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Search term: YCL017C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NFS1
SGD link S000000522
Alternative ID YCL017C
Description Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
Synonyms YCL017C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1549 ACDHYPE

KOGs classification KOGs description
METABOLISM Cysteine desulfurase NFS1

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g08490 GI:15223234
Arabidopsis thaliana (Ath) At3g62130 GI:15228693
Arabidopsis thaliana (Ath) At5g26595 GI:15240331
Arabidopsis thaliana (Ath) At5g65720 GI:15239125
Caenorhabditis elegans (Cel) CE02643
(WBGene00017442)		 GI:17533177 Q19434
Caenorhabditis elegans (Cel) CE17320 GI:17505288
Drosophila melanogaster (Dme) 7297896 GI:7297896
Drosophila melanogaster (Dme) 7297897
(FBgn0032393)		 GI:20129463
Homo sapiens (Hsa) Hs10864079 GI:10864079
Homo sapiens (Hsa) Hs19923803 GI:19923803
Homo sapiens (Hsa) Hs20560255 GI:20560255
Saccharomyces cerevisiae (Sce) YCL017c
(S000000522)		 GI:10383773 P25374
Schizosaccharomyces pombe (Spo) SPAC11D3.10 GI:19113719 Q10089
Schizosaccharomyces pombe (Spo) SPBC21D10.11c GI:19112794 O74351
Schizosaccharomyces pombe (Spo) SPBC660.12c GI:19111883 O94431
Schizosaccharomyces pombe (Spo) SPCC777.03c GI:19075749 O74542
Encephalitozoon cuniculi (Ecu) ECU11g1770 GI:19074977 Q8SQS2


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g62130
SpoSPAC11D3.10
GO:0005634 nucleus C
IDA
SceS000000522
SpoSPBC660.12c
SPCC777.03c
IMP
SceS000000522
GO:0005737 cytoplasm C
ISS
DmeFBgn0032393
GO:0005739 mitochondrion C
IDA
AthAt5g65720
SceS000000522
ISS
DmeFBgn0032393
NAS
DmeFBgn0032393
GO:0005759 mitochondrial matrix C
ISS
SpoSPBC21D10.11c
GO:0005829 cytosol C
IDA
SpoSPBC660.12c
SPCC777.03c
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0032393
GO:0009507 chloroplast C
IDA
AthAt1g08490
GO:0004123 cystathionine gamma-lyase activity F
ISS
DmeFBgn0032393
NAS
DmeFBgn0032393
GO:0005524 ATP binding F
IDA
AthAt5g65720
GO:0008270 zinc ion binding F
IDA
AthAt5g65720
GO:0008483 transaminase activity F
ISS
AthAt5g65720
At1g08490
GO:0009000 selenocysteine lyase activity F
IDA
AthAt1g08490
GO:0031071 cysteine desulfurase activity F
IDA
AthAt1g08490
At5g65720
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0001887 selenium metabolic process P
IDA
AthAt1g08490
GO:0002098 tRNA wobble uridine modification P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0006523 alanine biosynthetic process P
ISS
DmeFBgn0032393
GO:0006790 sulfur metabolic process P
IDA
AthAt1g08490
GO:0006879 cellular iron ion homeostasis P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0008150 biological_process P
ND
SpoSPAC11D3.10
SPBC660.12c
SPCC777.03c
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00017442
GO:0010269 response to selenium ion P
IMP
AthAt1g08490
GO:0016226 iron-sulfur cluster assembly P
IDA
AthAt5g65720
SceS000000522
IMP
SceS000000522
ISS
DmeFBgn0032393
SpoSPBC21D10.11c
NAS
DmeFBgn0032393
GO:0018283 iron incorporation into metallo-sulfur
cluster		 P
IDA
AthAt1g08490
GO:0034227 tRNA thio-modification P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5463

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) NFS1 GI:32307132
Pan troglodytes (Ptr) NFS1 GI:114681701
Canis familiaris (Cfa) NFS1 GI:73992307
Mus musculus (Mmu) Nfs1
(MGI:1316706)		 GI:6754846 Q8C6I5
Rattus norvegicus (Rno) Nfs1
(RGD:620912)		 GI:76880449
Gallus gallus (Gga) NFS1 GI:71895025
Drosophila melanogaster (Dme) CG12264
(FBgn0032393)		 GI:20129463
Anopheles gambiae (Aga) AgaP_AGAP009094 GI:118791608
Caenorhabditis elegans (Cel) aminotransferase GI:25143064
Schizosaccharomyces pombe (Spo) nfs1
(SPBC21D10.11c)		 GI:19112794 O74351
Saccharomyces cerevisiae (Sce) NFS1
(S000000522)		 GI:10383773 P25374
Kluyveromyces lactis (Kla) KLLA0D04928g GI:50306611
Eremothecium gossypii (Ego) AGOS_AAL013W GI:45184811
Magnaporthe grisea (Mgr) MGG_00767 GI:39974173
Neurospora crassa (Ncr) NCU04636.1 GI:32406758
Arabidopsis thaliana (Ath) NFS1 GI:15239125
Oryza sativa (Osa) Os09g0338400 GI:115478641
Plasmodium falciparum (Pfa) MAL7P1.150 GI:124512072


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
HsaNFS1
MmuMGI:1316706
SceS000000522
IMP
SceS000000522
GO:0005737 cytoplasm C
ISS
DmeFBgn0032393
GO:0005739 mitochondrion C
IDA
MmuMGI:1316706
SceS000000522
ISS
DmeFBgn0032393
NAS
DmeFBgn0032393
GO:0005759 mitochondrial matrix C
IDA
HsaNFS1
MmuMGI:1316706
ISS
SpoSPBC21D10.11c
GO:0005829 cytosol C
IDA
HsaNFS1
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0032393
GO:0020011 apicoplast C
RCA
PfaMAL7P1.150
GO:0004123 cystathionine gamma-lyase activity F
ISS
DmeFBgn0032393
PfaMAL7P1.150
NAS
DmeFBgn0032393
GO:0005515 protein binding F
IPI
HsaNFS1
GO:0031071 cysteine desulfurase activity F
IDA
HsaNFS1
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0042803 protein homodimerization activity F
IDA
HsaNFS1
GO:0000096 sulfur amino acid metabolic process P
TAS
HsaNFS1
GO:0002098 tRNA wobble uridine modification P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0006461 protein complex assembly P
TAS
HsaNFS1
GO:0006523 alanine biosynthetic process P
ISS
DmeFBgn0032393
GO:0006534 cysteine metabolic process P
ISS
PfaMAL7P1.150
GO:0006879 cellular iron ion homeostasis P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0016226 iron-sulfur cluster assembly P
IDA
SceS000000522
IMP
SceS000000522
ISS
DmeFBgn0032393
SpoSPBC21D10.11c
NAS
DmeFBgn0032393
GO:0018283 iron incorporation into metallo-sulfur
cluster		 P
IDA
HsaNFS1
MmuMGI:1316706
GO:0034227 tRNA thio-modification P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_363

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga11209 ENSANGP00000016500
Ashbya gossypii (Ago) ago174 AAL013W
Arabidopsis thaliana (Ath) ath28730 At5g65720.1
Caenorhabditis elegans (Cel) cel136 B0205.6
(CE30405;
WBGene00015021)
Caenorhabditis elegans (Cel) cel6245 F13H8.9
(CE02643;
WBGene00017442)
Candida glabrata (Cgl) cgl2227 CAGL0H03817g
Cryptococcus neoformans (Cne) cne478 163.m06336
Dictyostelium discoideum (Ddi) ddi5759 DDB0205700
Debaryomyces hansenii (Dha) dha6229 DEHA0G11902g
Debaryomyces hansenii (Dha) dha6230 DEHA0G11924g
Drosophila melanogaster (Dme) dme2064 CG12264-PA
(FBgn0032393)
Danio rerio (Dre) dre30432 ENSDARP00000014388
Danio rerio (Dre) dre2717 ENSDARP00000025667
Danio rerio (Dre) dre2716 ENSDARP00000026085
Escherichia coli (Eco) eco2451 49176235
Encephalitozoon cuniculi (Ecu) ecu1065 19074977
Takifugu rubripes (Fru) fru4573 SINFRUP00000142178
Takifugu rubripes (Fru) fru10378 SINFRUP00000142693
Takifugu rubripes (Fru) fru10379 SINFRUP00000170426
Gallus gallus (Gga) gga23035 ENSGALP00000001975
(SCLY)
Gallus gallus (Gga) gga11721 ENSGALP00000002382
(NFS1)		 Q5ZKP5
Homo sapiens (Hsa) hsa19537 ENSP00000254663
(SCLY)		 Q96I15-1
Homo sapiens (Hsa) hsa20127 ENSP00000262876
Kluyveromyces lactis (Kla) kla2278 KLLA0D04928g
Mus musculus (Mmu) mmu776 ENSMUSP00000027532
(MGI:1355310)		 Q9JLI6-1
Mus musculus (Mmu) mmu15863 ENSMUSP00000029147
(MGI:1316706)		 Q9Z1J3-1
Neurospora crassa (Ncr) ncr4504 NCU04636.2
Oryza sativa (Osa) osa48227 5661.m00111
Oryza sativa (Osa) osa48231 5661.m00135
Oryza sativa (Osa) osa48232 5661.m00136
Plasmodium falciparum (Pfa) pfa2510 MAL7P1.150
Rattus norvegicus (Rno) rno20108 ENSRNOP00000026820
(RGD:620912)		 Q3MHT2
Rattus norvegicus (Rno) rno30469 ENSRNOP00000027220
(RGD:1359514)		 Q68FT9
Saccharomyces cerevisiae (Sce) sce597 YCL017C
(S000000522)
Schizosaccharomyces pombe (Spo) spo3206 SPBC21D10.11c O74351
Yarrowia lipolytica (Yli) yli2476 YALI0C19041g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
MmuMGI:1316706
SceS000000522
IMP
SceS000000522
GO:0005737 cytoplasm C
ISS
DmeFBgn0032393
GO:0005739 mitochondrion C
IDA
AthAt5g65720
MmuMGI:1316706
SceS000000522
ISS
DmeFBgn0032393
NAS
DmeFBgn0032393
GO:0005759 mitochondrial matrix C
IDA
MmuMGI:1316706
ISS
SpoSPBC21D10.11c
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0032393
GO:0020011 apicoplast C
RCA
PfaMAL7P1.150
GO:0004123 cystathionine gamma-lyase activity F
ISS
DmeFBgn0032393
PfaMAL7P1.150
NAS
DmeFBgn0032393
GO:0005524 ATP binding F
IDA
AthAt5g65720
GO:0008270 zinc ion binding F
IDA
AthAt5g65720
GO:0008483 transaminase activity F
ISS
AthAt5g65720
GO:0031071 cysteine desulfurase activity F
IDA
AthAt5g65720
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0000003 reproduction P
IMP
CelWBGene00015021
GO:0002098 tRNA wobble uridine modification P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0002119 nematode larval development P
IMP
CelWBGene00015021
GO:0006523 alanine biosynthetic process P
ISS
DmeFBgn0032393
GO:0006534 cysteine metabolic process P
ISS
PfaMAL7P1.150
GO:0006879 cellular iron ion homeostasis P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00017442
WBGene00015021
GO:0016226 iron-sulfur cluster assembly P
IDA
AthAt5g65720
SceS000000522
IMP
SceS000000522
ISS
DmeFBgn0032393
SpoSPBC21D10.11c
NAS
DmeFBgn0032393
GO:0018283 iron incorporation into metallo-sulfur
cluster		 P
IDA
MmuMGI:1316706
GO:0034227 tRNA thio-modification P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0040007 growth P
IMP
CelWBGene00015021

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC21D10.11c
(O74351)		 YCL017C
(S000000522)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000000522
IMP
SceS000000522
GO:0005739 mitochondrion C
IDA
SceS000000522
GO:0005759 mitochondrial matrix C
ISS
SpoSPBC21D10.11c
GO:0031071 cysteine desulfurase activity F
IDA
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0002098 tRNA wobble uridine modification P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0006879 cellular iron ion homeostasis P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0016226 iron-sulfur cluster assembly P
IDA
SceS000000522
IMP
SceS000000522
ISS
SpoSPBC21D10.11c
GO:0034227 tRNA thio-modification P
IMP
SceS000000522
ISS
SpoSPBC21D10.11c

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