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Search term: YBR140C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name IRA1
SGD link S000000344
Alternative ID YBR140C
Description GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase
Synonyms YBR140C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1826 --DHY--

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Ras GTPase activating protein RasGAP/neurofibromin

Species KOG link NCBI link UniProt link
Drosophila melanogaster (Dme) 7301417 GI:7301417
Homo sapiens (Hsa) Hs17477842 GI:17477842
Homo sapiens (Hsa) Hs22042396 GI:22042396
Homo sapiens (Hsa) Hs22055943 GI:22055943
Homo sapiens (Hsa) Hs22055996 GI:22055996
Homo sapiens (Hsa) Hs4505373
(NEK2)
GI:4505373 P51955
Homo sapiens (Hsa) Hs4557793 GI:4557793 P21359
Saccharomyces cerevisiae (Sce) YBR140c
(S000000344)
GI:6319616 P18963
Saccharomyces cerevisiae (Sce) YOL081w
(S000005441)
GI:6324491 P19158


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000776 kinetochore C
IDA
HsaNEK2
NEK2
GO:0005737 cytoplasm C
IDA
SceS000005441
GO:0005739 mitochondrion C
IDA
SceS000005441
S000000344
GO:0005813 centrosome C
TAS
HsaNEK2
GO:0005829 cytosol C
EXP
HsaNEK2
GO:0016020 membrane C
IMP
SceS000000344
IPI
SceS000000344
GO:0043234 protein complex C
IMP
HsaNEK2
GO:0004672 protein kinase activity F
IDA
HsaNEK2
GO:0005099 Ras GTPase activator activity F
IDA
SceS000005441
IMP
SceS000000344
S000005441
GO:0005515 protein binding F
IPI
HsaNEK2
GO:0019903 protein phosphatase binding F
IPI
HsaNEK2
GO:0006950 response to stress P
IMP
SceS000005441
GO:0007059 chromosome segregation P
IDA
HsaNEK2
GO:0007067 mitosis P
TAS
HsaNEK2
GO:0007088 regulation of mitosis P
TAS
HsaNEK2
GO:0007568 aging P
RCA
SceS000005441
GO:0019932 second-messenger-mediated signaling P
RCA
SceS000005441
GO:0030818 negative regulation of cAMP biosynthetic
process
P
IMP
SceS000005441
S000000344
GO:0032320 positive regulation of Ras GTPase
activity
P
IMP
SceS000005441
S000000344
GO:0045761 regulation of adenylate cyclase
activity
P
IMP
SceS000000344
GO:0046580 negative regulation of Ras protein signal
transduction
P
IMP
SceS000000344
S000005441
GO:0046777 protein amino acid autophosphorylation P
IMP
HsaNEK2
GO:0051299 centrosome separation P
IDA
HsaNEK2

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
49034

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) IRA1
(S000000344)
GI:6319616 P18963
Saccharomyces cerevisiae (Sce) IRA2
(S000005441)
GI:6324491 P19158
Kluyveromyces lactis (Kla) KLLA0E17963g GI:50309497
Eremothecium gossypii (Ego) AGOS_AER025C GI:45190631


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000005441
GO:0005739 mitochondrion C
IDA
SceS000005441
S000000344
GO:0016020 membrane C
IMP
SceS000000344
IPI
SceS000000344
GO:0005099 Ras GTPase activator activity F
IDA
SceS000005441
IMP
SceS000000344
S000005441
GO:0006950 response to stress P
IMP
SceS000005441
GO:0007568 aging P
RCA
SceS000005441
GO:0019932 second-messenger-mediated signaling P
RCA
SceS000005441
GO:0030818 negative regulation of cAMP biosynthetic
process
P
IMP
SceS000005441
S000000344
GO:0032320 positive regulation of Ras GTPase
activity
P
IMP
SceS000005441
S000000344
GO:0045761 regulation of adenylate cyclase
activity
P
IMP
SceS000000344
GO:0046580 negative regulation of Ras protein signal
transduction
P
IMP
SceS000000344
S000005441

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_799

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga5427 ENSANGP00000003216
Anopheles gambiae (Aga) aga5426 ENSANGP00000025084
Ashbya gossypii (Ago) ago2530 AER025C
Candida glabrata (Cgl) cgl2864 CAGL0I07909g
Candida glabrata (Cgl) cgl5093 CAGL0M09999g
Cryptococcus neoformans (Cne) cne1156 180.m00084
Dictyostelium discoideum (Ddi) ddi5458 DDB0185273
Dictyostelium discoideum (Ddi) ddi8351 DDB0185880
Dictyostelium discoideum (Ddi) ddi1223 DDB0203607
Dictyostelium discoideum (Ddi) ddi5367 DDB0205121
Debaryomyces hansenii (Dha) dha6164 DEHA0G10494g
Drosophila melanogaster (Dme) dme14539 CG8318-PB
(FBgn0015269)
Drosophila melanogaster (Dme) dme14538 CG8318-PC
(FBgn0015269)
Danio rerio (Dre) dre2163 ENSDARP00000004724
Danio rerio (Dre) dre2165 ENSDARP00000006480
Danio rerio (Dre) dre2168 ENSDARP00000014824
Danio rerio (Dre) dre2167 ENSDARP00000040246
Danio rerio (Dre) dre6546 ENSDARP00000040420
Danio rerio (Dre) dre6543 ENSDARP00000041919
Danio rerio (Dre) dre6542 ENSDARP00000043039
Danio rerio (Dre) dre6545 ENSDARP00000044572
Danio rerio (Dre) dre2164 ENSDARP00000044691
Danio rerio (Dre) dre6541 ENSDARP00000045715
Danio rerio (Dre) dre6544 ENSDARP00000047244
Danio rerio (Dre) dre2166 ENSDARP00000049268
Takifugu rubripes (Fru) fru32722 SINFRUP00000145652
Gallus gallus (Gga) gga9088 ENSGALP00000008950
Gallus gallus (Gga) gga9096 ENSGALP00000009067
(NF1)
Gallus gallus (Gga) gga9097 ENSGALP00000009072
Homo sapiens (Hsa) hsa13404 ENSP00000348498
(NF1)
P21359-2
Homo sapiens (Hsa) hsa13403 ENSP00000351015
(NF1)
P21359-1
Homo sapiens (Hsa) hsa13405 ENSP00000352435
Kluyveromyces lactis (Kla) kla3756 KLLA0E17963g
Mus musculus (Mmu) mmu4351 ENSMUSP00000071289
(MGI:97306)
Q04690-1
Mus musculus (Mmu) mmu4354 ENSMUSP00000077722
Mus musculus (Mmu) mmu4353 ENSMUSP00000079018
Mus musculus (Mmu) mmu4352 ENSMUSP00000079110
Neurospora crassa (Ncr) ncr1596 NCU01642.2
Rattus norvegicus (Rno) rno5649 ENSRNOP00000018480
(RGD:3168)
Rattus norvegicus (Rno) rno5650 ENSRNOP00000045437
(RGD:3168)
Rattus norvegicus (Rno) rno5647 ENSRNOP00000049106
(RGD:3168)
Rattus norvegicus (Rno) rno5648 ENSRNOP00000050393
(RGD:3168)
P97526
Saccharomyces cerevisiae (Sce) sce405 YBR140C
(S000000344)
Saccharomyces cerevisiae (Sce) sce5633 YOL081W
(S000005441)
Yarrowia lipolytica (Yli) yli1043 YALI0B07535g