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Search term: YBR263W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SHM1
SGD link S000000467
Alternative ID YBR263W
Description Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
Synonyms YBR263W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2467 ACDHYPE

KOGs classification KOGs description
METABOLISM Glycine/serine hydroxymethyltransferase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g22020 GI:15219182
Arabidopsis thaliana (Ath) At1g36370 GI:12324475
Arabidopsis thaliana (Ath) At4g13890 GI:15236371
Arabidopsis thaliana (Ath) At4g13930 GI:15236375
Arabidopsis thaliana (Ath) At4g32520 GI:7433550
Arabidopsis thaliana (Ath) At4g37930 GI:15235745
Arabidopsis thaliana (Ath) At5g26780 GI:7433553
Caenorhabditis elegans (Cel) CE01130
(WBGene00003214)		 GI:17554316
Drosophila melanogaster (Dme) 7290652 GI:7290652 B7Z0X1
Homo sapiens (Hsa) Hs19923315
(SHMT2)		 GI:19923315 P34897
Homo sapiens (Hsa) Hs20070176 GI:20070176
Saccharomyces cerevisiae (Sce) YBR263w
(S000000467)		 GI:6319739
Saccharomyces cerevisiae (Sce) YLR058c
(S000004048)		 GI:6323087 P37291
Schizosaccharomyces pombe (Spo) SPAC18G6.04c GI:19114580 Q10104
Schizosaccharomyces pombe (Spo) SPAC24C9.12c GI:19114949 O13972
Encephalitozoon cuniculi (Ecu) ECU01g0190 GI:19075029
Encephalitozoon cuniculi (Ecu) ECU01g1420 GI:19075029


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000004048
GO:0005575 cellular_component C
ND
AthAt4g13890
At1g22020
GO:0005634 nucleus C
IDA
AthAt4g37930
GO:0005737 cytoplasm C
IDA
SceS000004048
IMP
SceS000004048
ISS
SpoSPAC24C9.12c
GO:0005739 mitochondrion C
IDA
AthAt4g37930
At5g26780
HsaSHMT2
SceS000000467
SpoSPAC18G6.04c
IMP
SceS000000467
ISS
SpoSPAC18G6.04c
GO:0005747 mitochondrial respiratory chain complex
I		 C
IDA
AthAt5g26780
GO:0005759 mitochondrial matrix C
IDA
HsaSHMT2
ISS
AthAt4g37930
GO:0005829 cytosol C
ISS
AthAt4g13930
GO:0005886 plasma membrane C
IDA
AthAt4g37930
At4g13930
GO:0009507 chloroplast C
IDA
AthAt4g32520
At4g37930
GO:0009536 plastid C
IDA
AthAt4g32520
GO:0010319 stromule C
IDA
AthAt4g37930
GO:0016020 membrane C
IDA
AthAt4g13930
At4g37930
GO:0022626 cytosolic ribosome C
IDA
AthAt4g37930
GO:0042645 mitochondrial nucleoid C
IDA
HsaSHMT2
GO:0043332 mating projection tip C
IDA
SceS000004048
GO:0048046 apoplast C
IDA
AthAt4g37930
GO:0004372 glycine hydroxymethyltransferase
activity		 F
IDA
AthAt4g32520
HsaSHMT2
IMP
SceS000000467
S000004048
ISS
AthAt1g36370
At4g13890
At4g13930
At1g22020
At5g26780
At4g32520
At4g37930
SpoSPAC18G6.04c
SPAC24C9.12c
TAS
AthAt4g37930
GO:0005515 protein binding F
IPI
HsaSHMT2
GO:0008266 poly(U) RNA binding F
IDA
AthAt4g37930
GO:0008270 zinc ion binding F
IDA
AthAt5g26780
GO:0050897 cobalt ion binding F
IDA
AthAt5g26780
GO:0006544 glycine metabolic process P
ISS
AthAt1g36370
At4g13930
At4g32520
At4g13890
At4g37930
At5g26780
At1g22020
SpoSPAC24C9.12c
SPAC18G6.04c
GO:0006563 L-serine metabolic process P
ISS
AthAt5g26780
At4g13890
At4g13930
At4g32520
At4g37930
At1g22020
At1g36370
SpoSPAC24C9.12c
GO:0006730 one-carbon metabolic process P
IC
SpoSPAC18G6.04c
IDA
HsaSHMT2
IGI
SceS000000467
S000004048
IMP
SceS000000467
S000004048
ISS
SpoSPAC24C9.12c
GO:0006800 oxygen and reactive oxygen species metabolic
process		 P
TAS
AthAt4g37930
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000004048
GO:0009070 serine family amino acid biosynthetic
process		 P
IGI
SceS000000467
ISS
SpoSPAC18G6.04c
GO:0009409 response to cold P
IEP
AthAt4g37930
GO:0009555 pollen development P
IMP
AthAt4g13890
GO:0009626 plant-type hypersensitive response P
TAS
AthAt4g37930
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003214
GO:0009853 photorespiration P
IMP
AthAt4g37930
GO:0010197 polar nucleus fusion P
IMP
AthAt4g13890
GO:0019464 glycine decarboxylation via glycine cleavage
system		 P
IMP
AthAt4g37930
GO:0032259 methylation P
ISS
SpoSPAC18G6.04c
SPAC24C9.12c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004048
GO:0046686 response to cadmium ion P
IEP
AthAt4g37930
At4g13930
At1g36370

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
38048

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SHMT2 GI:19923315 P34897
Pan troglodytes (Ptr) SHMT2 GI:114644063
Canis familiaris (Cfa) SHMT2 GI:73968476
Mus musculus (Mmu) Shmt2
(MGI:1277989)		 GI:21312298 Q3TFD0
Rattus norvegicus (Rno) Shmt2
(RGD:1308582)		 GI:56605722
Schizosaccharomyces pombe (Spo) shm2
(SPAC18G6.04c)		 GI:19114580 Q10104
Saccharomyces cerevisiae (Sce) SHM1
(S000000467)		 GI:37362622
Kluyveromyces lactis (Kla) KLLA0F01210g GI:50310229
Eremothecium gossypii (Ego) AGOS_AEL188W GI:45190419
Magnaporthe grisea (Mgr) MGG_13781 GI:145602941
Neurospora crassa (Ncr) NCU05805.1 GI:32410359
Arabidopsis thaliana (Ath) SHM1 GI:15235745
Oryza sativa (Osa) Os03g0738400 GI:115455221


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
AthSHM1
GO:0005739 mitochondrion C
IDA
AthSHM1
HsaSHMT2
MmuMGI:1277989
SceS000000467
SpoSPAC18G6.04c
IMP
SceS000000467
ISO
MmuMGI:1277989
ISS
SpoSPAC18G6.04c
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:1277989
ISO
MmuMGI:1277989
GO:0005758 mitochondrial intermembrane space C
ISO
MmuMGI:1277989
GO:0005759 mitochondrial matrix C
IDA
HsaSHMT2
ISO
MmuMGI:1277989
ISS
AthSHM1
GO:0005886 plasma membrane C
IDA
AthSHM1
GO:0009507 chloroplast C
IDA
AthSHM1
GO:0010319 stromule C
IDA
AthSHM1
GO:0016020 membrane C
IDA
AthSHM1
GO:0022626 cytosolic ribosome C
IDA
AthSHM1
GO:0042645 mitochondrial nucleoid C
IDA
HsaSHMT2
GO:0048046 apoplast C
IDA
AthSHM1
GO:0004372 glycine hydroxymethyltransferase
activity		 F
IDA
HsaSHMT2
IMP
SceS000000467
ISO
MmuMGI:1277989
ISS
AthSHM1
SpoSPAC18G6.04c
TAS
AthSHM1
GO:0005515 protein binding F
IPI
HsaSHMT2
GO:0008266 poly(U) RNA binding F
IDA
AthSHM1
GO:0008732 L-allo-threonine aldolase activity F
ISO
MmuMGI:1277989
GO:0016597 amino acid binding F
ISO
MmuMGI:1277989
GO:0030170 pyridoxal phosphate binding F
ISO
MmuMGI:1277989
GO:0042802 identical protein binding F
ISO
MmuMGI:1277989
GO:0006544 glycine metabolic process P
ISO
MmuMGI:1277989
ISS
AthSHM1
SpoSPAC18G6.04c
GO:0006545 glycine biosynthetic process P
ISO
MmuMGI:1277989
GO:0006563 L-serine metabolic process P
ISS
AthSHM1
GO:0006564 L-serine biosynthetic process P
ISO
MmuMGI:1277989
GO:0006730 one-carbon metabolic process P
IC
SpoSPAC18G6.04c
IDA
HsaSHMT2
IGI
SceS000000467
IMP
SceS000000467
GO:0006800 oxygen and reactive oxygen species metabolic
process		 P
TAS
AthSHM1
GO:0008284 positive regulation of cell proliferation P
ISO
MmuMGI:1277989
GO:0009070 serine family amino acid biosynthetic
process		 P
IGI
SceS000000467
ISS
SpoSPAC18G6.04c
GO:0009409 response to cold P
IEP
AthSHM1
GO:0009626 plant-type hypersensitive response P
TAS
AthSHM1
GO:0009853 photorespiration P
IMP
AthSHM1
GO:0019264 glycine biosynthetic process from
serine		 P
ISO
MmuMGI:1277989
GO:0019464 glycine decarboxylation via glycine cleavage
system		 P
IMP
AthSHM1
GO:0032259 methylation P
ISS
SpoSPAC18G6.04c
GO:0046686 response to cadmium ion P
IEP
AthSHM1
GO:0051289 protein homotetramerization P
ISO
MmuMGI:1277989

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_185

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga13205 ENSANGP00000000142
Anopheles gambiae (Aga) aga15784 ENSANGP00000022109
Ashbya gossypii (Ago) ago1262 ACR215C
Ashbya gossypii (Ago) ago2318 AEL188W
Arabidopsis thaliana (Ath) ath19158 At4g13890.1
Arabidopsis thaliana (Ath) ath19160 At4g13930.1
Arabidopsis thaliana (Ath) ath21349 At4g32520.1
Arabidopsis thaliana (Ath) ath21978 At4g37930.1
Arabidopsis thaliana (Ath) ath24948 At5g26780.1
Arabidopsis thaliana (Ath) ath24949 At5g26780.2
Arabidopsis thaliana (Ath) ath24950 At5g26780.3
Caenorhabditis elegans (Cel) cel1135 C05D11.11a
(CE01130;
WBGene00003214)
Caenorhabditis elegans (Cel) cel1136 C05D11.11b
(CE29661)
Candida glabrata (Cgl) cgl1306 CAGL0F01749g
Candida glabrata (Cgl) cgl2921 CAGL0I09284g
Cryptococcus neoformans (Cne) cne3808 185.m02385
Dictyostelium discoideum (Ddi) ddi12477 DDB0230072
Dictyostelium discoideum (Ddi) ddi13430 DDB0230073
Debaryomyces hansenii (Dha) dha2053 DEHA0C14113g
Debaryomyces hansenii (Dha) dha3553 DEHA0E07051g
Drosophila melanogaster (Dme) dme16655 CG3011-PA
(FBgn0029823)
Danio rerio (Dre) dre19924 ENSDARP00000004022
Escherichia coli (Eco) eco2472 16130476
Encephalitozoon cuniculi (Ecu) ecu1666 19075029
Encephalitozoon cuniculi (Ecu) ecu1792 19075155
Takifugu rubripes (Fru) fru28058 SINFRUP00000150265
Takifugu rubripes (Fru) fru14058 SINFRUP00000160470
Takifugu rubripes (Fru) fru28057 SINFRUP00000169730
Takifugu rubripes (Fru) fru28056 SINFRUP00000171194
Gallus gallus (Gga) gga6514 ENSGALP00000008079
(SHMT1)
Homo sapiens (Hsa) hsa13188 ENSP00000318805
(SHMT1)		 P34896-2
Homo sapiens (Hsa) hsa13187 ENSP00000318868
(SHMT1)		 P34896-1
Homo sapiens (Hsa) hsa7727 ENSP00000333667
(SHMT2)		 P34897
Homo sapiens (Hsa) hsa13189 ENSP00000345881
(SHMT1)		 P34896-3
Kluyveromyces lactis (Kla) kla4133 KLLA0F01210g
Kluyveromyces lactis (Kla) kla4485 KLLA0F08921g
Mus musculus (Mmu) mmu3849 ENSMUSP00000018744
(MGI:98299)		 Q8R0X9
Mus musculus (Mmu) mmu2977 ENSMUSP00000026470
(MGI:1277989)		 Q99K87
Mus musculus (Mmu) mmu24258 ENSMUSP00000072641
Mus musculus (Mmu) mmu24259 ENSMUSP00000075815
Neurospora crassa (Ncr) ncr2213 NCU02274.2
Neurospora crassa (Ncr) ncr5643 NCU05805.2
Oryza sativa (Osa) osa52657 6105.m00160
Oryza sativa (Osa) osa63606 6740.m00178
Oryza sativa (Osa) osa63627 6740.m00191
Oryza sativa (Osa) osa73909 7164.m00153
Oryza sativa (Osa) osa76833 7417.m00114
Plasmodium falciparum (Pfa) pfa5127 PFL1720w
Rattus norvegicus (Rno) rno5186 ENSRNOP00000007092
(RGD:1312011)		 Q6TXG7
Rattus norvegicus (Rno) rno26907 ENSRNOP00000011082
(RGD:1308582)		 Q5U3Z7
Saccharomyces cerevisiae (Sce) sce540 YBR263W
(S000000467)
Saccharomyces cerevisiae (Sce) sce4139 YLR058C
(S000004048)
Schizosaccharomyces pombe (Spo) spo3483 SPAC18G6.04c Q10104
Schizosaccharomyces pombe (Spo) spo1437 SPAC24C9.12c O13972
Yarrowia lipolytica (Yli) yli3647 YALI0D22484g
Yarrowia lipolytica (Yli) yli4533 YALI0E16346g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000004048
GO:0005575 cellular_component C
ND
AthAt4g13890
PfaPFL1720w
GO:0005634 nucleus C
IDA
AthAt4g37930
GO:0005737 cytoplasm C
IDA
SceS000004048
IMP
SceS000004048
ISS
SpoSPAC24C9.12c
GO:0005739 mitochondrion C
IDA
AthAt4g37930
At5g26780
MmuMGI:1277989
MGI:98299
SceS000000467
SpoSPAC18G6.04c
IMP
SceS000000467
ISO
MmuMGI:1277989
ISS
DmeFBgn0029823
SpoSPAC18G6.04c
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:1277989
ISO
MmuMGI:1277989
GO:0005747 mitochondrial respiratory chain complex
I		 C
IDA
AthAt5g26780
GO:0005758 mitochondrial intermembrane space C
ISO
MmuMGI:1277989
GO:0005759 mitochondrial matrix C
ISO
MmuMGI:1277989
ISS
AthAt4g37930
GO:0005829 cytosol C
ISO
MmuMGI:98299
ISS
AthAt4g13930
GO:0005886 plasma membrane C
IDA
AthAt4g37930
At4g13930
GO:0009507 chloroplast C
IDA
AthAt4g32520
At4g37930
GO:0009536 plastid C
IDA
AthAt4g32520
GO:0010319 stromule C
IDA
AthAt4g37930
GO:0016020 membrane C
IDA
AthAt4g13930
At4g37930
GO:0022626 cytosolic ribosome C
IDA
AthAt4g37930
GO:0043332 mating projection tip C
IDA
SceS000004048
GO:0048046 apoplast C
IDA
AthAt4g37930
GO:0004372 glycine hydroxymethyltransferase
activity		 F
IDA
AthAt4g32520
IMP
SceS000000467
S000004048
ISO
MmuMGI:1277989
MGI:98299
ISS
AthAt4g13890
At4g13930
At5g26780
At4g32520
At4g37930
DmeFBgn0029823
SpoSPAC18G6.04c
SPAC24C9.12c
TAS
AthAt4g37930
GO:0008266 poly(U) RNA binding F
IDA
AthAt4g37930
GO:0008270 zinc ion binding F
IDA
AthAt5g26780
GO:0008732 L-allo-threonine aldolase activity F
ISO
MmuMGI:1277989
MGI:98299
GO:0016597 amino acid binding F
ISO
MmuMGI:1277989
MGI:98299
GO:0030170 pyridoxal phosphate binding F
ISO
MmuMGI:1277989
MGI:98299
GO:0042802 identical protein binding F
ISO
MmuMGI:1277989
MGI:98299
GO:0050897 cobalt ion binding F
IDA
AthAt5g26780
GO:0006544 glycine metabolic process P
ISO
MmuMGI:1277989
MGI:98299
ISS
AthAt4g13930
At4g32520
At4g13890
At4g37930
At5g26780
SpoSPAC24C9.12c
SPAC18G6.04c
GO:0006545 glycine biosynthetic process P
ISO
MmuMGI:1277989
MGI:98299
GO:0006563 L-serine metabolic process P
ISS
AthAt5g26780
At4g13890
At4g13930
At4g32520
At4g37930
SpoSPAC24C9.12c
GO:0006564 L-serine biosynthetic process P
ISO
MmuMGI:1277989
ISS
DmeFBgn0029823
GO:0006730 one-carbon metabolic process P
IC
SpoSPAC18G6.04c
IGI
SceS000000467
S000004048
IMP
SceS000000467
S000004048
ISS
SpoSPAC24C9.12c
TAS
PfaPFL1720w
GO:0006800 oxygen and reactive oxygen species metabolic
process		 P
TAS
AthAt4g37930
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000004048
GO:0008284 positive regulation of cell proliferation P
ISO
MmuMGI:1277989
GO:0009070 serine family amino acid biosynthetic
process		 P
IGI
SceS000000467
ISS
SpoSPAC18G6.04c
GO:0009409 response to cold P
IEP
AthAt4g37930
GO:0009555 pollen development P
IMP
AthAt4g13890
GO:0009626 plant-type hypersensitive response P
TAS
AthAt4g37930
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003214
GO:0009853 photorespiration P
IMP
AthAt4g37930
GO:0010197 polar nucleus fusion P
IMP
AthAt4g13890
GO:0019264 glycine biosynthetic process from
serine		 P
ISO
MmuMGI:1277989
MGI:98299
GO:0019464 glycine decarboxylation via glycine cleavage
system		 P
IMP
AthAt4g37930
GO:0032259 methylation P
ISS
SpoSPAC18G6.04c
SPAC24C9.12c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004048
GO:0046686 response to cadmium ion P
IEP
AthAt4g37930
At4g13930
GO:0051289 protein homotetramerization P
ISO
MmuMGI:1277989
MGI:98299

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC18G6.04c
(Q10104)		 YBR263W
(S000000467)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000000467
SpoSPAC18G6.04c
IMP
SceS000000467
ISS
SpoSPAC18G6.04c
GO:0004372 glycine hydroxymethyltransferase
activity		 F
IMP
SceS000000467
ISS
SpoSPAC18G6.04c
GO:0006544 glycine metabolic process P
ISS
SpoSPAC18G6.04c
GO:0006730 one-carbon metabolic process P
IC
SpoSPAC18G6.04c
IGI
SceS000000467
IMP
SceS000000467
GO:0009070 serine family amino acid biosynthetic
process		 P
IGI
SceS000000467
ISS
SpoSPAC18G6.04c
GO:0032259 methylation P
ISS
SpoSPAC18G6.04c

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Query species:

Include wild-cards:   

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GO info in one table:

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