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Search term: YBR274W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name CHK1
SGD link S000000478
Alternative ID YBR274W
Description Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
Synonyms YBR274W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0590 -CDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Checkpoint kinase and related serine/threonine protein kinases

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE12478 GI:17562830
Caenorhabditis elegans (Cel) CE20636 GI:17559172
Caenorhabditis elegans (Cel) CE21086 GI:17562828
Caenorhabditis elegans (Cel) CE21879
(WBGene00012792)		 GI:17543412 Q9NF25
Caenorhabditis elegans (Cel) CE26076
(WBGene00000498)		 GI:17565600
Caenorhabditis elegans (Cel) CE27899 GI:17559174 Q965F6
Drosophila melanogaster (Dme) 7298323 GI:7298323
Homo sapiens (Hsa) Hs4502803 GI:4502803
Saccharomyces cerevisiae (Sce) YBR274w
(S000000478)		 GI:6319751 P38147
Saccharomyces cerevisiae (Sce) YCR008w
(S000000601)		 GI:6319853 P25333
Saccharomyces cerevisiae (Sce) YDL025c GI:6320179 Q12100
Saccharomyces cerevisiae (Sce) YDL214c
(S000002373)		 GI:6319987 Q12310
Saccharomyces cerevisiae (Sce) YJL165c
(S000003701)		 GI:6322296 P38970
Saccharomyces cerevisiae (Sce) YKL168c
(S000001651)		 GI:6322680
Saccharomyces cerevisiae (Sce) YNL183c
(S000005127)		 GI:6324146 P22211
Saccharomyces cerevisiae (Sce) YOR267c
(S000005793)		 GI:6324841 Q08732
Schizosaccharomyces pombe (Spo) SPAC22G7.08 GI:19113969 Q09792
Schizosaccharomyces pombe (Spo) SPAC29A4.16 GI:19115778 O14019
Schizosaccharomyces pombe (Spo) SPBC21.07c GI:19113133 O94647
Schizosaccharomyces pombe (Spo) SPCC1020.10 GI:19075449 O59763
Schizosaccharomyces pombe (Spo) SPCC1259.13 GI:19075570 P34208
Schizosaccharomyces pombe (Spo) SPCC70.05c GI:19076039 O74526
Encephalitozoon cuniculi (Ecu) ECU03g0620 GI:19173022 Q8SSA8
Caenorhabditis elegans (Cel) CE12478 GI:17562830
Caenorhabditis elegans (Cel) CE20636 GI:17559172
Caenorhabditis elegans (Cel) CE21086 GI:17562828
Caenorhabditis elegans (Cel) CE21879
(WBGene00012792)		 GI:17543412 Q9NF25
Caenorhabditis elegans (Cel) CE26076
(WBGene00000498)		 GI:17565600
Caenorhabditis elegans (Cel) CE27899 GI:17559174 Q965F6
Drosophila melanogaster (Dme) 7298323 GI:7298323
Homo sapiens (Hsa) Hs4502803 GI:4502803
Saccharomyces cerevisiae (Sce) YBR274w
(S000000478)		 GI:6319751 P38147
Saccharomyces cerevisiae (Sce) YCR008w
(S000000601)		 GI:6319853 P25333
Saccharomyces cerevisiae (Sce) YDL025c GI:6320179 Q12100
Saccharomyces cerevisiae (Sce) YDL214c
(S000002373)		 GI:6319987 Q12310
Saccharomyces cerevisiae (Sce) YJL165c
(S000003701)		 GI:6322296 P38970
Saccharomyces cerevisiae (Sce) YKL168c
(S000001651)		 GI:6322680
Saccharomyces cerevisiae (Sce) YNL183c
(S000005127)		 GI:6324146 P22211
Saccharomyces cerevisiae (Sce) YOR267c
(S000005793)		 GI:6324841 Q08732
Schizosaccharomyces pombe (Spo) SPAC22G7.08 GI:19113969 Q09792
Schizosaccharomyces pombe (Spo) SPAC29A4.16 GI:19115778 O14019
Schizosaccharomyces pombe (Spo) SPBC21.07c GI:19113133 O94647
Schizosaccharomyces pombe (Spo) SPCC1020.10 GI:19075449 O59763
Schizosaccharomyces pombe (Spo) SPCC1259.13 GI:19075570 P34208
Schizosaccharomyces pombe (Spo) SPCC70.05c GI:19076039 O74526
Encephalitozoon cuniculi (Ecu) ECU03g0620 GI:19173022 Q8SSA8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000000601
S000003701
GO:0005634 nucleus C
IDA
SpoSPAC22G7.08
SPCC1259.13
IPI
SceS000000478
ISS
SceS000002373
NAS
SpoSPCC1259.13
GO:0005654 nucleoplasm C
TAS
SpoSPCC1259.13
GO:0005737 cytoplasm C
IDA
SceS000001651
S000005127
S000005793
SpoSPCC1259.13
GO:0005739 mitochondrion C
IDA
SpoSPBC21.07c
GO:0005794 Golgi apparatus C
IDA
SceS000005127
GO:0005829 cytosol C
IDA
SpoSPAC22G7.08
SPCC1020.10
SPAC29A4.16
SPCC1259.13
SPCC70.05c
GO:0032153 cell division site C
IDA
SpoSPCC1020.10
GO:0051286 cell tip C
IDA
SpoSPCC1020.10
GO:0004672 protein kinase activity F
ISS
SceS000000601
S000003701
S000001651
S000005793
RCA
SceS000005127
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SceS000000478
SpoSPCC1020.10
SPCC1259.13
ISS
SceS000000478
S000005127
S000005793
SpoSPAC22G7.08
SPBC21.07c
SPCC70.05c
RCA
SceS000000601
S000003701
S000005127
S000001651
S000005793
TAS
SpoSPBC21.07c
SPAC29A4.16
GO:0004702 receptor signaling protein serine/threonine kinase
activity		 F
IMP
SceS000002373
ISS
SceS000002373
GO:0005515 protein binding F
IPI
SpoSPAC29A4.16
SPCC1020.10
SPCC1259.13
GO:0005524 ATP binding F
ISS
SpoSPAC22G7.08
SPAC29A4.16
SPCC1020.10
SPCC1259.13
SPCC70.05c
GO:0016301 kinase activity F
ISS
SceS000005127
TAS
SceS000005127
GO:0016773 phosphotransferase activity, alcohol group as
acceptor		 F
RCA
SceS000005127
GO:0000003 reproduction P
IMP
CelWBGene00000498
GO:0000077 DNA damage checkpoint P
IGI
SpoSPCC1259.13
IMP
SceS000000478
GO:0000082 G1/S transition of mitotic cell
cycle		 P
IGI
SceS000000601
GO:0002119 nematode larval development P
IMP
CelWBGene00000498
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000000478
SpoSPCC1020.10
SPCC1259.13
ISS
SceS000000478
SpoSPAC22G7.08
SPAC29A4.16
SPBC21.07c
SPCC70.05c
GO:0006808 regulation of nitrogen utilization P
IMP
SceS000005127
SpoSPCC1020.10
GO:0006873 cellular ion homeostasis P
IGI
SceS000005793
IMP
SceS000005793
GO:0007049 cell cycle P
IMP
CelWBGene00000498
GO:0007165 signal transduction P
IC
SpoSPCC70.05c
NAS
SpoSPAC22G7.08
SPBC21.07c
SPCC1020.10
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPCC1259.13
GO:0008150 biological_process P
ND
SceS000001651
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000498
GO:0010171 body morphogenesis P
IMP
CelWBGene00000498
GO:0019725 cellular homeostasis P
NAS
SpoSPAC29A4.16
GO:0030003 cellular cation homeostasis P
IGI
SceS000000601
S000003701
SpoSPAC29A4.16
IMP
SceS000000601
S000003701
SpoSPAC29A4.16
GO:0031138 negative regulation of conjugation with cellular
fusion		 P
IGI
SceS000002373
IMP
SceS000002373
GO:0033554 cellular response to stress P
IEP
SpoSPAC22G7.08
SPCC1020.10
GO:0034763 negative regulation of transmembrane
transport		 P
IEP
SpoSPCC1020.10
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000498
GO:0040011 locomotion P
IMP
CelWBGene00000498
GO:0042391 regulation of membrane potential P
IMP
SpoSPAC29A4.16
GO:0042493 response to drug P
IMP
SpoSPAC29A4.16
GO:0043157 response to cation stress P
IGI
SpoSPAC29A4.16
NAS
SpoSPAC29A4.16
GO:0046020 negative regulation of transcription from RNA
polymerase II promoter by pheromones		 P
IGI
SceS000002373
IMP
SceS000002373
GO:0048478 replication fork protection P
IGI
SceS000000478
GO:0051098 regulation of binding P
RCA
SceS000000601
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape		 P
IMP
SpoSPBC21.07c
SPAC29A4.16

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
975

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) CHEK1 GI:166295194
Pan troglodytes (Ptr) CHEK1 GI:114641077
Canis familiaris (Cfa) CHEK1 GI:73954910
Mus musculus (Mmu) Chek1
(MGI:1202065)		 GI:31542385 O35280
Rattus norvegicus (Rno) Chek1
(RGD:620545)		 GI:17939354
Drosophila melanogaster (Dme) grp
(FBgn0011598)		 GI:17136948
Anopheles gambiae (Aga) AgaP_AGAP008118 GI:158297035
Caenorhabditis elegans (Cel) chk-1
(CE26076;
WBGene00000498)		 GI:72001122
Schizosaccharomyces pombe (Spo) chk1
(SPCC1259.13)		 GI:19075570 P34208
Saccharomyces cerevisiae (Sce) CHK1
(S000000478)		 GI:6319751 P38147
Kluyveromyces lactis (Kla) KLLA0F01276g GI:50310235
Eremothecium gossypii (Ego) AGOS_AEL185C GI:45190422
Magnaporthe grisea (Mgr) MGG_03729 GI:145615888
Neurospora crassa (Ncr) NCU08346.1 GI:32417828


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IDA
HsaCHEK1
GO:0000794 condensed nuclear chromosome C
TAS
HsaCHEK1
GO:0005634 nucleus C
IDA
MmuMGI:1202065
SpoSPCC1259.13
IPI
SceS000000478
NAS
SpoSPCC1259.13
GO:0005654 nucleoplasm C
EXP
HsaCHEK1
MmuMGI:1202065
TAS
SpoSPCC1259.13
GO:0005657 replication fork C
IDA
MmuMGI:1202065
GO:0005737 cytoplasm C
IDA
SpoSPCC1259.13
GO:0005829 cytosol C
IDA
SpoSPCC1259.13
GO:0004672 protein kinase activity F
IMP
MmuMGI:1202065
ISO
MmuMGI:1202065
TAS
HsaCHEK1
GO:0004674 protein serine/threonine kinase
activity		 F
EXP
HsaCHEK1
IDA
SceS000000478
SpoSPCC1259.13
ISS
SceS000000478
GO:0005515 protein binding F
IPI
HsaCHEK1
MmuMGI:1202065
SpoSPCC1259.13
GO:0005524 ATP binding F
ISS
SpoSPCC1259.13
GO:0016301 kinase activity F
EXP
HsaCHEK1
GO:0000003 reproduction P
IMP
CelWBGene00000498
GO:0000077 DNA damage checkpoint P
IDA
MmuMGI:1202065
IGI
SpoSPCC1259.13
IMP
HsaCHEK1
MmuMGI:1202065
SceS000000478
GO:0000079 regulation of cyclin-dependent protein kinase
activity		 P
TAS
HsaCHEK1
GO:0000086 G2/M transition of mitotic cell
cycle		 P
IMP
MmuMGI:1202065
GO:0002119 nematode larval development P
IMP
CelWBGene00000498
GO:0006260 DNA replication P
EXP
HsaCHEK1
GO:0006281 DNA repair P
IDA
MmuMGI:1202065
IMP
HsaCHEK1
GO:0006468 protein amino acid phosphorylation P
IDA
MmuMGI:1202065
SceS000000478
SpoSPCC1259.13
ISO
MmuMGI:1202065
ISS
SceS000000478
GO:0006974 response to DNA damage stimulus P
IDA
MmuMGI:1202065
GO:0006975 DNA damage induced protein phosphorylation P
ISO
MmuMGI:1202065
GO:0007049 cell cycle P
IMP
CelWBGene00000498
GO:0007131 reciprocal meiotic recombination P
TAS
HsaCHEK1
GO:0007276 gamete generation P
TAS
HsaCHEK1
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPCC1259.13
GO:0008285 negative regulation of cell proliferation P
TAS
HsaCHEK1
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000498
GO:0010171 body morphogenesis P
IMP
CelWBGene00000498
GO:0016310 phosphorylation P
IMP
MmuMGI:1202065
GO:0031572 G2/M transition DNA damage checkpoint P
ISO
MmuMGI:1202065
GO:0033261 regulation of S phase P
ISO
MmuMGI:1202065
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000498
GO:0040011 locomotion P
IMP
CelWBGene00000498
GO:0048478 replication fork protection P
IGI
SceS000000478

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_4243

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga10098 ENSANGP00000010533
Ashbya gossypii (Ago) ago2321 AEL185C
Caenorhabditis elegans (Cel) cel18620 Y39H10A.7a
(CE26076;
WBGene00000498)
Caenorhabditis elegans (Cel) cel18621 Y39H10A.7b
(CE33867)
Candida glabrata (Cgl) cgl2931 CAGL0I09504g
Cryptococcus neoformans (Cne) cne4483 177.m03239
Debaryomyces hansenii (Dha) dha1832 DEHA0C09130g
Drosophila melanogaster (Dme) dme2652 CG17161-PA
(FBgn0011598)
Drosophila melanogaster (Dme) dme2650 CG17161-PB
(FBgn0011598)
Drosophila melanogaster (Dme) dme2651 CG17161-PC
(FBgn0011598)
Danio rerio (Dre) dre13579 ENSDARP00000003726
Encephalitozoon cuniculi (Ecu) ecu429 19173022
Takifugu rubripes (Fru) fru3076 SINFRUP00000154470
Takifugu rubripes (Fru) fru3077 SINFRUP00000176404
Gallus gallus (Gga) gga13088 ENSGALP00000001432
Homo sapiens (Hsa) hsa6774 ENSP00000278916
(CHEK1)		 O14757
Kluyveromyces lactis (Kla) kla4136 KLLA0F01276g
Mus musculus (Mmu) mmu27311 ENSMUSP00000034625
(MGI:1202065)		 O35280-1
Neurospora crassa (Ncr) ncr8135 NCU08346.2
Rattus norvegicus (Rno) rno28255 ENSRNOP00000011226
(RGD:620545)		 Q91ZN7-1
Saccharomyces cerevisiae (Sce) sce551 YBR274W
(S000000478)
Schizosaccharomyces pombe (Spo) spo3493 SPCC1259.13 P34208


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
MmuMGI:1202065
SpoSPCC1259.13
IPI
SceS000000478
NAS
SpoSPCC1259.13
GO:0005654 nucleoplasm C
EXP
MmuMGI:1202065
TAS
SpoSPCC1259.13
GO:0005657 replication fork C
IDA
MmuMGI:1202065
GO:0005737 cytoplasm C
IDA
SpoSPCC1259.13
GO:0005829 cytosol C
IDA
SpoSPCC1259.13
GO:0004672 protein kinase activity F
IMP
MmuMGI:1202065
ISO
MmuMGI:1202065
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SceS000000478
SpoSPCC1259.13
ISS
SceS000000478
GO:0005515 protein binding F
IPI
MmuMGI:1202065
SpoSPCC1259.13
GO:0005524 ATP binding F
ISS
SpoSPCC1259.13
GO:0000003 reproduction P
IMP
CelWBGene00000498
GO:0000077 DNA damage checkpoint P
IDA
MmuMGI:1202065
IGI
SpoSPCC1259.13
IMP
MmuMGI:1202065
SceS000000478
GO:0000086 G2/M transition of mitotic cell
cycle		 P
IMP
MmuMGI:1202065
GO:0002119 nematode larval development P
IMP
CelWBGene00000498
GO:0006281 DNA repair P
IDA
MmuMGI:1202065
GO:0006468 protein amino acid phosphorylation P
IDA
MmuMGI:1202065
SceS000000478
SpoSPCC1259.13
ISO
MmuMGI:1202065
ISS
SceS000000478
GO:0006974 response to DNA damage stimulus P
IDA
MmuMGI:1202065
GO:0006975 DNA damage induced protein phosphorylation P
ISO
MmuMGI:1202065
GO:0007049 cell cycle P
IMP
CelWBGene00000498
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPCC1259.13
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000498
GO:0010171 body morphogenesis P
IMP
CelWBGene00000498
GO:0016310 phosphorylation P
IMP
MmuMGI:1202065
GO:0031572 G2/M transition DNA damage checkpoint P
ISO
MmuMGI:1202065
GO:0033261 regulation of S phase P
ISO
MmuMGI:1202065
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000498
GO:0040011 locomotion P
IMP
CelWBGene00000498
GO:0048478 replication fork protection P
IGI
SceS000000478

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC1259.13
(P34208)		 YBR274W
(S000000478)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPCC1259.13
IPI
SceS000000478
NAS
SpoSPCC1259.13
GO:0005654 nucleoplasm C
TAS
SpoSPCC1259.13
GO:0005737 cytoplasm C
IDA
SpoSPCC1259.13
GO:0005829 cytosol C
IDA
SpoSPCC1259.13
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SceS000000478
SpoSPCC1259.13
ISS
SceS000000478
GO:0005515 protein binding F
IPI
SpoSPCC1259.13
GO:0005524 ATP binding F
ISS
SpoSPCC1259.13
GO:0000077 DNA damage checkpoint P
IGI
SpoSPCC1259.13
IMP
SceS000000478
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000000478
SpoSPCC1259.13
ISS
SceS000000478
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPCC1259.13
GO:0048478 replication fork protection P
IGI
SceS000000478

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