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Search term: YBR127C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name VMA2
SGD link S000000331
Alternative ID YBR127C
Description Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm
Synonyms YBR127C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1351 ACDHYPE

KOGs classification KOGs description
METABOLISM Vacuolar H+-ATPase V1 sector, subunit B

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g20260 GI:15217907
Arabidopsis thaliana (Ath) At1g76030 GI:15222929
Arabidopsis thaliana (Ath) At4g38510 GI:15233891
Caenorhabditis elegans (Cel) CE04424
(WBGene00006921)		 GI:17570191 Q19626
Caenorhabditis elegans (Cel) CE23245
(WBGene00022461)		 GI:17510931 Q9N5A0
Drosophila melanogaster (Dme) 7299652 GI:17136796
Homo sapiens (Hsa) Hs19913426
(ATP6V1B1)		 GI:19913426 Q71UA2
Homo sapiens (Hsa) Hs19913428
(ATP6V1B2)		 GI:19913428 P21281
Homo sapiens (Hsa) Hs22045054 GI:22045054
Saccharomyces cerevisiae (Sce) YBR127c
(S000000331)		 GI:6319603 P16140
Schizosaccharomyces pombe (Spo) SPAC637.05c GI:19115535 P31411
Encephalitozoon cuniculi (Ecu) ECU10g1040 GI:19074713 Q8SR34


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000221 vacuolar proton-transporting V-type ATPase, V1
domain		 C
IDA
SceS000000331
ISS
SpoSPAC637.05c
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000000331
GO:0005737 cytoplasm C
IDA
SceS000000331
SpoSPAC637.05c
GO:0005773 vacuole C
IDA
AthAt4g38510
At1g76030
At1g20260
GO:0005794 Golgi apparatus C
IDA
HsaATP6V1B2
GO:0005829 cytosol C
ISS
HsaATP6V1B2
GO:0005886 plasma membrane C
IDA
AthAt4g38510
At1g76030
At1g20260
ISS
HsaATP6V1B2
GO:0009507 chloroplast C
IDA
AthAt1g76030
At1g20260
GO:0009941 chloroplast envelope C
IDA
AthAt4g38510
GO:0016020 membrane C
IDA
AthAt4g38510
At1g76030
GO:0016324 apical plasma membrane C
IDA
HsaATP6V1B1
GO:0016471 vacuolar proton-transporting V-type ATPase
complex		 C
IMP
HsaATP6V1B1
GO:0043231 intracellular membrane-bounded
organelle		 C
IDA
HsaATP6V1B2
GO:0015078 hydrogen ion transmembrane transporter
activity		 F
TAS
HsaATP6V1B2
GO:0046933 hydrogen ion transporting ATP synthase activity,
rotational mechanism		 F
ISS
AthAt4g38510
At1g76030
GO:0046961 proton-transporting ATPase activity, rotational
mechanism		 F
IMP
SceS000000331
ISS
SpoSPAC637.05c
GO:0000003 reproduction P
IMP
CelWBGene00006921
WBGene00022461
GO:0001503 ossification P
IMP
HsaATP6V1B1
GO:0001666 response to hypoxia P
IMP
CelWBGene00006921
GO:0002119 nematode larval development P
IMP
CelWBGene00006921
GO:0006200 ATP catabolic process P
ISS
SpoSPAC637.05c
GO:0006811 ion transport P
RCA
SceS000000331
GO:0006874 cellular calcium ion homeostasis P
IMP
SceS000000331
GO:0006885 regulation of pH P
IMP
HsaATP6V1B1
GO:0007035 vacuolar acidification P
IMP
SceS000000331
ISS
SpoSPAC637.05c
GO:0007588 excretion P
IMP
HsaATP6V1B1
GO:0007605 sensory perception of sound P
IMP
HsaATP6V1B1
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00006921
WBGene00022461
GO:0009117 nucleotide metabolic process P
RCA
SceS000000331
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00022461
WBGene00006921
GO:0010255 glucose mediated signaling pathway P
IMP
AthAt1g76030
GO:0015991 ATP hydrolysis coupled proton transport P
ISS
SpoSPAC637.05c
GO:0015992 proton transport P
IMP
HsaATP6V1B1
TAS
HsaATP6V1B2
GO:0019915 lipid storage P
IMP
CelWBGene00022461
GO:0040007 growth P
IMP
CelWBGene00006921
GO:0040011 locomotion P
IMP
CelWBGene00006921
GO:0043068 positive regulation of programmed cell
death		 P
IGI
CelWBGene00006921
IMP
CelWBGene00006921
GO:0046686 response to cadmium ion P
IEP
AthAt1g76030
GO:0050801 ion homeostasis P
RCA
SceS000000331
GO:0051453 regulation of intracellular pH P
IGI
CelWBGene00006921
GO:0055085 transmembrane transport P
IMP
SceS000000331
GO:0060142 regulation of syncytium formation by plasma
membrane fusion		 P
IGI
CelWBGene00006921
IMP
CelWBGene00006921

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1279

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ATP6V1B2 GI:19913428 P21281
Pan troglodytes (Ptr) ATP6V1B2 GI:114619082
Canis familiaris (Cfa) ATP6V1B2 GI:73993818
Mus musculus (Mmu) Atp6v1b2
(MGI:109618)		 GI:19705578 B0LAC8
Rattus norvegicus (Rno) Atp6v1b2
(RGD:620284)		 GI:17105370
Gallus gallus (Gga) ATP6V1B2 GI:118101340
Drosophila melanogaster (Dme) Vha55
(FBgn0005671)		 GI:24646341
Anopheles gambiae (Aga) AgaP_AGAP002884 GI:118782047
Caenorhabditis elegans (Cel) vha-12
(CE04424;
WBGene00006921)		 GI:17570191 Q19626
Caenorhabditis elegans (Cel) tag-300
(CE23245;
WBGene00022461)		 GI:17510931 Q9N5A0
Schizosaccharomyces pombe (Spo) vma2
(SPAC637.05c)		 GI:19115535 P31411
Saccharomyces cerevisiae (Sce) VMA2
(S000000331)		 GI:6319603 P16140
Kluyveromyces lactis (Kla) KLLA0D09152g GI:50306985
Eremothecium gossypii (Ego) AGOS_ADL380W GI:45187493
Magnaporthe grisea (Mgr) MGG_03244 GI:39942328
Neurospora crassa (Ncr) NCU08515.1 GI:32418164
Arabidopsis thaliana (Ath) AT1G76030 GI:15222929
Oryza sativa (Osa) Os06g0568200 GI:115468606
Plasmodium falciparum (Pfa) PFD0300c GI:124505265


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000221 vacuolar proton-transporting V-type ATPase, V1
domain		 C
IDA
SceS000000331
ISS
DmeFBgn0005671
SpoSPAC637.05c
NAS
DmeFBgn0005671
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000000331
GO:0005737 cytoplasm C
IDA
SceS000000331
SpoSPAC637.05c
GO:0005769 early endosome C
IDA
DmeFBgn0005671
GO:0005773 vacuole C
IDA
AthAt1g76030
GO:0005794 Golgi apparatus C
IDA
HsaATP6V1B2
GO:0005829 cytosol C
IDA
MmuMGI:109618
ISS
HsaATP6V1B2
GO:0005886 plasma membrane C
IDA
AthAt1g76030
DmeFBgn0005671
MmuMGI:109618
ISS
HsaATP6V1B2
GO:0009507 chloroplast C
IDA
AthAt1g76030
GO:0016020 membrane C
IDA
AthAt1g76030
GO:0016021 integral to membrane C
ISO
MmuMGI:109618
GO:0043231 intracellular membrane-bounded
organelle		 C
IDA
HsaATP6V1B2
GO:0008553 hydrogen-exporting ATPase activity,
phosphorylative mechanism		 F
ISS
DmeFBgn0005671
NAS
DmeFBgn0005671
GO:0015078 hydrogen ion transmembrane transporter
activity		 F
TAS
HsaATP6V1B2
GO:0046933 hydrogen ion transporting ATP synthase activity,
rotational mechanism		 F
ISS
AthAt1g76030
GO:0046961 proton-transporting ATPase activity, rotational
mechanism		 F
IMP
SceS000000331
ISS
SpoSPAC637.05c
GO:0000003 reproduction P
IMP
CelWBGene00006921
WBGene00022461
GO:0001666 response to hypoxia P
IMP
CelWBGene00006921
GO:0002119 nematode larval development P
IMP
CelWBGene00006921
GO:0006200 ATP catabolic process P
ISS
SpoSPAC637.05c
GO:0006811 ion transport P
RCA
SceS000000331
GO:0006874 cellular calcium ion homeostasis P
IMP
SceS000000331
GO:0007035 vacuolar acidification P
IMP
SceS000000331
ISS
SpoSPAC637.05c
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00006921
WBGene00022461
GO:0009117 nucleotide metabolic process P
RCA
SceS000000331
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00022461
WBGene00006921
GO:0010255 glucose mediated signaling pathway P
IMP
AthAt1g76030
GO:0015991 ATP hydrolysis coupled proton transport P
ISS
SpoSPAC637.05c
GO:0015992 proton transport P
NAS
DmeFBgn0005671
TAS
HsaATP6V1B2
GO:0019915 lipid storage P
IMP
CelWBGene00022461
GO:0040007 growth P
IMP
CelWBGene00006921
GO:0040011 locomotion P
IMP
CelWBGene00006921
GO:0043068 positive regulation of programmed cell
death		 P
IGI
CelWBGene00006921
IMP
CelWBGene00006921
GO:0046686 response to cadmium ion P
IEP
AthAt1g76030
GO:0050801 ion homeostasis P
RCA
SceS000000331
GO:0051453 regulation of intracellular pH P
IGI
CelWBGene00006921
GO:0055085 transmembrane transport P
IMP
SceS000000331
GO:0060142 regulation of syncytium formation by plasma
membrane fusion		 P
IGI
CelWBGene00006921
IMP
CelWBGene00006921

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_667

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5111 ENSANGP00000018716
Ashbya gossypii (Ago) ago1361 ADL380W
Arabidopsis thaliana (Ath) ath6917 At1g76030.1
Arabidopsis thaliana (Ath) ath22044 At4g38510.1
Arabidopsis thaliana (Ath) ath22045 At4g38510.2
Caenorhabditis elegans (Cel) cel6792 F20B6.2
(CE04424;
WBGene00006921)
Caenorhabditis elegans (Cel) cel17616 Y110A7A.12
(CE23245;
WBGene00022461)
Candida glabrata (Cgl) cgl448 CAGL0C00649g
Cryptococcus neoformans (Cne) cne220 162.m02668
Dictyostelium discoideum (Ddi) ddi12271 DDB0185207
Debaryomyces hansenii (Dha) dha4256 DEHA0E23100g
Drosophila melanogaster (Dme) dme12292 CG17369-PA
(FBgn0005671)
Drosophila melanogaster (Dme) dme12291 CG17369-PB
(FBgn0005671)
Danio rerio (Dre) dre8069 ENSDARP00000008834
(atp6v1ba)		 Q6PC68
Danio rerio (Dre) dre1665 ENSDARP00000022258
Encephalitozoon cuniculi (Ecu) ecu629 19074713
Takifugu rubripes (Fru) fru4628 SINFRUP00000160807
Takifugu rubripes (Fru) fru4629 SINFRUP00000170108
Gallus gallus (Gga) gga24291 ENSGALP00000002624
Gallus gallus (Gga) gga24290 ENSGALP00000002625
(ATP6V1B2)		 P49712
Homo sapiens (Hsa) hsa17963 ENSP00000234396
(ATP6V1B1)		 P15313
Homo sapiens (Hsa) hsa29993 ENSP00000276390
(ATP6V1B2)		 P21281
Kluyveromyces lactis (Kla) kla2469 KLLA0D09152g
Mus musculus (Mmu) mmu22202 ENSMUSP00000006431
(MGI:103285)		 Q8C3L6
Mus musculus (Mmu) mmu26055 ENSMUSP00000006435
(MGI:109618)		 P62814
Neurospora crassa (Ncr) ncr8297 NCU08515.2
Oryza sativa (Osa) osa11077 2763.m00152
Oryza sativa (Osa) osa30823 4367.m00136
Oryza sativa (Osa) osa38642 4898.m00159
Oryza sativa (Osa) osa38854 5073.m00087
Oryza sativa (Osa) osa40976 5105.m00213
Plasmodium falciparum (Pfa) pfa3428 PFD0305c
Rattus norvegicus (Rno) rno12297 ENSRNOP00000015931
(RGD:620284)		 P62815
Rattus norvegicus (Rno) rno21721 ENSRNOP00000018302
(RGD:1310619)
Saccharomyces cerevisiae (Sce) sce391 YBR127C
(S000000331)
Schizosaccharomyces pombe (Spo) spo1204 SPAC637.05c P31411
Yarrowia lipolytica (Yli) yli4987 YALI0E27346g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000221 vacuolar proton-transporting V-type ATPase, V1
domain		 C
IDA
SceS000000331
ISS
DmeFBgn0005671
SpoSPAC637.05c
NAS
DmeFBgn0005671
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000000331
GO:0005624 membrane fraction C
IDA
MmuMGI:103285
GO:0005737 cytoplasm C
IDA
SceS000000331
SpoSPAC637.05c
GO:0005769 early endosome C
IDA
DmeFBgn0005671
GO:0005773 vacuole C
IDA
AthAt4g38510
At1g76030
GO:0005829 cytosol C
IDA
MmuMGI:109618
GO:0005886 plasma membrane C
IDA
AthAt4g38510
At1g76030
DmeFBgn0005671
MmuMGI:109618
GO:0009507 chloroplast C
IDA
AthAt1g76030
GO:0009941 chloroplast envelope C
IDA
AthAt4g38510
GO:0016020 membrane C
IDA
AthAt4g38510
At1g76030
GO:0016021 integral to membrane C
ISO
MmuMGI:109618
GO:0016323 basolateral plasma membrane C
IDA
MmuMGI:103285
ISO
MmuMGI:103285
GO:0008553 hydrogen-exporting ATPase activity,
phosphorylative mechanism		 F
ISS
DmeFBgn0005671
NAS
DmeFBgn0005671
GO:0015078 hydrogen ion transmembrane transporter
activity		 F
IMP
MmuMGI:103285
GO:0032403 protein complex binding F
ISO
MmuMGI:103285
GO:0046933 hydrogen ion transporting ATP synthase activity,
rotational mechanism		 F
ISS
AthAt4g38510
At1g76030
GO:0046961 proton-transporting ATPase activity, rotational
mechanism		 F
IMP
SceS000000331
ISS
SpoSPAC637.05c
GO:0000003 reproduction P
IMP
CelWBGene00006921
WBGene00022461
GO:0001666 response to hypoxia P
IMP
CelWBGene00006921
GO:0002119 nematode larval development P
IMP
CelWBGene00006921
GO:0006200 ATP catabolic process P
ISS
SpoSPAC637.05c
GO:0006811 ion transport P
RCA
SceS000000331
GO:0006874 cellular calcium ion homeostasis P
IMP
SceS000000331
GO:0006885 regulation of pH P
IMP
MmuMGI:103285
ISO
MmuMGI:103285
GO:0007035 vacuolar acidification P
IMP
SceS000000331
ISS
SpoSPAC637.05c
TAS
PfaPFD0305c
GO:0007605 sensory perception of sound P
ISO
MmuMGI:103285
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00006921
WBGene00022461
GO:0009117 nucleotide metabolic process P
RCA
SceS000000331
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00022461
WBGene00006921
GO:0010255 glucose mediated signaling pathway P
IMP
AthAt1g76030
GO:0015991 ATP hydrolysis coupled proton transport P
ISS
SpoSPAC637.05c
GO:0015992 proton transport P
IMP
MmuMGI:103285
NAS
DmeFBgn0005671
GO:0019915 lipid storage P
IMP
CelWBGene00022461
GO:0034220 ion transmembrane transport P
IMP
MmuMGI:103285
GO:0040007 growth P
IMP
CelWBGene00006921
GO:0040011 locomotion P
IMP
CelWBGene00006921
GO:0043068 positive regulation of programmed cell
death		 P
IGI
CelWBGene00006921
IMP
CelWBGene00006921
GO:0046686 response to cadmium ion P
IEP
AthAt1g76030
GO:0050801 ion homeostasis P
RCA
SceS000000331
GO:0051453 regulation of intracellular pH P
IGI
CelWBGene00006921
GO:0055085 transmembrane transport P
IMP
SceS000000331
GO:0060142 regulation of syncytium formation by plasma
membrane fusion		 P
IGI
CelWBGene00006921
IMP
CelWBGene00006921

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC637.05c
(P31411)		 YBR127C
(S000000331)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000221 vacuolar proton-transporting V-type ATPase, V1
domain		 C
IDA
SceS000000331
ISS
SpoSPAC637.05c
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000000331
GO:0005737 cytoplasm C
IDA
SceS000000331
SpoSPAC637.05c
GO:0046961 proton-transporting ATPase activity, rotational
mechanism		 F
IMP
SceS000000331
ISS
SpoSPAC637.05c
GO:0006200 ATP catabolic process P
ISS
SpoSPAC637.05c
GO:0006811 ion transport P
RCA
SceS000000331
GO:0006874 cellular calcium ion homeostasis P
IMP
SceS000000331
GO:0007035 vacuolar acidification P
IMP
SceS000000331
ISS
SpoSPAC637.05c
GO:0009117 nucleotide metabolic process P
RCA
SceS000000331
GO:0015991 ATP hydrolysis coupled proton transport P
ISS
SpoSPAC637.05c
GO:0050801 ion homeostasis P
RCA
SceS000000331
GO:0055085 transmembrane transport P
IMP
SceS000000331

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Query species:

Include wild-cards:   

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GO info in one table:

s.khadayate@ucl.ac.uk