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Search term: YCL004W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PGS1
SGD link S000000510
Alternative ID YCL004W
Description Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis
Synonyms YCL004W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3964 -CDHYPE

KOGs classification KOGs description
METABOLISM Phosphatidylglycerolphosphate synthase

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE25321 GI:17510139
Caenorhabditis elegans (Cel) CE27264 GI:17510141
Drosophila melanogaster (Dme) 7300436 GI:7300436
Homo sapiens (Hsa) Hs21314624 GI:18586810
Homo sapiens (Hsa) HsM13259370 GI:13259370
Saccharomyces cerevisiae (Sce) YCL004w
(S000000510)		 GI:10383778 P25578
Schizosaccharomyces pombe (Spo) SPBP18G5.02 GI:19112784 Q9HDW1
Encephalitozoon cuniculi (Ecu) ECU11g0850 GI:19074885 Q8SQW8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBP18G5.02
GO:0005739 mitochondrion C
IDA
SceS000000510
ISS
SpoSPBP18G5.02
GO:0005829 cytosol C
IDA
SpoSPBP18G5.02
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate
3-phosphatidyltransferase activity		 F
IMP
SceS000000510
ISS
SpoSPBP18G5.02
GO:0006655 phosphatidylglycerol biosynthetic
process		 P
ISS
SpoSPBP18G5.02
GO:0008654 phospholipid biosynthetic process P
IMP
SceS000000510
GO:0046168 glycerol-3-phosphate catabolic
process		 P
ISS
SpoSPBP18G5.02

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5467

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PGS1 GI:84508631
Pan troglodytes (Ptr) PGS1 GI:114670716
Canis familiaris (Cfa) PGS1 GI:73964965
Mus musculus (Mmu) Pgs1
(MGI:1921701)		 GI:110626163 B9EKS7
Rattus norvegicus (Rno) Pgs1 GI:109489439
Gallus gallus (Gga) PGS1 GI:56605920
Drosophila melanogaster (Dme) CG7718
(FBgn0038649)		 GI:28572961
Anopheles gambiae (Aga) AgaP_AGAP002662 GI:158290691
Caenorhabditis elegans (Cel) Y48G1C.4
(CE30021;
WBGene00021677)		 GI:25143331
Schizosaccharomyces pombe (Spo) SPBP18G5.02 GI:19112784 Q9HDW1
Saccharomyces cerevisiae (Sce) PGS1
(S000000510)		 GI:10383778 P25578
Kluyveromyces lactis (Kla) KLLA0A08580g GI:50302879
Eremothecium gossypii (Ego) AGOS_AAL003W GI:45184821
Magnaporthe grisea (Mgr) MGG_07543 GI:145609361
Neurospora crassa (Ncr) NCU01141.1 GI:32412308


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBP18G5.02
GO:0005739 mitochondrion C
IDA
MmuMGI:1921701
SceS000000510
ISS
SpoSPBP18G5.02
GO:0005783 endoplasmic reticulum C
IDA
HsaPGS1
GO:0005829 cytosol C
IDA
SpoSPBP18G5.02
GO:0003674 molecular_function F
ND
MmuMGI:1921701
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate
3-phosphatidyltransferase activity		 F
IMP
SceS000000510
ISS
DmeFBgn0038649
SpoSPBP18G5.02
GO:0000003 reproduction P
IMP
CelWBGene00021677
GO:0006655 phosphatidylglycerol biosynthetic
process		 P
ISS
SpoSPBP18G5.02
GO:0008150 biological_process P
ND
MmuMGI:1921701
GO:0008654 phospholipid biosynthetic process P
IMP
SceS000000510
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00021677
GO:0046168 glycerol-3-phosphate catabolic
process		 P
ISS
SpoSPBP18G5.02

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2930

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4881 ENSANGP00000021095
Ashbya gossypii (Ago) ago184 AAL003W
Caenorhabditis elegans (Cel) cel19293 Y48G1C.4
(CE30021;
WBGene00021677)
Candida glabrata (Cgl) cgl410 CAGL0B04741g
Cryptococcus neoformans (Cne) cne5539 179.m00394
Dictyostelium discoideum (Ddi) ddi2510 DDB0217874
Debaryomyces hansenii (Dha) dha6238 DEHA0G12089g
Drosophila melanogaster (Dme) dme13293 CG7718-PA
(FBgn0038649)
Danio rerio (Dre) dre24551 ENSDARP00000009348
(LOC561577)
Escherichia coli (Eco) eco2506 49176243
Encephalitozoon cuniculi (Ecu) ecu973 19074885
Gallus gallus (Gga) gga16461 ENSGALP00000011616
(PGS1)		 Q5ZHN9
Homo sapiens (Hsa) hsa14434 ENSP00000262764
(PGS1)		 Q32NB8-1
Kluyveromyces lactis (Kla) kla374 KLLA0A08580g
Mus musculus (Mmu) mmu5238 ENSMUSP00000017859
(MGI:1921701)		 Q8BHF7
Neurospora crassa (Ncr) ncr1105 NCU01141.2
Plasmodium falciparum (Pfa) pfa2050 MAL8P1.58
Rattus norvegicus (Rno) rno6507 ENSRNOP00000004007
(RGD:1305052)
Saccharomyces cerevisiae (Sce) sce586 YCL004W
(S000000510)
Schizosaccharomyces pombe (Spo) spo4673 SPBP18G5.02 Q9HDW1
Yarrowia lipolytica (Yli) yli4445 YALI0E14102g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBP18G5.02
GO:0005739 mitochondrion C
IDA
MmuMGI:1921701
SceS000000510
ISS
SpoSPBP18G5.02
GO:0005829 cytosol C
IDA
SpoSPBP18G5.02
GO:0003674 molecular_function F
ND
MmuMGI:1921701
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate
3-phosphatidyltransferase activity		 F
IMP
SceS000000510
ISS
DmeFBgn0038649
PfaMAL8P1.58
SpoSPBP18G5.02
GO:0000003 reproduction P
IMP
CelWBGene00021677
GO:0006072 glycerol-3-phosphate metabolic
process		 P
ISS
PfaMAL8P1.58
GO:0006655 phosphatidylglycerol biosynthetic
process		 P
ISS
PfaMAL8P1.58
SpoSPBP18G5.02
GO:0008150 biological_process P
ND
MmuMGI:1921701
GO:0008654 phospholipid biosynthetic process P
IMP
SceS000000510
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00021677
GO:0046168 glycerol-3-phosphate catabolic
process		 P
ISS
SpoSPBP18G5.02

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBP18G5.02
(Q9HDW1)		 YCL004W
(S000000510)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBP18G5.02
GO:0005739 mitochondrion C
IDA
SceS000000510
ISS
SpoSPBP18G5.02
GO:0005829 cytosol C
IDA
SpoSPBP18G5.02
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate
3-phosphatidyltransferase activity		 F
IMP
SceS000000510
ISS
SpoSPBP18G5.02
GO:0006655 phosphatidylglycerol biosynthetic
process		 P
ISS
SpoSPBP18G5.02
GO:0008654 phospholipid biosynthetic process P
IMP
SceS000000510
GO:0046168 glycerol-3-phosphate catabolic
process		 P
ISS
SpoSPBP18G5.02

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GO info in one table:

s.khadayate@ucl.ac.uk