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Search term: YBR217W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ATG12
SGD link S000000421
Alternative ID YBR217W
Description Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
Synonyms YBR217W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3439 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Protein conjugation factor involved in autophagy

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g54210 GI:15221755
Arabidopsis thaliana (Ath) At3g13970 GI:15231419
Caenorhabditis elegans (Cel) CE00776
(WBGene00002982)		 GI:17554204 Q10931
Drosophila melanogaster (Dme) 7294616 GI:20454837
Homo sapiens (Hsa) Hs4757758 GI:4757758
Saccharomyces cerevisiae (Sce) YBR217w
(S000000421)		 GI:6319694 P38316
Schizosaccharomyces pombe (Spo) SPAC1783.06c GI:19114573 Q9US24


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000000421
GO:0005634 nucleus C
IDA
SpoSPAC1783.06c
GO:0005737 cytoplasm C
ISS
SpoSPAC1783.06c
GO:0005829 cytosol C
IDA
SpoSPAC1783.06c
GO:0034274 Atg12-Atg5-Atg16 complex C
IDA
SceS000000421
GO:0003674 molecular_function F
ND
AthAt3g13970
GO:0005515 protein binding F
ISS
AthAt1g54210
GO:0019776 Atg8 ligase activity F
IDA
SceS000000421
ISS
SpoSPAC1783.06c
GO:0031386 protein tag F
IPI
SceS000000421
ISS
SpoSPAC1783.06c
GO:0000003 reproduction P
IMP
CelWBGene00002982
GO:0000045 autophagic vacuole assembly P
ISS
SpoSPAC1783.06c
GO:0000422 mitochondrion degradation P
IMP
SceS000000421
GO:0006501 C-terminal protein lipidation P
IDA
SceS000000421
ISS
SpoSPAC1783.06c
GO:0006914 autophagy P
IGI
AthAt3g13970
At1g54210
IMP
SpoSPAC1783.06c
ISS
AthAt3g13970
At1g54210
RCA
SceS000000421
GO:0006995 cellular response to nitrogen starvation P
IMP
SpoSPAC1783.06c
GO:0008340 determination of adult lifespan P
IGI
CelWBGene00002982
IMP
CelWBGene00002982
GO:0016236 macroautophagy P
IC
SpoSPAC1783.06c
IMP
SceS000000421
GO:0030437 ascospore formation P
IMP
SpoSPAC1783.06c
GO:0032258 CVT pathway P
IMP
SceS000000421
ISS
SpoSPAC1783.06c
GO:0034727 piecemeal microautophagy of nucleus P
IMP
SceS000000421
GO:0042594 response to starvation P
RCA
SceS000000421
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
ISS
AthAt1g54210

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
38456

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) ATG12
(S000000421)		 GI:6319694 P38316
Kluyveromyces lactis (Kla) KLLA0C05720g GI:50304993
Eremothecium gossypii (Ego) AGOS_AAR160W GI:45184985


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000000421
GO:0034274 Atg12-Atg5-Atg16 complex C
IDA
SceS000000421
GO:0019776 Atg8 ligase activity F
IDA
SceS000000421
GO:0031386 protein tag F
IPI
SceS000000421
GO:0000422 mitochondrion degradation P
IMP
SceS000000421
GO:0006501 C-terminal protein lipidation P
IDA
SceS000000421
GO:0006914 autophagy P
RCA
SceS000000421
GO:0016236 macroautophagy P
IMP
SceS000000421
GO:0032258 CVT pathway P
IMP
SceS000000421
GO:0034727 piecemeal microautophagy of nucleus P
IMP
SceS000000421
GO:0042594 response to starvation P
RCA
SceS000000421

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_4029

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga12935 ENSANGP00000002536
Anopheles gambiae (Aga) aga2723 ENSANGP00000016064
Ashbya gossypii (Ago) ago348 AAR160W
Arabidopsis thaliana (Ath) ath4731 At1g54210.1
Arabidopsis thaliana (Ath) ath13584 At3g13970.1
Caenorhabditis elegans (Cel) cel374 B0336.8
(CE00776;
WBGene00002982)
Candida glabrata (Cgl) cgl3812 CAGL0K06765g
Dictyostelium discoideum (Ddi) ddi12418 DDB0191412
Debaryomyces hansenii (Dha) dha2096 DEHA0C15070g
Drosophila melanogaster (Dme) dme9200 CG10861-PA
(FBgn0036255)
Takifugu rubripes (Fru) fru28043 SINFRUP00000161393
Gallus gallus (Gga) gga28180 ENSGALP00000003688
(ATG12)
Homo sapiens (Hsa) hsa25607 ENSP00000274459
(ATG12)		 O94817-1
Kluyveromyces lactis (Kla) kla1453 KLLA0C05720g
Mus musculus (Mmu) mmu12677 ENSMUSP00000038489
(MGI:1914776)		 Q9CQY1
Neurospora crassa (Ncr) ncr9784 NCU10049.2
Oryza sativa (Osa) osa51391 5876.m00133
Rattus norvegicus (Rno) rno14128 ENSRNOP00000000170
(RGD:1306306)		 Q2TBJ5
Saccharomyces cerevisiae (Sce) sce489 YBR217W
(S000000421)
Schizosaccharomyces pombe (Spo) spo1432 SPAC1783.06c Q9US24
Yarrowia lipolytica (Yli) yli6563 YALI0F29689g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000000421
ISO
MmuMGI:1914776
GO:0005625 soluble fraction C
ISO
MmuMGI:1914776
GO:0005634 nucleus C
IDA
SpoSPAC1783.06c
GO:0005737 cytoplasm C
ISS
SpoSPAC1783.06c
NAS
DmeFBgn0036255
GO:0005829 cytosol C
IDA
SpoSPAC1783.06c
GO:0034045 pre-autophagosomal structure membrane C
IDA
MmuMGI:1914776
GO:0034274 Atg12-Atg5-Atg16 complex C
IDA
SceS000000421
GO:0003674 molecular_function F
ND
AthAt3g13970
DmeFBgn0036255
GO:0005515 protein binding F
IPI
MmuMGI:1914776
ISS
AthAt1g54210
GO:0019776 Atg8 ligase activity F
IDA
SceS000000421
ISS
SpoSPAC1783.06c
GO:0031386 protein tag F
IPI
SceS000000421
ISS
SpoSPAC1783.06c
GO:0000003 reproduction P
IMP
CelWBGene00002982
GO:0000045 autophagic vacuole assembly P
IMP
MmuMGI:1914776
ISS
SpoSPAC1783.06c
GO:0000422 mitochondrion degradation P
IMP
SceS000000421
GO:0006501 C-terminal protein lipidation P
IDA
SceS000000421
ISS
SpoSPAC1783.06c
GO:0006914 autophagy P
IGI
AthAt3g13970
At1g54210
IMP
DmeFBgn0036255
SpoSPAC1783.06c
ISS
AthAt3g13970
At1g54210
NAS
DmeFBgn0036255
RCA
SceS000000421
TAS
MmuMGI:1914776
GO:0006995 cellular response to nitrogen starvation P
IMP
SpoSPAC1783.06c
GO:0008340 determination of adult lifespan P
IGI
CelWBGene00002982
IMP
CelWBGene00002982
GO:0016236 macroautophagy P
IC
SpoSPAC1783.06c
IMP
SceS000000421
GO:0030437 ascospore formation P
IMP
SpoSPAC1783.06c
GO:0032258 CVT pathway P
IMP
SceS000000421
ISS
SpoSPAC1783.06c
GO:0034727 piecemeal microautophagy of nucleus P
IMP
SceS000000421
GO:0035071 salivary gland cell autophagic cell
death		 P
IEP
DmeFBgn0036255
GO:0042594 response to starvation P
RCA
SceS000000421
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
ISS
AthAt1g54210
GO:0048102 autophagic cell death P
IEP
DmeFBgn0036255

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC1783.06c
(Q9US24)		 YBR217W
(S000000421)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000000421
GO:0005634 nucleus C
IDA
SpoSPAC1783.06c
GO:0005737 cytoplasm C
ISS
SpoSPAC1783.06c
GO:0005829 cytosol C
IDA
SpoSPAC1783.06c
GO:0034274 Atg12-Atg5-Atg16 complex C
IDA
SceS000000421
GO:0019776 Atg8 ligase activity F
IDA
SceS000000421
ISS
SpoSPAC1783.06c
GO:0031386 protein tag F
IPI
SceS000000421
ISS
SpoSPAC1783.06c
GO:0000045 autophagic vacuole assembly P
ISS
SpoSPAC1783.06c
GO:0000422 mitochondrion degradation P
IMP
SceS000000421
GO:0006501 C-terminal protein lipidation P
IDA
SceS000000421
ISS
SpoSPAC1783.06c
GO:0006914 autophagy P
IMP
SpoSPAC1783.06c
RCA
SceS000000421
GO:0006995 cellular response to nitrogen starvation P
IMP
SpoSPAC1783.06c
GO:0016236 macroautophagy P
IC
SpoSPAC1783.06c
IMP
SceS000000421
GO:0030437 ascospore formation P
IMP
SpoSPAC1783.06c
GO:0032258 CVT pathway P
IMP
SceS000000421
ISS
SpoSPAC1783.06c
GO:0034727 piecemeal microautophagy of nucleus P
IMP
SceS000000421
GO:0042594 response to starvation P
RCA
SceS000000421

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GO info in one table:

s.khadayate@ucl.ac.uk