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Search term: YBR136W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MEC1
SGD link S000000340
Alternative ID YBR136W
Description Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination
Synonyms YBR136W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0890 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGINFORMATION STORAGE AND PROCESSINGINFORMATION STORAGE AND PROCESSINGCELLULAR PROCESSES AND SIGNALING Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g40820 GI:10177961
Caenorhabditis elegans (Cel) CE25103
(WBGene00000226)		 GI:17557212
Caenorhabditis elegans (Cel) CE28250 GI:17557210
Drosophila melanogaster (Dme) 7293222 GI:17647625
Homo sapiens (Hsa) Hs22041606 GI:22041606
Homo sapiens (Hsa) Hs4502325 GI:4502325
Saccharomyces cerevisiae (Sce) YBR136w
(S000000340)		 GI:6319612 P38111
Schizosaccharomyces pombe (Spo) SPBC216.05 GI:19112149 Q02099
Encephalitozoon cuniculi (Ecu) ECU02g1130 GI:19074032 Q8SSE7
Arabidopsis thaliana (Ath) At5g40820 GI:10177961
Caenorhabditis elegans (Cel) CE25103
(WBGene00000226)		 GI:17557212
Caenorhabditis elegans (Cel) CE28250 GI:17557210
Drosophila melanogaster (Dme) 7293222 GI:17647625
Homo sapiens (Hsa) Hs22041606 GI:22041606
Homo sapiens (Hsa) Hs4502325 GI:4502325
Saccharomyces cerevisiae (Sce) YBR136w
(S000000340)		 GI:6319612 P38111
Schizosaccharomyces pombe (Spo) SPBC216.05 GI:19112149 Q02099
Encephalitozoon cuniculi (Ecu) ECU02g1130 GI:19074032 Q8SSE7


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IDA
SpoSPBC216.05
GO:0000794 condensed nuclear chromosome C
TAS
CelWBGene00000226
GO:0005634 nucleus C
IC
SceS000000340
IDA
CelWBGene00000226
GO:0005739 mitochondrion C
IDA
SceS000000340
GO:0005829 cytosol C
IDA
SpoSPBC216.05
GO:0043234 protein complex C
NAS
SpoSPBC216.05
GO:0004428 inositol or phosphatidylinositol kinase
activity		 F
ISS
AthAt5g40820
GO:0004672 protein kinase activity F
IDA
SceS000000340
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SpoSPBC216.05
GO:0005515 protein binding F
IPI
SpoSPBC216.05
GO:0016303 1-phosphatidylinositol-3-kinase
activity		 F
ISS
CelWBGene00000226
GO:0000003 reproduction P
IMP
CelWBGene00000226
GO:0000077 DNA damage checkpoint P
TAS
SceS000000340
GO:0000722 telomere maintenance via recombination P
IGI
SceS000000340
GO:0000723 telomere maintenance P
IDA
SceS000000340
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process		 P
IGI
SceS000000340
GO:0006260 DNA replication P
IMP
SceS000000340
GO:0006281 DNA repair P
IGI
AthAt5g40820
RCA
SceS000000340
GO:0006310 DNA recombination P
IMP
SceS000000340
GO:0006974 response to DNA damage stimulus P
RCA
SceS000000340
GO:0006975 DNA damage induced protein phosphorylation P
IMP
SceS000000340
GO:0007004 telomere maintenance via telomerase P
IMP
AthAt5g40820
GO:0007126 meiosis P
IGI
AthAt5g40820
IMP
CelWBGene00000226
GO:0007131 reciprocal meiotic recombination P
IMP
SceS000000340
SpoSPBC216.05
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPBC216.05
GO:0009790 embryo development P
IMP
CelWBGene00000226
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000226
GO:0010044 response to aluminum ion P
IMP
AthAt5g40820
GO:0010332 response to gamma radiation P
IMP
AthAt5g40820
GO:0016572 histone phosphorylation P
IGI
SceS000000340
IMP
SceS000000340
GO:0031573 intra-S DNA damage checkpoint P
IDA
SpoSPBC216.05
IMP
SpoSPBC216.05
GO:0032204 regulation of telomere maintenance P
IGI
AthAt5g40820
GO:0032504 multicellular organism reproduction P
IGI
AthAt5g40820
GO:0033044 regulation of chromosome organization P
IGI
AthAt5g40820
GO:0043247 telomere maintenance in response to DNA
damage		 P
TAS
AthAt5g40820
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00000226
GO:0050790 regulation of catalytic activity P
RCA
SceS000000340
GO:0051321 meiotic cell cycle P
RCA
SceS000000340

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
99739

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) rad3
(SPBC216.05)		 GI:19112149 Q02099
Saccharomyces cerevisiae (Sce) MEC1
(S000000340)		 GI:6319612 P38111
Kluyveromyces lactis (Kla) KLLA0C15785g GI:50305889
Eremothecium gossypii (Ego) AGOS_ABR108C GI:45185338
Magnaporthe grisea (Mgr) MGG_02656 GI:145610197
Neurospora crassa (Ncr) NCU00625.1 GI:32408649


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IDA
SpoSPBC216.05
GO:0005634 nucleus C
IC
SceS000000340
GO:0005739 mitochondrion C
IDA
SceS000000340
GO:0005829 cytosol C
IDA
SpoSPBC216.05
GO:0043234 protein complex C
NAS
SpoSPBC216.05
GO:0004672 protein kinase activity F
IDA
SceS000000340
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SpoSPBC216.05
GO:0005515 protein binding F
IPI
SpoSPBC216.05
GO:0000077 DNA damage checkpoint P
TAS
SceS000000340
GO:0000722 telomere maintenance via recombination P
IGI
SceS000000340
GO:0000723 telomere maintenance P
IDA
SceS000000340
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process		 P
IGI
SceS000000340
GO:0006260 DNA replication P
IMP
SceS000000340
GO:0006281 DNA repair P
RCA
SceS000000340
GO:0006310 DNA recombination P
IMP
SceS000000340
GO:0006974 response to DNA damage stimulus P
RCA
SceS000000340
GO:0006975 DNA damage induced protein phosphorylation P
IMP
SceS000000340
GO:0007131 reciprocal meiotic recombination P
IMP
SceS000000340
SpoSPBC216.05
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPBC216.05
GO:0016572 histone phosphorylation P
IGI
SceS000000340
IMP
SceS000000340
GO:0031573 intra-S DNA damage checkpoint P
IDA
SpoSPBC216.05
IMP
SpoSPBC216.05
GO:0050790 regulation of catalytic activity P
RCA
SceS000000340
GO:0051321 meiotic cell cycle P
RCA
SceS000000340

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2567

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga14131 ENSANGP00000018055
Ashbya gossypii (Ago) ago700 ABR108C
Arabidopsis thaliana (Ath) ath25859 At5g40820.1
Caenorhabditis elegans (Cel) cel14770 T06E4.3a
(CE25103;
WBGene00000226)
Caenorhabditis elegans (Cel) cel14771 T06E4.3b
(CE28250)
Candida glabrata (Cgl) cgl440 CAGL0C00473g
Cryptococcus neoformans (Cne) cne3122 167.m05885
Dictyostelium discoideum (Ddi) ddi13581 DDB0229332
Debaryomyces hansenii (Dha) dha4293 DEHA0E23925g
Drosophila melanogaster (Dme) dme18179 CG4252-PA
(FBgn0004367)
Danio rerio (Dre) dre14319 ENSDARP00000019069
Encephalitozoon cuniculi (Ecu) ecu111 19074032
Takifugu rubripes (Fru) fru23680 SINFRUP00000137662
Gallus gallus (Gga) gga23140 ENSGALP00000004185
Homo sapiens (Hsa) hsa23252 ENSP00000343741
(ATR)		 Q13535-1
Kluyveromyces lactis (Kla) kla1904 KLLA0C15785g
Mus musculus (Mmu) mmu28092 ENSMUSP00000034980
(MGI:108028)		 Q9JKK8
Neurospora crassa (Ncr) ncr606 NCU00625.2
Oryza sativa (Osa) osa2660 1949.m00104
Oryza sativa (Osa) osa3185 1966.m00147
Rattus norvegicus (Rno) rno29100 ENSRNOP00000043760
Saccharomyces cerevisiae (Sce) sce401 YBR136W
(S000000340)
Schizosaccharomyces pombe (Spo) spo947 SPBC216.05 Q02099
Yarrowia lipolytica (Yli) yli6210 YALI0F20636g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IDA
SpoSPBC216.05
GO:0000794 condensed nuclear chromosome C
TAS
CelWBGene00000226
GO:0001741 XY body C
IDA
MmuMGI:108028
GO:0005634 nucleus C
IC
SceS000000340
IDA
CelWBGene00000226
TAS
MmuMGI:108028
GO:0005739 mitochondrion C
IDA
SceS000000340
GO:0005829 cytosol C
IDA
SpoSPBC216.05
GO:0043234 protein complex C
NAS
SpoSPBC216.05
GO:0004428 inositol or phosphatidylinositol kinase
activity		 F
ISS
AthAt5g40820
GO:0004672 protein kinase activity F
IDA
MmuMGI:108028
SceS000000340
NAS
DmeFBgn0004367
TAS
MmuMGI:108028
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SpoSPBC216.05
GO:0005515 protein binding F
IPI
MmuMGI:108028
SpoSPBC216.05
GO:0016301 kinase activity F
ISS
DmeFBgn0004367
GO:0016303 1-phosphatidylinositol-3-kinase
activity		 F
ISS
CelWBGene00000226
GO:0032405 MutLalpha complex binding F
ISO
MmuMGI:108028
GO:0032407 MutSalpha complex binding F
ISO
MmuMGI:108028
GO:0000003 reproduction P
IMP
CelWBGene00000226
GO:0000075 cell cycle checkpoint P
TAS
DmeFBgn0004367
GO:0000077 DNA damage checkpoint P
IMP
DmeFBgn0004367
MmuMGI:108028
TAS
DmeFBgn0004367
SceS000000340
GO:0000722 telomere maintenance via recombination P
IGI
SceS000000340
GO:0000723 telomere maintenance P
IDA
SceS000000340
IGI
DmeFBgn0004367
GO:0001700 embryonic development via the syncytial
blastoderm		 P
TAS
DmeFBgn0004367
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process		 P
IGI
SceS000000340
GO:0006260 DNA replication P
IMP
SceS000000340
GO:0006281 DNA repair P
IDA
MmuMGI:108028
IGI
AthAt5g40820
RCA
SceS000000340
TAS
DmeFBgn0004367
GO:0006310 DNA recombination P
IMP
SceS000000340
GO:0006468 protein amino acid phosphorylation P
IDA
MmuMGI:108028
GO:0006974 response to DNA damage stimulus P
IDA
MmuMGI:108028
IMP
DmeFBgn0004367
RCA
SceS000000340
GO:0006975 DNA damage induced protein phosphorylation P
IMP
SceS000000340
GO:0007004 telomere maintenance via telomerase P
IMP
AthAt5g40820
GO:0007015 actin filament organization P
IMP
DmeFBgn0004367
GO:0007088 regulation of mitosis P
IGI
DmeFBgn0004367
IMP
DmeFBgn0004367
GO:0007093 mitotic cell cycle checkpoint P
TAS
DmeFBgn0004367
GO:0007126 meiosis P
IGI
AthAt5g40820
IMP
CelWBGene00000226
TAS
DmeFBgn0004367
GO:0007131 reciprocal meiotic recombination P
IMP
DmeFBgn0004367
SceS000000340
SpoSPBC216.05
GO:0007133 meiotic anaphase I P
IMP
DmeFBgn0004367
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPBC216.05
GO:0007348 regulation of syncytial blastoderm mitotic cell
cycle		 P
TAS
DmeFBgn0004367
GO:0007349 cellularization P
TAS
DmeFBgn0004367
GO:0007444 imaginal disc development P
TAS
DmeFBgn0004367
GO:0008360 regulation of cell shape P
IMP
DmeFBgn0004367
GO:0009314 response to radiation P
TAS
DmeFBgn0004367
GO:0009790 embryo development P
IMP
CelWBGene00000226
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000226
GO:0010044 response to aluminum ion P
IMP
AthAt5g40820
GO:0010332 response to gamma radiation P
IMP
AthAt5g40820
GO:0016310 phosphorylation P
NAS
DmeFBgn0004367
TAS
MmuMGI:108028
GO:0016321 female meiosis chromosome segregation P
IMP
DmeFBgn0004367
GO:0016572 histone phosphorylation P
IGI
SceS000000340
IMP
SceS000000340
GO:0030261 chromosome condensation P
IGI
DmeFBgn0004367
GO:0031573 intra-S DNA damage checkpoint P
IDA
SpoSPBC216.05
IMP
SpoSPBC216.05
GO:0032204 regulation of telomere maintenance P
IGI
AthAt5g40820
GO:0032504 multicellular organism reproduction P
IGI
AthAt5g40820
GO:0033044 regulation of chromosome organization P
IGI
AthAt5g40820
GO:0043247 telomere maintenance in response to DNA
damage		 P
TAS
AthAt5g40820
GO:0043393 regulation of protein binding P
IDA
MmuMGI:108028
GO:0045002 double-strand break repair via single-strand
annealing		 P
IMP
DmeFBgn0004367
GO:0045003 double-strand break repair via synthesis-dependent
strand annealing		 P
IMP
DmeFBgn0004367
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00000226
GO:0048477 oogenesis P
TAS
DmeFBgn0004367
GO:0050790 regulation of catalytic activity P
RCA
SceS000000340
GO:0051321 meiotic cell cycle P
RCA
SceS000000340

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC216.05
(Q02099)		 YBR136W
(S000000340)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IDA
SpoSPBC216.05
GO:0005634 nucleus C
IC
SceS000000340
GO:0005739 mitochondrion C
IDA
SceS000000340
GO:0005829 cytosol C
IDA
SpoSPBC216.05
GO:0043234 protein complex C
NAS
SpoSPBC216.05
GO:0004672 protein kinase activity F
IDA
SceS000000340
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SpoSPBC216.05
GO:0005515 protein binding F
IPI
SpoSPBC216.05
GO:0000077 DNA damage checkpoint P
TAS
SceS000000340
GO:0000722 telomere maintenance via recombination P
IGI
SceS000000340
GO:0000723 telomere maintenance P
IDA
SceS000000340
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process		 P
IGI
SceS000000340
GO:0006260 DNA replication P
IMP
SceS000000340
GO:0006281 DNA repair P
RCA
SceS000000340
GO:0006310 DNA recombination P
IMP
SceS000000340
GO:0006974 response to DNA damage stimulus P
RCA
SceS000000340
GO:0006975 DNA damage induced protein phosphorylation P
IMP
SceS000000340
GO:0007131 reciprocal meiotic recombination P
IMP
SceS000000340
SpoSPBC216.05
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPBC216.05
GO:0016572 histone phosphorylation P
IGI
SceS000000340
IMP
SceS000000340
GO:0031573 intra-S DNA damage checkpoint P
IDA
SpoSPBC216.05
IMP
SpoSPBC216.05
GO:0050790 regulation of catalytic activity P
RCA
SceS000000340
GO:0051321 meiotic cell cycle P
RCA
SceS000000340

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GO info in one table:

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