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Search term: YBR034C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HMT1
SGD link S000000238
Alternative ID YBR034C
Description Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; also methylates ribosomal protein Rps2p
Synonyms YBR034C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1499 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGINFORMATION STORAGE AND PROCESSINGCELLULAR PROCESSES AND SIGNALING Protein arginine N-methyltransferase PRMT1 and related enzymes

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g04870 GI:18390448
Arabidopsis thaliana (Ath) At2g19670 GI:15224820
Arabidopsis thaliana (Ath) At3g12270 GI:15230446
Arabidopsis thaliana (Ath) At3g20020 GI:15231011
Arabidopsis thaliana (Ath) At4g29510 GI:15233606
Caenorhabditis elegans (Cel) CE18281
(WBGene00011939)		 GI:17542516
Caenorhabditis elegans (Cel) CE23297
(WBGene00013766)		 GI:17566490 Q9U2X0
Caenorhabditis elegans (Cel) CE28343
(WBGene00010441)		 GI:17541154
Drosophila melanogaster (Dme) 7295728 GI:7295728
Drosophila melanogaster (Dme) 7297802 GI:7297802
Drosophila melanogaster (Dme) 7299364 GI:7299364
Drosophila melanogaster (Dme) 7299823 GI:7299823 Q9VFP9
Drosophila melanogaster (Dme) 7299824 GI:7299824
Drosophila melanogaster (Dme) 7299975 GI:7299975
Homo sapiens (Hsa) Hs14780868 GI:14780868
Homo sapiens (Hsa) Hs17473331 GI:17473331
Homo sapiens (Hsa) Hs21314692 GI:18490669
Homo sapiens (Hsa) Hs22061930 GI:22061930
Homo sapiens (Hsa) Hs4504495 GI:4504495
Homo sapiens (Hsa) Hs4504497 GI:4504497
Homo sapiens (Hsa) Hs8922515
(PRMT6)		 GI:8922515
Homo sapiens (Hsa) HsM9789979 GI:9789979
Saccharomyces cerevisiae (Sce) YBR034c
(S000000238)		 GI:6319508 P38074
Schizosaccharomyces pombe (Spo) SPAC890.07c GI:19115737 Q9URX7
Schizosaccharomyces pombe (Spo) SPBC8D2.10c GI:19112364 O13648
Schizosaccharomyces pombe (Spo) SPBPI055 GI:19112344


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
AthAt4g29510
HsaPRMT6
SceS000000238
SpoSPAC890.07c
GO:0005737 cytoplasm C
IDA
SpoSPBC8D2.10c
GO:0005829 cytosol C
IDA
SpoSPAC890.07c
SPBC8D2.10c
GO:0022627 cytosolic small ribosomal subunit C
IDA
SpoSPBC8D2.10c
GO:0005515 protein binding F
IPI
HsaPRMT6
SpoSPAC890.07c
SPBC8D2.10c
GO:0008168 methyltransferase activity F
IDA
SpoSPBC8D2.10c
ISS
AthAt3g12270
At1g04870
At3g20020
GO:0008469 histone-arginine N-methyltransferase
activity		 F
IDA
AthAt1g04870
GO:0016274 protein-arginine N-methyltransferase
activity		 F
IDA
AthAt4g29510
IMP
SpoSPAC890.07c
SPBC8D2.10c
ISS
AthAt4g29510
At2g19670
GO:0016277 [myelin basic protein]-arginine
N-methyltransferase activity		 F
IDA
AthAt1g04870
GO:0035241 protein-arginine omega-N monomethyltransferase
activity		 F
IDA
AthAt1g04870
HsaPRMT6
SceS000000238
IMP
SceS000000238
GO:0035242 protein-arginine omega-N asymmetric
methyltransferase activity		 F
IDA
AthAt1g04870
HsaPRMT6
SceS000000238
IMP
SceS000000238
GO:0042393 histone binding F
IDA
HsaPRMT6
GO:0043022 ribosome binding F
IDA
SpoSPBC8D2.10c
GO:0044020 histone methyltransferase activity (H4-R3
specific)		 F
IDA
HsaPRMT6
GO:0070611 histone methyltransferase activity (H3-R2
specific)		 F
IDA
HsaPRMT6
GO:0070612 histone methyltransferase activity (H2A-R3
specific)		 F
IDA
HsaPRMT6
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00013766
GO:0006284 base-excision repair P
TAS
HsaPRMT6
GO:0006399 tRNA metabolic process P
RCA
SceS000000238
GO:0006406 mRNA export from nucleus P
IGI
SceS000000238
ISS
SpoSPAC890.07c
GO:0009451 RNA modification P
RCA
SceS000000238
GO:0010228 vegetative to reproductive phase transition of
meristem		 P
IGI
AthAt1g04870
IMP
AthAt1g04870
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000238
GO:0018216 peptidyl-arginine methylation P
IDA
SceS000000238
IMP
SceS000000238
GO:0019919 peptidyl-arginine methylation, to
asymmetrical-dimethyl arginine		 P
IDA
AthAt1g04870
HsaPRMT6
IPI
SpoSPBC8D2.10c
TAS
SpoSPAC890.07c
GO:0034970 histone H3-R2 methylation P
IDA
HsaPRMT6
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013766
GO:0040011 locomotion P
IMP
CelWBGene00013766
GO:0042254 ribosome biogenesis P
IMP
SpoSPBC8D2.10c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000000238
GO:0045892 negative regulation of transcription,
DNA-dependent		 P
IDA
HsaPRMT6
GO:0060567 negative regulation of transcription
termination		 P
IMP
SceS000000238
GO:0090040 positive regulation of gene-specific transcription
elongation from RNA polymerase II
promoter		 P
IMP
SceS000000238

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
21477

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PRMT1 GI:154759421
Canis familiaris (Cfa) PRMT1 GI:73947042
Mus musculus (Mmu) Prmt1
(MGI:107846)		 GI:9790109 Q3TPF5
Rattus norvegicus (Rno) Prmt1 GI:13242255
Drosophila melanogaster (Dme) Art1
(FBgn0037834)		 GI:21356361
Anopheles gambiae (Aga) AgaP_AGAP003462 GI:158290170
Caenorhabditis elegans (Cel) Y113G7B.17
(CE23297;
WBGene00013766)		 GI:17566490 Q9U2X0
Schizosaccharomyces pombe (Spo) prmt1 GI:19115737
Saccharomyces cerevisiae (Sce) HMT1
(S000000238)		 GI:6319508 P38074
Kluyveromyces lactis (Kla) KLLA0B07117g GI:50303801
Eremothecium gossypii (Ego) AGOS_AAR190W GI:45185015
Magnaporthe grisea (Mgr) MGG_04584 GI:145614560
Neurospora crassa (Ncr) NCU07459.1 GI:32414531
Arabidopsis thaliana (Ath) PRMT11 GI:15233606
Arabidopsis thaliana (Ath) PRMT1A GI:15224820
Oryza sativa (Osa) Os09g0359800 GI:115478763
Plasmodium falciparum (Pfa) PF14_0242 GI:124808818


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
PfaPF14_0242
GO:0005634 nucleus C
IDA
AthPRMT11
HsaPRMT1
SceS000000238
ISO
MmuMGI:107846
GO:0043234 protein complex C
ISO
MmuMGI:107846
GO:0005515 protein binding F
IPI
HsaPRMT1
MmuMGI:107846
GO:0008168 methyltransferase activity F
TAS
HsaPRMT1
GO:0008170 N-methyltransferase activity F
TAS
HsaPRMT1
GO:0008276 protein methyltransferase activity F
IMP
MmuMGI:107846
ISO
MmuMGI:107846
GO:0008469 histone-arginine N-methyltransferase
activity		 F
ISO
MmuMGI:107846
GO:0016273 arginine N-methyltransferase activity F
ISS
PfaPF14_0242
GO:0016274 protein-arginine N-methyltransferase
activity		 F
IDA
AthPRMT11
ISS
AthPRMT11
PRMT1A
DmeFBgn0037834
GO:0016275 [cytochrome c]-arginine N-methyltransferase
activity		 F
ISO
MmuMGI:107846
GO:0030519 snoRNP binding F
ISO
MmuMGI:107846
GO:0035241 protein-arginine omega-N monomethyltransferase
activity		 F
IDA
DmeFBgn0037834
SceS000000238
IMP
SceS000000238
ISO
MmuMGI:107846
GO:0035242 protein-arginine omega-N asymmetric
methyltransferase activity		 F
IDA
DmeFBgn0037834
SceS000000238
IMP
SceS000000238
ISO
MmuMGI:107846
GO:0042054 histone methyltransferase activity F
IDA
DmeFBgn0037834
GO:0001701 in utero embryonic development P
IMP
MmuMGI:107846
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00013766
GO:0006399 tRNA metabolic process P
RCA
SceS000000238
GO:0006406 mRNA export from nucleus P
IGI
SceS000000238
GO:0006479 protein amino acid methylation P
IMP
MmuMGI:107846
ISO
MmuMGI:107846
TAS
HsaPRMT1
GO:0007166 cell surface receptor linked signaling
pathway		 P
TAS
HsaPRMT1
GO:0008150 biological_process P
ND
PfaPF14_0242
GO:0009451 RNA modification P
RCA
SceS000000238
GO:0016571 histone methylation P
IDA
DmeFBgn0037834
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000238
GO:0018216 peptidyl-arginine methylation P
IDA
SceS000000238
IMP
SceS000000238
ISO
MmuMGI:107846
GO:0019919 peptidyl-arginine methylation, to
asymmetrical-dimethyl arginine		 P
IDA
DmeFBgn0037834
ISO
MmuMGI:107846
GO:0034969 histone arginine methylation P
ISO
MmuMGI:107846
GO:0035247 peptidyl-arginine omega-N-methylation P
ISO
MmuMGI:107846
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013766
GO:0040011 locomotion P
IMP
CelWBGene00013766
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000000238
GO:0060567 negative regulation of transcription
termination		 P
IMP
SceS000000238
GO:0090040 positive regulation of gene-specific transcription
elongation from RNA polymerase II
promoter		 P
IMP
SceS000000238

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1275

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5874 ENSANGP00000014289
Ashbya gossypii (Ago) ago378 AAR190W
Arabidopsis thaliana (Ath) ath8826 At2g19670.1
Arabidopsis thaliana (Ath) ath20993 At4g29510.1
Caenorhabditis elegans (Cel) cel17686 Y113G7B.17
(CE23297;
WBGene00013766)
Candida glabrata (Cgl) cgl2726 CAGL0I04730g
Cryptococcus neoformans (Cne) cne4891 186.m03796
Dictyostelium discoideum (Ddi) ddi10242 DDB0183976
Debaryomyces hansenii (Dha) dha722 DEHA0B00946g
Drosophila melanogaster (Dme) dme11943 CG6554-PA
(FBgn0037834)
Danio rerio (Dre) dre18081 ENSDARP00000005903
Danio rerio (Dre) dre17551 ENSDARP00000010384
(prmt1)		 Q6PFN7
Danio rerio (Dre) dre2844 ENSDARP00000046338
Takifugu rubripes (Fru) fru12953 SINFRUP00000128320
Takifugu rubripes (Fru) fru2925 SINFRUP00000147234
Gallus gallus (Gga) gga26296 ENSGALP00000021646
(PRMT8)
Homo sapiens (Hsa) hsa16838 ENSP00000246789
(PRMT1)		 Q99873-1
Homo sapiens (Hsa) hsa16837 ENSP00000246790
Homo sapiens (Hsa) hsa6916 ENSP00000280677
Homo sapiens (Hsa) hsa16839 ENSP00000354435
Kluyveromyces lactis (Kla) kla845 KLLA0B07117g
Mus musculus (Mmu) mmu22783 ENSMUSP00000032500
(MGI:3043083)		 Q6PAK3
Mus musculus (Mmu) mmu23915 ENSMUSP00000045365
(MGI:107846)
Mus musculus (Mmu) mmu23914 ENSMUSP00000071862
Neurospora crassa (Ncr) ncr7261 NCU07459.2
Oryza sativa (Osa) osa40172 5181.m00227
Plasmodium falciparum (Pfa) pfa1676 PF14_0242
Rattus norvegicus (Rno) rno22273 ENSRNOP00000006878
(GI:688502)
Rattus norvegicus (Rno) rno1809 ENSRNOP00000027761
(RGD:62020)
Saccharomyces cerevisiae (Sce) sce287 YBR034C
(S000000238)
Schizosaccharomyces pombe (Spo) spo4656 SPAC890.07c Q9URX7
Yarrowia lipolytica (Yli) yli4616 YALI0E18282g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
PfaPF14_0242
GO:0005634 nucleus C
IDA
AthAt4g29510
SceS000000238
SpoSPAC890.07c
ISO
MmuMGI:107846
GO:0005829 cytosol C
IDA
SpoSPAC890.07c
GO:0005886 plasma membrane C
ISS
MmuMGI:3043083
GO:0043234 protein complex C
ISO
MmuMGI:107846
GO:0005515 protein binding F
IPI
MmuMGI:107846
SpoSPAC890.07c
GO:0008276 protein methyltransferase activity F
IMP
MmuMGI:107846
ISO
MmuMGI:107846
GO:0008469 histone-arginine N-methyltransferase
activity		 F
ISO
MmuMGI:107846
GO:0016273 arginine N-methyltransferase activity F
ISS
PfaPF14_0242
GO:0016274 protein-arginine N-methyltransferase
activity		 F
IDA
AthAt4g29510
IMP
SpoSPAC890.07c
ISS
AthAt4g29510
At2g19670
DmeFBgn0037834
GO:0016275 [cytochrome c]-arginine N-methyltransferase
activity		 F
ISO
MmuMGI:107846
GO:0030519 snoRNP binding F
ISO
MmuMGI:107846
GO:0035241 protein-arginine omega-N monomethyltransferase
activity		 F
IDA
DmeFBgn0037834
SceS000000238
IMP
SceS000000238
ISO
MmuMGI:107846
GO:0035242 protein-arginine omega-N asymmetric
methyltransferase activity		 F
IDA
DmeFBgn0037834
SceS000000238
IMP
SceS000000238
ISO
MmuMGI:107846
GO:0042054 histone methyltransferase activity F
IDA
DmeFBgn0037834
GO:0001701 in utero embryonic development P
IMP
MmuMGI:107846
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00013766
GO:0006399 tRNA metabolic process P
RCA
SceS000000238
GO:0006406 mRNA export from nucleus P
IGI
SceS000000238
ISS
SpoSPAC890.07c
GO:0006479 protein amino acid methylation P
IMP
MmuMGI:107846
ISO
MmuMGI:107846
GO:0008150 biological_process P
ND
PfaPF14_0242
GO:0009451 RNA modification P
RCA
SceS000000238
GO:0016571 histone methylation P
IDA
DmeFBgn0037834
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000238
GO:0018216 peptidyl-arginine methylation P
IDA
SceS000000238
IMP
SceS000000238
ISO
MmuMGI:107846
GO:0019919 peptidyl-arginine methylation, to
asymmetrical-dimethyl arginine		 P
IDA
DmeFBgn0037834
ISO
MmuMGI:107846
TAS
SpoSPAC890.07c
GO:0034969 histone arginine methylation P
ISO
MmuMGI:107846
GO:0035247 peptidyl-arginine omega-N-methylation P
ISO
MmuMGI:107846
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013766
GO:0040011 locomotion P
IMP
CelWBGene00013766
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000000238
GO:0060567 negative regulation of transcription
termination		 P
IMP
SceS000000238
GO:0090040 positive regulation of gene-specific transcription
elongation from RNA polymerase II
promoter		 P
IMP
SceS000000238

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC890.07c
(Q9URX7)		 YBR034C
(S000000238)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000000238
SpoSPAC890.07c
GO:0005829 cytosol C
IDA
SpoSPAC890.07c
GO:0005515 protein binding F
IPI
SpoSPAC890.07c
GO:0016274 protein-arginine N-methyltransferase
activity		 F
IMP
SpoSPAC890.07c
GO:0035241 protein-arginine omega-N monomethyltransferase
activity		 F
IDA
SceS000000238
IMP
SceS000000238
GO:0035242 protein-arginine omega-N asymmetric
methyltransferase activity		 F
IDA
SceS000000238
IMP
SceS000000238
GO:0006399 tRNA metabolic process P
RCA
SceS000000238
GO:0006406 mRNA export from nucleus P
IGI
SceS000000238
ISS
SpoSPAC890.07c
GO:0009451 RNA modification P
RCA
SceS000000238
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000238
GO:0018216 peptidyl-arginine methylation P
IDA
SceS000000238
IMP
SceS000000238
GO:0019919 peptidyl-arginine methylation, to
asymmetrical-dimethyl arginine		 P
TAS
SpoSPAC890.07c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000000238
GO:0060567 negative regulation of transcription
termination		 P
IMP
SceS000000238
GO:0090040 positive regulation of gene-specific transcription
elongation from RNA polymerase II
promoter		 P
IMP
SceS000000238

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