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Search term: YBR201W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DER1
SGD link S000000405
Alternative ID YBR201W
Description Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
Synonyms YBR201W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0858 ACDHYPE

KOGs classification KOGs description
POORLY CHARACTERIZED Predicted membrane protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g04860 GI:15234480
Arabidopsis thaliana (Ath) At4g21810 GI:15234598
Arabidopsis thaliana (Ath) At4g29330 GI:15233534
Caenorhabditis elegans (Cel) CE00828 GI:17554708
Caenorhabditis elegans (Cel) CE09629
(WBGene00000843)		 GI:17506783 Q93561
Drosophila melanogaster (Dme) 7296027
(FBgn0031376)		 GI:20129161
Drosophila melanogaster (Dme) 7300159 GI:7300159
Homo sapiens (Hsa) Hs14774629 GI:14774629
Homo sapiens (Hsa) Hs20561463 GI:20561463
Homo sapiens (Hsa) Hs13236516
(DERL1)		 GI:13236516 Q9BUN8
Homo sapiens (Hsa) Hs7705604 GI:7705604
Saccharomyces cerevisiae (Sce) YBR201w
(S000000405)		 GI:6319678 P38307
Saccharomyces cerevisiae (Sce) YDR411c
(S000002819)		 GI:6320619 Q12743
Schizosaccharomyces pombe (Spo) SPAC1687.17c GI:19114048 O94458
Schizosaccharomyces pombe (Spo) SPBC365.08c GI:19112829 Q9Y7Y0
Encephalitozoon cuniculi (Ecu) ECU11g1920 GI:19074992 Q8SQR4
Arabidopsis thaliana (Ath) At4g04860 GI:15234480
Arabidopsis thaliana (Ath) At4g21810 GI:15234598
Arabidopsis thaliana (Ath) At4g29330 GI:15233534
Caenorhabditis elegans (Cel) CE00828 GI:17554708
Caenorhabditis elegans (Cel) CE09629
(WBGene00000843)		 GI:17506783 Q93561
Drosophila melanogaster (Dme) 7296027
(FBgn0031376)		 GI:20129161
Drosophila melanogaster (Dme) 7300159 GI:7300159
Homo sapiens (Hsa) Hs14774629 GI:14774629
Homo sapiens (Hsa) Hs20561463 GI:20561463
Homo sapiens (Hsa) Hs13236516
(DERL1)		 GI:13236516 Q9BUN8
Homo sapiens (Hsa) Hs7705604 GI:7705604
Saccharomyces cerevisiae (Sce) YBR201w
(S000000405)		 GI:6319678 P38307
Saccharomyces cerevisiae (Sce) YDR411c
(S000002819)		 GI:6320619 Q12743
Schizosaccharomyces pombe (Spo) SPAC1687.17c GI:19114048 O94458
Schizosaccharomyces pombe (Spo) SPBC365.08c GI:19112829 Q9Y7Y0
Encephalitozoon cuniculi (Ecu) ECU11g1920 GI:19074992 Q8SQR4


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IDA
SceS000000405
GO:0005575 cellular_component C
ND
AthAt4g29330
At4g21810
At4g04860
GO:0005768 endosome C
IDA
CelWBGene00000843
GO:0005783 endoplasmic reticulum C
IDA
CelWBGene00000843
HsaDERL1
SceS000002819
SpoSPAC1687.17c
SPBC365.08c
IMP
HsaDERL1
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000000405
ISS
DmeFBgn0031376
SpoSPAC1687.17c
SPBC365.08c
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
HsaDERL1
GO:0043229 intracellular organelle C
IDA
CelWBGene00000843
GO:0003674 molecular_function F
ND
AthAt4g29330
At4g21810
SceS000002819
SpoSPBC365.08c
SPAC1687.17c
GO:0004872 receptor activity F
NAS
HsaDERL1
GO:0005515 protein binding F
IDA
SceS000000405
IMP
SceS000000405
IPI
HsaDERL1
GO:0008233 peptidase activity F
ISS
DmeFBgn0031376
GO:0042288 MHC class I protein binding F
IDA
HsaDERL1
GO:0000003 reproduction P
IMP
CelWBGene00000843
GO:0006508 proteolysis P
ISS
AthAt4g04860
At4g29330
At4g21810
GO:0006515 misfolded or incompletely synthesized protein
catabolic process		 P
ISS
DmeFBgn0031376
GO:0006897 endocytosis P
IMP
CelWBGene00000843
GO:0019060 intracellular transport of viral proteins in host
cell		 P
TAS
HsaDERL1
GO:0030433 ER-associated protein catabolic
process		 P
IDA
HsaDERL1
IMP
SceS000000405
IPI
SceS000000405
ISS
DmeFBgn0031376
SpoSPAC1687.17c
SPBC365.08c
GO:0030968 endoplasmic reticulum unfolded protein
response		 P
IDA
HsaDERL1
IGI
SceS000002819
IMP
SceS000002819
GO:0030970 retrograde protein transport, ER to
cytosol		 P
IDA
HsaDERL1
GO:0045184 establishment of protein localization P
TAS
HsaDERL1
GO:0051788 response to misfolded protein P
IMP
CelWBGene00000843

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_707

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15513 ENSANGP00000001887
Ashbya gossypii (Ago) ago2269 AEL237W
Arabidopsis thaliana (Ath) ath18368 At4g04860.1
Arabidopsis thaliana (Ath) ath20098 At4g21810.1
Arabidopsis thaliana (Ath) ath20974 At4g29330.1
Caenorhabditis elegans (Cel) cel14060 R151.6
(CE39620;
WBGene00020109)
Candida glabrata (Cgl) cgl1351 CAGL0F02827g
Candida glabrata (Cgl) cgl4890 CAGL0M05379g
Cryptococcus neoformans (Cne) cne2732 183.m01666
Dictyostelium discoideum (Ddi) ddi9176 DDB0186360
Debaryomyces hansenii (Dha) dha642 DEHA0A14344g
Debaryomyces hansenii (Dha) dha4351 DEHA0E25278g
Drosophila melanogaster (Dme) dme12943 CG14899-PA
(FBgn0038438)
Danio rerio (Dre) dre23550 ENSDARP00000043250
Encephalitozoon cuniculi (Ecu) ecu1080 19074992
Takifugu rubripes (Fru) fru14996 SINFRUP00000145274
Gallus gallus (Gga) gga8725 ENSGALP00000002514
(DERL2)
Gallus gallus (Gga) gga7415 ENSGALP00000009627
(RCJMB04_34k12)
Homo sapiens (Hsa) hsa12899 ENSP00000158771
(DERL2)		 Q9GZP9
Homo sapiens (Hsa) hsa21353 ENSP00000290730
Kluyveromyces lactis (Kla) kla90 KLLA0A02101g
Kluyveromyces lactis (Kla) kla4001 KLLA0E23353g
Mus musculus (Mmu) mmu2347 ENSMUSP00000009236
(MGI:1917627)		 Q9D8K3-1
Mus musculus (Mmu) mmu4117 ENSMUSP00000018586
(MGI:2151483)		 Q8BNI4-1
Neurospora crassa (Ncr) ncr139 NCU00146.2
Oryza sativa (Osa) osa14779 2975.m00075
Oryza sativa (Osa) osa14048 3002.m00091
Oryza sativa (Osa) osa54084 6301.m00197
Plasmodium falciparum (Pfa) pfa535 PF10_0317
Plasmodium falciparum (Pfa) pfa1480 PF14_0653
Rattus norvegicus (Rno) rno5448 ENSRNOP00000009585
(GI:691956)
Rattus norvegicus (Rno) rno17772 ENSRNOP00000029737
(RGD:1597373)		 B2RZ58
Saccharomyces cerevisiae (Sce) sce473 YBR201W
(S000000405)
Saccharomyces cerevisiae (Sce) sce1477 YDR411C
(S000002819)
Schizosaccharomyces pombe (Spo) spo3169 SPAC1687.17c O94458
Schizosaccharomyces pombe (Spo) spo936 SPBC365.08c Q9Y7Y0
Yarrowia lipolytica (Yli) yli6478 YALI0F27225g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IDA
SceS000000405
GO:0005575 cellular_component C
ND
AthAt4g29330
At4g21810
At4g04860
GO:0005783 endoplasmic reticulum C
IDA
SceS000002819
SpoSPAC1687.17c
SPBC365.08c
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000000405
ISS
SpoSPAC1687.17c
SPBC365.08c
GO:0003674 molecular_function F
ND
AthAt4g29330
At4g21810
MmuMGI:2151483
PfaPF10_0317
PF14_0653
SceS000002819
SpoSPBC365.08c
SPAC1687.17c
GO:0005515 protein binding F
IDA
SceS000000405
IMP
SceS000000405
GO:0006508 proteolysis P
ISS
AthAt4g04860
At4g29330
At4g21810
GO:0008150 biological_process P
ND
MmuMGI:2151483
PfaPF14_0653
PF10_0317
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000405
IPI
SceS000000405
ISS
SpoSPAC1687.17c
SPBC365.08c
GO:0030968 endoplasmic reticulum unfolded protein
response		 P
IGI
SceS000002819
IMP
SceS000002819

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC365.08c
(Q9Y7Y0)		 YBR201W
(S000000405)
SPAC1687.17c
(O94458)		 YBR201W
(S000000405)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IDA
SceS000000405
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC1687.17c
SPBC365.08c
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000000405
ISS
SpoSPAC1687.17c
SPBC365.08c
GO:0003674 molecular_function F
ND
SpoSPBC365.08c
SPAC1687.17c
GO:0005515 protein binding F
IDA
SceS000000405
IMP
SceS000000405
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000000405
IPI
SceS000000405
ISS
SpoSPAC1687.17c
SPBC365.08c

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