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Search term: YDL019C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name OSH2
SGD link S000002177
Alternative ID YDL019C
Description Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
Synonyms YDL019C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1737 ACDHYP-

KOGs classification KOGs description
METABOLISM Oxysterol-binding protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g13170 GI:15222204
Arabidopsis thaliana (Ath) At1g77730 GI:15217449
Arabidopsis thaliana (Ath) At2g31020 GI:15224597
Arabidopsis thaliana (Ath) At2g31030 GI:15224598
Arabidopsis thaliana (Ath) At3g09300 GI:15232633
Arabidopsis thaliana (Ath) At4g08180 GI:15236424
Arabidopsis thaliana (Ath) At4g12460 GI:15235381
Arabidopsis thaliana (Ath) At4g22540 GI:7486604
Arabidopsis thaliana (Ath) At5g02100 GI:15241681
Arabidopsis thaliana (Ath) At5g59420 GI:15238398
Caenorhabditis elegans (Cel) CE26105
(WBGene00012930)		 GI:17555950 Q9U2C7
Caenorhabditis elegans (Cel) CE28126 GI:17555948 Q9U2C7
Drosophila melanogaster (Dme) 7301240
(FBgn0020626)		 GI:17137400
Homo sapiens (Hsa) Hs13540513
(OSBP2)		 GI:13540513 Q8NA37
Homo sapiens (Hsa) Hs14149704
(OSBPL3)		 GI:14149704 Q8NFH1
Homo sapiens (Hsa) Hs14210532
(OSBPL6)		 GI:14210532 Q9BZF3
Homo sapiens (Hsa) Hs21735580 GI:20531135 Q8NFH1
Homo sapiens (Hsa) Hs21735582 GI:20531137 Q8NFH1
Homo sapiens (Hsa) Hs21735584 GI:20531139 Q8NFH1
Homo sapiens (Hsa) Hs21735586 GI:20531141 Q8NFH1
Homo sapiens (Hsa) Hs21735588 GI:20531143 Q8NFH1
Homo sapiens (Hsa) Hs22035612 GI:22035612 Q9BZF3
Homo sapiens (Hsa) Hs22035614 GI:20139132 Q8WXP9
Homo sapiens (Hsa) Hs4505531
(OSBP)		 GI:4505531 P22059
Homo sapiens (Hsa) HsM19923507 GI:19923507
Saccharomyces cerevisiae (Sce) YAR044w GI:6319339
Saccharomyces cerevisiae (Sce) YDL019c
(S000002177)		 GI:6320185 Q12451
Saccharomyces cerevisiae (Sce) YHR073w
(S000001115)		 GI:6321864 P38713
Schizosaccharomyces pombe (Spo) SPAC23H4.01c GI:19114317 O13944
Schizosaccharomyces pombe (Spo) SPBC2F12.05c_2 GI:19112502 O14340


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g08180
At4g22540
At2g31030
At5g59420
At4g12460
GO:0005737 cytoplasm C
IDA
SceS000001115
SpoSPBC2F12.05c
GO:0005783 endoplasmic reticulum C
IDA
AthAt5g02100
SceS000002177
ISS
SpoSPBC2F12.05c
SPAC23H4.01c
GO:0005829 cytosol C
IDA
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0005886 plasma membrane C
IDA
SceS000002177
GO:0005935 cellular bud neck C
IDA
SceS000002177
GO:0043234 protein complex C
NAS
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0005515 protein binding F
IPI
HsaOSBPL3
GO:0005545 phosphatidylinositol binding F
ISS
SceS000002177
S000001115
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0008142 oxysterol binding F
ISS
AthAt2g31030
At3g09300
At4g08180
At2g31020
At1g13170
At5g02100
At4g22540
At5g59420
At4g12460
DmeFBgn0020626
SceS000001115
S000002177
SpoSPAC23H4.01c
SPBC2F12.05c
NAS
DmeFBgn0020626
TAS
HsaOSBP
GO:0032934 sterol binding F
IDA
AthAt5g02100
GO:0035091 phosphoinositide binding F
ISS
AthAt4g08180
At4g22540
At1g77730
GO:0000742 karyogamy involved in conjugation with cellular
fusion		 P
IGI
SceS000001115
GO:0001403 invasive growth in response to glucose
limitation		 P
IGI
SceS000001115
GO:0006887 exocytosis P
IGI
SceS000001115
S000002177
ISS
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0006897 endocytosis P
IGI
SceS000001115
S000002177
ISS
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0007124 pseudohyphal growth P
IMP
SceS000001115
GO:0007165 signal transduction P
ISS
AthAt4g08180
At1g77730
At4g22540
GO:0008202 steroid metabolic process P
ISS
AthAt1g13170
At4g22540
At3g09300
At4g08180
At2g31020
At5g59420
At5g02100
At4g12460
At2g31030
GO:0009567 double fertilization forming a zygote and
endosperm		 P
IMP
AthAt5g02100
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012930
GO:0015918 sterol transport P
IGI
SceS000002177
S000001115
IMP
SceS000001115
ISS
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0030011 maintenance of cell polarity P
IGI
SceS000001115
S000002177
GO:0033554 cellular response to stress P
IEP
SpoSPBC2F12.05c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
75303

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) OSBP2 GI:13540513 Q8NA37
Pan troglodytes (Ptr) OSBP2 GI:114685876
Canis familiaris (Cfa) OSBP2 GI:73995439
Mus musculus (Mmu) Osbp2
(MGI:1921559)		 GI:61744458 Q5QNQ6
Rattus norvegicus (Rno) Osbp2 GI:109499976
Gallus gallus (Gga) OSBP2 GI:118098821
Drosophila melanogaster (Dme) Osbp
(FBgn0020626)		 GI:17137400
Anopheles gambiae (Aga) AgaP_AGAP010893 GI:158287927
Caenorhabditis elegans (Cel) obr-1
(CE26105;
WBGene00012930)		 GI:17555950 Q9U2C7
Saccharomyces cerevisiae (Sce) OSH2
(S000002177)		 GI:6320185 Q12451
Magnaporthe grisea (Mgr) MGG_03047 GI:39971161
Neurospora crassa (Ncr) NCU00579.1 GI:32408555
Arabidopsis thaliana (Ath) ORP2A GI:18415950
Arabidopsis thaliana (Ath) ORP2B GI:145340141
Oryza sativa (Osa) Os08g0154900 GI:115474841


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthORP2A
ORP2B
MmuMGI:1921559
GO:0005783 endoplasmic reticulum C
IDA
SceS000002177
GO:0005886 plasma membrane C
IDA
SceS000002177
GO:0005935 cellular bud neck C
IDA
SceS000002177
GO:0003674 molecular_function F
ND
MmuMGI:1921559
GO:0005545 phosphatidylinositol binding F
ISS
SceS000002177
GO:0008142 oxysterol binding F
ISS
AthORP2B
ORP2A
DmeFBgn0020626
SceS000002177
NAS
DmeFBgn0020626
GO:0035091 phosphoinositide binding F
ISS
AthORP2A
GO:0006887 exocytosis P
IGI
SceS000002177
GO:0006897 endocytosis P
IGI
SceS000002177
GO:0007165 signal transduction P
ISS
AthORP2A
GO:0008150 biological_process P
ND
MmuMGI:1921559
GO:0008202 steroid metabolic process P
ISS
AthORP2A
ORP2B
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012930
GO:0015918 sterol transport P
IGI
SceS000002177
GO:0030011 maintenance of cell polarity P
IGI
SceS000002177

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_325

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga7903 ENSANGP00000012524
Anopheles gambiae (Aga) aga7904 ENSANGP00000026865
Ashbya gossypii (Ago) ago2727 AER225W
Arabidopsis thaliana (Ath) ath10092 At2g31020.1
Arabidopsis thaliana (Ath) ath10093 At2g31030.1
Arabidopsis thaliana (Ath) ath18539 At4g08180.1
Arabidopsis thaliana (Ath) ath18540 At4g08180.2
Arabidopsis thaliana (Ath) ath18541 At4g08180.3
Arabidopsis thaliana (Ath) ath18994 At4g12460.1
Arabidopsis thaliana (Ath) ath20181 At4g22540.1
Arabidopsis thaliana (Ath) ath20182 At4g22540.2
Caenorhabditis elegans (Cel) cel6369 F14H8.1
Caenorhabditis elegans (Cel) cel19061 Y47D3A.17a
(CE26105;
WBGene00012930)
Caenorhabditis elegans (Cel) cel19062 Y47D3A.17b
(CE28126)
Candida glabrata (Cgl) cgl633 CAGL0C05049g
Candida glabrata (Cgl) cgl3596 CAGL0K01749g
Cryptococcus neoformans (Cne) cne62 162.m02824
Debaryomyces hansenii (Dha) dha1158 DEHA0B11044g
Drosophila melanogaster (Dme) dme14331 CG6708-PA
(FBgn0020626)
Danio rerio (Dre) dre14955 ENSDARP00000006917
(osbpl2)		 Q7ZVL1
Danio rerio (Dre) dre1103 ENSDARP00000009631
Danio rerio (Dre) dre1105 ENSDARP00000036494
(LOC564372)
Danio rerio (Dre) dre1104 ENSDARP00000038098
Danio rerio (Dre) dre15700 ENSDARP00000040522
Danio rerio (Dre) dre14947 ENSDARP00000042303
Danio rerio (Dre) dre13315 ENSDARP00000044237
(zgc:92066)		 Q6DHT8
Takifugu rubripes (Fru) fru18620 SINFRUP00000130298
Takifugu rubripes (Fru) fru32760 SINFRUP00000136591
Takifugu rubripes (Fru) fru26524 SINFRUP00000146119
Takifugu rubripes (Fru) fru10236 SINFRUP00000155153
Takifugu rubripes (Fru) fru10234 SINFRUP00000155155
Takifugu rubripes (Fru) fru10233 SINFRUP00000155157
Takifugu rubripes (Fru) fru8565 SINFRUP00000158927
Takifugu rubripes (Fru) fru8564 SINFRUP00000158928
Takifugu rubripes (Fru) fru17626 SINFRUP00000160413
Takifugu rubripes (Fru) fru26523 SINFRUP00000169800
Takifugu rubripes (Fru) fru8566 SINFRUP00000176817
Takifugu rubripes (Fru) fru10235 SINFRUP00000176956
Gallus gallus (Gga) gga11956 ENSGALP00000008330
(OSBPL2)		 Q5ZLC4
Gallus gallus (Gga) gga7587 ENSGALP00000012564
(OSBP2)
Homo sapiens (Hsa) hsa5689 ENSP00000263847
(OSBP)		 P22059-1
Homo sapiens (Hsa) hsa20573 ENSP00000316649
(OSBPL2)		 Q9H1P3-1
Homo sapiens (Hsa) hsa21501 ENSP00000332576
(OSBP2)		 Q969R2
Homo sapiens (Hsa) hsa20572 ENSP00000350755
(OSBPL2)		 Q9H1P3-2
Kluyveromyces lactis (Kla) kla1381 KLLA0C04147g
Mus musculus (Mmu) mmu13391 ENSMUSP00000025590
(MGI:97447)		 Q3B7Z2-1
Mus musculus (Mmu) mmu13393 ENSMUSP00000025591
Mus musculus (Mmu) mmu16242 ENSMUSP00000046538
(MGI:2442832)		 Q8BX94
Mus musculus (Mmu) mmu13392 ENSMUSP00000080388
Neurospora crassa (Ncr) ncr563 NCU00579.2
Oryza sativa (Osa) osa69691 7085.m00050
Oryza sativa (Osa) osa463 756.m00117
Plasmodium falciparum (Pfa) pfa778 PF11_0327
Rattus norvegicus (Rno) rno20468 ENSRNOP00000010632
(RGD:1311312)		 Q5BK47
Rattus norvegicus (Rno) rno3780 ENSRNOP00000028595
(RGD:1308069)
Rattus norvegicus (Rno) rno3782 ENSRNOP00000034691
Rattus norvegicus (Rno) rno3781 ENSRNOP00000041440
Saccharomyces cerevisiae (Sce) sce107 YAR042W
(S000000081)
Saccharomyces cerevisiae (Sce) sce786 YDL019C
(S000002177)
Schizosaccharomyces pombe (Spo) spo3551 SPBC2F12.05c O14340
Yarrowia lipolytica (Yli) yli6052 YALI0F16940g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000138 Golgi trans cisterna C
IDA
SceS000000081
GO:0005575 cellular_component C
ND
AthAt4g08180
At4g22540
At2g31030
At4g12460
MmuMGI:2442832
GO:0005635 nuclear envelope C
IDA
SceS000000081
GO:0005737 cytoplasm C
IDA
SpoSPBC2F12.05c
GO:0005769 early endosome C
IDA
SceS000000081
GO:0005783 endoplasmic reticulum C
IDA
SceS000002177
S000000081
ISS
SpoSPBC2F12.05c
GO:0005829 cytosol C
IDA
SpoSPBC2F12.05c
GO:0005886 plasma membrane C
IDA
SceS000002177
GO:0005935 cellular bud neck C
IDA
SceS000002177
GO:0043234 protein complex C
NAS
SpoSPBC2F12.05c
GO:0003674 molecular_function F
ND
MmuMGI:2442832
GO:0005545 phosphatidylinositol binding F
ISS
SceS000002177
S000000081
SpoSPBC2F12.05c
GO:0008142 oxysterol binding F
ISS
AthAt2g31030
At4g08180
At2g31020
At4g22540
At4g12460
DmeFBgn0020626
SceS000002177
S000000081
SpoSPBC2F12.05c
NAS
DmeFBgn0020626
GO:0035091 phosphoinositide binding F
ISS
AthAt4g08180
At4g22540
GO:0006414 translational elongation P
RCA
SceS000000081
GO:0006887 exocytosis P
IGI
SceS000002177
S000000081
ISS
SpoSPBC2F12.05c
GO:0006897 endocytosis P
IGI
SceS000002177
S000000081
ISS
SpoSPBC2F12.05c
GO:0007165 signal transduction P
ISS
AthAt4g08180
At4g22540
GO:0008150 biological_process P
ND
MmuMGI:2442832
GO:0008202 steroid metabolic process P
ISS
AthAt4g22540
At4g08180
At2g31020
At4g12460
At2g31030
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012930
GO:0015918 sterol transport P
IGI
SceS000002177
S000000081
ISS
SpoSPBC2F12.05c
GO:0030011 maintenance of cell polarity P
IGI
SceS000002177
S000000081
GO:0033554 cellular response to stress P
IEP
SpoSPBC2F12.05c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC2F12.05c
(O14340)		 YDL019C
(S000002177)
SPAC23H4.01c
(O13944)		 YDL019C
(S000002177)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SpoSPBC2F12.05c
GO:0005783 endoplasmic reticulum C
IDA
SceS000002177
ISS
SpoSPBC2F12.05c
SPAC23H4.01c
GO:0005829 cytosol C
IDA
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0005886 plasma membrane C
IDA
SceS000002177
GO:0005935 cellular bud neck C
IDA
SceS000002177
GO:0043234 protein complex C
NAS
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0005545 phosphatidylinositol binding F
ISS
SceS000002177
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0008142 oxysterol binding F
ISS
SceS000002177
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0006887 exocytosis P
IGI
SceS000002177
ISS
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0006897 endocytosis P
IGI
SceS000002177
ISS
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0015918 sterol transport P
IGI
SceS000002177
ISS
SpoSPAC23H4.01c
SPBC2F12.05c
GO:0030011 maintenance of cell polarity P
IGI
SceS000002177
GO:0033554 cellular response to stress P
IEP
SpoSPBC2F12.05c

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s.khadayate@ucl.ac.uk