•decreased protein localization to actin fusion focus | •ectopic actin fusion focus assembly | •bent spindle during meiosis I | •multiple spindles during meiosis II |
•increased duration of Rad52 focus presence during meiotic cell cycle | •abnormal meiotic centromere clustering during meiotic prophase I | •microtubule bundles present in decreased numbers at spindle pole body during meiosis I | •abnormal microtubule depolymerization |
•decreased rate of microtubule depolymerization involved in meiotic centromere clustering during meiotic prophase I | •abnormal microtubule cytoskeleton organization during meiotic cell cycle | •mitotic sister chromatid separation in absence of mitotic spindle | •abnormal mitotic chromosome movement towards spindle pole |
•normal protein localization to medial cortical node during mitotic interphase | •abolished protein localization to medial cortical node during mitotic interphase | •abolished endodeoxyribonuclease activity | •decreased microtubule bundle formation |
•normal polyphosphate catabolism during cellular response to phosphate starvation | •normal polyphosphate biosynthesis during cellular response to replete phosphate | •increased protein localization to medial cortical node | •abnormal histone binding |
•abnormal DNA replication-dependent nucleosome assembly | •resistance to oxidative stress | •abnormal microtubule-based movement | •normal protein localization to cell cortex during meiotic prophase I |
•abolished protein localization to medial cortex during mitotic interphase | •small mitochondria | •mitochondria present in increased numbers | •decreased sister chromatid cohesion along chromosome arms during mitotic interphase |
•normal mitochondrial volume | •decreased chromatin silencing at heterochromatin island | •decreased histone H3-K9 dimethylation at heterochromatin island during vegetative growth | •abolished protein localization to chromatin at MCB promoters during cellular response to hydroxyurea |
•normal chromatin silencing by small RNA | •normal protein localization to old growing cell tip | •abolished mitotic G2 DNA damage checkpoint during cellular response to ionizing radiation | •normal level of X-shaped replication intermediates |
•abnormal lipid binding | •decreased lipid binding | •premature protein localization to meiotic spindle pole body during prophase I | •delayed onset of protein localization to meiotic spindle pole body during meiosis I |
•abnormal meiotic spindle pole body duplication | •increased meiotic spindle pole body duplication | •abnormal cellular process during meiotic cell cycle |
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