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Search term: YBR265W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TSC10
SGD link S000000469
Alternative ID YBR265W
Description 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
Synonyms YBR265W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1210 ACDHYPE

KOGs classification KOGs description
METABOLISM Predicted 3-ketosphinganine reductase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g06060 GI:15230620
Arabidopsis thaliana (Ath) At5g19200 GI:15239681
Caenorhabditis elegans (Cel) CE26060 GI:17543088
Drosophila melanogaster (Dme) 7301303 GI:7301303
Homo sapiens (Hsa) Hs4503817
(KDSR)		 GI:4503817 Q06136
Saccharomyces cerevisiae (Sce) YBR265w
(S000000469)		 GI:6319742 P38342
Schizosaccharomyces pombe (Spo) SPCC1450.15_1 GI:19075814 Q9Y7P2
Encephalitozoon cuniculi (Ecu) ECU10g0560 GI:19074665 Q8SR58
Encephalitozoon cuniculi (Ecu) ECU11g1070 GI:19074907 Q8SU39
Arabidopsis thaliana (Ath) At3g06060 GI:15230620
Arabidopsis thaliana (Ath) At5g19200 GI:15239681
Caenorhabditis elegans (Cel) CE26060 GI:17543088
Drosophila melanogaster (Dme) 7301303 GI:7301303
Homo sapiens (Hsa) Hs4503817
(KDSR)		 GI:4503817 Q06136
Saccharomyces cerevisiae (Sce) YBR265w
(S000000469)		 GI:6319742 P38342
Schizosaccharomyces pombe (Spo) SPCC1450.15_1 GI:19075814 Q9Y7P2
Encephalitozoon cuniculi (Ecu) ECU10g0560 GI:19074665 Q8SR58
Encephalitozoon cuniculi (Ecu) ECU11g1070 GI:19074907 Q8SU39


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005615 extracellular space C
TAS
HsaKDSR
GO:0005737 cytoplasm C
IDA
SceS000000469
GO:0005741 mitochondrial outer membrane C
IDA
SceS000000469
GO:0005783 endoplasmic reticulum C
IDA
HsaKDSR
SceS000000469
ISS
SpoSPCC1450.15
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaKDSR
ISS
SpoSPCC1450.15
GO:0000234 phosphoethanolamine N-methyltransferase
activity		 F
ISS
SpoSPCC1450.15
GO:0016491 oxidoreductase activity F
ISS
AthAt5g19200
At3g06060
GO:0016651 oxidoreductase activity, acting on NADH or
NADPH		 F
IDA
SceS000000469
ISS
SpoSPCC1450.15
GO:0047560 3-dehydrosphinganine reductase
activity		 F
EXP
HsaKDSR
IDA
HsaKDSR
GO:0051377 mannose-ethanolamine phosphotransferase
activity		 F
ISS
SpoSPCC1450.15
GO:0006506 GPI anchor biosynthetic process P
ISS
SpoSPCC1450.15
GO:0006666 3-keto-sphinganine metabolic process P
IDA
HsaKDSR
SceS000000469
ISS
SpoSPCC1450.15
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000469
GO:0030148 sphingolipid biosynthetic process P
IDA
SceS000000469
IMP
SceS000000469
ISS
SceS000000469
GO:0032259 methylation P
ISS
SpoSPCC1450.15

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
38470

Species Gene ID NCBI link UniProt link
Gallus gallus (Gga) FVT1 GI:71897113
Schizosaccharomyces pombe (Spo) SPCC1450.15 GI:19075814 Q9Y7P2
Saccharomyces cerevisiae (Sce) TSC10
(S000000469)		 GI:6319742 P38342
Kluyveromyces lactis (Kla) KLLA0F01749g GI:50310279
Eremothecium gossypii (Ego) AGOS_AEL164C GI:45190443


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000000469
GO:0005741 mitochondrial outer membrane C
IDA
SceS000000469
GO:0005783 endoplasmic reticulum C
IDA
SceS000000469
ISS
SpoSPCC1450.15
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPCC1450.15
GO:0000234 phosphoethanolamine N-methyltransferase
activity		 F
ISS
SpoSPCC1450.15
GO:0016651 oxidoreductase activity, acting on NADH or
NADPH		 F
IDA
SceS000000469
ISS
SpoSPCC1450.15
GO:0051377 mannose-ethanolamine phosphotransferase
activity		 F
ISS
SpoSPCC1450.15
GO:0006506 GPI anchor biosynthetic process P
ISS
SpoSPCC1450.15
GO:0006666 3-keto-sphinganine metabolic process P
IDA
SceS000000469
ISS
SpoSPCC1450.15
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000469
GO:0030148 sphingolipid biosynthetic process P
IDA
SceS000000469
IMP
SceS000000469
ISS
SceS000000469
GO:0032259 methylation P
ISS
SpoSPCC1450.15

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2018

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6491 ENSANGP00000014198
Ashbya gossypii (Ago) ago2342 AEL164C
Arabidopsis thaliana (Ath) ath12676 At3g06060.1
Arabidopsis thaliana (Ath) ath24189 At5g19200.1
Candida glabrata (Cgl) cgl2923 CAGL0I09328g
Cryptococcus neoformans (Cne) cne4121 177.m02879
Cryptococcus neoformans (Cne) cne1382 180.m00330
Dictyostelium discoideum (Ddi) ddi2881 DDB0202992
Dictyostelium discoideum (Ddi) ddi3768 DDB0217420
Debaryomyces hansenii (Dha) dha3474 DEHA0E05302g
Drosophila melanogaster (Dme) dme14406 CG10425-PA
(FBgn0039304)
Danio rerio (Dre) dre10882 ENSDARP00000009670
Encephalitozoon cuniculi (Ecu) ecu995 19074907
Takifugu rubripes (Fru) fru21415 SINFRUP00000165182
Gallus gallus (Gga) gga10566 ENSGALP00000020981
(FVT1)		 Q5ZKZ6
Homo sapiens (Hsa) hsa15046 ENSP00000312939
(KDSR)		 B4DMX0
Homo sapiens (Hsa) hsa15047 ENSP00000343932
Kluyveromyces lactis (Kla) kla4158 KLLA0F01749g
Mus musculus (Mmu) mmu870 ENSMUSP00000010049
(MGI:1918000)		 Q6GV12
Neurospora crassa (Ncr) ncr288 NCU00302.2
Oryza sativa (Osa) osa5819 2465.m00114
Plasmodium falciparum (Pfa) pfa3218 PFD0465c
Rattus norvegicus (Rno) rno8846 ENSRNOP00000003728
(RGD:1307775)
Saccharomyces cerevisiae (Sce) sce542 YBR265W
(S000000469)
Schizosaccharomyces pombe (Spo) spo3646 SPCC1450.15 Q9Y7P2
Yarrowia lipolytica (Yli) yli1481 YALI0B17688g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000000469
GO:0005741 mitochondrial outer membrane C
IDA
SceS000000469
GO:0005783 endoplasmic reticulum C
IDA
SceS000000469
ISO
MmuMGI:1918000
ISS
SpoSPCC1450.15
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPCC1450.15
GO:0000234 phosphoethanolamine N-methyltransferase
activity		 F
ISS
SpoSPCC1450.15
GO:0016491 oxidoreductase activity F
ISS
AthAt5g19200
At3g06060
DmeFBgn0039304
GO:0016651 oxidoreductase activity, acting on NADH or
NADPH		 F
IDA
SceS000000469
ISS
SpoSPCC1450.15
GO:0047560 3-dehydrosphinganine reductase
activity		 F
ISO
MmuMGI:1918000
GO:0051377 mannose-ethanolamine phosphotransferase
activity		 F
ISS
SpoSPCC1450.15
GO:0006506 GPI anchor biosynthetic process P
ISS
SpoSPCC1450.15
GO:0006666 3-keto-sphinganine metabolic process P
IDA
SceS000000469
ISO
MmuMGI:1918000
ISS
SpoSPCC1450.15
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000469
GO:0030148 sphingolipid biosynthetic process P
IDA
SceS000000469
IGI
MmuMGI:1918000
IMP
SceS000000469
ISS
SceS000000469
GO:0032259 methylation P
ISS
SpoSPCC1450.15

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GO info in one table:

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