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Search term: YDL003W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MCD1
SGD link S000002161
Alternative ID YDL003W
Description Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
Synonyms YDL003W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1213 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g59550 GI:15231707
Arabidopsis thaliana (Ath) At5g05490 GI:15239141
Arabidopsis thaliana (Ath) At5g16270 GI:15237318
Arabidopsis thaliana (Ath) At5g40840 GI:10177963
Caenorhabditis elegans (Cel) CE02628
(WBGene00004737)		 GI:17532617 Q19325
Caenorhabditis elegans (Cel) CE04726
(WBGene00000591)		 GI:17551254 Q21306
Drosophila melanogaster (Dme) 7289833 GI:7289833
Homo sapiens (Hsa) Hs5453994
(RAD21)		 GI:5453994 O60216
Homo sapiens (Hsa) Hs9845293 GI:9845293
Homo sapiens (Hsa) Hs17461558 GI:17461558
Homo sapiens (Hsa) Hs18592523 GI:18592523
Saccharomyces cerevisiae (Sce) YDL003w
(S000002161)		 GI:6320201 Q12158
Schizosaccharomyces pombe (Spo) SPBC29A10.14 GI:19112851 P36626
Schizosaccharomyces pombe (Spo) SPCC338.17c GI:19075651 P30776
Encephalitozoon cuniculi (Ecu) ECU04g1370 GI:19074216 Q8SVR5
Arabidopsis thaliana (Ath) At3g59550 GI:15231707
Arabidopsis thaliana (Ath) At5g05490 GI:15239141
Arabidopsis thaliana (Ath) At5g16270 GI:15237318
Arabidopsis thaliana (Ath) At5g40840 GI:10177963
Caenorhabditis elegans (Cel) CE02628
(WBGene00004737)		 GI:17532617 Q19325
Caenorhabditis elegans (Cel) CE04726
(WBGene00000591)		 GI:17551254 Q21306
Drosophila melanogaster (Dme) 7289833 GI:7289833
Homo sapiens (Hsa) Hs5453994
(RAD21)		 GI:5453994 O60216
Homo sapiens (Hsa) Hs9845293 GI:9845293
Homo sapiens (Hsa) Hs17461558 GI:17461558
Homo sapiens (Hsa) Hs18592523 GI:18592523
Saccharomyces cerevisiae (Sce) YDL003w
(S000002161)		 GI:6320201 Q12158
Schizosaccharomyces pombe (Spo) SPBC29A10.14 GI:19112851 P36626
Schizosaccharomyces pombe (Spo) SPCC338.17c GI:19075651 P30776
Encephalitozoon cuniculi (Ecu) ECU04g1370 GI:19074216 Q8SVR5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IC
SpoSPBC29A10.14
GO:0000794 condensed nuclear chromosome C
IC
SpoSPCC338.17c
IDA
SceS000002161
GO:0000798 nuclear cohesin complex C
ISS
AthAt3g59550
At5g40840
GO:0000939 inner kinetochore of condensed
chromosome		 C
IDA
SpoSPBC29A10.14
GO:0005634 nucleus C
IDA
CelWBGene00000591
WBGene00004737
HsaRAD21
SceS000002161
SpoSPBC29A10.14
SPCC338.17c
ISS
AthAt5g40840
At3g59550
GO:0005694 chromosome C
IDA
AthAt5g05490
GO:0005730 nucleolus C
IDA
AthAt3g59550
GO:0005739 mitochondrion C
IDA
SceS000002161
GO:0008278 cohesin complex C
IDA
SpoSPBC29A10.14
ISS
AthAt5g05490
TAS
HsaRAD21
GO:0030892 mitotic cohesin complex C
IDA
SpoSPCC338.17c
GO:0030893 meiotic cohesin complex C
IDA
SpoSPBC29A10.14
GO:0034990 nuclear mitotic cohesin complex C
IDA
SceS000002161
GO:0003674 molecular_function F
ND
AthAt5g05490
At3g59550
At5g40840
At5g16270
GO:0003682 chromatin binding F
IDA
SceS000002161
GO:0003684 damaged DNA binding F
ISS
CelWBGene00000591
WBGene00004737
GO:0005515 protein binding F
IPI
HsaRAD21
SpoSPBC29A10.14
SPCC338.17c
GO:0000003 reproduction P
IMP
CelWBGene00004737
GO:0000724 double-strand break repair via homologous
recombination		 P
IGI
SpoSPCC338.17c
GO:0002119 nematode larval development P
IMP
CelWBGene00004737
GO:0006302 double-strand break repair P
IMP
AthAt5g40840
SceS000002161
SpoSPCC338.17c
TAS
HsaRAD21
GO:0006310 DNA recombination P
TAS
HsaRAD21
GO:0006325 chromatin organization P
IMP
AthAt5g05490
GO:0006915 apoptosis P
IMP
SceS000002161
GO:0006974 response to DNA damage stimulus P
IMP
SceS000002161
GO:0007062 sister chromatid cohesion P
IMP
AthAt5g05490
At5g16270
ISS
AthAt5g16270
GO:0007064 mitotic sister chromatid cohesion P
IMP
SpoSPCC338.17c
GO:0007067 mitosis P
IEP
AthAt3g59550
At5g40840
GO:0007076 mitotic chromosome condensation P
IMP
SceS000002161
GO:0007126 meiosis P
IMP
CelWBGene00000591
WBGene00004737
GO:0007130 synaptonemal complex assembly P
TAS
CelWBGene00000591
WBGene00004737
GO:0007131 reciprocal meiotic recombination P
IMP
SpoSPBC29A10.14
TAS
HsaRAD21
GO:0008608 attachment of spindle microtubules to
kinetochore		 P
IMP
SpoSPCC338.17c
GO:0009555 pollen development P
IMP
AthAt3g59550
GO:0009561 megagametogenesis P
IMP
AthAt3g59550
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000591
WBGene00004737
GO:0010032 meiotic chromosome condensation P
IMP
AthAt5g05490
GO:0010551 regulation of gene-specific transcription from RNA
polymerase II promoter		 P
IDA
HsaRAD21
GO:0030999 linear element assembly P
IMP
SpoSPBC29A10.14
GO:0034087 establishment of mitotic sister chromatid
cohesion		 P
IMP
SceS000002161
GO:0040002 collagen and cuticulin-based cuticle
development		 P
IMP
CelWBGene00004737
GO:0040007 growth P
IMP
CelWBGene00004737
GO:0040011 locomotion P
IMP
CelWBGene00000591
WBGene00004737
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00004737
GO:0042138 meiotic DNA double-strand break
formation		 P
IMP
SpoSPBC29A10.14
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00004737
WBGene00000591
GO:0045143 homologous chromosome segregation P
IDA
SpoSPBC29A10.14
GO:0045144 meiotic sister chromatid segregation P
IDA
SpoSPBC29A10.14
IMP
SpoSPBC29A10.14
GO:0051455 attachment of spindle microtubules to kinetochore
involved in homologous chromosome
segregation		 P
IMP
AthAt5g05490
SpoSPBC29A10.14
GO:0051754 meiotic sister chromatid cohesion,
centromeric		 P
IMP
AthAt5g05490

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
80202

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) rad21
(SPCC338.17c)		 GI:19075651 P30776
Saccharomyces cerevisiae (Sce) MCD1
(S000002161)		 GI:6320201 Q12158
Kluyveromyces lactis (Kla) KLLA0F14795g GI:50311441
Eremothecium gossypii (Ego) AGOS_AEL007W GI:45190600
Magnaporthe grisea (Mgr) MGG_09891 GI:145605395
Neurospora crassa (Ncr) NCU03291.1 GI:32420567


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000794 condensed nuclear chromosome C
IC
SpoSPCC338.17c
IDA
SceS000002161
GO:0005634 nucleus C
IDA
SceS000002161
SpoSPCC338.17c
GO:0005739 mitochondrion C
IDA
SceS000002161
GO:0030892 mitotic cohesin complex C
IDA
SpoSPCC338.17c
GO:0034990 nuclear mitotic cohesin complex C
IDA
SceS000002161
GO:0003682 chromatin binding F
IDA
SceS000002161
GO:0005515 protein binding F
IPI
SpoSPCC338.17c
GO:0000724 double-strand break repair via homologous
recombination		 P
IGI
SpoSPCC338.17c
GO:0006302 double-strand break repair P
IMP
SceS000002161
SpoSPCC338.17c
GO:0006915 apoptosis P
IMP
SceS000002161
GO:0006974 response to DNA damage stimulus P
IMP
SceS000002161
GO:0007064 mitotic sister chromatid cohesion P
IMP
SpoSPCC338.17c
GO:0007076 mitotic chromosome condensation P
IMP
SceS000002161
GO:0008608 attachment of spindle microtubules to
kinetochore		 P
IMP
SpoSPCC338.17c
GO:0034087 establishment of mitotic sister chromatid
cohesion		 P
IMP
SceS000002161

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2014

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga7115 ENSANGP00000003994
Anopheles gambiae (Aga) aga7114 ENSANGP00000027806
Ashbya gossypii (Ago) ago2499 AEL007W
Arabidopsis thaliana (Ath) ath23847 At5g16270.1
Caenorhabditis elegans (Cel) cel5965 F10G7.4
(CE02628;
WBGene00004737)
Caenorhabditis elegans (Cel) cel12209 K08A8.3
(CE04726;
WBGene00000591)
Candida glabrata (Cgl) cgl608 CAGL0C04433g
Cryptococcus neoformans (Cne) cne784 163.m04709
Dictyostelium discoideum (Ddi) ddi1729 DDB0202625
Debaryomyces hansenii (Dha) dha648 DEHA0A14476g
Drosophila melanogaster (Dme) dme19005 CG17436-PA
Danio rerio (Dre) dre7697 ENSDARP00000009867
(rad21)		 Q6TEL1
Encephalitozoon cuniculi (Ecu) ecu854 19074216
Takifugu rubripes (Fru) fru4977 SINFRUP00000136090
Takifugu rubripes (Fru) fru32969 SINFRUP00000162508
Gallus gallus (Gga) gga12067 ENSGALP00000009968
(RAD21L1)
Gallus gallus (Gga) gga11468 ENSGALP00000025921
(RAD21)		 Q5ZLK3
Homo sapiens (Hsa) hsa19651 ENSP00000246108
(RAD21L1)		 B7ZBB0
Homo sapiens (Hsa) hsa30654 ENSP00000297338
(RAD21)		 O60216
Kluyveromyces lactis (Kla) kla4745 KLLA0F14795g
Mus musculus (Mmu) mmu8964 ENSMUSP00000022927
(MGI:108016)		 Q3UTE4
Neurospora crassa (Ncr) ncr3189 NCU03291.2
Oryza sativa (Osa) osa12369 2823.m00051
Oryza sativa (Osa) osa47513 5782.m00046
Rattus norvegicus (Rno) rno27051 ENSRNOP00000006209
(RGD:1594529)		 Q4KLH7
Rattus norvegicus (Rno) rno19962 ENSRNOP00000012752
(GI:691331)
Saccharomyces cerevisiae (Sce) sce770 YDL003W
(S000002161)
Schizosaccharomyces pombe (Spo) spo1671 SPCC338.17c P30776
Yarrowia lipolytica (Yli) yli1087 YALI0B08470g