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Search term: YBL035C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name POL12
SGD link S000000131
Alternative ID YBL035C
Description B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
Synonyms YBL035C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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Search for GO info:  

GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1625 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA polymerase alpha-primase complex, polymerase-associated subunit B

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g67630 GI:15220488
Caenorhabditis elegans (Cel) CE28840
(WBGene00001002)
GI:17554432 Q21625
Drosophila melanogaster (Dme) 7301561 GI:17738243
Homo sapiens (Hsa) Hs20127448
(POLA2)
GI:20127448 Q14181
Saccharomyces cerevisiae (Sce) YBL035c
(S000000131)
GI:6319436 P38121
Schizosaccharomyces pombe (Spo) SPCC553.09c GI:19075265 O74946
Encephalitozoon cuniculi (Ecu) ECU10g1080 GI:19074717 Q8SR32


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IC
SpoSPCC553.09c
GO:0005634 nucleus C
IDA
SceS000000131
SpoSPCC553.09c
NAS
HsaPOLA2
GO:0005635 nuclear envelope C
IDA
SceS000000131
GO:0005654 nucleoplasm C
EXP
HsaPOLA2
GO:0005658 alpha DNA polymerase:primase complex C
IDA
SceS000000131
TAS
SpoSPCC553.09c
GO:0005739 mitochondrion C
IDA
AthAt1g67630
GO:0005829 cytosol C
IDA
SpoSPCC553.09c
GO:0003674 molecular_function F
ND
HsaPOLA2
GO:0003887 DNA-directed DNA polymerase activity F
IDA
SceS000000131
ISS
AthAt1g67630
GO:0005515 protein binding F
IPI
HsaPOLA2
SpoSPCC553.09c
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00001002
GO:0002119 nematode larval development P
IMP
CelWBGene00001002
GO:0006260 DNA replication P
NAS
HsaPOLA2
GO:0006269 DNA replication, synthesis of RNA
primer
P
IC
SpoSPCC553.09c
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SceS000000131
NAS
SpoSPCC553.09c
GO:0006273 lagging strand elongation P
IC
SceS000000131
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00001002
GO:0016233 telomere capping P
IGI
SceS000000131
IMP
SceS000000131
IPI
SceS000000131
GO:0040007 growth P
IMP
CelWBGene00001002

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
48121

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) POLA2 GI:20127448 Q14181
Pan troglodytes (Ptr) POLA2 GI:114638540
Canis familiaris (Cfa) POLA2 GI:73983698
Mus musculus (Mmu) Pola2
(MGI:99690)
GI:31982107 P33611
Rattus norvegicus (Rno) Pola2
(RGD:621817)
GI:67514566
Drosophila melanogaster (Dme) DNApol-alpha73 GI:45551989
Anopheles gambiae (Aga) AgaP_AGAP004392 GI:158292119
Schizosaccharomyces pombe (Spo) pol12 GI:19075265
Saccharomyces cerevisiae (Sce) POL12
(S000000131)
GI:6319436 P38121
Kluyveromyces lactis (Kla) KLLA0B12309g GI:50304257
Eremothecium gossypii (Ego) AGOS_ADL299C GI:45187574
Magnaporthe grisea (Mgr) MGG_00706 GI:39974295
Neurospora crassa (Ncr) NCU03597.1 GI:32404572
Arabidopsis thaliana (Ath) POLA2 GI:30697540
Oryza sativa (Osa) Os12g0242900 GI:115487992


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
MmuMGI:99690
SceS000000131
NAS
HsaPOLA2
GO:0005635 nuclear envelope C
IDA
SceS000000131
GO:0005654 nucleoplasm C
EXP
HsaPOLA2
GO:0005658 alpha DNA polymerase:primase complex C
IDA
MmuMGI:99690
SceS000000131
ISS
DmeDNApol-alpha73
GO:0003674 molecular_function F
ND
HsaPOLA2
GO:0003887 DNA-directed DNA polymerase activity F
IDA
SceS000000131
ISO
MmuMGI:99690
ISS
DmeDNApol-alpha73
GO:0005515 protein binding F
IPI
HsaPOLA2
MmuMGI:99690
GO:0046982 protein heterodimerization activity F
IPI
MmuMGI:99690
GO:0000060 protein import into nucleus, translocation P
IDA
MmuMGI:99690
GO:0006260 DNA replication P
IDA
MmuMGI:99690
ISO
MmuMGI:99690
NAS
HsaPOLA2
GO:0006261 DNA-dependent DNA replication P
ISS
DmeDNApol-alpha73
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SceS000000131
GO:0006273 lagging strand elongation P
IC
SceS000000131
GO:0016233 telomere capping P
IGI
SceS000000131
IMP
SceS000000131
IPI
SceS000000131

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2509

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga6935 ENSANGP00000013049
Ashbya gossypii (Ago) ago1442 ADL299C
Arabidopsis thaliana (Ath) ath5997 At1g67630.1
Caenorhabditis elegans (Cel) cel13155 R01H10.1
(CE28840;
WBGene00001002)
Candida glabrata (Cgl) cgl1417 CAGL0F04323g
Cryptococcus neoformans (Cne) cne1625 164.m02809
Dictyostelium discoideum (Ddi) ddi6798 DDB0204953
Debaryomyces hansenii (Dha) dha5609 DEHA0F27357g
Drosophila melanogaster (Dme) dme14731 CG5923-PA
(FBgn0005696)
Drosophila melanogaster (Dme) dme14732 CG5923-PB
(FBgn0005696)
Danio rerio (Dre) dre22506 ENSDARP00000002618
(pola2)
Q6P0S9
Encephalitozoon cuniculi (Ecu) ecu633 19074717
Takifugu rubripes (Fru) fru24941 SINFRUP00000142046
Homo sapiens (Hsa) hsa5956 ENSP00000265465
(POLA2)
Q14181
Kluyveromyces lactis (Kla) kla1076 KLLA0B12309g
Mus musculus (Mmu) mmu13173 ENSMUSP00000025752
(MGI:99690)
Q3UZI8
Neurospora crassa (Ncr) ncr3488 NCU03597.2
Oryza sativa (Osa) osa75660 7239.m00159
Plasmodium falciparum (Pfa) pfa1357 PF14_0602
Rattus norvegicus (Rno) rno3536 ENSRNOP00000028406
(RGD:621817)
O89043
Saccharomyces cerevisiae (Sce) sce161 YBL035C
(S000000131)
Schizosaccharomyces pombe (Spo) spo3499 SPCC553.09c O74946
Yarrowia lipolytica (Yli) yli4639 YALI0E18832g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IC
SpoSPCC553.09c
GO:0005634 nucleus C
IDA
MmuMGI:99690
SceS000000131
SpoSPCC553.09c
GO:0005635 nuclear envelope C
IDA
SceS000000131
GO:0005658 alpha DNA polymerase:primase complex C
IDA
MmuMGI:99690
SceS000000131
ISS
DmeFBgn0005696
PfaPF14_0602
TAS
SpoSPCC553.09c
GO:0005739 mitochondrion C
IDA
AthAt1g67630
GO:0005829 cytosol C
IDA
SpoSPCC553.09c
GO:0003887 DNA-directed DNA polymerase activity F
IDA
SceS000000131
ISO
MmuMGI:99690
ISS
AthAt1g67630
DmeFBgn0005696
PfaPF14_0602
GO:0005515 protein binding F
IPI
MmuMGI:99690
SpoSPCC553.09c
GO:0046982 protein heterodimerization activity F
IPI
MmuMGI:99690
GO:0000060 protein import into nucleus, translocation P
IDA
MmuMGI:99690
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00001002
GO:0002119 nematode larval development P
IMP
CelWBGene00001002
GO:0006260 DNA replication P
IDA
MmuMGI:99690
ISO
MmuMGI:99690
GO:0006261 DNA-dependent DNA replication P
ISS
DmeFBgn0005696
GO:0006269 DNA replication, synthesis of RNA
primer
P
IC
SpoSPCC553.09c
ISS
PfaPF14_0602
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SceS000000131
NAS
SpoSPCC553.09c
GO:0006273 lagging strand elongation P
IC
SceS000000131
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00001002
GO:0016233 telomere capping P
IGI
SceS000000131
IMP
SceS000000131
IPI
SceS000000131
GO:0040007 growth P
IMP
CelWBGene00001002

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPCC553.09c
(O74946)
YBL035C
(S000000131)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IC
SpoSPCC553.09c
GO:0005634 nucleus C
IDA
SceS000000131
SpoSPCC553.09c
GO:0005635 nuclear envelope C
IDA
SceS000000131
GO:0005658 alpha DNA polymerase:primase complex C
IDA
SceS000000131
TAS
SpoSPCC553.09c
GO:0005829 cytosol C
IDA
SpoSPCC553.09c
GO:0003887 DNA-directed DNA polymerase activity F
IDA
SceS000000131
GO:0005515 protein binding F
IPI
SpoSPCC553.09c
GO:0006269 DNA replication, synthesis of RNA
primer
P
IC
SpoSPCC553.09c
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SceS000000131
NAS
SpoSPCC553.09c
GO:0006273 lagging strand elongation P
IC
SceS000000131
GO:0016233 telomere capping P
IGI
SceS000000131
IMP
SceS000000131
IPI
SceS000000131

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GO info in one table:

s.khadayate@ucl.ac.uk