Bahler Lab

Search term: YBL017C

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name PEP1

SGD link S000000113

Alternative ID YBL017C

Description Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments

Synonyms YBL017C

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG3511 A--HYP-

KOGs classification KOGs description

POORLY CHARACTERIZED Sortilin and related receptors

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000003758
YCR099c
YNR065c
YCR100c

GO:0005624 membrane fraction C
IDA
Sce YNR066c
YCR101c

GO:0005768 endosome C
IDA
Sce S000001435
NAS
Hsa SORT1
RCA
Sce S000000113

GO:0005769 early endosome C
IDA
Hsa SORT1

GO:0005792 microsome C
IDA
Hsa SORT1

GO:0005794 Golgi apparatus C
IDA
Hsa SORT1
Spo SPBC16C6.06
TAS
Sce S000000113

GO:0005886 plasma membrane C
IDA
Hsa SORT1
NAS
Hsa SORT1

GO:0005887 integral to plasma membrane C
TAS
Hsa SORL1

GO:0005905 coated pit C
IDA
Hsa SORT1

GO:0009507 chloroplast C
IDA
Ath At5g23120

GO:0009533 chloroplast stromal thylakoid C
IDA
Ath At5g23120

GO:0009535 chloroplast thylakoid membrane C
IDA
Ath At5g23120

GO:0009543 chloroplast thylakoid lumen C
IDA
Ath At5g23120
ISS
Ath At5g23120

GO:0009570 chloroplast stroma C
IDA
Ath At5g23120

GO:0009579 thylakoid C
IDA
Ath At5g23120

GO:0009986 cell surface C
IDA
Hsa SORT1

GO:0016020 membrane C
NAS
Hsa SORCS3

GO:0016021 integral to membrane C
IDA
Hsa SORT1

GO:0016023 cytoplasmic membrane-bounded vesicle C
IDA
Hsa SORT1

GO:0030095 chloroplast photosystem II C
ISS
Ath At5g23120

GO:0030136 clathrin-coated vesicle C
IDA
Hsa SORT1

GO:0031977 thylakoid lumen C
IDA
Ath At5g23120

GO:0048471 perinuclear region of cytoplasm C
IDA
Hsa SORT1

GO:0003674 molecular_function F
ND
Sce YCR101c
YCR099c
YCR100c
YNR065c
YNR066c

GO:0004888 transmembrane receptor activity F
TAS
Hsa SORL1

GO:0005048 signal sequence binding F
IGI
Sce S000001435
S000003758
IMP
Sce S000000113
IPI
Sce S000000113
ISS
Sce S000001435
S000003758
Spo SPBC16C6.06

GO:0005515 protein binding F
IPI
Hsa SORT1

GO:0008188 neuropeptide receptor activity F
NAS
Hsa SORCS3

GO:0010465 nerve growth factor receptor activity F
IDA
Hsa SORT1

GO:0019899 enzyme binding F
IPI
Hsa SORT1

GO:0030169 low-density lipoprotein binding F
IPI
Hsa SORL1

GO:0030379 neurotensin receptor activity, non-G-protein
coupled F
IDA
Hsa SORT1

GO:0048406 nerve growth factor binding F
IPI
Hsa SORT1

GO:0006461 protein complex assembly P
IMP
Ath At5g23120

GO:0006623 protein targeting to vacuole P
IMP
Sce S000000113
Spo SPBC16C6.06
IPI
Sce S000000113

GO:0006895 Golgi to endosome transport P
IDA
Hsa SORT1

GO:0006896 Golgi to vacuole transport P
IGI
Sce S000001435
S000003758
RCA
Sce S000000113

GO:0006897 endocytosis P
IDA
Hsa SORT1

GO:0006898 receptor-mediated endocytosis P
TAS
Hsa SORL1

GO:0007034 vacuolar transport P
IMP
Sce S000000113
Spo SPBC16C6.06
IPI
Sce S000000113

GO:0007186 G-protein coupled receptor protein signaling
pathway P
IMP
Hsa SORT1

GO:0007218 neuropeptide signaling pathway P
IDA
Hsa SORT1
NAS
Hsa SORCS3

GO:0008150 biological_process P
ND
Sce YCR101c
YNR066c
YCR099c
YCR100c
YNR065c

GO:0008333 endosome to lysosome transport P
IDA
Hsa SORT1

GO:0008624 induction of apoptosis by extracellular
signals P
IMP
Hsa SORT1

GO:0009657 plastid organization P
IMP
Ath At5g23120

GO:0010468 regulation of gene expression P
IMP
Hsa SORT1

GO:0014902 myotube differentiation P
IMP
Hsa SORT1

GO:0016050 vesicle organization P
IDA
Hsa SORT1

GO:0016192 vesicle-mediated transport P
RCA
Sce S000000113

GO:0030433 ER-associated protein catabolic
process P
IMP
Sce S000000113

GO:0032509 endosome transport via multivesicular body sorting
pathway P
IDA
Hsa SORT1

GO:0032868 response to insulin stimulus P
IMP
Hsa SORT1

GO:0043066 negative regulation of apoptosis P
IDA
Hsa SORT1

GO:0045184 establishment of protein localization P
RCA
Sce S000000113

GO:0046323 glucose import P
IMP
Hsa SORT1

GO:0046686 response to cadmium ion P
IEP
Ath At5g23120

GO:0048011 nerve growth factor receptor signaling
pathway P
IMP
Hsa SORT1

GO:0048227 plasma membrane to endosome transport P
IDA
Hsa SORT1

GO:0051005 negative regulation of lipoprotein lipase
activity P
IDA
Hsa SORT1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

117723

Species Gene ID NCBI link UniProt link

Homo sapiens (Hsa) SORT1 GI:17149834 Q99523

Pan troglodytes (Ptr) SORT1 GI:114558219

Canis familiaris (Cfa) SORT1 GI:73959939

Mus musculus (Mmu) Sort1
(MGI:1338015) GI:34610211 Q6PHU5

Rattus norvegicus (Rno) Sort1
(RGD:619999) GI:109465377

Schizosaccharomyces pombe (Spo) pep1 GI:19113596

Saccharomyces cerevisiae (Sce) PEP1
(S000000113) GI:6319454 P32319

Saccharomyces cerevisiae (Sce) VTH1
(S000001435) GI:6322020 P40438

Saccharomyces cerevisiae (Sce) VTH2
(S000003758) GI:6322239 P40890

Saccharomyces cerevisiae (Sce) YNR065C GI:6324393 P53751

Kluyveromyces lactis (Kla) KLLA0E10505g GI:50308841

Magnaporthe grisea (Mgr) MGG_00506 GI:145611298

Neurospora crassa (Ncr) NCU02669.1 GI:32422849

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000003758
YNR065c

GO:0005768 endosome C
IDA
Sce S000001435
NAS
Hsa SORT1
RCA
Sce S000000113

GO:0005769 early endosome C
IDA
Hsa SORT1

GO:0005792 microsome C
IDA
Hsa SORT1
Mmu MGI:1338015
ISO
Mmu MGI:1338015

GO:0005794 Golgi apparatus C
IDA
Hsa SORT1
TAS
Sce S000000113

GO:0005886 plasma membrane C
IDA
Hsa SORT1
Mmu MGI:1338015
ISO
Mmu MGI:1338015
NAS
Hsa SORT1

GO:0005905 coated pit C
IDA
Hsa SORT1

GO:0009986 cell surface C
IDA
Hsa SORT1

GO:0016021 integral to membrane C
IDA
Hsa SORT1
ISO
Mmu MGI:1338015

GO:0016023 cytoplasmic membrane-bounded vesicle C
IDA
Hsa SORT1

GO:0030136 clathrin-coated vesicle C
IDA
Hsa SORT1

GO:0030140 trans-Golgi network transport vesicle C
IDA
Mmu MGI:1338015

GO:0030425 dendrite C
ISO
Mmu MGI:1338015

GO:0043025 neuronal cell body C
ISO
Mmu MGI:1338015

GO:0043231 intracellular membrane-bounded
organelle C
ISO
Mmu MGI:1338015

GO:0048471 perinuclear region of cytoplasm C
IDA
Hsa SORT1

GO:0003674 molecular_function F
ND
Sce YNR065c

GO:0005048 signal sequence binding F
IGI
Sce S000001435
S000003758
IMP
Sce S000000113
IPI
Sce S000000113
ISS
Sce S000001435
S000003758

GO:0005515 protein binding F
IPI
Hsa SORT1

GO:0010465 nerve growth factor receptor activity F
IDA
Hsa SORT1

GO:0019899 enzyme binding F
IPI
Hsa SORT1

GO:0030379 neurotensin receptor activity, non-G-protein
coupled F
IDA
Hsa SORT1

GO:0048406 nerve growth factor binding F
IPI
Hsa SORT1

GO:0006623 protein targeting to vacuole P
IMP
Sce S000000113
IPI
Sce S000000113

GO:0006895 Golgi to endosome transport P
IDA
Hsa SORT1

GO:0006896 Golgi to vacuole transport P
IGI
Sce S000001435
S000003758
RCA
Sce S000000113

GO:0006897 endocytosis P
IDA
Hsa SORT1

GO:0007034 vacuolar transport P
IMP
Sce S000000113
IPI
Sce S000000113

GO:0007186 G-protein coupled receptor protein signaling
pathway P
IMP
Hsa SORT1

GO:0007218 neuropeptide signaling pathway P
IDA
Hsa SORT1

GO:0008150 biological_process P
ND
Sce YNR065c

GO:0008333 endosome to lysosome transport P
IDA
Hsa SORT1

GO:0008624 induction of apoptosis by extracellular
signals P
IMP
Hsa SORT1

GO:0010468 regulation of gene expression P
IMP
Hsa SORT1

GO:0014902 myotube differentiation P
IMP
Hsa SORT1
Mmu MGI:1338015

GO:0016050 vesicle organization P
IDA
Hsa SORT1
IMP
Mmu MGI:1338015

GO:0016192 vesicle-mediated transport P
RCA
Sce S000000113

GO:0030433 ER-associated protein catabolic
process P
IMP
Sce S000000113

GO:0032509 endosome transport via multivesicular body sorting
pathway P
IDA
Hsa SORT1

GO:0032868 response to insulin stimulus P
IMP
Hsa SORT1
Mmu MGI:1338015

GO:0043066 negative regulation of apoptosis P
IDA
Hsa SORT1

GO:0045184 establishment of protein localization P
RCA
Sce S000000113

GO:0046323 glucose import P
IMP
Hsa SORT1
Mmu MGI:1338015

GO:0048011 nerve growth factor receptor signaling
pathway P
IMP
Hsa SORT1

GO:0048227 plasma membrane to endosome transport P
IDA
Hsa SORT1

GO:0051005 negative regulation of lipoprotein lipase
activity P
IDA
Hsa SORT1

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_1038

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga7911 ENSANGP00000012534

Anopheles gambiae (Aga) aga7912 ENSANGP00000012567

Ashbya gossypii (Ago) ago3210 AFR018C

Candida glabrata (Cgl) cgl3176 CAGL0J04312g

Cryptococcus neoformans (Cne) cne3132 167.m03463

Dictyostelium discoideum (Ddi) ddi8946 DDB0188715

Debaryomyces hansenii (Dha) dha4023 DEHA0E17666g

Danio rerio (Dre) dre22700 ENSDARP00000001603

Danio rerio (Dre) dre6332 ENSDARP00000002702

Danio rerio (Dre) dre18481 ENSDARP00000006185

Danio rerio (Dre) dre6329 ENSDARP00000021667
(LOC568361)

Danio rerio (Dre) dre2950 ENSDARP00000025601

Danio rerio (Dre) dre6330 ENSDARP00000031638

Takifugu rubripes (Fru) fru10837 SINFRUP00000128585

Takifugu rubripes (Fru) fru16590 SINFRUP00000131050

Takifugu rubripes (Fru) fru21358 SINFRUP00000146839

Takifugu rubripes (Fru) fru21359 SINFRUP00000146843

Takifugu rubripes (Fru) fru2951 SINFRUP00000147368

Gallus gallus (Gga) gga13193 ENSGALP00000010625
(SORL1)

Gallus gallus (Gga) gga13194 ENSGALP00000010635
(SORL1) Q98930

Gallus gallus (Gga) gga20831 ENSGALP00000013781
(SORCS1)

Homo sapiens (Hsa) hsa1632 ENSP00000256637
(SORT1) Q99523

Homo sapiens (Hsa) hsa6707 ENSP00000260197
(SORL1) Q92673

Kluyveromyces lactis (Kla) kla3424 KLLA0E10505g

Mus musculus (Mmu) mmu27446 ENSMUSP00000058613
(MGI:1202296) Q3U2X9

Mus musculus (Mmu) mmu31254 ENSMUSP00000071300

Mus musculus (Mmu) mmu17393 ENSMUSP00000073313

Neurospora crassa (Ncr) ncr2585 NCU02669.2

Plasmodium falciparum (Pfa) pfa1173 PF14_0493

Rattus norvegicus (Rno) rno28417 ENSRNOP00000031088

Rattus norvegicus (Rno) rno16849 ENSRNOP00000042760
(RGD:619999)

Rattus norvegicus (Rno) rno16850 ENSRNOP00000051102
(RGD:619999) O54861

Saccharomyces cerevisiae (Sce) sce142 YBL017C
(S000000113)

Saccharomyces cerevisiae (Sce) sce3200 YIL173W
(S000001435)

Saccharomyces cerevisiae (Sce) sce3488 YJL222W
(S000003758)

Saccharomyces cerevisiae (Sce) sce5534 YNR065C

Schizosaccharomyces pombe (Spo) spo380 SPBC16C6.06 O42930

Yarrowia lipolytica (Yli) yli4080 YALI0E05247g

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000003758
YNR065c

GO:0005768 endosome C
IDA
Sce S000001435
RCA
Sce S000000113

GO:0005771 multivesicular body C
ISO
Mmu MGI:1202296

GO:0005794 Golgi apparatus C
IDA
Spo SPBC16C6.06
TAS
Sce S000000113

GO:0043025 neuronal cell body C
ISO
Mmu MGI:1202296

GO:0003674 molecular_function F
ND
Sce YNR065c

GO:0005048 signal sequence binding F
IGI
Sce S000001435
S000003758
IMP
Sce S000000113
IPI
Sce S000000113
ISS
Sce S000001435
S000003758
Spo SPBC16C6.06

GO:0005319 lipid transporter activity F
ISS
Pfa PF14_0493

GO:0006623 protein targeting to vacuole P
IMP
Sce S000000113
Spo SPBC16C6.06
IPI
Sce S000000113

GO:0006896 Golgi to vacuole transport P
IGI
Sce S000001435
S000003758
RCA
Sce S000000113

GO:0006897 endocytosis P
ISS
Pfa PF14_0493

GO:0007034 vacuolar transport P
IMP
Sce S000000113
Spo SPBC16C6.06
IPI
Sce S000000113

GO:0008150 biological_process P
ND
Sce YNR065c

GO:0016192 vesicle-mediated transport P
RCA
Sce S000000113

GO:0016477 cell migration P
ISO
Mmu MGI:1202296

GO:0030433 ER-associated protein catabolic
process P
IMP
Sce S000000113

GO:0045184 establishment of protein localization P
RCA
Sce S000000113

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPBC16C6.06
(O42930) YBL017C
(S000000113)

GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005768 endosome C
RCA
Sce S000000113

GO:0005794 Golgi apparatus C
IDA
Spo SPBC16C6.06
TAS
Sce S000000113

GO:0005048 signal sequence binding F
IMP
Sce S000000113
IPI
Sce S000000113
ISS
Spo SPBC16C6.06

GO:0006623 protein targeting to vacuole P
IMP
Sce S000000113
Spo SPBC16C6.06
IPI
Sce S000000113

GO:0006896 Golgi to vacuole transport P
RCA
Sce S000000113

GO:0007034 vacuolar transport P
IMP
Sce S000000113
Spo SPBC16C6.06
IPI
Sce S000000113

GO:0016192 vesicle-mediated transport P
RCA
Sce S000000113

GO:0030433 ER-associated protein catabolic
process P
IMP
Sce S000000113

GO:0045184 establishment of protein localization P
RCA
Sce S000000113

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG3511	A--HYP-

KOGs classification	KOGs description
POORLY CHARACTERIZED	Sortilin and related receptors

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At5g23120	GI:15237225
Homo sapiens (Hsa)	Hs4507157_1 (SORL1)	GI:4507157	Q92673
Homo sapiens (Hsa)	Hs17149834 (SORT1)	GI:17149834	Q99523
Homo sapiens (Hsa)	Hs18379342	GI:18379342
Homo sapiens (Hsa)	Hs18379344	GI:18379344
Homo sapiens (Hsa)	Hs18379346 (SORCS3)	GI:18379346	Q9UPU3
Saccharomyces cerevisiae (Sce)	YBL017c (S000000113)	GI:6319454	P32319
Saccharomyces cerevisiae (Sce)	YCR099c	GI:6319942	P25657
Saccharomyces cerevisiae (Sce)	YCR100c	GI:6319943	P25606
Saccharomyces cerevisiae (Sce)	YCR101c	GI:6319944	P25607
Saccharomyces cerevisiae (Sce)	YIL173w (S000001435)	GI:6322020	P40438
Saccharomyces cerevisiae (Sce)	YJL222w (S000003758)	GI:6322239	P40890
Saccharomyces cerevisiae (Sce)	YNR065c	GI:6324393	P53751
Saccharomyces cerevisiae (Sce)	YNR066c	GI:6324394	P53752
Schizosaccharomyces pombe (Spo)	SPBC16C6.06	GI:19113596	O42930

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	SORT1	GI:17149834	Q99523
Pan troglodytes (Ptr)	SORT1	GI:114558219
Canis familiaris (Cfa)	SORT1	GI:73959939
Mus musculus (Mmu)	Sort1 (MGI:1338015)	GI:34610211	Q6PHU5
Rattus norvegicus (Rno)	Sort1 (RGD:619999)	GI:109465377
Schizosaccharomyces pombe (Spo)	pep1	GI:19113596
Saccharomyces cerevisiae (Sce)	PEP1 (S000000113)	GI:6319454	P32319
Saccharomyces cerevisiae (Sce)	VTH1 (S000001435)	GI:6322020	P40438
Saccharomyces cerevisiae (Sce)	VTH2 (S000003758)	GI:6322239	P40890
Saccharomyces cerevisiae (Sce)	YNR065C	GI:6324393	P53751
Kluyveromyces lactis (Kla)	KLLA0E10505g	GI:50308841
Magnaporthe grisea (Mgr)	MGG_00506	GI:145611298
Neurospora crassa (Ncr)	NCU02669.1	GI:32422849

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga7911	ENSANGP00000012534
Anopheles gambiae (Aga)	aga7912	ENSANGP00000012567
Ashbya gossypii (Ago)	ago3210	AFR018C
Candida glabrata (Cgl)	cgl3176	CAGL0J04312g
Cryptococcus neoformans (Cne)	cne3132	167.m03463
Dictyostelium discoideum (Ddi)	ddi8946	DDB0188715
Debaryomyces hansenii (Dha)	dha4023	DEHA0E17666g
Danio rerio (Dre)	dre22700	ENSDARP00000001603
Danio rerio (Dre)	dre6332	ENSDARP00000002702
Danio rerio (Dre)	dre18481	ENSDARP00000006185
Danio rerio (Dre)	dre6329	ENSDARP00000021667 (LOC568361)
Danio rerio (Dre)	dre2950	ENSDARP00000025601
Danio rerio (Dre)	dre6330	ENSDARP00000031638
Takifugu rubripes (Fru)	fru10837	SINFRUP00000128585
Takifugu rubripes (Fru)	fru16590	SINFRUP00000131050
Takifugu rubripes (Fru)	fru21358	SINFRUP00000146839
Takifugu rubripes (Fru)	fru21359	SINFRUP00000146843
Takifugu rubripes (Fru)	fru2951	SINFRUP00000147368
Gallus gallus (Gga)	gga13193	ENSGALP00000010625 (SORL1)
Gallus gallus (Gga)	gga13194	ENSGALP00000010635 (SORL1)	Q98930
Gallus gallus (Gga)	gga20831	ENSGALP00000013781 (SORCS1)
Homo sapiens (Hsa)	hsa1632	ENSP00000256637 (SORT1)	Q99523
Homo sapiens (Hsa)	hsa6707	ENSP00000260197 (SORL1)	Q92673
Kluyveromyces lactis (Kla)	kla3424	KLLA0E10505g
Mus musculus (Mmu)	mmu27446	ENSMUSP00000058613 (MGI:1202296)	Q3U2X9
Mus musculus (Mmu)	mmu31254	ENSMUSP00000071300
Mus musculus (Mmu)	mmu17393	ENSMUSP00000073313
Neurospora crassa (Ncr)	ncr2585	NCU02669.2
Plasmodium falciparum (Pfa)	pfa1173	PF14_0493
Rattus norvegicus (Rno)	rno28417	ENSRNOP00000031088
Rattus norvegicus (Rno)	rno16849	ENSRNOP00000042760 (RGD:619999)
Rattus norvegicus (Rno)	rno16850	ENSRNOP00000051102 (RGD:619999)	O54861
Saccharomyces cerevisiae (Sce)	sce142	YBL017C (S000000113)
Saccharomyces cerevisiae (Sce)	sce3200	YIL173W (S000001435)
Saccharomyces cerevisiae (Sce)	sce3488	YJL222W (S000003758)
Saccharomyces cerevisiae (Sce)	sce5534	YNR065C
Schizosaccharomyces pombe (Spo)	spo380	SPBC16C6.06	O42930
Yarrowia lipolytica (Yli)	yli4080	YALI0E05247g

S. pombe systematic ID	S. cerevisiae systematic ID
SPBC16C6.06 (O42930)	YBL017C (S000000113)