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Search term: YBR170C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NPL4
SGD link S000000374
Alternative ID YBR170C
Description Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation
Synonyms YBR170C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2834 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Nuclear pore complex, rNpl4 component (sc Npl4)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g47970 GI:15227178
Arabidopsis thaliana (Ath) At3g63000 GI:15229360
Caenorhabditis elegans (Cel) CE08654_1 GI:17550936
Caenorhabditis elegans (Cel) CE11526
(WBGene00019121)		 GI:17534583 O01894
Caenorhabditis elegans (Cel) CE28572
(WBGene00019120)		 GI:17534579 Q95QZ7
Caenorhabditis elegans (Cel) CE28573 GI:17534581 Q95QZ7
Caenorhabditis elegans (Cel) CE28574 GI:17534585 O01894
Drosophila melanogaster (Dme) 7301352 GI:7301352
Homo sapiens (Hsa) Hs8923609 GI:8923609
Saccharomyces cerevisiae (Sce) YBR170c
(S000000374)		 GI:6319647 P33755
Schizosaccharomyces pombe (Spo) SPBC1711.10c GI:19112675 Q9P780
Encephalitozoon cuniculi (Ecu) ECU07g0770 GI:19074499 Q8SRJ9


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000837 Doa10p ubiquitin ligase complex C
IDA
SceS000000374
GO:0005575 cellular_component C
ND
AthAt2g47970
At3g63000
GO:0005634 nucleus C
IDA
CelWBGene00019121
WBGene00019120
SpoSPBC1711.10c
GO:0005783 endoplasmic reticulum C
IDA
SceS000000374
ISS
SpoSPBC1711.10c
GO:0005829 cytosol C
IDA
SpoSPBC1711.10c
GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex C
IDA
SceS000000374
IPI
CelWBGene00019121
ISS
SpoSPBC1711.10c
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IDA
SceS000000374
ISS
SpoSPBC1711.10c
GO:0003674 molecular_function F
ND
AthAt3g63000
At2g47970
SceS000000374
SpoSPBC1711.10c
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00019120
WBGene00019121
GO:0002119 nematode larval development P
IMP
CelWBGene00019121
WBGene00019120
GO:0006508 proteolysis P
RCA
SceS000000374
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00019121
WBGene00019120
GO:0008150 biological_process P
ND
AthAt3g63000
At2g47970
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00019120
WBGene00019121
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019120
WBGene00019121
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000374
ISS
SpoSPBC1711.10c
GO:0040007 growth P
IMP
CelWBGene00019120
WBGene00019121
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00019121
WBGene00019120
GO:0040011 locomotion P
IMP
CelWBGene00019121
WBGene00019120
GO:0071712 ER-associated misfolded protein catabolic
process		 P
IMP
CelWBGene00019121

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5403

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) NPLOC4 GI:157426879
Canis familiaris (Cfa) NPLOC4 GI:73964791
Mus musculus (Mmu) Nploc4
(MGI:2679787)		 GI:41054974 P60670
Rattus norvegicus (Rno) Nploc4
(RGD:620794)		 GI:18034779
Gallus gallus (Gga) NPLOC4 GI:118099816
Drosophila melanogaster (Dme) CG4673
(FBgn0039348)		 GI:62484495
Anopheles gambiae (Aga) AgaP_AGAP001986 GI:158301365
Caenorhabditis elegans (Cel) npl-4.1
(CE28572;
WBGene00019120)		 GI:17534581 Q95QZ7
Caenorhabditis elegans (Cel) npl-4.2
(CE11526;
WBGene00019121)		 GI:17534585 O01894
Schizosaccharomyces pombe (Spo) npl4
(SPBC1711.10c)		 GI:19112675 Q9P780
Saccharomyces cerevisiae (Sce) NPL4
(S000000374)		 GI:6319647 P33755
Kluyveromyces lactis (Kla) KLLA0E24596g GI:50310089
Eremothecium gossypii (Ego) AGOS_AGR211W GI:45201307
Magnaporthe grisea (Mgr) MGG_04413 GI:145614646
Neurospora crassa (Ncr) NCU02680.1 GI:32422871


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000837 Doa10p ubiquitin ligase complex C
IDA
SceS000000374
GO:0005575 cellular_component C
ND
MmuMGI:2679787
GO:0005634 nucleus C
IDA
CelWBGene00019121
WBGene00019120
SpoSPBC1711.10c
GO:0005643 nuclear pore C
ISS
DmeFBgn0039348
GO:0005783 endoplasmic reticulum C
IDA
SceS000000374
ISS
HsaNPLOC4
SpoSPBC1711.10c
GO:0005829 cytosol C
IDA
SpoSPBC1711.10c
GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex C
IDA
SceS000000374
IPI
CelWBGene00019121
ISS
SpoSPBC1711.10c
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IDA
SceS000000374
ISS
HsaNPLOC4
SpoSPBC1711.10c
GO:0003674 molecular_function F
ND
SceS000000374
SpoSPBC1711.10c
GO:0005515 protein binding F
IPI
HsaNPLOC4
GO:0017056 structural constituent of nuclear
pore		 F
ISS
DmeFBgn0039348
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00019120
WBGene00019121
GO:0002119 nematode larval development P
IMP
CelWBGene00019121
WBGene00019120
GO:0006508 proteolysis P
RCA
SceS000000374
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00019121
WBGene00019120
GO:0006944 cellular membrane fusion P
ISO
MmuMGI:2679787
ISS
HsaNPLOC4
GO:0007030 Golgi organization P
ISO
MmuMGI:2679787
ISS
HsaNPLOC4
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00019120
WBGene00019121
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019120
WBGene00019121
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000374
ISS
HsaNPLOC4
SpoSPBC1711.10c
GO:0040007 growth P
IMP
CelWBGene00019120
WBGene00019121
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00019121
WBGene00019120
GO:0040011 locomotion P
IMP
CelWBGene00019121
WBGene00019120
GO:0071712 ER-associated misfolded protein catabolic
process		 P
IMP
CelWBGene00019121

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1630

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4092 ENSANGP00000027105
Ashbya gossypii (Ago) ago4522 AGR211W
Arabidopsis thaliana (Ath) ath12059 At2g47970.1
Arabidopsis thaliana (Ath) ath12060 At2g47970.2
Arabidopsis thaliana (Ath) ath17753 At3g63000.1
Caenorhabditis elegans (Cel) cel11116 F59E12.4a
(CE28572;
WBGene00019120)
Caenorhabditis elegans (Cel) cel11117 F59E12.4b
(CE28573)
Caenorhabditis elegans (Cel) cel11118 F59E12.5a
(CE11526;
WBGene00019121)
Caenorhabditis elegans (Cel) cel11119 F59E12.5b
(CE28574)
Candida glabrata (Cgl) cgl4922 CAGL0M06105g
Cryptococcus neoformans (Cne) cne5365 179.m00217
Dictyostelium discoideum (Ddi) ddi9720 DDB0188792
Debaryomyces hansenii (Dha) dha3071 DEHA0D17193g
Drosophila melanogaster (Dme) dme14472 CG4673-PA
(FBgn0039348)
Drosophila melanogaster (Dme) dme14471 CG4673-PB
(FBgn0039348)
Danio rerio (Dre) dre3753 ENSDARP00000028133
Encephalitozoon cuniculi (Ecu) ecu1885 19074499
Takifugu rubripes (Fru) fru24202 SINFRUP00000163562
Gallus gallus (Gga) gga8611 ENSGALP00000007280
(NPLOC4)
Homo sapiens (Hsa) hsa14511 ENSP00000331487
(NPLOC4)		 Q8TAT6-1
Kluyveromyces lactis (Kla) kla4057 KLLA0E24596g
Mus musculus (Mmu) mmu5308 ENSMUSP00000035851
(MGI:2679787)		 P60670-1
Mus musculus (Mmu) mmu5309 ENSMUSP00000079642
Neurospora crassa (Ncr) ncr2596 NCU02680.2
Oryza sativa (Osa) osa11135 2765.m00132
Oryza sativa (Osa) osa11149 2765.m00173
Plasmodium falciparum (Pfa) pfa3527 PFE0380c
Saccharomyces cerevisiae (Sce) sce437 YBR170C
(S000000374)
Schizosaccharomyces pombe (Spo) spo2386 SPBC1711.10c Q9P780
Yarrowia lipolytica (Yli) yli4409 YALI0E13233g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000837 Doa10p ubiquitin ligase complex C
IDA
SceS000000374
GO:0005575 cellular_component C
ND
AthAt2g47970
At3g63000
MmuMGI:2679787
GO:0005634 nucleus C
IDA
CelWBGene00019121
WBGene00019120
SpoSPBC1711.10c
GO:0005643 nuclear pore C
ISS
DmeFBgn0039348
GO:0005783 endoplasmic reticulum C
IDA
SceS000000374
ISS
SpoSPBC1711.10c
GO:0005829 cytosol C
IDA
SpoSPBC1711.10c
GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex C
IDA
SceS000000374
IPI
CelWBGene00019121
ISS
SpoSPBC1711.10c
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IDA
SceS000000374
ISS
SpoSPBC1711.10c
GO:0003674 molecular_function F
ND
AthAt3g63000
At2g47970
SceS000000374
SpoSPBC1711.10c
GO:0017056 structural constituent of nuclear
pore		 F
ISS
DmeFBgn0039348
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00019120
WBGene00019121
GO:0002119 nematode larval development P
IMP
CelWBGene00019121
WBGene00019120
GO:0006508 proteolysis P
RCA
SceS000000374
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00019121
WBGene00019120
GO:0006944 cellular membrane fusion P
ISO
MmuMGI:2679787
GO:0007030 Golgi organization P
ISO
MmuMGI:2679787
GO:0008150 biological_process P
ND
AthAt3g63000
At2g47970
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00019120
WBGene00019121
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019120
WBGene00019121
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000374
ISS
SpoSPBC1711.10c
GO:0040007 growth P
IMP
CelWBGene00019120
WBGene00019121
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00019121
WBGene00019120
GO:0040011 locomotion P
IMP
CelWBGene00019121
WBGene00019120
GO:0071712 ER-associated misfolded protein catabolic
process		 P
IMP
CelWBGene00019121

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1711.10c
(Q9P780)		 YBR170C
(S000000374)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000837 Doa10p ubiquitin ligase complex C
IDA
SceS000000374
GO:0005634 nucleus C
IDA
SpoSPBC1711.10c
GO:0005783 endoplasmic reticulum C
IDA
SceS000000374
ISS
SpoSPBC1711.10c
GO:0005829 cytosol C
IDA
SpoSPBC1711.10c
GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex C
IDA
SceS000000374
ISS
SpoSPBC1711.10c
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IDA
SceS000000374
ISS
SpoSPBC1711.10c
GO:0003674 molecular_function F
ND
SceS000000374
SpoSPBC1711.10c
GO:0006508 proteolysis P
RCA
SceS000000374
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000374
ISS
SpoSPBC1711.10c

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GO info in one table:

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