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Search term: YAL058W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name CNE1
SGD link S000000054
Alternative ID YAL058W
Description Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
Synonyms YAL058W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0675 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Calnexin

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g07340 GI:15240773
Arabidopsis thaliana (Ath) At5g61790 GI:15240353
Caenorhabditis elegans (Cel) CE00423
(WBGene00000567)		 GI:17552760 P34652
Drosophila melanogaster (Dme) 7292752 GI:20129017
Drosophila melanogaster (Dme) 7293236 GI:7293236
Drosophila melanogaster (Dme) 7301776 GI:7301776
Homo sapiens (Hsa) Hs4758004 GI:4758004 O14967
Homo sapiens (Hsa) Hs10716563
(CANX)		 GI:10716563 P27824
Saccharomyces cerevisiae (Sce) YAL058w
(S000000054)		 GI:6319260 P27825
Schizosaccharomyces pombe (Spo) SPAC3C7.11c GI:19114524 P36581
Schizosaccharomyces pombe (Spo) SPBP4H10.19c GI:19112985 Q9P7D0
Arabidopsis thaliana (Ath) At5g07340 GI:15240773
Arabidopsis thaliana (Ath) At5g61790 GI:15240353
Caenorhabditis elegans (Cel) CE00423
(WBGene00000567)		 GI:17552760 P34652
Drosophila melanogaster (Dme) 7292752 GI:20129017
Drosophila melanogaster (Dme) 7293236 GI:7293236
Drosophila melanogaster (Dme) 7301776 GI:7301776
Homo sapiens (Hsa) Hs4758004 GI:4758004 O14967
Homo sapiens (Hsa) Hs10716563
(CANX)		 GI:10716563 P27824
Saccharomyces cerevisiae (Sce) YAL058w
(S000000054)		 GI:6319260 P27825
Schizosaccharomyces pombe (Spo) SPAC3C7.11c GI:19114524 P36581
Schizosaccharomyces pombe (Spo) SPBP4H10.19c GI:19112985 Q9P7D0


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
AthAt5g61790
GO:0005773 vacuole C
IDA
AthAt5g61790
GO:0005783 endoplasmic reticulum C
IDA
AthAt5g61790
At5g07340
HsaCANX
SpoSPBP4H10.19c
SPAC3C7.11c
GO:0005789 endoplasmic reticulum membrane C
TAS
SpoSPAC3C7.11c
GO:0005792 microsome C
IDA
AthAt5g61790
GO:0005886 plasma membrane C
IDA
AthAt5g61790
At5g07340
GO:0009505 plant-type cell wall C
IDA
AthAt5g61790
GO:0009507 chloroplast C
IDA
AthAt5g61790
At5g07340
GO:0016020 membrane C
IDA
AthAt5g61790
At5g07340
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
SceS000000054
GO:0005509 calcium ion binding F
TAS
SpoSPAC3C7.11c
GO:0005515 protein binding F
IPI
HsaCANX
SpoSPAC3C7.11c
GO:0051082 unfolded protein binding F
IMP
SceS000000054
ISS
SceS000000054
NAS
HsaCANX
GO:0002119 nematode larval development P
IMP
CelWBGene00000567
GO:0006414 translational elongation P
RCA
SceS000000054
GO:0006457 protein folding P
IMP
SceS000000054
NAS
SpoSPBP4H10.19c
GO:0006515 misfolded or incompletely synthesized protein
catabolic process		 P
IMP
SpoSPAC3C7.11c
GO:0006886 intracellular protein transport P
NAS
SpoSPBP4H10.19c
GO:0006915 apoptosis P
IMP
SpoSPAC3C7.11c
GO:0007281 germ cell development P
IMP
CelWBGene00000567
GO:0009306 protein secretion P
TAS
HsaCANX
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000567
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000054
ISS
SpoSPAC3C7.11c
NAS
SpoSPBP4H10.19c
GO:0034605 cellular response to heat P
TAS
SpoSPAC3C7.11c
GO:0034975 protein folding in endoplasmic
reticulum		 P
IDA
SpoSPAC3C7.11c
GO:0040007 growth P
IMP
CelWBGene00000567
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000567

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1324

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) CANX GI:10716563 P27824
Pan troglodytes (Ptr) CANX GI:114603805
Canis familiaris (Cfa) CANX GI:50979014
Mus musculus (Mmu) Canx
(MGI:88261)		 GI:6671664 P35564
Rattus norvegicus (Rno) Canx
(RGD:2266)		 GI:25282419
Gallus gallus (Gga) CANX GI:71895293
Caenorhabditis elegans (Cel) cnx-1
(CE00423;
WBGene00000567)		 GI:17552760 P34652
Schizosaccharomyces pombe (Spo) cnx1
(SPAC3C7.11c)		 GI:19114524 P36581
Saccharomyces cerevisiae (Sce) CNE1
(S000000054)		 GI:6319260 P27825
Kluyveromyces lactis (Kla) KLLA0F00462g GI:50310161
Magnaporthe grisea (Mgr) MGG_01607 GI:39951929
Neurospora crassa (Ncr) NCU09265.1 GI:32422427
Arabidopsis thaliana (Ath) AT5G61790 GI:15240353
Arabidopsis thaliana (Ath) AT5G07340 GI:15240773
Oryza sativa (Osa) Os04g0402100 GI:115458184


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
ISO
MmuMGI:88261
GO:0005739 mitochondrion C
IDA
AthAt5g61790
GO:0005773 vacuole C
IDA
AthAt5g61790
GO:0005783 endoplasmic reticulum C
IDA
AthAt5g61790
At5g07340
HsaCANX
MmuMGI:88261
SpoSPAC3C7.11c
ISO
MmuMGI:88261
GO:0005789 endoplasmic reticulum membrane C
TAS
SpoSPAC3C7.11c
GO:0005791 rough endoplasmic reticulum C
ISO
MmuMGI:88261
GO:0005792 microsome C
IDA
AthAt5g61790
GO:0005840 ribosome C
ISO
MmuMGI:88261
GO:0005886 plasma membrane C
IDA
AthAt5g61790
At5g07340
GO:0009505 plant-type cell wall C
IDA
AthAt5g61790
GO:0009507 chloroplast C
IDA
AthAt5g61790
At5g07340
GO:0016020 membrane C
IDA
AthAt5g61790
At5g07340
GO:0016021 integral to membrane C
IDA
MmuMGI:88261
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
SceS000000054
GO:0030424 axon C
ISO
MmuMGI:88261
GO:0032839 dendrite cytoplasm C
ISO
MmuMGI:88261
GO:0043025 neuronal cell body C
ISO
MmuMGI:88261
GO:0043197 dendritic spine C
ISO
MmuMGI:88261
GO:0005509 calcium ion binding F
TAS
SpoSPAC3C7.11c
GO:0005515 protein binding F
IPI
HsaCANX
MmuMGI:88261
SpoSPAC3C7.11c
GO:0051082 unfolded protein binding F
IMP
SceS000000054
ISS
SceS000000054
NAS
HsaCANX
GO:0002119 nematode larval development P
IMP
CelWBGene00000567
GO:0006414 translational elongation P
RCA
SceS000000054
GO:0006457 protein folding P
IMP
SceS000000054
GO:0006515 misfolded or incompletely synthesized protein
catabolic process		 P
IMP
SpoSPAC3C7.11c
GO:0006915 apoptosis P
IMP
SpoSPAC3C7.11c
GO:0007281 germ cell development P
IMP
CelWBGene00000567
GO:0009306 protein secretion P
TAS
HsaCANX
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000567
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000054
ISS
SpoSPAC3C7.11c
GO:0034605 cellular response to heat P
TAS
SpoSPAC3C7.11c
GO:0034975 protein folding in endoplasmic
reticulum		 P
IDA
SpoSPAC3C7.11c
GO:0040007 growth P
IMP
CelWBGene00000567
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000567

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2137

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga395 ENSANGP00000021843
Anopheles gambiae (Aga) aga396 ENSANGP00000024049
Arabidopsis thaliana (Ath) ath22943 At5g07340.1
Arabidopsis thaliana (Ath) ath28280 At5g61790.1
Caenorhabditis elegans (Cel) cel22071 ZK632.6
(CE00423;
WBGene00000567)
Candida glabrata (Cgl) cgl669 CAGL0D00242g
Cryptococcus neoformans (Cne) cne2930 167.m03218
Dictyostelium discoideum (Ddi) ddi12011 DDB0215348
Debaryomyces hansenii (Dha) dha3408 DEHA0E03861g
Drosophila melanogaster (Dme) dme15001 CG11958-PA
(FBgn0015622)
Drosophila melanogaster (Dme) dme15002 CG11958-PB
(FBgn0015622)
Drosophila melanogaster (Dme) dme17554 CG1924-PA
(FBgn0030377)
Drosophila melanogaster (Dme) dme18196 CG9906-PA
(FBgn0030755)
Danio rerio (Dre) dre8631 ENSDARP00000006642
Takifugu rubripes (Fru) fru16934 SINFRUP00000156269
Takifugu rubripes (Fru) fru16936 SINFRUP00000167714
Takifugu rubripes (Fru) fru16935 SINFRUP00000172974
Gallus gallus (Gga) gga5952 ENSGALP00000009549
(CANX)		 Q5ZMF5
Gallus gallus (Gga) gga17310 ENSGALP00000015961
(CLGN)
Homo sapiens (Hsa) hsa26294 ENSP00000247461
(CANX)		 P27824
Homo sapiens (Hsa) hsa24672 ENSP00000326699
(CLGN)		 O14967
Kluyveromyces lactis (Kla) kla4099 KLLA0F00462g
Mus musculus (Mmu) mmu26275 ENSMUSP00000002259
(MGI:107472)		 Q80YU3
Mus musculus (Mmu) mmu3570 ENSMUSP00000020637
(MGI:88261)		 P35564
Neurospora crassa (Ncr) ncr9031 NCU09265.2
Oryza sativa (Osa) osa83602 8250.m00086
Rattus norvegicus (Rno) rno14811 ENSRNOP00000005071
(RGD:1592643)
Rattus norvegicus (Rno) rno4901 ENSRNOP00000040859
(RGD:2266)		 P35565
Rattus norvegicus (Rno) rno4902 ENSRNOP00000045313
Rattus norvegicus (Rno) rno4904 ENSRNOP00000051053
Saccharomyces cerevisiae (Sce) sce67 YAL058W
(S000000054)
Schizosaccharomyces pombe (Spo) spo3718 SPAC3C7.11c P36581
Yarrowia lipolytica (Yli) yli1282 YALI0B13156g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005635 nuclear envelope C
IDA
MmuMGI:107472
GO:0005737 cytoplasm C
ISO
MmuMGI:88261
GO:0005739 mitochondrion C
IDA
AthAt5g61790
GO:0005773 vacuole C
IDA
AthAt5g61790
GO:0005783 endoplasmic reticulum C
IDA
AthAt5g61790
At5g07340
MmuMGI:88261
MGI:107472
SpoSPAC3C7.11c
ISO
MmuMGI:88261
ISS
DmeFBgn0015622
FBgn0030377
NAS
DmeFBgn0015622
GO:0005789 endoplasmic reticulum membrane C
TAS
SpoSPAC3C7.11c
GO:0005791 rough endoplasmic reticulum C
ISO
MmuMGI:88261
GO:0005792 microsome C
IDA
AthAt5g61790
GO:0005840 ribosome C
ISO
MmuMGI:88261
GO:0005886 plasma membrane C
IDA
AthAt5g61790
At5g07340
DmeFBgn0015622
ISS
DmeFBgn0015622
NAS
DmeFBgn0015622
GO:0009505 plant-type cell wall C
IDA
AthAt5g61790
GO:0009507 chloroplast C
IDA
AthAt5g61790
At5g07340
GO:0016020 membrane C
IDA
AthAt5g61790
At5g07340
GO:0016021 integral to membrane C
IDA
MmuMGI:88261
ISS
DmeFBgn0030377
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
SceS000000054
GO:0030424 axon C
ISO
MmuMGI:88261
GO:0032839 dendrite cytoplasm C
ISO
MmuMGI:88261
GO:0043025 neuronal cell body C
ISO
MmuMGI:88261
GO:0043197 dendritic spine C
ISO
MmuMGI:88261
GO:0005509 calcium ion binding F
IDA
MmuMGI:107472
ISS
DmeFBgn0030755
FBgn0030377
TAS
SpoSPAC3C7.11c
GO:0005515 protein binding F
IPI
MmuMGI:88261
SpoSPAC3C7.11c
GO:0051082 unfolded protein binding F
IMP
SceS000000054
ISS
DmeFBgn0030755
FBgn0015622
SceS000000054
GO:0002119 nematode larval development P
IMP
CelWBGene00000567
GO:0006414 translational elongation P
RCA
SceS000000054
GO:0006457 protein folding P
IMP
SceS000000054
ISS
DmeFBgn0030377
NAS
DmeFBgn0015622
GO:0006461 protein complex assembly P
IMP
MmuMGI:107472
GO:0006515 misfolded or incompletely synthesized protein
catabolic process		 P
IMP
SpoSPAC3C7.11c
GO:0006915 apoptosis P
IMP
SpoSPAC3C7.11c
GO:0007281 germ cell development P
IMP
CelWBGene00000567
GO:0007339 binding of sperm to zona pellucida P
IMP
MmuMGI:107472
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000567
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000054
ISS
SpoSPAC3C7.11c
GO:0034605 cellular response to heat P
TAS
SpoSPAC3C7.11c
GO:0034975 protein folding in endoplasmic
reticulum		 P
IDA
SpoSPAC3C7.11c
GO:0040007 growth P
IMP
CelWBGene00000567
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000567

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC3C7.11c
(P36581)		 YAL058W
(S000000054)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC3C7.11c
GO:0005789 endoplasmic reticulum membrane C
TAS
SpoSPAC3C7.11c
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
SceS000000054
GO:0005509 calcium ion binding F
TAS
SpoSPAC3C7.11c
GO:0005515 protein binding F
IPI
SpoSPAC3C7.11c
GO:0051082 unfolded protein binding F
IMP
SceS000000054
ISS
SceS000000054
GO:0006414 translational elongation P
RCA
SceS000000054
GO:0006457 protein folding P
IMP
SceS000000054
GO:0006515 misfolded or incompletely synthesized protein
catabolic process		 P
IMP
SpoSPAC3C7.11c
GO:0006915 apoptosis P
IMP
SpoSPAC3C7.11c
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000054
ISS
SpoSPAC3C7.11c
GO:0034605 cellular response to heat P
TAS
SpoSPAC3C7.11c
GO:0034975 protein folding in endoplasmic
reticulum		 P
IDA
SpoSPAC3C7.11c

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s.khadayate@ucl.ac.uk