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Search term: YBR084W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MIS1
SGD link S000000288
Alternative ID YBR084W
Description Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
Synonyms YBR084W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4230 -C-HYP-

KOGs classification KOGs description
METABOLISM C1-tetrahydrofolate synthase

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE25047
(WBGene00000929)		 GI:17568735 Q21285
Homo sapiens (Hsa) Hs13699868 GI:13699868
Homo sapiens (Hsa) Hs22053503 GI:22053503
Homo sapiens (Hsa) Hs22055576 GI:22055576
Saccharomyces cerevisiae (Sce) YBR084w
(S000000288)		 GI:6319558 P09440
Saccharomyces cerevisiae (Sce) YGR204w
(S000003436)		 GI:6321643 P07245
Schizosaccharomyces pombe (Spo) SPBC2G2.08 GI:19113229 O43007
Schizosaccharomyces pombe (Spo) SPBC839.16 GI:19112048 Q8WZJ7


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000003436
GO:0005737 cytoplasm C
IDA
SceS000003436
GO:0005739 mitochondrion C
IDA
SceS000000288
SpoSPBC2G2.08
GO:0005829 cytosol C
IDA
SpoSPBC839.16
GO:0003697 single-stranded DNA binding F
IDA
SpoSPBC839.16
GO:0004329 formate-tetrahydrofolate ligase
activity		 F
IDA
SceS000000288
SpoSPBC839.16
IMP
SceS000003436
ISS
SpoSPBC2G2.08
TAS
SceS000003436
GO:0004477 methenyltetrahydrofolate cyclohydrolase
activity		 F
IDA
SceS000000288
SpoSPBC839.16
IMP
SceS000003436
ISS
SpoSPBC2G2.08
GO:0004479 methionyl-tRNA formyltransferase
activity		 F
IMP
SceS000000288
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+)
activity		 F
IDA
SceS000000288
SpoSPBC839.16
IMP
SceS000003436
ISS
SpoSPBC2G2.08
GO:0005524 ATP binding F
ISS
SpoSPBC2G2.08
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process		 P
IMP
SceS000000288
GO:0006417 regulation of translation P
RCA
SceS000003436
GO:0006730 one-carbon metabolic process P
IDA
SpoSPBC839.16
GO:0006760 folic acid and derivative metabolic
process		 P
TAS
SceS000003436
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003436
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00000929
GO:0009113 purine base biosynthetic process P
IDA
SpoSPBC839.16
IMP
SceS000003436
ISS
SpoSPBC2G2.08
GO:0009257 10-formyltetrahydrofolate biosynthetic
process		 P
IDA
SpoSPBC839.16
ISS
SpoSPBC2G2.08
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000929
GO:0046656 folic acid biosynthetic process P
IDA
SceS000000288
SpoSPBC839.16
ISS
SpoSPBC2G2.08

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68581

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) ade9
(SPBC2G2.08)		 GI:19113229 O43007
Saccharomyces cerevisiae (Sce) MIS1
(S000000288)		 GI:6319558 P09440
Kluyveromyces lactis (Kla) KLLA0E12485g GI:50309011
Eremothecium gossypii (Ego) AGOS_AER178W GI:45190781


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000000288
SpoSPBC2G2.08
GO:0004329 formate-tetrahydrofolate ligase
activity		 F
IDA
SceS000000288
ISS
SpoSPBC2G2.08
GO:0004477 methenyltetrahydrofolate cyclohydrolase
activity		 F
IDA
SceS000000288
ISS
SpoSPBC2G2.08
GO:0004479 methionyl-tRNA formyltransferase
activity		 F
IMP
SceS000000288
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+)
activity		 F
IDA
SceS000000288
ISS
SpoSPBC2G2.08
GO:0005524 ATP binding F
ISS
SpoSPBC2G2.08
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process		 P
IMP
SceS000000288
GO:0009113 purine base biosynthetic process P
ISS
SpoSPBC2G2.08
GO:0009257 10-formyltetrahydrofolate biosynthetic
process		 P
ISS
SpoSPBC2G2.08
GO:0046656 folic acid biosynthetic process P
IDA
SceS000000288
ISS
SpoSPBC2G2.08

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_143

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5057 ENSANGP00000016878
Anopheles gambiae (Aga) aga13588 ENSANGP00000019296
Anopheles gambiae (Aga) aga13586 ENSANGP00000022519
Anopheles gambiae (Aga) aga13587 ENSANGP00000024584
Anopheles gambiae (Aga) aga5056 ENSANGP00000025525
Ashbya gossypii (Ago) ago928 ACL121C
Ashbya gossypii (Ago) ago2680 AER178W
Arabidopsis thaliana (Ath) ath4320 At1g50480.1
Arabidopsis thaliana (Ath) ath13367 At3g12290.1
Arabidopsis thaliana (Ath) ath17903 At4g00600.1
Arabidopsis thaliana (Ath) ath17905 At4g00620.1
Caenorhabditis elegans (Cel) cel12147 K07E3.3
(CE25047;
WBGene00000929)
Caenorhabditis elegans (Cel) cel12148 K07E3.4a
Caenorhabditis elegans (Cel) cel12149 K07E3.4b
(CE18020)
Candida glabrata (Cgl) cgl3559 CAGL0K00913g
Candida glabrata (Cgl) cgl4728 CAGL0M01694g
Cryptococcus neoformans (Cne) cne4151 177.m02911
Dictyostelium discoideum (Ddi) ddi13044 DDB0230114
Dictyostelium discoideum (Ddi) ddi12751 DDB0230115
Dictyostelium discoideum (Ddi) ddi12332 DDB0230117
Debaryomyces hansenii (Dha) dha4094 DEHA0E19283g
Debaryomyces hansenii (Dha) dha4096 DEHA0E19316g
Debaryomyces hansenii (Dha) dha6808 DEHA0G24970g
Drosophila melanogaster (Dme) dme11631 CG18466-PA
(FBgn0010222)
Drosophila melanogaster (Dme) dme11630 CG18466-PB
(FBgn0010222)
Drosophila melanogaster (Dme) dme11912 CG4067-PA
(FBgn0020385)
Drosophila melanogaster (Dme) dme11911 CG4067-PB
(FBgn0020385)
Drosophila melanogaster (Dme) dme11913 CG4067-PC
(FBgn0020385)
Danio rerio (Dre) dre12447 ENSDARP00000017895
(si:dkey-1h6.1)		 Q5RIH2
Danio rerio (Dre) dre12446 ENSDARP00000020770
Danio rerio (Dre) dre4018 ENSDARP00000023193
Danio rerio (Dre) dre22875 ENSDARP00000043366
Danio rerio (Dre) dre22876 ENSDARP00000044814
Danio rerio (Dre) dre22874 ENSDARP00000047366
Escherichia coli (Eco) eco518 16128513
Takifugu rubripes (Fru) fru791 SINFRUP00000136165
Takifugu rubripes (Fru) fru6377 SINFRUP00000145071
Takifugu rubripes (Fru) fru31109 SINFRUP00000146531
Takifugu rubripes (Fru) fru9934 SINFRUP00000150733
Takifugu rubripes (Fru) fru793 SINFRUP00000168615
Takifugu rubripes (Fru) fru31110 SINFRUP00000174624
Gallus gallus (Gga) gga17587 ENSGALP00000017621
(MTHFD2L)
Gallus gallus (Gga) gga19918 ENSGALP00000019224
(MTHFD1)		 Q5ZI76
Gallus gallus (Gga) gga19919 ENSGALP00000019225
Gallus gallus (Gga) gga19920 ENSGALP00000019226
Gallus gallus (Gga) gga26547 ENSGALP00000021926
(RCJMB04_12b8)
Homo sapiens (Hsa) hsa9665 ENSP00000216605
(MTHFD1)		 P11586
Homo sapiens (Hsa) hsa18018 ENSP00000264090
(MTHFD2)		 Q7Z650
Kluyveromyces lactis (Kla) kla3510 KLLA0E12485g
Kluyveromyces lactis (Kla) kla3694 KLLA0E16588g
Mus musculus (Mmu) mmu22187 ENSMUSP00000005810
(MGI:1338850)		 P18155
Mus musculus (Mmu) mmu5874 ENSMUSP00000021443
(MGI:1342005)		 Q3TW74
Mus musculus (Mmu) mmu20357 ENSMUSP00000071578
(GI:665563)
Neurospora crassa (Ncr) ncr3766 NCU03877.2
Oryza sativa (Osa) osa6865 2486.m00116
Oryza sativa (Osa) osa15534 2995.m00158
Oryza sativa (Osa) osa45448 5682.m00136
Oryza sativa (Osa) osa55497 6374.m00113
Plasmodium falciparum (Pfa) pfa3193 PFF1490w
Rattus norvegicus (Rno) rno25291 ENSRNOP00000008374
(RGD:708531)		 P27653
Rattus norvegicus (Rno) rno21703 ENSRNOP00000014603
(RGD:1311313)
Rattus norvegicus (Rno) rno19689 ENSRNOP00000023913
Rattus norvegicus (Rno) rno19690 ENSRNOP00000030547
Rattus norvegicus (Rno) rno10135 ENSRNOP00000038512
Rattus norvegicus (Rno) rno10134 ENSRNOP00000044342
(RGD:1310879)
Saccharomyces cerevisiae (Sce) sce341 YBR084W
(S000000288)
Saccharomyces cerevisiae (Sce) sce2585 YGR204W
(S000003436)
Schizosaccharomyces pombe (Spo) spo103 SPBC2G2.08 O43007
Schizosaccharomyces pombe (Spo) spo406 SPBC839.16 Q8WZJ7
Yarrowia lipolytica (Yli) yli3901 YALI0E01056g
Yarrowia lipolytica (Yli) yli6606 YALI0F30745g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000003436
GO:0005737 cytoplasm C
IDA
SceS000003436
GO:0005739 mitochondrion C
IDA
MmuMGI:1338850
MGI:1342005
SceS000000288
SpoSPBC2G2.08
ISS
DmeFBgn0010222
NAS
DmeFBgn0010222
GO:0005811 lipid particle C
IDA
DmeFBgn0020385
GO:0005829 cytosol C
IDA
SpoSPBC839.16
GO:0005886 plasma membrane C
IDA
AthAt1g50480
GO:0009507 chloroplast C
IDA
AthAt3g12290
At1g50480
At4g00620
GO:0048046 apoplast C
IDA
AthAt1g50480
GO:0000287 magnesium ion binding F
NAS
DmeFBgn0010222
GO:0003697 single-stranded DNA binding F
IDA
SpoSPBC839.16
GO:0003824 catalytic activity F
ISS
AthAt3g12290
At4g00600
At4g00620
GO:0004329 formate-tetrahydrofolate ligase
activity		 F
IDA
SceS000000288
SpoSPBC839.16
IMP
SceS000003436
ISS
AthAt1g50480
DmeFBgn0020385
SpoSPBC2G2.08
TAS
SceS000003436
GO:0004477 methenyltetrahydrofolate cyclohydrolase
activity		 F
IDA
SceS000000288
SpoSPBC839.16
IMP
SceS000003436
ISS
DmeFBgn0020385
FBgn0010222
SpoSPBC2G2.08
NAS
DmeFBgn0010222
GO:0004479 methionyl-tRNA formyltransferase
activity		 F
IMP
SceS000000288
GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+)
activity		 F
NAS
DmeFBgn0010222
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+)
activity		 F
IDA
SceS000000288
SpoSPBC839.16
IMP
SceS000003436
ISS
DmeFBgn0010222
FBgn0020385
SpoSPBC2G2.08
NAS
DmeFBgn0010222
GO:0005507 copper ion binding F
IDA
AthAt1g50480
GO:0005524 ATP binding F
ISS
AthAt1g50480
SpoSPBC2G2.08
GO:0016155 formyltetrahydrofolate dehydrogenase
activity		 F
IMP
MmuMGI:1342005
GO:0005975 carbohydrate metabolic process P
ISS
DmeFBgn0010222
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process		 P
IMP
SceS000000288
GO:0006417 regulation of translation P
RCA
SceS000003436
GO:0006548 histidine catabolic process P
IMP
MmuMGI:1342005
GO:0006730 one-carbon metabolic process P
IDA
SpoSPBC839.16
GO:0006760 folic acid and derivative metabolic
process		 P
TAS
SceS000003436
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003436
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00000929
GO:0009113 purine base biosynthetic process P
IDA
SpoSPBC839.16
IMP
SceS000003436
ISS
SpoSPBC2G2.08
GO:0009256 10-formyltetrahydrofolate metabolic
process		 P
ISS
DmeFBgn0010222
GO:0009257 10-formyltetrahydrofolate biosynthetic
process		 P
IDA
SpoSPBC839.16
ISS
SpoSPBC2G2.08
GO:0009396 folic acid and derivative biosynthetic
process		 P
ISS
AthAt1g50480
At3g12290
At4g00600
At4g00620
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000929
GO:0046656 folic acid biosynthetic process P
IDA
SceS000000288
SpoSPBC839.16
ISS
SpoSPBC2G2.08
GO:0046686 response to cadmium ion P
IEP
AthAt1g50480

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC839.16
(Q8WZJ7)		 YBR084W
(S000000288)
SPBC2G2.08
(O43007)		 YBR084W
(S000000288)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000000288
SpoSPBC2G2.08
GO:0005829 cytosol C
IDA
SpoSPBC839.16
GO:0003697 single-stranded DNA binding F
IDA
SpoSPBC839.16
GO:0004329 formate-tetrahydrofolate ligase
activity		 F
IDA
SceS000000288
SpoSPBC839.16
ISS
SpoSPBC2G2.08
GO:0004477 methenyltetrahydrofolate cyclohydrolase
activity		 F
IDA
SceS000000288
SpoSPBC839.16
ISS
SpoSPBC2G2.08
GO:0004479 methionyl-tRNA formyltransferase
activity		 F
IMP
SceS000000288
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+)
activity		 F
IDA
SceS000000288
SpoSPBC839.16
ISS
SpoSPBC2G2.08
GO:0005524 ATP binding F
ISS
SpoSPBC2G2.08
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process		 P
IMP
SceS000000288
GO:0006730 one-carbon metabolic process P
IDA
SpoSPBC839.16
GO:0009113 purine base biosynthetic process P
IDA
SpoSPBC839.16
ISS
SpoSPBC2G2.08
GO:0009257 10-formyltetrahydrofolate biosynthetic
process		 P
IDA
SpoSPBC839.16
ISS
SpoSPBC2G2.08
GO:0046656 folic acid biosynthetic process P
IDA
SceS000000288
SpoSPBC839.16
ISS
SpoSPBC2G2.08

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GO info in one table:

s.khadayate@ucl.ac.uk