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Search term: YAL026C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DRS2
SGD link S000000024
Alternative ID YAL026C
Description Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
Synonyms YAL026C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0206 ACDHYPE

KOGs classification KOGs description
POORLY CHARACTERIZED P-type ATPase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g13210 GI:15222212
Arabidopsis thaliana (Ath) At1g17500 GI:15220134
Arabidopsis thaliana (Ath) At1g26130 GI:15222647
Arabidopsis thaliana (Ath) At1g54280 GI:15221763
Arabidopsis thaliana (Ath) At1g59820 GI:15218927
Arabidopsis thaliana (Ath) At1g68710 GI:15221488
Arabidopsis thaliana (Ath) At1g72700 GI:15218567
Arabidopsis thaliana (Ath) At3g13900 GI:15231408
Arabidopsis thaliana (Ath) At3g25610 GI:15230859
Arabidopsis thaliana (Ath) At3g27870 GI:15232278
Arabidopsis thaliana (Ath) At5g44240 GI:15241449
Caenorhabditis elegans (Cel) CE16563 GI:17555532
Caenorhabditis elegans (Cel) CE21203
(WBGene00020784)		 GI:17536491 Q7JPE3
Caenorhabditis elegans (Cel) CE21204 GI:17536489 Q7JPE3
Caenorhabditis elegans (Cel) CE27180
(WBGene00019166)		 GI:17540994
Caenorhabditis elegans (Cel) CE28133
(WBGene00013034)		 GI:17556056
Drosophila melanogaster (Dme) 7293223 GI:7293223 Q9VXG7
Drosophila melanogaster (Dme) 7293224 GI:7293224
Drosophila melanogaster (Dme) 7297523 GI:7297523
Drosophila melanogaster (Dme) 7297524 GI:7297524
Drosophila melanogaster (Dme) 7299563 GI:7299563
Drosophila melanogaster (Dme) 7303318 GI:7303318
Homo sapiens (Hsa) Hs17978471
(ATP8A1)		 GI:17978471 Q9Y2Q0
Homo sapiens (Hsa) Hs5031697
(ATP8B1)		 GI:5031697 O43520
Homo sapiens (Hsa) Hs18544435 GI:18544435
Homo sapiens (Hsa) Hs18545080 GI:18545080
Homo sapiens (Hsa) Hs18559777 GI:18559777
Homo sapiens (Hsa) Hs18573385_1 GI:18573385
Homo sapiens (Hsa) Hs18582551 GI:18582551
Homo sapiens (Hsa) Hs18591302 GI:18591302
Homo sapiens (Hsa) Hs18596506 GI:18596506
Homo sapiens (Hsa) Hs20471415 GI:20471415
Homo sapiens (Hsa) Hs20533656 GI:20533656
Homo sapiens (Hsa) Hs20548566 GI:20548566
Homo sapiens (Hsa) Hs13376249 GI:13376249
Homo sapiens (Hsa) Hs13376749 GI:13376749
Homo sapiens (Hsa) Hs14424433
(ATP10A)		 GI:14424433 O60312
Homo sapiens (Hsa) Hs7706561 GI:7706561
Saccharomyces cerevisiae (Sce) YAL026c
(S000000024)		 GI:6319293 P39524
Saccharomyces cerevisiae (Sce) YDR093w
(S000002500)		 GI:6320298 Q12675
Saccharomyces cerevisiae (Sce) YER166w
(S000000968)		 GI:6321014 P32660
Saccharomyces cerevisiae (Sce) YMR162c
(S000004772)		 GI:6323814 Q12674
Schizosaccharomyces pombe (Spo) SPAC24B11.12c GI:19113761 Q09891
Schizosaccharomyces pombe (Spo) SPAC4F10.16c GI:19115671 O36028
Schizosaccharomyces pombe (Spo) SPAC821.13c GI:19114078 Q9UT43
Schizosaccharomyces pombe (Spo) SPBC887.12 GI:19113278 O94296
Encephalitozoon cuniculi (Ecu) ECU06g0930 GI:19074343 Q8SRQ0
Arabidopsis thaliana (Ath) At1g13210 GI:15222212
Arabidopsis thaliana (Ath) At1g17500 GI:15220134
Arabidopsis thaliana (Ath) At1g26130 GI:15222647
Arabidopsis thaliana (Ath) At1g54280 GI:15221763
Arabidopsis thaliana (Ath) At1g59820 GI:15218927
Arabidopsis thaliana (Ath) At1g68710 GI:15221488
Arabidopsis thaliana (Ath) At1g72700 GI:15218567
Arabidopsis thaliana (Ath) At3g13900 GI:15231408
Arabidopsis thaliana (Ath) At3g25610 GI:15230859
Arabidopsis thaliana (Ath) At3g27870 GI:15232278
Arabidopsis thaliana (Ath) At5g44240 GI:15241449
Caenorhabditis elegans (Cel) CE16563 GI:17555532
Caenorhabditis elegans (Cel) CE21203
(WBGene00020784)		 GI:17536491 Q7JPE3
Caenorhabditis elegans (Cel) CE21204 GI:17536489 Q7JPE3
Caenorhabditis elegans (Cel) CE27180
(WBGene00019166)		 GI:17540994
Caenorhabditis elegans (Cel) CE28133
(WBGene00013034)		 GI:17556056
Drosophila melanogaster (Dme) 7293223 GI:7293223 Q9VXG7
Drosophila melanogaster (Dme) 7293224 GI:7293224
Drosophila melanogaster (Dme) 7297523 GI:7297523
Drosophila melanogaster (Dme) 7297524 GI:7297524
Drosophila melanogaster (Dme) 7299563 GI:7299563
Drosophila melanogaster (Dme) 7303318 GI:7303318
Homo sapiens (Hsa) Hs17978471
(ATP8A1)		 GI:17978471 Q9Y2Q0
Homo sapiens (Hsa) Hs5031697
(ATP8B1)		 GI:5031697 O43520
Homo sapiens (Hsa) Hs18544435 GI:18544435
Homo sapiens (Hsa) Hs18545080 GI:18545080
Homo sapiens (Hsa) Hs18559777 GI:18559777
Homo sapiens (Hsa) Hs18573385_1 GI:18573385
Homo sapiens (Hsa) Hs18582551 GI:18582551
Homo sapiens (Hsa) Hs18591302 GI:18591302
Homo sapiens (Hsa) Hs18596506 GI:18596506
Homo sapiens (Hsa) Hs20471415 GI:20471415
Homo sapiens (Hsa) Hs20533656 GI:20533656
Homo sapiens (Hsa) Hs20548566 GI:20548566
Homo sapiens (Hsa) Hs13376249 GI:13376249
Homo sapiens (Hsa) Hs13376749 GI:13376749
Homo sapiens (Hsa) Hs14424433
(ATP10A)		 GI:14424433 O60312
Homo sapiens (Hsa) Hs7706561 GI:7706561
Saccharomyces cerevisiae (Sce) YAL026c
(S000000024)		 GI:6319293 P39524
Saccharomyces cerevisiae (Sce) YDR093w
(S000002500)		 GI:6320298 Q12675
Saccharomyces cerevisiae (Sce) YER166w
(S000000968)		 GI:6321014 P32660
Saccharomyces cerevisiae (Sce) YMR162c
(S000004772)		 GI:6323814 Q12674
Schizosaccharomyces pombe (Spo) SPAC24B11.12c GI:19113761 Q09891
Schizosaccharomyces pombe (Spo) SPAC4F10.16c GI:19115671 O36028
Schizosaccharomyces pombe (Spo) SPAC821.13c GI:19114078 Q9UT43
Schizosaccharomyces pombe (Spo) SPBC887.12 GI:19113278 O94296
Encephalitozoon cuniculi (Ecu) ECU06g0930 GI:19074343 Q8SRQ0
Arabidopsis thaliana (Ath) At1g13210 GI:15222212
Arabidopsis thaliana (Ath) At1g17500 GI:15220134
Arabidopsis thaliana (Ath) At1g26130 GI:15222647
Arabidopsis thaliana (Ath) At1g54280 GI:15221763
Arabidopsis thaliana (Ath) At1g59820 GI:15218927
Arabidopsis thaliana (Ath) At1g68710 GI:15221488
Arabidopsis thaliana (Ath) At1g72700 GI:15218567
Arabidopsis thaliana (Ath) At3g13900 GI:15231408
Arabidopsis thaliana (Ath) At3g25610 GI:15230859
Arabidopsis thaliana (Ath) At3g27870 GI:15232278
Arabidopsis thaliana (Ath) At5g44240 GI:15241449
Caenorhabditis elegans (Cel) CE16563 GI:17555532
Caenorhabditis elegans (Cel) CE21203
(WBGene00020784)		 GI:17536491 Q7JPE3
Caenorhabditis elegans (Cel) CE21204 GI:17536489 Q7JPE3
Caenorhabditis elegans (Cel) CE27180
(WBGene00019166)		 GI:17540994
Caenorhabditis elegans (Cel) CE28133
(WBGene00013034)		 GI:17556056
Drosophila melanogaster (Dme) 7293223 GI:7293223 Q9VXG7
Drosophila melanogaster (Dme) 7293224 GI:7293224
Drosophila melanogaster (Dme) 7297523 GI:7297523
Drosophila melanogaster (Dme) 7297524 GI:7297524
Drosophila melanogaster (Dme) 7299563 GI:7299563
Drosophila melanogaster (Dme) 7303318 GI:7303318
Homo sapiens (Hsa) Hs17978471
(ATP8A1)		 GI:17978471 Q9Y2Q0
Homo sapiens (Hsa) Hs5031697
(ATP8B1)		 GI:5031697 O43520
Homo sapiens (Hsa) Hs18544435 GI:18544435
Homo sapiens (Hsa) Hs18545080 GI:18545080
Homo sapiens (Hsa) Hs18559777 GI:18559777
Homo sapiens (Hsa) Hs18573385_1 GI:18573385
Homo sapiens (Hsa) Hs18582551 GI:18582551
Homo sapiens (Hsa) Hs18591302 GI:18591302
Homo sapiens (Hsa) Hs18596506 GI:18596506
Homo sapiens (Hsa) Hs20471415 GI:20471415
Homo sapiens (Hsa) Hs20533656 GI:20533656
Homo sapiens (Hsa) Hs20548566 GI:20548566
Homo sapiens (Hsa) Hs13376249 GI:13376249
Homo sapiens (Hsa) Hs13376749 GI:13376749
Homo sapiens (Hsa) Hs14424433
(ATP10A)		 GI:14424433 O60312
Homo sapiens (Hsa) Hs7706561 GI:7706561
Saccharomyces cerevisiae (Sce) YAL026c
(S000000024)		 GI:6319293 P39524
Saccharomyces cerevisiae (Sce) YDR093w
(S000002500)		 GI:6320298 Q12675
Saccharomyces cerevisiae (Sce) YER166w
(S000000968)		 GI:6321014 P32660
Saccharomyces cerevisiae (Sce) YMR162c
(S000004772)		 GI:6323814 Q12674
Schizosaccharomyces pombe (Spo) SPAC24B11.12c GI:19113761 Q09891
Schizosaccharomyces pombe (Spo) SPAC4F10.16c GI:19115671 O36028
Schizosaccharomyces pombe (Spo) SPAC821.13c GI:19114078 Q9UT43
Schizosaccharomyces pombe (Spo) SPBC887.12 GI:19113278 O94296
Encephalitozoon cuniculi (Ecu) ECU06g0930 GI:19074343 Q8SRQ0


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
HsaATP8B1
SceS000002500
GO:0005737 cytoplasm C
IDA
CelWBGene00013034
GO:0005739 mitochondrion C
IDA
SceS000000968
GO:0005768 endosome C
IDA
CelWBGene00013034
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC24B11.12c
SPAC4F10.16c
SPBC887.12
GO:0005794 Golgi apparatus C
IDA
AthAt1g59820
CelWBGene00013034
GO:0005802 trans-Golgi network C
IDA
SceS000000024
GO:0005886 plasma membrane C
IDA
AthAt1g26130
At3g25610
At1g59820
At1g13210
SceS000002500
S000000968
ISS
SpoSPAC24B11.12c
SPAC4F10.16c
SPBC887.12
GO:0005887 integral to plasma membrane C
IDA
CelWBGene00013034
NAS
HsaATP8B1
GO:0009941 chloroplast envelope C
IDA
AthAt1g26130
GO:0016021 integral to membrane C
ISS
SpoSPAC821.13c
NAS
HsaATP10A
ATP8A1
GO:0016323 basolateral plasma membrane C
IDA
CelWBGene00013034
GO:0016324 apical plasma membrane C
IDA
CelWBGene00013034
HsaATP8B1
GO:0030140 trans-Golgi network transport vesicle C
IDA
SceS000004772
ISS
SpoSPAC821.13c
GO:0004012 phospholipid-translocating ATPase
activity		 F
IGI
SceS000000024
S000002500
S000004772
S000000968
IMP
CelWBGene00013034
SceS000000024
S000004772
S000002500
S000000968
ISS
SpoSPAC4F10.16c
SPAC24B11.12c
SPBC887.12
SPAC821.13c
NAS
HsaATP10A
TAS
HsaATP8B1
GO:0005516 calmodulin binding F
ISS
AthAt1g13210
GO:0005524 ATP binding F
IC
SpoSPBC887.12
NAS
HsaATP8A1
GO:0005548 phospholipid transporter activity F
IDA
AthAt1g59820
GO:0008270 zinc ion binding F
IDA
AthAt1g54280
GO:0015247 aminophospholipid transporter activity F
NAS
HsaATP8A1
GO:0015399 primary active transmembrane transporter
activity		 F
RCA
SceS000004772
GO:0015405 P-P-bond-hydrolysis-driven transmembrane
transporter activity		 F
RCA
SceS000004772
GO:0015662 ATPase activity, coupled to transmembrane movement
of ions, phosphorylative mechanism		 F
ISS
AthAt1g59820
At1g68710
At5g44240
At1g72700
At1g26130
At1g17500
At1g13210
At1g54280
At3g13900
At3g27870
At3g25610
SceS000000024
S000000968
RCA
SceS000004772
GO:0016820 hydrolase activity, acting on acid anhydrides,
catalyzing transmembrane movement of
substances		 F
RCA
SceS000004772
GO:0016887 ATPase activity F
RCA
HsaATP8B1
GO:0019829 cation-transporting ATPase activity F
NAS
HsaATP8A1
GO:0022804 active transmembrane transporter
activity		 F
RCA
SceS000004772
GO:0042625 ATPase activity, coupled to transmembrane movement
of ions		 F
RCA
SceS000004772
GO:0042626 ATPase activity, coupled to transmembrane movement
of substances		 F
RCA
SceS000004772
GO:0000003 reproduction P
IMP
CelWBGene00020784
GO:0000028 ribosomal small subunit assembly P
IMP
SceS000000024
GO:0002119 nematode larval development P
IMP
CelWBGene00020784
GO:0006200 ATP catabolic process P
ISS
SpoSPAC4F10.16c
SPAC24B11.12c
SPAC821.13c
SPBC887.12
GO:0006869 lipid transport P
RCA
SceS000002500
S000000968
S000000024
S000004772
GO:0006886 intracellular protein transport P
IGI
SceS000000024
S000002500
S000000968
S000004772
ISS
SpoSPAC24B11.12c
SPAC4F10.16c
GO:0006892 post-Golgi vesicle-mediated transport P
IGI
SceS000000024
IMP
SceS000000024
ISS
SpoSPBC887.12
GO:0006897 endocytosis P
IGI
SceS000000024
S000002500
S000000968
IMP
CelWBGene00013034
SceS000002500
S000000968
ISS
SpoSPAC24B11.12c
SPAC4F10.16c
GO:0007040 lysosome organization P
IMP
CelWBGene00013034
GO:0007163 establishment or maintenance of cell
polarity		 P
IGI
SceS000002500
S000000968
GO:0008360 regulation of cell shape P
NAS
HsaATP10A
GO:0009117 nucleotide metabolic process P
RCA
SceS000000968
S000002500
S000000024
S000004772
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013034
GO:0015721 bile acid and bile salt transport P
NAS
HsaATP8B1
GO:0015917 aminophospholipid transport P
NAS
HsaATP8A1
GO:0016125 sterol metabolic process P
IGI
CelWBGene00020784
IMP
CelWBGene00020784
WBGene00019166
GO:0016192 vesicle-mediated transport P
RCA
SceS000000024
GO:0016481 negative regulation of transcription P
IMP
HsaATP8B1
GO:0032502 developmental process P
IMP
CelWBGene00020784
WBGene00019166
GO:0040007 growth P
IMP
CelWBGene00020784
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00019166
WBGene00013034
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00020784
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00020784
GO:0045184 establishment of protein localization P
RCA
SceS000000024
GO:0045332 phospholipid translocation P
IGI
SceS000002500
S000000968
IMP
CelWBGene00013034
SceS000000024
S000002500
S000000968
S000004772
ISS
SpoSPAC24B11.12c
SPAC4F10.16c
SPAC821.13c
TAS
SpoSPBC887.12
GO:0048194 Golgi vesicle budding P
IMP
AthAt1g59820
GO:0048364 root development P
IMP
AthAt1g59820
GO:0048367 shoot development P
IMP
AthAt1g59820
GO:0060100 positive regulation of phagocytosis,
engulfment		 P
IMP
CelWBGene00013034
GO:0060101 negative regulation of phagocytosis,
engulfment		 P
IMP
CelWBGene00013034
GO:0070265 necrotic cell death P
IMP
CelWBGene00013034

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4443

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ATP8A2 GI:117168245
Pan troglodytes (Ptr) ATP8A2 GI:114649166
Mus musculus (Mmu) Atp8a2
(MGI:1354710)		 GI:7656912 P98200
Gallus gallus (Gga) ATP8A2 GI:118085026
Schizosaccharomyces pombe (Spo) SPBC887.12 GI:19113278 O94296
Saccharomyces cerevisiae (Sce) DRS2
(S000000024)		 GI:6319293 P39524
Kluyveromyces lactis (Kla) KLLA0A04015g GI:50302485
Eremothecium gossypii (Ego) AGOS_ADR350W GI:45188223
Magnaporthe grisea (Mgr) MGG_12922 GI:145602111
Neurospora crassa (Ncr) NCU00352.1 GI:32403650


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC887.12
GO:0005802 trans-Golgi network C
IDA
SceS000000024
GO:0005886 plasma membrane C
ISS
SpoSPBC887.12
GO:0004012 phospholipid-translocating ATPase
activity		 F
IGI
SceS000000024
IMP
SceS000000024
ISS
SpoSPBC887.12
GO:0005524 ATP binding F
IC
SpoSPBC887.12
GO:0015662 ATPase activity, coupled to transmembrane movement
of ions, phosphorylative mechanism		 F
ISS
SceS000000024
GO:0000028 ribosomal small subunit assembly P
IMP
SceS000000024
GO:0006200 ATP catabolic process P
ISS
SpoSPBC887.12
GO:0006869 lipid transport P
RCA
SceS000000024
GO:0006886 intracellular protein transport P
IGI
SceS000000024
GO:0006892 post-Golgi vesicle-mediated transport P
IGI
SceS000000024
IMP
SceS000000024
ISS
SpoSPBC887.12
GO:0006897 endocytosis P
IGI
SceS000000024
GO:0008285 negative regulation of cell proliferation P
TAS
HsaATP8A2
GO:0009117 nucleotide metabolic process P
RCA
SceS000000024
GO:0016192 vesicle-mediated transport P
RCA
SceS000000024
GO:0045184 establishment of protein localization P
RCA
SceS000000024
GO:0045332 phospholipid translocation P
IMP
SceS000000024
TAS
SpoSPBC887.12

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