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Search term: YBL068W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PRS4
SGD link S000000164
Alternative ID YBL068W
Description 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
Synonyms YBL068W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1448 ACDHYP-

KOGs classification KOGs description
METABOLISMMETABOLISM Ribose-phosphate pyrophosphokinase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g10700 GI:15220191
Arabidopsis thaliana (Ath) At1g32380 GI:15223189
Arabidopsis thaliana (Ath) At2g35390 GI:15226977
Arabidopsis thaliana (Ath) At2g42910 GI:15228027
Arabidopsis thaliana (Ath) At2g44530 GI:15224894
Caenorhabditis elegans (Cel) CE00745
(WBGene00020107)		 GI:17554702 Q21994
Caenorhabditis elegans (Cel) CE27199 GI:17554700
Caenorhabditis elegans (Cel) CE29454 GI:17554704 Q21994
Drosophila melanogaster (Dme) 7294893 GI:7294893
Drosophila melanogaster (Dme) 7294894 GI:7294894
Homo sapiens (Hsa) Hs20539448 GI:20539448
Homo sapiens (Hsa) Hs20542182 GI:20542182
Homo sapiens (Hsa) Hs4506127
(PRPS1)		 GI:4506127 Q15244
Homo sapiens (Hsa) Hs4506129 GI:4506129 P11908
Saccharomyces cerevisiae (Sce) YBL068w
(S000000164)		 GI:6319403
Saccharomyces cerevisiae (Sce) YER099c
(S000000901)		 GI:6320946 P38620
Saccharomyces cerevisiae (Sce) YHL011c
(S000001003)		 GI:6321776 P38689
Saccharomyces cerevisiae (Sce) YKL181w
(S000001664)		 GI:6322667 P32895
Saccharomyces cerevisiae (Sce) YOL061w
(S000005422)		 GI:6324511 Q12265
Schizosaccharomyces pombe (Spo) SPAC4A8.14 GI:19114738 P41831
Schizosaccharomyces pombe (Spo) SPBC3D6.06c GI:19112310 P87171
Schizosaccharomyces pombe (Spo) SPCC1620.06c GI:19075964 O94413


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC4A8.14
GO:0005737 cytoplasm C
IDA
AthAt2g42910
SceS000000901
S000005422
S000000164
S000001003
S000001664
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0005829 cytosol C
EXP
HsaPRPS1
IDA
SpoSPCC1620.06c
SPAC4A8.14
GO:0005886 plasma membrane C
IDA
AthAt2g42910
GO:0004749 ribose phosphate diphosphokinase
activity		 F
EXP
HsaPRPS1
IDA
HsaPRPS1
IGI
SceS000000901
S000000164
S000001003
S000001664
S000005422
IMP
HsaPRPS1
ISS
AthAt1g32380
At2g35390
At2g44530
At2g42910
At1g10700
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0005524 ATP binding F
IDA
HsaPRPS1
GO:0042803 protein homodimerization activity F
IPI
HsaPRPS1
GO:0000105 histidine biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0000162 tryptophan biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic
process		 P
IGI
SceS000001664
S000001003
S000000901
S000000164
S000005422
IMP
SceS000000164
S000000901
S000005422
S000001003
S000001664
GO:0006144 purine base metabolic process P
IMP
HsaPRPS1
GO:0006164 purine nucleotide biosynthetic
process		 P
IMP
HsaPRPS1
GO:0006166 purine ribonucleoside salvage P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006189 'de novo' IMP biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006207 'de novo' pyrimidine base biosynthetic
process		 P
ISS
SpoSPBC3D6.06c
SPAC4A8.14
SPCC1620.06c
GO:0006221 pyrimidine nucleotide biosynthetic
process		 P
NAS
HsaPRPS1
GO:0007399 nervous system development P
IMP
HsaPRPS1
GO:0008361 regulation of cell size P
IMP
SceS000001003
GO:0009116 nucleoside metabolic process P
RCA
SceS000000164
S000000901
S000001003
S000005422
GO:0009117 nucleotide metabolic process P
RCA
SceS000000901
S000001003
S000000164
S000001664
S000005422
GO:0009165 nucleotide biosynthetic process P
ISS
AthAt2g44530
At1g10700
At2g35390
At2g42910
At1g32380
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00020107
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000164
GO:0031505 fungal-type cell wall organization P
IPI
SceS000000164
S000000901
S000001003
S000001664
S000005422
GO:0034418 urate biosynthetic process P
IMP
HsaPRPS1
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001003
S000005422
S000001664
GO:0046101 hypoxanthine biosynthetic process P
IMP
HsaPRPS1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68565

Species Gene ID NCBI link UniProt link
Rattus norvegicus (Rno) LOC314140
(RGD:1359636)		 GI:57527447
Schizosaccharomyces pombe (Spo) SPCC1620.06c GI:19075964 O94413
Saccharomyces cerevisiae (Sce) PRS4
(S000000164)		 GI:37362615
Saccharomyces cerevisiae (Sce) PRS2
(S000000901)		 GI:6320946 P38620
Kluyveromyces lactis (Kla) KLLA0E20471g GI:50309719
Eremothecium gossypii (Ego) AGOS_AGR371C GI:45201467
Magnaporthe grisea (Mgr) MGG_07148 GI:145612465
Neurospora crassa (Ncr) NCU06970.1 GI:32413553
Arabidopsis thaliana (Ath) AT2G35390 GI:30686404
Arabidopsis thaliana (Ath) AT1G32380 GI:15223189
Plasmodium falciparum (Pfa) PF13_0143 GI:124513270


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000000901
S000000164
ISS
SpoSPCC1620.06c
GO:0005829 cytosol C
IDA
SpoSPCC1620.06c
GO:0004749 ribose phosphate diphosphokinase
activity		 F
IGI
SceS000000901
S000000164
ISS
AthAt1g32380
At2g35390
SpoSPCC1620.06c
GO:0000105 histidine biosynthetic process P
ISS
SpoSPCC1620.06c
GO:0000162 tryptophan biosynthetic process P
ISS
SpoSPCC1620.06c
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic
process		 P
IGI
SceS000000901
S000000164
IMP
SceS000000164
S000000901
GO:0006098 pentose-phosphate shunt P
ISS
PfaPF13_0143
GO:0006166 purine ribonucleoside salvage P
ISS
PfaPF13_0143
SpoSPCC1620.06c
GO:0006189 'de novo' IMP biosynthetic process P
ISS
SpoSPCC1620.06c
GO:0006207 'de novo' pyrimidine base biosynthetic
process		 P
ISS
SpoSPCC1620.06c
GO:0009116 nucleoside metabolic process P
RCA
SceS000000164
S000000901
GO:0009117 nucleotide metabolic process P
RCA
SceS000000901
S000000164
GO:0009165 nucleotide biosynthetic process P
ISS
AthAt2g35390
At1g32380
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000164
GO:0031505 fungal-type cell wall organization P
IPI
SceS000000164
S000000901

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_262

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga242 ENSANGP00000013157
Ashbya gossypii (Ago) ago4231 AGL080C
Ashbya gossypii (Ago) ago4682 AGR371C
Arabidopsis thaliana (Ath) ath3389 At1g32380.1
Arabidopsis thaliana (Ath) ath10593 At2g35390.1
Arabidopsis thaliana (Ath) ath10594 At2g35390.2
Arabidopsis thaliana (Ath) ath11667 At2g44530.1
Caenorhabditis elegans (Cel) cel14051 R151.2a
(CE00745;
WBGene00020107)
Caenorhabditis elegans (Cel) cel14052 R151.2b
(CE29987)
Caenorhabditis elegans (Cel) cel14053 R151.2c
(CE29454)
Caenorhabditis elegans (Cel) cel14054 R151.2d
(CE37138)
Candida glabrata (Cgl) cgl2759 CAGL0I05500g
Candida glabrata (Cgl) cgl3631 CAGL0K02541g
Cryptococcus neoformans (Cne) cne4330 177.m03085
Dictyostelium discoideum (Ddi) ddi8422 DDB0186131
Debaryomyces hansenii (Dha) dha3168 DEHA0D19437g
Debaryomyces hansenii (Dha) dha5875 DEHA0G04048g
Drosophila melanogaster (Dme) dme8817 CG6767-PA
(FBgn0036030)
Drosophila melanogaster (Dme) dme8818 CG6767-PB
(FBgn0036030)
Danio rerio (Dre) dre4950 ENSDARP00000008663
(prps1a)		 Q4KME9
Danio rerio (Dre) dre4951 ENSDARP00000039868
Escherichia coli (Eco) eco1169 16129170
Takifugu rubripes (Fru) fru21000 SINFRUP00000129872
Takifugu rubripes (Fru) fru29498 SINFRUP00000132009
Gallus gallus (Gga) gga8389 ENSGALP00000002877
Gallus gallus (Gga) gga16716 ENSGALP00000007836
Gallus gallus (Gga) gga16717 ENSGALP00000007837
(PRPS1)
Gallus gallus (Gga) gga2437 ENSGALP00000026729
(PRPS2)
Gallus gallus (Gga) gga2438 ENSGALP00000026730
(PRPS2)		 Q5ZI49
Homo sapiens (Hsa) hsa32444 ENSP00000218027
Homo sapiens (Hsa) hsa33208 ENSP00000276174
Homo sapiens (Hsa) hsa28292 ENSP00000283289
Kluyveromyces lactis (Kla) kla3871 KLLA0E20471g
Kluyveromyces lactis (Kla) kla5225 KLLA0F25718g
Mus musculus (Mmu) mmu29884 ENSMUSP00000026839
(MGI:97776)		 Q9CS42
Mus musculus (Mmu) mmu29633 ENSMUSP00000033809
(MGI:97775)		 Q76MX9
Mus musculus (Mmu) mmu5626 ENSMUSP00000059358
Neurospora crassa (Ncr) ncr6782 NCU06970.2
Oryza sativa (Osa) osa2068 1937.m00161
Oryza sativa (Osa) osa2069 1937.m00195
Oryza sativa (Osa) osa2071 1937.m00196
Oryza sativa (Osa) osa2079 1937.m00200
Plasmodium falciparum (Pfa) pfa4331 PF13_0143
Rattus norvegicus (Rno) rno31247 ENSRNOP00000005615
(RGD:3415)		 P09330
Rattus norvegicus (Rno) rno32106 ENSRNOP00000029405
(RGD:61955)		 P60892
Rattus norvegicus (Rno) rno32105 ENSRNOP00000040723
Rattus norvegicus (Rno) rno25143 ENSRNOP00000043734
(RGD:1359636)
Rattus norvegicus (Rno) rno25007 ENSRNOP00000048319
Saccharomyces cerevisiae (Sce) sce197 YBL068W
(S000000164)
Saccharomyces cerevisiae (Sce) sce1836 YER099C
(S000000901)
Saccharomyces cerevisiae (Sce) sce2697 YHL011C
(S000001003)
Schizosaccharomyces pombe (Spo) spo4020 SPCC1620.06c O94413
Yarrowia lipolytica (Yli) yli5208 YALI0E32351g
Yarrowia lipolytica (Yli) yli6392 YALI0F25047g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005625 soluble fraction C
ISO
MmuMGI:97775
MGI:97776
GO:0005737 cytoplasm C
IDA
SceS000000901
S000000164
S000001003
ISS
SpoSPCC1620.06c
GO:0005829 cytosol C
IDA
SpoSPCC1620.06c
GO:0043234 protein complex C
ISO
MmuMGI:97775
MGI:97776
GO:0000287 magnesium ion binding F
ISO
MmuMGI:97775
MGI:97776
GO:0004749 ribose phosphate diphosphokinase
activity		 F
IGI
SceS000000901
S000000164
S000001003
ISO
MmuMGI:97776
MGI:97775
ISS
AthAt1g32380
At2g35390
At2g44530
DmeFBgn0036030
SpoSPCC1620.06c
GO:0005524 ATP binding F
ISO
MmuMGI:97776
MGI:97775
GO:0005529 sugar binding F
ISO
MmuMGI:97776
MGI:97775
GO:0016208 AMP binding F
ISO
MmuMGI:97775
MGI:97776
GO:0019003 GDP binding F
ISO
MmuMGI:97775
MGI:97776
GO:0043531 ADP binding F
ISO
MmuMGI:97775
MGI:97776
GO:0000105 histidine biosynthetic process P
ISS
SpoSPCC1620.06c
GO:0000162 tryptophan biosynthetic process P
ISS
SpoSPCC1620.06c
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic
process		 P
IGI
SceS000001003
S000000901
S000000164
IMP
SceS000000164
S000000901
S000001003
GO:0006098 pentose-phosphate shunt P
ISS
PfaPF13_0143
GO:0006166 purine ribonucleoside salvage P
ISS
PfaPF13_0143
SpoSPCC1620.06c
GO:0006167 AMP biosynthetic process P
ISO
MmuMGI:97775
MGI:97776
GO:0006189 'de novo' IMP biosynthetic process P
ISS
SpoSPCC1620.06c
GO:0006207 'de novo' pyrimidine base biosynthetic
process		 P
ISS
SpoSPCC1620.06c
GO:0008361 regulation of cell size P
IMP
SceS000001003
GO:0009116 nucleoside metabolic process P
RCA
SceS000000164
S000000901
S000001003
GO:0009117 nucleotide metabolic process P
RCA
SceS000000901
S000001003
S000000164
GO:0009165 nucleotide biosynthetic process P
ISO
MmuMGI:97776
MGI:97775
ISS
AthAt2g44530
At2g35390
At1g32380
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00020107
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000164
GO:0019693 ribose phosphate metabolic process P
ISO
MmuMGI:97775
MGI:97776
GO:0031505 fungal-type cell wall organization P
IPI
SceS000000164
S000000901
S000001003
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001003

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC1620.06c
(O94413)		 YBL068W
(S000000164)
SPBC3D6.06c
(P87171)		 YBL068W
(S000000164)
SPAC4A8.14
(P41831)		 YBL068W
(S000000164)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC4A8.14
GO:0005737 cytoplasm C
IDA
SceS000000164
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0005829 cytosol C
IDA
SpoSPCC1620.06c
SPAC4A8.14
GO:0004749 ribose phosphate diphosphokinase
activity		 F
IGI
SceS000000164
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0000105 histidine biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0000162 tryptophan biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic
process		 P
IGI
SceS000000164
IMP
SceS000000164
GO:0006166 purine ribonucleoside salvage P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006189 'de novo' IMP biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006207 'de novo' pyrimidine base biosynthetic
process		 P
ISS
SpoSPBC3D6.06c
SPAC4A8.14
SPCC1620.06c
GO:0009116 nucleoside metabolic process P
RCA
SceS000000164
GO:0009117 nucleotide metabolic process P
RCA
SceS000000164
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000164
GO:0031505 fungal-type cell wall organization P
IPI
SceS000000164

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GO info in one table:

s.khadayate@ucl.ac.uk