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Search term: YCL008C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name STP22
SGD link S000000514
Alternative ID YCL008C
Description Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
Synonyms YCL008C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2391 ACDHY--

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Vacuolar sorting protein/ubiquitin receptor VPS23

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g38830 GI:15224967
Arabidopsis thaliana (Ath) At3g12400 GI:18399596
Arabidopsis thaliana (Ath) At5g13860 GI:15240732
Caenorhabditis elegans (Cel) CE19350 GI:17538634
Drosophila melanogaster (Dme) 7294051 GI:7294051
Homo sapiens (Hsa) Hs5454140
(TSG101)		 GI:5454140 Q99816
Homo sapiens (Hsa) Hs8922850_1 GI:8922850
Saccharomyces cerevisiae (Sce) YCL008c
(S000000514)		 GI:10383776


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000813 ESCRT I complex C
IDA
SceS000000514
IPI
SceS000000514
ISS
AthAt5g13860
At3g12400
GO:0005730 nucleolus C
IDA
HsaTSG101
GO:0005737 cytoplasm C
IDA
HsaTSG101
ISS
HsaTSG101
GO:0005768 endosome C
IDA
SceS000000514
IPI
SceS000000514
GO:0005769 early endosome C
IDA
AthAt3g12400
HsaTSG101
GO:0005770 late endosome C
IDA
AthAt3g12400
IMP
HsaTSG101
GO:0005771 multivesicular body C
TAS
HsaTSG101
GO:0005886 plasma membrane C
IDA
HsaTSG101
GO:0009898 internal side of plasma membrane C
IDA
SceS000000514
GO:0043234 protein complex C
IDA
AthAt3g12400
GO:0003674 molecular_function F
ND
AthAt2g38830
GO:0003677 DNA binding F
TAS
HsaTSG101
GO:0004842 ubiquitin-protein ligase activity F
RCA
SceS000000514
GO:0005515 protein binding F
IDA
SceS000000514
IPI
HsaTSG101
GO:0016874 ligase activity F
RCA
SceS000000514
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
RCA
SceS000000514
GO:0016881 acid-amino acid ligase activity F
RCA
SceS000000514
GO:0019787 small conjugating protein ligase
activity		 F
RCA
SceS000000514
GO:0031625 ubiquitin protein ligase binding F
IPI
HsaTSG101
GO:0043130 ubiquitin binding F
IDA
AthAt3g12400
SceS000000514
TAS
HsaTSG101
GO:0048306 calcium-dependent protein binding F
IPI
HsaTSG101
GO:0006612 protein targeting to membrane P
IMP
SceS000000514
IPI
SceS000000514
GO:0006623 protein targeting to vacuole P
IMP
SceS000000514
IPI
SceS000000514
GO:0010091 trichome branching P
IMP
AthAt3g12400
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IC
SceS000000514
IDA
HsaTSG101
GO:0045324 late endosome to vacuole transport P
IMP
SceS000000514
GO:0046755 non-lytic virus budding P
IMP
HsaTSG101
ISS
HsaTSG101
GO:0051301 cell division P
IMP
AthAt3g12400

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
104071

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) STP22
(S000000514)		 GI:42759852
Eremothecium gossypii (Ego) AGOS_AAL006C GI:45184818


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000813 ESCRT I complex C
IDA
SceS000000514
IPI
SceS000000514
GO:0005768 endosome C
IDA
SceS000000514
IPI
SceS000000514
GO:0009898 internal side of plasma membrane C
IDA
SceS000000514
GO:0004842 ubiquitin-protein ligase activity F
RCA
SceS000000514
GO:0005515 protein binding F
IDA
SceS000000514
GO:0016874 ligase activity F
RCA
SceS000000514
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
RCA
SceS000000514
GO:0016881 acid-amino acid ligase activity F
RCA
SceS000000514
GO:0019787 small conjugating protein ligase
activity		 F
RCA
SceS000000514
GO:0043130 ubiquitin binding F
IDA
SceS000000514
GO:0006612 protein targeting to membrane P
IMP
SceS000000514
IPI
SceS000000514
GO:0006623 protein targeting to vacuole P
IMP
SceS000000514
IPI
SceS000000514
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IC
SceS000000514
GO:0045324 late endosome to vacuole transport P
IMP
SceS000000514

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1747

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga1376 ENSANGP00000013561
Ashbya gossypii (Ago) ago181 AAL006C
Arabidopsis thaliana (Ath) ath10993 At2g38830.1
Arabidopsis thaliana (Ath) ath13377 At3g12400.1
Arabidopsis thaliana (Ath) ath23584 At5g13860.1
Caenorhabditis elegans (Cel) cel1663 C09G12.9
(CE34675;
WBGene00015658)
Candida glabrata (Cgl) cgl2232 CAGL0H03927g
Cryptococcus neoformans (Cne) cne5356 179.m00208
Dictyostelium discoideum (Ddi) ddi7906 DDB0218848
Debaryomyces hansenii (Dha) dha1969 DEHA0C12177g
Debaryomyces hansenii (Dha) dha6251 DEHA0G12397g
Drosophila melanogaster (Dme) dme9883 CG9712-PA
(FBgn0036666)
Danio rerio (Dre) dre21907 ENSDARP00000013839
(LOC558584)
Danio rerio (Dre) dre16871 ENSDARP00000014398
Danio rerio (Dre) dre21908 ENSDARP00000039280
(tsg101)		 Q6IQ70
Takifugu rubripes (Fru) fru31871 SINFRUP00000154354
Takifugu rubripes (Fru) fru31873 SINFRUP00000167605
Takifugu rubripes (Fru) fru31870 SINFRUP00000175231
Takifugu rubripes (Fru) fru31872 SINFRUP00000176378
Gallus gallus (Gga) gga18857 ENSGALP00000010192
Gallus gallus (Gga) gga18858 ENSGALP00000010193
Homo sapiens (Hsa) hsa5289 ENSP00000251968
(TSG101)		 Q99816-1
Homo sapiens (Hsa) hsa5292 ENSP00000300038
(UEVLD)		 Q8IX04-5
Homo sapiens (Hsa) hsa5290 ENSP00000349721
(TSG101)		 Q99816-2
Kluyveromyces lactis (Kla) kla2270 KLLA0D04752g
Mus musculus (Mmu) mmu24022 ENSMUSP00000014546
(MGI:106581)		 Q61187
Neurospora crassa (Ncr) ncr5591 NCU05753.2
Oryza sativa (Osa) osa38829 4910.m00126
Rattus norvegicus (Rno) rno1928 ENSRNOP00000018194
(RGD:3909)		 Q6IRE4
Saccharomyces cerevisiae (Sce) sce590 YCL008C
(S000000514)
Yarrowia lipolytica (Yli) yli6152 YALI0F19272g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000813 ESCRT I complex C
IDA
SceS000000514
IPI
CelWBGene00015658
SceS000000514
ISS
AthAt5g13860
At3g12400
GO:0005634 nucleus C
IC
MmuMGI:106581
ISO
MmuMGI:106581
GO:0005737 cytoplasm C
IDA
MmuMGI:106581
GO:0005768 endosome C
IDA
SceS000000514
IPI
SceS000000514
GO:0005769 early endosome C
IDA
AthAt3g12400
GO:0005770 late endosome C
IDA
AthAt3g12400
GO:0009898 internal side of plasma membrane C
IDA
SceS000000514
GO:0010008 endosome membrane C
IDA
CelWBGene00015658
GO:0043234 protein complex C
IDA
AthAt3g12400
GO:0003674 molecular_function F
ND
AthAt2g38830
GO:0003714 transcription corepressor activity F
IDA
MmuMGI:106581
GO:0004842 ubiquitin-protein ligase activity F
RCA
SceS000000514
GO:0005515 protein binding F
IDA
SceS000000514
IPI
DmeFBgn0036666
MmuMGI:106581
GO:0016874 ligase activity F
RCA
SceS000000514
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
RCA
SceS000000514
GO:0016881 acid-amino acid ligase activity F
RCA
SceS000000514
GO:0019787 small conjugating protein ligase
activity		 F
RCA
SceS000000514
GO:0030374 ligand-dependent nuclear receptor transcription
coactivator activity		 F
ISO
MmuMGI:106581
GO:0043130 ubiquitin binding F
IDA
AthAt3g12400
SceS000000514
GO:0001558 regulation of cell growth P
IDA
MmuMGI:106581
GO:0002119 nematode larval development P
IMP
CelWBGene00015658
GO:0006513 protein monoubiquitination P
ISO
MmuMGI:106581
GO:0006612 protein targeting to membrane P
IMP
SceS000000514
IPI
SceS000000514
GO:0006623 protein targeting to vacuole P
IMP
SceS000000514
IPI
SceS000000514
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00015658
GO:0007050 cell cycle arrest P
IDA
MmuMGI:106581
GO:0008285 negative regulation of cell proliferation P
IDA
MmuMGI:106581
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00015658
GO:0010091 trichome branching P
IMP
AthAt3g12400
GO:0030154 cell differentiation P
IDA
MmuMGI:106581
GO:0030163 protein catabolic process P
IMP
CelWBGene00015658
GO:0030216 keratinocyte differentiation P
IDA
MmuMGI:106581
GO:0032510 endosome to lysosome transport via multivesicular
body sorting pathway		 P
IMP
CelWBGene00015658
GO:0032801 receptor catabolic process P
IMP
CelWBGene00015658
GO:0035090 maintenance of apical/basal cell
polarity		 P
IMP
DmeFBgn0036666
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IC
SceS000000514
GO:0045324 late endosome to vacuole transport P
IMP
SceS000000514
GO:0045571 negative regulation of imaginal disc
growth		 P
IMP
DmeFBgn0036666
GO:0045892 negative regulation of transcription,
DNA-dependent		 P
IDA
MmuMGI:106581
GO:0045926 negative regulation of growth P
IMP
DmeFBgn0036666
GO:0046425 regulation of JAK-STAT cascade P
IMP
DmeFBgn0036666
GO:0046755 non-lytic virus budding P
IMP
MmuMGI:106581
GO:0051301 cell division P
IMP
AthAt3g12400

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC11H11.01
(Q7Z992)		 YCL008C
(S000000514)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000813 ESCRT I complex C
IDA
SceS000000514
IPI
SceS000000514
ISS
SpoSPAC11H11.01
GO:0005634 nucleus C
IDA
SpoSPAC11H11.01
GO:0005635 nuclear envelope C
IDA
SpoSPAC11H11.01
GO:0005737 cytoplasm C
IDA
SpoSPAC11H11.01
GO:0005768 endosome C
IDA
SceS000000514
IPI
SceS000000514
GO:0005829 cytosol C
IDA
SpoSPAC11H11.01
GO:0009898 internal side of plasma membrane C
IDA
SceS000000514
GO:0003674 molecular_function F
ND
SpoSPAC11H11.01
GO:0004842 ubiquitin-protein ligase activity F
RCA
SceS000000514
GO:0005515 protein binding F
IDA
SceS000000514
GO:0016874 ligase activity F
RCA
SceS000000514
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
RCA
SceS000000514
GO:0016881 acid-amino acid ligase activity F
RCA
SceS000000514
GO:0019787 small conjugating protein ligase
activity		 F
RCA
SceS000000514
GO:0043130 ubiquitin binding F
IDA
SceS000000514
GO:0006612 protein targeting to membrane P
IMP
SceS000000514
IPI
SceS000000514
GO:0006623 protein targeting to vacuole P
IMP
SceS000000514
IPI
SceS000000514
GO:0006897 endocytosis P
IMP
SpoSPAC11H11.01
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IC
SceS000000514
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SpoSPAC11H11.01
GO:0045324 late endosome to vacuole transport P
IMP
SceS000000514
SpoSPAC11H11.01

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