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Search term: YBL040C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERD2
SGD link S000000136
Alternative ID YBL040C
Description HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
Synonyms YBL040C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3106 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING ER lumen protein retaining receptor

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g19970 GI:15223724
Arabidopsis thaliana (Ath) At1g29330 GI:18397049
Arabidopsis thaliana (Ath) At1g75760 GI:15222871
Arabidopsis thaliana (Ath) At2g21190 GI:15226483
Arabidopsis thaliana (Ath) At3g25040 GI:15230245
Arabidopsis thaliana (Ath) At3g25160 GI:15230808
Arabidopsis thaliana (Ath) At4g38790 GI:7487841
Caenorhabditis elegans (Cel) CE01826
(WBGene00016195)		 GI:17552358 Q09473
Caenorhabditis elegans (Cel) CE23635
(WBGene00001331)		 GI:17551392 P48583
Drosophila melanogaster (Dme) 7297696 GI:17137442
Homo sapiens (Hsa) Hs5803048
(KDELR1)		 GI:5803048 P24390
Homo sapiens (Hsa) Hs5803050
(KDELR2)		 GI:5803050 P33947
Homo sapiens (Hsa) Hs8051611 GI:8051611 O43731
Homo sapiens (Hsa) Hs6857802
(KDELR3)		 GI:6857802 O43731
Saccharomyces cerevisiae (Sce) YBL040c
(S000000136)		 GI:6319431 P18414
Schizosaccharomyces pombe (Spo) SPBP8B7.22 GI:19113321 O94270
Encephalitozoon cuniculi (Ecu) ECU06g1570 GI:19074408 Q8SRM5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
TAS
HsaKDELR1
GO:0005783 endoplasmic reticulum C
IDA
AthAt1g29330
SpoSPBP8B7.22
GO:0005793 ER-Golgi intermediate compartment C
IDA
HsaKDELR1
GO:0005794 Golgi apparatus C
IDA
AthAt3g25040
At1g29330
SpoSPBP8B7.22
TAS
HsaKDELR2
GO:0005801 cis-Golgi network C
IDA
AthAt1g29330
GO:0016021 integral to membrane C
ISS
AthAt4g38790
At3g25040
At2g21190
At3g25160
At1g29330
At1g19970
At1g75760
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
SceS000000136
ISS
SpoSPBP8B7.22
GO:0004872 receptor activity F
ISS
AthAt3g25040
At4g38790
At1g29330
At1g19970
At3g25160
At2g21190
At1g75760
GO:0005046 KDEL sequence binding F
IGI
AthAt1g29330
TAS
HsaKDELR1
KDELR2
GO:0005515 protein binding F
IPI
HsaKDELR1
KDELR2
GO:0045015 HDEL sequence binding F
IGI
SceS000000136
IMP
SceS000000136
IPI
SceS000000136
ISS
SpoSPBP8B7.22
GO:0006621 protein retention in ER lumen P
IGI
AthAt1g29330
SceS000000136
ISS
SpoSPBP8B7.22
GO:0006886 intracellular protein transport P
IC
SpoSPBP8B7.22
TAS
HsaKDELR2
KDELR1
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SceS000000136
ISS
SpoSPBP8B7.22
GO:0010204 defense response signaling pathway, resistance
gene-independent		 P
IMP
AthAt3g25040
GO:0015031 protein transport P
ISS
AthAt1g19970
At3g25040
At4g38790
At2g21190
At3g25160
At1g29330
At1g75760

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
38236

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) KDELR2 GI:5803050 P33947
Canis familiaris (Cfa) KDELR2 GI:73958024
Mus musculus (Mmu) Kdelr2
(MGI:1914163)		 GI:13385318 Q9CQM2
Rattus norvegicus (Rno) Kdelr2
(RGD:1304618)		 GI:61557025
Gallus gallus (Gga) KDELR2 GI:118098103
Drosophila melanogaster (Dme) KdelR
(FBgn0022268)		 GI:24583423
Anopheles gambiae (Aga) AgaP_AGAP012756 GI:58375374
Anopheles gambiae (Aga) AgaP_AGAP010224 GI:58392495
Schizosaccharomyces pombe (Spo) erd2
(SPBP8B7.22)		 GI:19113321 O94270
Saccharomyces cerevisiae (Sce) ERD2
(S000000136)		 GI:6319431 P18414
Kluyveromyces lactis (Kla) KLLA0E05566g GI:50308395
Eremothecium gossypii (Ego) AGOS_AGL323C GI:45200774
Magnaporthe grisea (Mgr) MGG_02423 GI:145606272
Neurospora crassa (Ncr) NCU06771.1 GI:32413154
Arabidopsis thaliana (Ath) ERD2 GI:18397049
Oryza sativa (Osa) Os05g0529300 GI:115465043


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1914163
GO:0005783 endoplasmic reticulum C
IDA
AthERD2
SpoSPBP8B7.22
NAS
DmeFBgn0022268
GO:0005794 Golgi apparatus C
IDA
AthERD2
SpoSPBP8B7.22
TAS
HsaKDELR2
GO:0005801 cis-Golgi network C
IDA
AthERD2
GO:0009507 chloroplast C
IDA
AthERD2
GO:0009941 chloroplast envelope C
IDA
AthERD2
GO:0016021 integral to membrane C
ISS
AthERD2
NAS
DmeFBgn0022268
GO:0030140 trans-Golgi network transport vesicle C
ISS
DmeFBgn0022268
NAS
DmeFBgn0022268
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
SceS000000136
ISS
SpoSPBP8B7.22
GO:0003674 molecular_function F
ND
MmuMGI:1914163
GO:0004872 receptor activity F
ISS
AthERD2
GO:0005046 KDEL sequence binding F
IGI
AthERD2
ISS
DmeFBgn0022268
NAS
DmeFBgn0022268
TAS
HsaKDELR2
GO:0005515 protein binding F
IPI
HsaKDELR2
GO:0045015 HDEL sequence binding F
IGI
SceS000000136
IMP
SceS000000136
IPI
SceS000000136
ISS
SpoSPBP8B7.22
GO:0006457 protein folding P
TAS
AthERD2
GO:0006621 protein retention in ER lumen P
IGI
AthERD2
SceS000000136
ISS
SpoSPBP8B7.22
NAS
DmeFBgn0022268
GO:0006886 intracellular protein transport P
IC
SpoSPBP8B7.22
TAS
HsaKDELR2
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SceS000000136
ISS
SpoSPBP8B7.22
GO:0006890 retrograde vesicle-mediated transport, Golgi to
ER		 P
ISS
DmeFBgn0022268
NAS
DmeFBgn0022268
GO:0006891 intra-Golgi vesicle-mediated transport P
NAS
DmeFBgn0022268
GO:0008150 biological_process P
ND
MmuMGI:1914163
GO:0009408 response to heat P
IEP
AthERD2
GO:0010204 defense response signaling pathway, resistance
gene-independent		 P
IMP
AthERD2
GO:0015031 protein transport P
ISS
AthERD2
GO:0046686 response to cadmium ion P
IEP
AthERD2

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_813

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga14047 ENSANGP00000012108
Anopheles gambiae (Aga) aga12537 ENSANGP00000014488
Ashbya gossypii (Ago) ago3989 AGL323C
Arabidopsis thaliana (Ath) ath3060 At1g29330.1
Arabidopsis thaliana (Ath) ath14829 At3g25040.1
Caenorhabditis elegans (Cel) cel2940 C28H8.4
(CE01826;
WBGene00016195)
Caenorhabditis elegans (Cel) cel5745 F09B9.3
(CE23635;
WBGene00001331)
Candida glabrata (Cgl) cgl1423 CAGL0F04455g
Dictyostelium discoideum (Ddi) ddi3571 DDB0168686
Debaryomyces hansenii (Dha) dha6556 DEHA0G19140g
Drosophila melanogaster (Dme) dme1832 CG5183-PA
(FBgn0022268)
Drosophila melanogaster (Dme) dme1833 CG5183-PB
(FBgn0022268)
Drosophila melanogaster (Dme) dme1834 CG5183-PC
(FBgn0022268)
Danio rerio (Dre) dre24514 ENSDARP00000011420
(kdelr2)		 Q6PEH1
Encephalitozoon cuniculi (Ecu) ecu1635 19074408
Takifugu rubripes (Fru) fru5144 SINFRUP00000134709
Takifugu rubripes (Fru) fru11675 SINFRUP00000147795
Takifugu rubripes (Fru) fru22294 SINFRUP00000150111
Takifugu rubripes (Fru) fru25859 SINFRUP00000156542
Gallus gallus (Gga) gga6730 ENSGALP00000011467
(KDELR2)		 Q5ZKX9
Gallus gallus (Gga) gga908 ENSGALP00000019982
(KDELR3)
Homo sapiens (Hsa) hsa21663 ENSP00000216014
(KDELR3)		 O43731-1
Homo sapiens (Hsa) hsa28223 ENSP00000258739
(KDELR2)		 P33947-1
Homo sapiens (Hsa) hsa16742 ENSP00000329471
(KDELR1)		 P24390
Kluyveromyces lactis (Kla) kla3198 KLLA0E05566g
Mus musculus (Mmu) mmu21259 ENSMUSP00000001908
Mus musculus (Mmu) mmu23988 ENSMUSP00000002855
(MGI:1915387)		 Q99JH8
Mus musculus (Mmu) mmu9300 ENSMUSP00000010974
(MGI:2145953)		 Q8R1L4
Neurospora crassa (Ncr) ncr6585 NCU06771.2
Oryza sativa (Osa) osa21436 3648.m00169
Oryza sativa (Osa) osa42871 5430.m00129
Oryza sativa (Osa) osa71203 7159.m00190
Oryza sativa (Osa) osa83065 8201.m00119
Plasmodium falciparum (Pfa) pfa3797 PF13_0280
Rattus norvegicus (Rno) rno8083 ENSRNOP00000001438
(RGD:1304618)		 Q5U305
Rattus norvegicus (Rno) rno27400 ENSRNOP00000018174
Rattus norvegicus (Rno) rno1893 ENSRNOP00000028627
(RGD:1306764)		 Q569A6
Saccharomyces cerevisiae (Sce) sce168 YBL040C
(S000000136)
Schizosaccharomyces pombe (Spo) spo3685 SPBP8B7.22 O94270
Yarrowia lipolytica (Yli) yli2974 YALI0D06545g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1915387
MGI:2145953
GO:0005783 endoplasmic reticulum C
IDA
AthAt1g29330
SpoSPBP8B7.22
NAS
DmeFBgn0022268
PfaPF13_0280
GO:0005794 Golgi apparatus C
IDA
AthAt3g25040
At1g29330
SpoSPBP8B7.22
GO:0005801 cis-Golgi network C
IDA
AthAt1g29330
GO:0016021 integral to membrane C
ISS
AthAt3g25040
At1g29330
NAS
DmeFBgn0022268
GO:0030140 trans-Golgi network transport vesicle C
ISS
DmeFBgn0022268
NAS
DmeFBgn0022268
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
SceS000000136
ISS
SpoSPBP8B7.22
GO:0003674 molecular_function F
ND
MmuMGI:2145953
MGI:1915387
GO:0004872 receptor activity F
ISS
AthAt3g25040
At1g29330
NAS
PfaPF13_0280
GO:0005046 KDEL sequence binding F
IGI
AthAt1g29330
ISS
DmeFBgn0022268
PfaPF13_0280
NAS
DmeFBgn0022268
GO:0045015 HDEL sequence binding F
IGI
SceS000000136
IMP
SceS000000136
IPI
SceS000000136
ISS
SpoSPBP8B7.22
GO:0006621 protein retention in ER lumen P
IGI
AthAt1g29330
SceS000000136
ISS
SpoSPBP8B7.22
NAS
DmeFBgn0022268
GO:0006886 intracellular protein transport P
IC
SpoSPBP8B7.22
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SceS000000136
ISS
SpoSPBP8B7.22
GO:0006890 retrograde vesicle-mediated transport, Golgi to
ER		 P
ISS
DmeFBgn0022268
NAS
DmeFBgn0022268
GO:0006891 intra-Golgi vesicle-mediated transport P
NAS
DmeFBgn0022268
GO:0008150 biological_process P
ND
MmuMGI:2145953
MGI:1915387
GO:0010204 defense response signaling pathway, resistance
gene-independent		 P
IMP
AthAt3g25040
GO:0015031 protein transport P
ISS
AthAt3g25040
At1g29330

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBP8B7.22
(O94270)		 YBL040C
(S000000136)