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Search term: YBR274W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name CHK1
SGD link S000000478
Alternative ID YBR274W
Description Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
Synonyms YBR274W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0590 -CDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Checkpoint kinase and related serine/threonine protein kinases

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE12478 GI:17562830
Caenorhabditis elegans (Cel) CE20636 GI:17559172
Caenorhabditis elegans (Cel) CE21086 GI:17562828
Caenorhabditis elegans (Cel) CE21879
(WBGene00012792)
GI:17543412 Q9NF25
Caenorhabditis elegans (Cel) CE26076
(WBGene00000498)
GI:17565600
Caenorhabditis elegans (Cel) CE27899 GI:17559174 Q965F6
Drosophila melanogaster (Dme) 7298323 GI:7298323
Homo sapiens (Hsa) Hs4502803 GI:4502803
Saccharomyces cerevisiae (Sce) YBR274w
(S000000478)
GI:6319751 P38147
Saccharomyces cerevisiae (Sce) YCR008w
(S000000601)
GI:6319853 P25333
Saccharomyces cerevisiae (Sce) YDL025c GI:6320179 Q12100
Saccharomyces cerevisiae (Sce) YDL214c
(S000002373)
GI:6319987 Q12310
Saccharomyces cerevisiae (Sce) YJL165c
(S000003701)
GI:6322296 P38970
Saccharomyces cerevisiae (Sce) YKL168c
(S000001651)
GI:6322680
Saccharomyces cerevisiae (Sce) YNL183c
(S000005127)
GI:6324146 P22211
Saccharomyces cerevisiae (Sce) YOR267c
(S000005793)
GI:6324841 Q08732
Schizosaccharomyces pombe (Spo) SPAC22G7.08 GI:19113969 Q09792
Schizosaccharomyces pombe (Spo) SPAC29A4.16 GI:19115778 O14019
Schizosaccharomyces pombe (Spo) SPBC21.07c GI:19113133 O94647
Schizosaccharomyces pombe (Spo) SPCC1020.10 GI:19075449 O59763
Schizosaccharomyces pombe (Spo) SPCC1259.13 GI:19075570 P34208
Schizosaccharomyces pombe (Spo) SPCC70.05c GI:19076039 O74526
Encephalitozoon cuniculi (Ecu) ECU03g0620 GI:19173022 Q8SSA8
Caenorhabditis elegans (Cel) CE12478 GI:17562830
Caenorhabditis elegans (Cel) CE20636 GI:17559172
Caenorhabditis elegans (Cel) CE21086 GI:17562828
Caenorhabditis elegans (Cel) CE21879
(WBGene00012792)
GI:17543412 Q9NF25
Caenorhabditis elegans (Cel) CE26076
(WBGene00000498)
GI:17565600
Caenorhabditis elegans (Cel) CE27899 GI:17559174 Q965F6
Drosophila melanogaster (Dme) 7298323 GI:7298323
Homo sapiens (Hsa) Hs4502803 GI:4502803
Saccharomyces cerevisiae (Sce) YBR274w
(S000000478)
GI:6319751 P38147
Saccharomyces cerevisiae (Sce) YCR008w
(S000000601)
GI:6319853 P25333
Saccharomyces cerevisiae (Sce) YDL025c GI:6320179 Q12100
Saccharomyces cerevisiae (Sce) YDL214c
(S000002373)
GI:6319987 Q12310
Saccharomyces cerevisiae (Sce) YJL165c
(S000003701)
GI:6322296 P38970
Saccharomyces cerevisiae (Sce) YKL168c
(S000001651)
GI:6322680
Saccharomyces cerevisiae (Sce) YNL183c
(S000005127)
GI:6324146 P22211
Saccharomyces cerevisiae (Sce) YOR267c
(S000005793)
GI:6324841 Q08732
Schizosaccharomyces pombe (Spo) SPAC22G7.08 GI:19113969 Q09792
Schizosaccharomyces pombe (Spo) SPAC29A4.16 GI:19115778 O14019
Schizosaccharomyces pombe (Spo) SPBC21.07c GI:19113133 O94647
Schizosaccharomyces pombe (Spo) SPCC1020.10 GI:19075449 O59763
Schizosaccharomyces pombe (Spo) SPCC1259.13 GI:19075570 P34208
Schizosaccharomyces pombe (Spo) SPCC70.05c GI:19076039 O74526
Encephalitozoon cuniculi (Ecu) ECU03g0620 GI:19173022 Q8SSA8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000000601
S000003701
GO:0005634 nucleus C
IDA
SpoSPAC22G7.08
SPCC1259.13
IPI
SceS000000478
ISS
SceS000002373
NAS
SpoSPCC1259.13
GO:0005654 nucleoplasm C
TAS
SpoSPCC1259.13
GO:0005737 cytoplasm C
IDA
SceS000001651
S000005127
S000005793
SpoSPCC1259.13
GO:0005739 mitochondrion C
IDA
SpoSPBC21.07c
GO:0005794 Golgi apparatus C
IDA
SceS000005127
GO:0005829 cytosol C
IDA
SpoSPAC22G7.08
SPCC1020.10
SPAC29A4.16
SPCC1259.13
SPCC70.05c
GO:0032153 cell division site C
IDA
SpoSPCC1020.10
GO:0051286 cell tip C
IDA
SpoSPCC1020.10
GO:0004672 protein kinase activity F
ISS
SceS000000601
S000003701
S000001651
S000005793
RCA
SceS000005127
GO:0004674 protein serine/threonine kinase
activity
F
IDA
SceS000000478
SpoSPCC1020.10
SPCC1259.13
ISS
SceS000000478
S000005127
S000005793
SpoSPAC22G7.08
SPBC21.07c
SPCC70.05c
RCA
SceS000000601
S000003701
S000005127
S000001651
S000005793
TAS
SpoSPBC21.07c
SPAC29A4.16
GO:0004702 receptor signaling protein serine/threonine kinase
activity
F
IMP
SceS000002373
ISS
SceS000002373
GO:0005515 protein binding F
IPI
SpoSPAC29A4.16
SPCC1020.10
SPCC1259.13
GO:0005524 ATP binding F
ISS
SpoSPAC22G7.08
SPAC29A4.16
SPCC1020.10
SPCC1259.13
SPCC70.05c
GO:0016301 kinase activity F
ISS
SceS000005127
TAS
SceS000005127
GO:0016773 phosphotransferase activity, alcohol group as
acceptor
F
RCA
SceS000005127
GO:0000003 reproduction P
IMP
CelWBGene00000498
GO:0000077 DNA damage checkpoint P
IGI
SpoSPCC1259.13
IMP
SceS000000478
GO:0000082 G1/S transition of mitotic cell
cycle
P
IGI
SceS000000601
GO:0002119 nematode larval development P
IMP
CelWBGene00000498
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000000478
SpoSPCC1020.10
SPCC1259.13
ISS
SceS000000478
SpoSPAC22G7.08
SPAC29A4.16
SPBC21.07c
SPCC70.05c
GO:0006808 regulation of nitrogen utilization P
IMP
SceS000005127
SpoSPCC1020.10
GO:0006873 cellular ion homeostasis P
IGI
SceS000005793
IMP
SceS000005793
GO:0007049 cell cycle P
IMP
CelWBGene00000498
GO:0007165 signal transduction P
IC
SpoSPCC70.05c
NAS
SpoSPAC22G7.08
SPBC21.07c
SPCC1020.10
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPCC1259.13
GO:0008150 biological_process P
ND
SceS000001651
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00000498
GO:0010171 body morphogenesis P
IMP
CelWBGene00000498
GO:0019725 cellular homeostasis P
NAS
SpoSPAC29A4.16
GO:0030003 cellular cation homeostasis P
IGI
SceS000000601
S000003701
SpoSPAC29A4.16
IMP
SceS000000601
S000003701
SpoSPAC29A4.16
GO:0031138 negative regulation of conjugation with cellular
fusion
P
IGI
SceS000002373
IMP
SceS000002373
GO:0033554 cellular response to stress P
IEP
SpoSPAC22G7.08
SPCC1020.10
GO:0034763 negative regulation of transmembrane
transport
P
IEP
SpoSPCC1020.10
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000498
GO:0040011 locomotion P
IMP
CelWBGene00000498
GO:0042391 regulation of membrane potential P
IMP
SpoSPAC29A4.16
GO:0042493 response to drug P
IMP
SpoSPAC29A4.16
GO:0043157 response to cation stress P
IGI
SpoSPAC29A4.16
NAS
SpoSPAC29A4.16
GO:0046020 negative regulation of transcription from RNA
polymerase II promoter by pheromones
P
IGI
SceS000002373
IMP
SceS000002373
GO:0048478 replication fork protection P
IGI
SceS000000478
GO:0051098 regulation of binding P
RCA
SceS000000601
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape
P
IMP
SpoSPBC21.07c
SPAC29A4.16

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
975

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) CHEK1 GI:166295194
Pan troglodytes (Ptr) CHEK1 GI:114641077
Canis familiaris (Cfa) CHEK1 GI:73954910
Mus musculus (Mmu) Chek1
(MGI:1202065)
GI:31542385 O35280
Rattus norvegicus (Rno) Chek1
(RGD:620545)
GI:17939354
Drosophila melanogaster (Dme) grp
(FBgn0011598)
GI:17136948
Anopheles gambiae (Aga) AgaP_AGAP008118 GI:158297035
Caenorhabditis elegans (Cel) chk-1
(CE26076;
WBGene00000498)
GI:72001122
Schizosaccharomyces pombe (Spo) chk1
(SPCC1259.13)
GI:19075570 P34208
Saccharomyces cerevisiae (Sce) CHK1
(S000000478)
GI:6319751 P38147
Kluyveromyces lactis (Kla) KLLA0F01276g GI:50310235
Eremothecium gossypii (Ego) AGOS_AEL185C GI:45190422
Magnaporthe grisea (Mgr) MGG_03729 GI:145615888
Neurospora crassa (Ncr) NCU08346.1 GI:32417828


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IDA
HsaCHEK1
GO:0000794 condensed nuclear chromosome C
TAS
HsaCHEK1
GO:0005634 nucleus C
IDA
MmuMGI:1202065
SpoSPCC1259.13
IPI
SceS000000478
NAS
SpoSPCC1259.13
GO:0005654 nucleoplasm C
EXP
HsaCHEK1
MmuMGI:1202065
TAS
SpoSPCC1259.13
GO:0005657 replication fork C
IDA
MmuMGI:1202065