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Search term: YDL033C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SLM3
SGD link S000002191
Alternative ID YDL033C
Description tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
Synonyms YDL033C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2805 ACDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g51310 GI:15223816
Caenorhabditis elegans (Cel) CE26926
(WBGene00007114)		 GI:17538240 Q17440
Drosophila melanogaster (Dme) 7290113 GI:15291857
Homo sapiens (Hsa) Hs8922248 GI:8922248
Saccharomyces cerevisiae (Sce) YDL033c
(S000002191)		 GI:6320172 Q12093
Schizosaccharomyces pombe (Spo) SPAC23H4.04 GI:19114314 O13947


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000002191
SpoSPAC23H4.04
ISS
SpoSPAC23H4.04
GO:0004808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
activity		 F
IMP
SceS000002191
ISS
AthAt1g51310
SceS000002191
SpoSPAC23H4.04
GO:0006396 RNA processing P
ISS
AthAt1g51310
GO:0008033 tRNA processing P
ISS
SpoSPAC23H4.04
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000002191
GO:0032543 mitochondrial translation P
ISS
SpoSPAC23H4.04
GO:0070903 mitochondrial tRNA thio-modification P
IMP
SceS000002191

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5589

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) TRMU GI:31542641
Pan troglodytes (Ptr) TRMU GI:114686941
Canis familiaris (Cfa) TRMU GI:73969262
Mus musculus (Mmu) Trmu
(MGI:1919276)		 GI:21312518 Q9DAT5
Rattus norvegicus (Rno) Trmu GI:62652886
Gallus gallus (Gga) RCJMB04_8p20 GI:71897067
Drosophila melanogaster (Dme) CG3021
(FBgn0040337)		 GI:21357477
Anopheles gambiae (Aga) AgaP_AGAP011960 GI:158300718
Caenorhabditis elegans (Cel) B0035.16
(CE26926;
WBGene00007114)		 GI:17538240 Q17440
Schizosaccharomyces pombe (Spo) SPAC23H4.04 GI:19114314 O13947
Saccharomyces cerevisiae (Sce) SLM3
(S000002191)		 GI:6320172 Q12093
Kluyveromyces lactis (Kla) KLLA0F24706g GI:50312295
Eremothecium gossypii (Ego) AGOS_AEL087C GI:45190520
Arabidopsis thaliana (Ath) AT1G51310 GI:145336613
Oryza sativa (Osa) Os03g0174600 GI:115451057


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
MmuMGI:1919276
SceS000002191
SpoSPAC23H4.04
ISS
HsaTRMU
SpoSPAC23H4.04
GO:0003674 molecular_function F
ND
MmuMGI:1919276
GO:0004808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
activity		 F
IMP
SceS000002191
ISS
AthAt1g51310
DmeFBgn0040337
SceS000002191
SpoSPAC23H4.04
NAS
HsaTRMU
GO:0006396 RNA processing P
ISS
AthAt1g51310
GO:0006399 tRNA metabolic process P
NAS
HsaTRMU
GO:0008033 tRNA processing P
ISS
SpoSPAC23H4.04
NAS
HsaTRMU
GO:0008150 biological_process P
ND
MmuMGI:1919276
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000002191
GO:0032543 mitochondrial translation P
ISS
SpoSPAC23H4.04
GO:0070903 mitochondrial tRNA thio-modification P
IMP
SceS000002191

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1128

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9109 ENSANGP00000015341
Ashbya gossypii (Ago) ago2419 AEL087C
Arabidopsis thaliana (Ath) ath4397 At1g51310.1
Caenorhabditis elegans (Cel) cel99 B0035.16
(CE26926;
WBGene00007114)
Candida glabrata (Cgl) cgl3586 CAGL0K01529g
Cryptococcus neoformans (Cne) cne1702 164.m02036
Dictyostelium discoideum (Ddi) ddi7388 DDB0188196
Debaryomyces hansenii (Dha) dha2545 DEHA0D05599g
Drosophila melanogaster (Dme) dme15994 CG3021-PA
(FBgn0040337)
Danio rerio (Dre) dre27784 ENSDARP00000015217
Escherichia coli (Eco) eco1097 49176082
Takifugu rubripes (Fru) fru11994 SINFRUP00000162858
Gallus gallus (Gga) gga26170 ENSGALP00000021231
Gallus gallus (Gga) gga26171 ENSGALP00000021232
Gallus gallus (Gga) gga26172 ENSGALP00000021233
Homo sapiens (Hsa) hsa21883 ENSP00000290846
(TRMU)		 O75648-1
Kluyveromyces lactis (Kla) kla5180 KLLA0F24706g
Mus musculus (Mmu) mmu9459 ENSMUSP00000023019
(MGI:1919276)		 Q9DAT5
Oryza sativa (Osa) osa19137 3353.m00159
Plasmodium falciparum (Pfa) pfa412 PF10_0191
Rattus norvegicus (Rno) rno27547 ENSRNOP00000022511
(RGD:1311229)
Saccharomyces cerevisiae (Sce) sce802 YDL033C
(S000002191)
Schizosaccharomyces pombe (Spo) spo238 SPAC23H4.04 O13947
Yarrowia lipolytica (Yli) yli6393 YALI0F25069g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
MmuMGI:1919276
SceS000002191
SpoSPAC23H4.04
ISS
SpoSPAC23H4.04
GO:0003674 molecular_function F
ND
MmuMGI:1919276
GO:0004808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
activity		 F
IMP
SceS000002191
ISS
AthAt1g51310
DmeFBgn0040337
SceS000002191
SpoSPAC23H4.04
GO:0006396 RNA processing P
ISS
AthAt1g51310
GO:0008033 tRNA processing P
ISS
SpoSPAC23H4.04
GO:0008150 biological_process P
ND
MmuMGI:1919276
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000002191
GO:0032543 mitochondrial translation P
ISS
SpoSPAC23H4.04
GO:0070903 mitochondrial tRNA thio-modification P
IMP
SceS000002191

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC23H4.04
(O13947)		 YDL033C
(S000002191)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000002191
SpoSPAC23H4.04
ISS
SpoSPAC23H4.04
GO:0004808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
activity		 F
IMP
SceS000002191
ISS
SceS000002191
SpoSPAC23H4.04
GO:0008033 tRNA processing P
ISS
SpoSPAC23H4.04
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000002191
GO:0032543 mitochondrial translation P
ISS
SpoSPAC23H4.04
GO:0070903 mitochondrial tRNA thio-modification P
IMP
SceS000002191

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