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Search term: YBL022C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PIM1
SGD link S000000118
Alternative ID YBL022C
Description ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
Synonyms YBL022C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2004 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Mitochondrial ATP-dependent protease PIM1/LON

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g07190 GI:15222315
Arabidopsis thaliana (Ath) At3g05780 GI:18397363
Arabidopsis thaliana (Ath) At3g05790 GI:18397365
Arabidopsis thaliana (Ath) At5g26860 GI:18421054
Arabidopsis thaliana (Ath) At5g47040 GI:18422747
Caenorhabditis elegans (Cel) CE16894
(WBGene00016391)		 GI:17505831 O44952
Caenorhabditis elegans (Cel) CE23016
(WBGene00013541)		 GI:17556486 Q9XW87
Drosophila melanogaster (Dme) 7293766 GI:7293766 Q9VW20
Homo sapiens (Hsa) Hs20562018 GI:20562018
Homo sapiens (Hsa) Hs21396489 GI:12644239 P36776
Homo sapiens (Hsa) HsM4758682 GI:4758682
Saccharomyces cerevisiae (Sce) YBL022c
(S000000118)		 GI:6319449 P36775
Schizosaccharomyces pombe (Spo) SPAC22F3.06c GI:19113947 Q09769


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g07190
GO:0005739 mitochondrion C
IDA
AthAt3g05780
At3g05790
At5g26860
SceS000000118
SpoSPAC22F3.06c
GO:0005759 mitochondrial matrix C
IMP
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0005777 peroxisome C
IDA
AthAt5g47040
GO:0005829 cytosol C
IDA
AthAt5g26860
GO:0009507 chloroplast C
IDA
AthAt3g05790
GO:0042645 mitochondrial nucleoid C
ISS
SpoSPAC22F3.06c
GO:0043233 organelle lumen C
IDA
AthAt5g47040
GO:0003674 molecular_function F
ND
AthAt1g07190
GO:0003697 single-stranded DNA binding F
ISS
SpoSPAC22F3.06c
GO:0003727 single-stranded RNA binding F
ISS
SpoSPAC22F3.06c
GO:0004176 ATP-dependent peptidase activity F
IMP
SceS000000118
ISS
AthAt3g05790
At3g05780
At5g26860
At5g47040
SpoSPAC22F3.06c
GO:0004252 serine-type endopeptidase activity F
ISS
SpoSPAC22F3.06c
GO:0005515 protein binding F
IPI
AthAt5g26860
GO:0005524 ATP binding F
IDA
AthAt5g26860
ISS
AthAt3g05780
At3g05790
At5g47040
At5g26860
SpoSPAC22F3.06c
GO:0008236 serine-type peptidase activity F
ISS
AthAt5g26860
At3g05780
At5g47040
At3g05790
GO:0070361 mitochondrial light strand promoter anti-sense
binding		 F
ISS
SpoSPAC22F3.06c
GO:0001666 response to hypoxia P
ISS
SpoSPAC22F3.06c
GO:0006200 ATP catabolic process P
ISS
SpoSPAC22F3.06c
GO:0006515 misfolded or incompletely synthesized protein
catabolic process		 P
IGI
SceS000000118
IMP
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0007005 mitochondrion organization P
ISS
SpoSPAC22F3.06c
GO:0008150 biological_process P
ND
AthAt1g07190
GO:0016560 protein import into peroxisome matrix,
docking		 P
IDA
AthAt5g47040
GO:0034599 cellular response to oxidative
stress		 P
ISS
SpoSPAC22F3.06c
GO:0034619 cellular chaperone-mediated protein complex
assembly		 P
IGI
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0040007 growth P
IMP
AthAt5g47040
GO:0048527 lateral root development P
IMP
AthAt5g47040
GO:0051098 regulation of binding P
RCA
SceS000000118
GO:0051260 protein homooligomerization P
ISS
SpoSPAC22F3.06c
GO:0070407 oxidation-dependent protein catabolic
process		 P
ISS
SpoSPAC22F3.06c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
3521

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) LONP1 GI:21396489
Pan troglodytes (Ptr) LONP1 GI:114674808
Canis familiaris (Cfa) LONP1 GI:73987072
Mus musculus (Mmu) Lonp1
(MGI:1921392)		 GI:116089322 Q3V2D0
Rattus norvegicus (Rno) Lonp1 GI:19173766
Gallus gallus (Gga) LONP1 GI:118103080
Drosophila melanogaster (Dme) CG8798
(FBgn0036892)		 GI:24666867
Anopheles gambiae (Aga) AgaP_AGAP010451 GI:158289863
Caenorhabditis elegans (Cel) protease GI:17505831 O44952
Schizosaccharomyces pombe (Spo) lon1
(SPAC22F3.06c)		 GI:19113947 Q09769
Saccharomyces cerevisiae (Sce) PIM1
(S000000118)		 GI:6319449 P36775
Kluyveromyces lactis (Kla) KLLA0E10395g GI:50308831
Magnaporthe grisea (Mgr) MGG_11141 GI:145613239
Neurospora crassa (Ncr) NCU05261.1 GI:32408273
Arabidopsis thaliana (Ath) LON1 GI:79522090
Arabidopsis thaliana (Ath) LON3 GI:18397363
Arabidopsis thaliana (Ath) LON4 GI:18397365
Oryza sativa (Osa) Os03g0306400 GI:115452575
Plasmodium falciparum (Pfa) PF14_0147 GI:124808464


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
AthLON1
LON3
LON4
HsaLONP1
MmuMGI:1921392
SceS000000118
SpoSPAC22F3.06c
ISO
MmuMGI:1921392
GO:0005759 mitochondrial matrix C
IMP
HsaLONP1
SceS000000118
ISO
MmuMGI:1921392
ISS
DmeFBgn0036892
SpoSPAC22F3.06c
GO:0005777 peroxisome C
ISO
MmuMGI:1921392
GO:0005829 cytosol C
IDA
AthLON1
GO:0009507 chloroplast C
IDA
AthLON4
GO:0042645 mitochondrial nucleoid C
IDA
HsaLONP1
ISS
SpoSPAC22F3.06c
GO:0003697 single-stranded DNA binding F
IDA
MmuMGI:1921392
ISS
SpoSPAC22F3.06c
GO:0003727 single-stranded RNA binding F
IDA
HsaLONP1
ISS
SpoSPAC22F3.06c
GO:0004176 ATP-dependent peptidase activity F
IDA
HsaLONP1
MmuMGI:1921392
IMP
SceS000000118
ISO
MmuMGI:1921392
ISS
AthLON1
LON4
LON3
SpoSPAC22F3.06c
GO:0004252 serine-type endopeptidase activity F
ISS
DmeFBgn0036892
SpoSPAC22F3.06c
GO:0005515 protein binding F
IPI
AthLON1
HsaLONP1
GO:0005524 ATP binding F
IDA
AthLON1
HsaLONP1
ISS
AthLON1
LON4
LON3
SpoSPAC22F3.06c
GO:0008236 serine-type peptidase activity F
ISS
AthLON1
LON4
LON3
GO:0016887 ATPase activity F
IDA
MmuMGI:1921392
GO:0043531 ADP binding F
IDA
HsaLONP1
GO:0043565 sequence-specific DNA binding F
IDA
HsaLONP1
GO:0051880 G-quadruplex DNA binding F
IDA
HsaLONP1
GO:0070182 DNA polymerase binding F
IPI
HsaLONP1
GO:0070361 mitochondrial light strand promoter anti-sense
binding		 F
IDA
HsaLONP1
MmuMGI:1921392
ISS
SpoSPAC22F3.06c
GO:0070362 mitochondrial heavy strand promoter anti-sense
binding		 F
IDA
HsaLONP1
GO:0000002 mitochondrial genome maintenance P
NAS
HsaLONP1
GO:0001666 response to hypoxia P
IEP
HsaLONP1
ISS
SpoSPAC22F3.06c
GO:0006200 ATP catabolic process P
IDA
MmuMGI:1921392
ISS
SpoSPAC22F3.06c
GO:0006508 proteolysis P
IDA
MmuMGI:1921392
GO:0006515 misfolded or incompletely synthesized protein
catabolic process		 P
IGI
SceS000000118
IMP
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0007005 mitochondrion organization P
IMP
HsaLONP1
ISS
SpoSPAC22F3.06c
GO:0032042 mitochondrial DNA metabolic process P
NAS
HsaLONP1
GO:0034599 cellular response to oxidative
stress		 P
IC
HsaLONP1
IDA
HsaLONP1
ISS
SpoSPAC22F3.06c
GO:0034619 cellular chaperone-mediated protein complex
assembly		 P
IGI
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0043623 cellular protein complex assembly P
ISO
MmuMGI:1921392
GO:0051098 regulation of binding P
RCA
SceS000000118
GO:0051260 protein homooligomerization P
IDA
HsaLONP1
ISS
SpoSPAC22F3.06c
GO:0051603 proteolysis involved in cellular protein catabolic
process		 P
IDA
HsaLONP1
GO:0070407 oxidation-dependent protein catabolic
process		 P
IMP
HsaLONP1
ISS
SpoSPAC22F3.06c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_419

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga7301 ENSANGP00000013687
Ashbya gossypii (Ago) ago3074 AFL121W
Ashbya gossypii (Ago) ago3205 AFR013C
Arabidopsis thaliana (Ath) ath12642 At3g05780.1
Arabidopsis thaliana (Ath) ath12643 At3g05790.1
Arabidopsis thaliana (Ath) ath24959 At5g26860.1
Arabidopsis thaliana (Ath) ath26574 At5g47040.1
Caenorhabditis elegans (Cel) cel3358 C34B2.6
(CE16894;
WBGene00016391)
Caenorhabditis elegans (Cel) cel20869 Y75B8A.4
(CE23016;
WBGene00013541)
Candida glabrata (Cgl) cgl3181 CAGL0J04422g
Cryptococcus neoformans (Cne) cne975 163.m06450
Dictyostelium discoideum (Ddi) ddi6341 DDB0204395
Dictyostelium discoideum (Ddi) ddi6935 DDB0217928
Debaryomyces hansenii (Dha) dha5404 DEHA0F22825g
Debaryomyces hansenii (Dha) dha5800 DEHA0G02310g
Drosophila melanogaster (Dme) dme10248 CG8798-PA
(FBgn0036892)
Drosophila melanogaster (Dme) dme10247 CG8798-PB
(FBgn0036892)
Danio rerio (Dre) dre9058 ENSDARP00000018462
(zgc:92557)		 Q5PQY6
Danio rerio (Dre) dre1177 ENSDARP00000025974
Escherichia coli (Eco) eco429 16128424
Takifugu rubripes (Fru) fru21224 SINFRUP00000169324
Takifugu rubripes (Fru) fru21225 SINFRUP00000174944
Gallus gallus (Gga) gga13975 ENSGALP00000000670
(LONP1)
Gallus gallus (Gga) gga4601 ENSGALP00000006273
(LONP2)
Gallus gallus (Gga) gga4603 ENSGALP00000006274
Homo sapiens (Hsa) hsa12155 ENSP00000285737
(LONP2)		 Q86WA8
Homo sapiens (Hsa) hsa15413 ENSP00000351177
(LONP1)		 B3KXS5
Homo sapiens (Hsa) hsa15414 ENSP00000353826
(LONP1)		 P36776
Kluyveromyces lactis (Kla) kla613 KLLA0B01892g
Kluyveromyces lactis (Kla) kla3419 KLLA0E10395g
Mus musculus (Mmu) mmu26376 ENSMUSP00000034141
(MGI:1914137)		 Q9DBN5-1
Mus musculus (Mmu) mmu11953 ENSMUSP00000041814
(MGI:1921392)		 Q8CGK3
Neurospora crassa (Ncr) ncr5106 NCU05261.2
Neurospora crassa (Ncr) ncr8092 NCU08303.2
Oryza sativa (Osa) osa31338 4407.m00151
Oryza sativa (Osa) osa38107 4886.m00126
Oryza sativa (Osa) osa54904 6093.m00036
Oryza sativa (Osa) osa53031 6121.m00143
Plasmodium falciparum (Pfa) pfa1475 PF14_0147
Rattus norvegicus (Rno) rno14670 ENSRNOP00000020770
(RGD:1305466)		 Q3MIB4
Rattus norvegicus (Rno) rno14671 ENSRNOP00000040168
(RGD:1305466)		 Q6TXI3
Saccharomyces cerevisiae (Sce) sce147 YBL022C
(S000000118)
Schizosaccharomyces pombe (Spo) spo1795 SPAC22F3.06c Q09769
Yarrowia lipolytica (Yli) yli6335 YALI0F23595g
Yarrowia lipolytica (Yli) yli6438 YALI0F26169g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
MmuMGI:1914137
GO:0005737 cytoplasm C
IDA
MmuMGI:1914137
GO:0005739 mitochondrion C
IDA
AthAt3g05780
At3g05790
At5g26860
MmuMGI:1921392
SceS000000118
SpoSPAC22F3.06c
ISO
MmuMGI:1921392
GO:0005759 mitochondrial matrix C
IMP
SceS000000118
ISO
MmuMGI:1921392
ISS
DmeFBgn0036892
SpoSPAC22F3.06c
GO:0005777 peroxisome C
IDA
AthAt5g47040
ISO
MmuMGI:1921392
GO:0005782 peroxisomal matrix C
ISO
MmuMGI:1914137
ISS
MmuMGI:1914137
GO:0005829 cytosol C
IDA
AthAt5g26860
GO:0009507 chloroplast C
IDA
AthAt3g05790
GO:0042645 mitochondrial nucleoid C
ISS
SpoSPAC22F3.06c
GO:0043233 organelle lumen C
IDA
AthAt5g47040
GO:0003697 single-stranded DNA binding F
IDA
MmuMGI:1921392
ISS
SpoSPAC22F3.06c
GO:0003727 single-stranded RNA binding F
ISS
SpoSPAC22F3.06c
GO:0004176 ATP-dependent peptidase activity F
IDA
MmuMGI:1921392
IMP
SceS000000118
ISO
MmuMGI:1921392
ISS
AthAt3g05790
At3g05780
At5g26860
At5g47040
SpoSPAC22F3.06c
GO:0004252 serine-type endopeptidase activity F
ISS
DmeFBgn0036892
SpoSPAC22F3.06c
GO:0005515 protein binding F
IPI
AthAt5g26860
MmuMGI:1914137
GO:0005524 ATP binding F
IDA
AthAt5g26860
ISS
AthAt3g05780
At3g05790
At5g47040
At5g26860
SpoSPAC22F3.06c
GO:0008236 serine-type peptidase activity F
ISS
AthAt5g26860
At3g05780
At5g47040
At3g05790
GO:0016887 ATPase activity F
IDA
MmuMGI:1921392
GO:0070361 mitochondrial light strand promoter anti-sense
binding		 F
IDA
MmuMGI:1921392
ISS
SpoSPAC22F3.06c
GO:0001666 response to hypoxia P
ISS
SpoSPAC22F3.06c
GO:0006200 ATP catabolic process P
IDA
MmuMGI:1921392
ISS
SpoSPAC22F3.06c
GO:0006508 proteolysis P
IDA
MmuMGI:1921392
GO:0006515 misfolded or incompletely synthesized protein
catabolic process		 P
IGI
SceS000000118
IMP
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0007005 mitochondrion organization P
ISS
SpoSPAC22F3.06c
GO:0008150 biological_process P
ND
MmuMGI:1914137
GO:0016560 protein import into peroxisome matrix,
docking		 P
IDA
AthAt5g47040
GO:0034599 cellular response to oxidative
stress		 P
ISS
SpoSPAC22F3.06c
GO:0034619 cellular chaperone-mediated protein complex
assembly		 P
IGI
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0040007 growth P
IMP
AthAt5g47040
GO:0043623 cellular protein complex assembly P
ISO
MmuMGI:1921392
GO:0048527 lateral root development P
IMP
AthAt5g47040
GO:0051098 regulation of binding P
RCA
SceS000000118
GO:0051260 protein homooligomerization P
ISS
SpoSPAC22F3.06c
GO:0070407 oxidation-dependent protein catabolic
process		 P
ISS
SpoSPAC22F3.06c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC22F3.06c
(Q09769)		 YBL022C
(S000000118)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000000118
SpoSPAC22F3.06c
GO:0005759 mitochondrial matrix C
IMP
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0042645 mitochondrial nucleoid C
ISS
SpoSPAC22F3.06c
GO:0003697 single-stranded DNA binding F
ISS
SpoSPAC22F3.06c
GO:0003727 single-stranded RNA binding F
ISS
SpoSPAC22F3.06c
GO:0004176 ATP-dependent peptidase activity F
IMP
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0004252 serine-type endopeptidase activity F
ISS
SpoSPAC22F3.06c
GO:0005524 ATP binding F
ISS
SpoSPAC22F3.06c
GO:0070361 mitochondrial light strand promoter anti-sense
binding		 F
ISS
SpoSPAC22F3.06c
GO:0001666 response to hypoxia P
ISS
SpoSPAC22F3.06c
GO:0006200 ATP catabolic process P
ISS
SpoSPAC22F3.06c
GO:0006515 misfolded or incompletely synthesized protein
catabolic process		 P
IGI
SceS000000118
IMP
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0007005 mitochondrion organization P
ISS
SpoSPAC22F3.06c
GO:0034599 cellular response to oxidative
stress		 P
ISS
SpoSPAC22F3.06c
GO:0034619 cellular chaperone-mediated protein complex
assembly		 P
IGI
SceS000000118
ISS
SpoSPAC22F3.06c
GO:0051098 regulation of binding P
RCA
SceS000000118
GO:0051260 protein homooligomerization P
ISS
SpoSPAC22F3.06c
GO:0070407 oxidation-dependent protein catabolic
process		 P
ISS
SpoSPAC22F3.06c

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GO info in one table:

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