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Search term: YBR115C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LYS2
SGD link S000000319
Alternative ID YBR115C
Description Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
Synonyms YBR115C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1178 ACDHYP-

KOGs classification KOGs description
METABOLISM Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g35930_1 GI:15239238
Caenorhabditis elegans (Cel) CE04187_2 GI:17550940 Q18559
Caenorhabditis elegans (Cel) CE19015_1 GI:17555518
Caenorhabditis elegans (Cel) CE28795
(WBGene00013440)		 GI:17556356
Drosophila melanogaster (Dme) 7297420 GI:7297420
Drosophila melanogaster (Dme) 7300724 GI:7300724
Homo sapiens (Hsa) Hs21687121 GI:18599531
Saccharomyces cerevisiae (Sce) YBR115c
(S000000319)		 GI:6319591 P07702
Schizosaccharomyces pombe (Spo) SPAC23G3.02c GI:19114014 Q9P7T1
Schizosaccharomyces pombe (Spo) SPAP7G5.04c GI:19115226 P40976
Schizosaccharomyces pombe (Spo) SPCC162.02c GI:19075742 O74419
Arabidopsis thaliana (Ath) At5g35930_1 GI:15239238
Caenorhabditis elegans (Cel) CE04187_2 GI:17550940 Q18559
Caenorhabditis elegans (Cel) CE19015_1 GI:17555518
Caenorhabditis elegans (Cel) CE28795
(WBGene00013440)		 GI:17556356
Drosophila melanogaster (Dme) 7297420 GI:7297420
Drosophila melanogaster (Dme) 7300724 GI:7300724
Homo sapiens (Hsa) Hs21687121 GI:18599531
Saccharomyces cerevisiae (Sce) YBR115c
(S000000319)		 GI:6319591 P07702
Schizosaccharomyces pombe (Spo) SPAC23G3.02c GI:19114014 Q9P7T1
Schizosaccharomyces pombe (Spo) SPAP7G5.04c GI:19115226 P40976
Schizosaccharomyces pombe (Spo) SPCC162.02c GI:19075742 O74419


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g35930
GO:0005634 nucleus C
IDA
SpoSPCC162.02c
GO:0005737 cytoplasm C
IDA
SceS000000319
ISS
SpoSPAP7G5.04c
NAS
SceS000000319
GO:0005829 cytosol C
IDA
SpoSPAC23G3.02c
SPAP7G5.04c
SPCC162.02c
GO:0000062 acyl-CoA binding F
IDA
SpoSPAP7G5.04c
GO:0004043 L-aminoadipate-semialdehyde dehydrogenase
activity		 F
IDA
SceS000000319
SpoSPAP7G5.04c
IMP
SceS000000319
GO:0016208 AMP binding F
ISS
AthAt5g35930
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
IC
SpoSPAC23G3.02c
GO:0031177 phosphopantetheine binding F
ISS
SpoSPAC23G3.02c
GO:0006879 cellular iron ion homeostasis P
TAS
SpoSPAC23G3.02c
GO:0006880 intracellular sequestering of iron
ion		 P
TAS
SpoSPAC23G3.02c
GO:0008150 biological_process P
ND
SpoSPCC162.02c
GO:0009085 lysine biosynthetic process P
IDA
SpoSPAP7G5.04c
GO:0019184 nonribosomal peptide biosynthetic
process		 P
TAS
SpoSPAC23G3.02c
GO:0019290 siderophore biosynthetic process P
TAS
SpoSPAC23G3.02c
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IDA
SceS000000319
IMP
SceS000000319
GO:0031169 ferrichrome biosynthetic process P
TAS
SpoSPAC23G3.02c
GO:0033214 iron assimilation by chelation and
transport		 P
TAS
SpoSPAC23G3.02c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5390

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) lys1
(SPAP7G5.04c)		 GI:19115226 P40976
Saccharomyces cerevisiae (Sce) LYS2
(S000000319)		 GI:6319591 P07702
Kluyveromyces lactis (Kla) KLLA0B09218g GI:50303979
Magnaporthe grisea (Mgr) MGG_02611 GI:145610272
Neurospora crassa (Ncr) NCU03010.1 GI:32419507


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000000319
ISS
SpoSPAP7G5.04c
NAS
SceS000000319
GO:0005829 cytosol C
IDA
SpoSPAP7G5.04c
GO:0000062 acyl-CoA binding F
IDA
SpoSPAP7G5.04c
GO:0004043 L-aminoadipate-semialdehyde dehydrogenase
activity		 F
IDA
SceS000000319
SpoSPAP7G5.04c
IMP
SceS000000319
GO:0009085 lysine biosynthetic process P
IDA
SpoSPAP7G5.04c
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IDA
SceS000000319
IMP
SceS000000319

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_712

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga12372 ENSANGP00000006087
Anopheles gambiae (Aga) aga4442 ENSANGP00000021728
Anopheles gambiae (Aga) aga13209 ENSANGP00000028259
Ashbya gossypii (Ago) ago1394 ADL346W
Arabidopsis thaliana (Ath) ath25372 At5g35930.1
Caenorhabditis elegans (Cel) cel17310 W09D6.1a
(CE31855;
WBGene00012356)
Caenorhabditis elegans (Cel) cel17311 W09D6.1b
(CE31856)
Caenorhabditis elegans (Cel) cel20313 Y66D12A.14
(CE28795;
WBGene00013440)
Candida glabrata (Cgl) cgl3856 CAGL0K07788g
Cryptococcus neoformans (Cne) cne4114 177.m02872
Dictyostelium discoideum (Ddi) ddi8974 DDB0188746
Debaryomyces hansenii (Dha) dha2681 DEHA0D08734g
Drosophila melanogaster (Dme) dme1474 CG13401-PA
(FBgn0027780)
Drosophila melanogaster (Dme) dme1475 CG13401-PB
(FBgn0027780)
Drosophila melanogaster (Dme) dme13661 CG3331-PA
(FBgn0000527)
Danio rerio (Dre) dre26754 ENSDARP00000033217
(si:dkeyp-117h8.3)		 Q5RG49
Escherichia coli (Eco) eco575 16128569
Takifugu rubripes (Fru) fru26517 SINFRUP00000146114
Gallus gallus (Gga) gga18735 ENSGALP00000008572
Gallus gallus (Gga) gga18052 ENSGALP00000022317
(AASDH)
Homo sapiens (Hsa) hsa24120 ENSP00000205214
(AASDH)		 Q4L235-1
Kluyveromyces lactis (Kla) kla937 KLLA0B09218g
Mus musculus (Mmu) mmu20255 ENSMUSP00000069279
(MGI:2442517)		 Q80WC9-1
Neurospora crassa (Ncr) ncr2915 NCU03010.2
Neurospora crassa (Ncr) ncr4400 NCU04531.2
Neurospora crassa (Ncr) ncr6927 NCU07119.2
Neurospora crassa (Ncr) ncr8226 NCU08441.2
Oryza sativa (Osa) osa14466 3014.m00121
Rattus norvegicus (Rno) rno10271 ENSRNOP00000002907
(RGD:1311135)
Saccharomyces cerevisiae (Sce) sce376 YBR115C
(S000000319)
Schizosaccharomyces pombe (Spo) spo3588 SPAC23G3.02c Q9P7T1
Schizosaccharomyces pombe (Spo) spo441 SPAP7G5.04c P40976
Yarrowia lipolytica (Yli) yli4131 YALI0E06457g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g35930
DmeFBgn0027780
MmuMGI:2442517
GO:0005737 cytoplasm C
IDA
DmeFBgn0000527
SceS000000319
ISS
SpoSPAP7G5.04c
NAS
SceS000000319
GO:0005829 cytosol C
IDA
SpoSPAC23G3.02c
SPAP7G5.04c
GO:0000062 acyl-CoA binding F
IDA
SpoSPAP7G5.04c
GO:0003674 molecular_function F
ND
MmuMGI:2442517
GO:0003833 beta-alanyl-dopamine synthase activity F
IDA
DmeFBgn0000527
IMP
DmeFBgn0000527
TAS
DmeFBgn0000527
GO:0004043 L-aminoadipate-semialdehyde dehydrogenase
activity		 F
IDA
SceS000000319
SpoSPAP7G5.04c
IMP
SceS000000319
GO:0016208 AMP binding F
ISS
AthAt5g35930
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
IC
SpoSPAC23G3.02c
GO:0031177 phosphopantetheine binding F
ISS
SpoSPAC23G3.02c
GO:0001692 histamine metabolic process P
IMP
DmeFBgn0000527
GO:0006583 melanin biosynthetic process from
tyrosine		 P
TAS
DmeFBgn0000527
GO:0006879 cellular iron ion homeostasis P
TAS
SpoSPAC23G3.02c
GO:0006880 intracellular sequestering of iron
ion		 P
TAS
SpoSPAC23G3.02c
GO:0007593 chitin-based cuticle tanning P
IMP
DmeFBgn0000527
GO:0007623 circadian rhythm P
NAS
DmeFBgn0000527
GO:0008150 biological_process P
ND
MmuMGI:2442517
GO:0009085 lysine biosynthetic process P
IDA
SpoSPAP7G5.04c
GO:0019184 nonribosomal peptide biosynthetic
process		 P
TAS
SpoSPAC23G3.02c
GO:0019290 siderophore biosynthetic process P
TAS
SpoSPAC23G3.02c
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IDA
SceS000000319
IMP
SceS000000319
GO:0031169 ferrichrome biosynthetic process P
TAS
SpoSPAC23G3.02c
GO:0033214 iron assimilation by chelation and
transport		 P
TAS
SpoSPAC23G3.02c
GO:0042417 dopamine metabolic process P
IDA
DmeFBgn0000527
GO:0042440 pigment metabolic process P
TAS
DmeFBgn0000527
GO:0043042 amino acid adenylylation by nonribosomal peptide
synthase		 P
IDA
DmeFBgn0000527
GO:0045475 locomotor rhythm P
NAS
DmeFBgn0000527
GO:0048022 negative regulation of melanin biosynthetic
process		 P
IMP
DmeFBgn0000527
GO:0048066 developmental pigmentation P
TAS
DmeFBgn0000527
GO:0048067 cuticle pigmentation P
IGI
DmeFBgn0000527
IMP
DmeFBgn0000527
GO:0048082 regulation of adult chitin-containing cuticle
pigmentation		 P
IMP
DmeFBgn0000527

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAP7G5.04c
(P40976)		 YBR115C
(S000000319)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000000319
ISS
SpoSPAP7G5.04c
NAS
SceS000000319
GO:0005829 cytosol C
IDA
SpoSPAP7G5.04c
GO:0000062 acyl-CoA binding F
IDA
SpoSPAP7G5.04c
GO:0004043 L-aminoadipate-semialdehyde dehydrogenase
activity		 F
IDA
SceS000000319
SpoSPAP7G5.04c
IMP
SceS000000319
GO:0009085 lysine biosynthetic process P
IDA
SpoSPAP7G5.04c
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IDA
SceS000000319
IMP
SceS000000319

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Query species:

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Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk