Search term: YDL042C

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG2684	-CDHYPE

KOGs classification	KOGs description
INFORMATION STORAGE AND PROCESSINGINFORMATION STORAGE AND PROCESSING	Sirtuin 5 and related class III sirtuins (SIR2 family)

Species	KOG link	NCBI link	UniProt link
Caenorhabditis elegans (Cel)	CE06302 (WBGene00004800)	GI:17541892	Q21921
Drosophila melanogaster (Dme)	7298007 (FBgn0024291)	GI:17137536	Q9VK34
Homo sapiens (Hsa)	Hs13787215	GI:13787215	Q9NXA8
Homo sapiens (Hsa)	Hs22045591	GI:22045591
Homo sapiens (Hsa)	Hs6912664 (SIRT5)	GI:6912664	Q9NXA8
Homo sapiens (Hsa)	Hs7657575 (SIRT1)	GI:7657575	Q96EB6
Saccharomyces cerevisiae (Sce)	YDL042c (S000002200)	GI:6320163	P06700
Saccharomyces cerevisiae (Sce)	YDR191w (S000002599)	GI:6320397	P53688
Saccharomyces cerevisiae (Sce)	YOL068c (S000005429)	GI:6324504	P53685
Saccharomyces cerevisiae (Sce)	YOR025w (S000005551)	GI:6324599	P53687
Schizosaccharomyces pombe (Spo)	SPAC1783.04c	GI:19114571	Q9UR39
Schizosaccharomyces pombe (Spo)	SPBC16D10.07c	GI:19113294	O94640
Encephalitozoon cuniculi (Ecu)	ECU03g0460	GI:19173006	Q8SSB6

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000775	chromosome, centromeric region	C	IDA Spo SPBC16D10.07c
GO:0000781	chromosome, telomeric region	C	IDA Spo SPBC16D10.07c
GO:0000783	nuclear telomere cap complex	C	IDA Sce S000002200
GO:0000790	nuclear chromatin	C	IC Spo SPAC1783.04c SPBC16D10.07c
GO:0005634	nucleus	C	IC Sce S000005551 IDA Cel WBGene00004800 Dme FBgn0024291 Hsa SIRT1 Sce S000002599 Spo SPAC1783.04c SPBC16D10.07c
GO:0005635	nuclear envelope	C	IDA Hsa SIRT1
GO:0005654	nucleoplasm	C	IDA Dme FBgn0024291 Hsa SIRT1
GO:0005677	chromatin silencing complex	C	IDA Hsa SIRT1 Sce S000002200
GO:0005724	nuclear telomeric heterochromatin	C	IDA Sce S000002200
GO:0005730	nucleolus	C	IDA Hsa SIRT1 Sce S000002200 Spo SPAC1783.04c
GO:0005737	cytoplasm	C	IDA Dme FBgn0024291 Hsa SIRT1 Sce S000002599
GO:0016585	chromatin remodeling complex	C	ISS Spo SPAC1783.04c SPBC16D10.07c
GO:0016605	PML body	C	IDA Hsa SIRT1
GO:0030869	RENT complex	C	IDA Sce S000002200
GO:0031934	mating-type region heterochromatin	C	IDA Spo SPBC16D10.07c
GO:0033553	rDNA heterochromatin	C	IDA Hsa SIRT1
GO:0034967	Set3 complex	C	IDA Sce S000005429
GO:0002039	p53 binding	F	IPI Hsa SIRT1
GO:0003677	DNA binding	F	ISS Sce S000002599 S000005551
GO:0003714	transcription corepressor activity	F	IEP Spo SPAC1783.04c ISS Hsa SIRT1
GO:0004407	histone deacetylase activity	F	IDA Dme FBgn0024291 IMP Sce S000002599 S000005551
GO:0005515	protein binding	F	IPI Hsa SIRT1
GO:0008022	protein C-terminus binding	F	IPI Hsa SIRT1
GO:0016564	transcription repressor activity	F	IDA Hsa SIRT1
GO:0016566	specific transcriptional repressor activity	F	IEP Spo SPAC1783.04c
GO:0017136	NAD-dependent histone deacetylase activity	F	IDA Dme FBgn0024291 Hsa SIRT1 Sce S000002200 S000005429 ISS Dme FBgn0024291 TAS Spo SPAC1783.04c
GO:0019213	deacetylase activity	F	IDA Cel WBGene00004800 Hsa SIRT1
GO:0030528	transcription regulator activity	F	IC Spo SPBC16D10.07c
GO:0031491	nucleosome binding	F	IDA Sce S000002200
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	F	IDA Sce S000002200 ISS Sce S000002200
GO:0032129	histone deacetylase activity (H3-K9 specific)	F	IDA Spo SPBC16D10.07c
GO:0034979	NAD-dependent protein deacetylase activity	F	IMP Hsa SIRT1
GO:0042393	histone binding	F	IPI Hsa SIRT1
GO:0042802	identical protein binding	F	IPI Hsa SIRT1
GO:0045129	NAD-independent histone deacetylase activity	F	IDA Sce S000005429
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	F	IDA Sce S000002200 Spo SPBC16D10.07c ISS Sce S000002200
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	F	IDA Sce S000002200 Spo SPBC16D10.07c ISS Sce S000002200
GO:0070403	NAD binding	F	IDA Spo SPBC16D10.07c
GO:0000070	mitotic sister chromatid segregation	P	IMP Spo SPAC1783.04c
GO:0000077	DNA damage checkpoint	P	IMP Spo SPAC1783.04c
GO:0000183	chromatin silencing at rDNA	P	IDA Hsa SIRT1 IMP Sce S000002200
GO:0001300	chronological cell aging	P	IMP Sce S000002200
GO:0001302	replicative cell aging	P	IMP Sce S000002200 ISS Spo SPBC16D10.07c
GO:0001308	loss of chromatin silencing involved in replicative cell aging	P	TAS Sce S000002200
GO:0006260	DNA replication	P	TAS Hsa SIRT1
GO:0006281	DNA repair	P	TAS Hsa SIRT1
GO:0006303	double-strand break repair via nonhomologous end joining	P	IDA Sce S000002200
GO:0006333	chromatin assembly or disassembly	P	IDA Sce S000002200
GO:0006338	chromatin remodeling	P	ISS Spo SPAC1783.04c SPBC16D10.07c
GO:0006342	chromatin silencing	P	IGI Sce S000005429 IMP Dme FBgn0024291 Sce S000005429 TAS Hsa SIRT1
GO:0006343	establishment of chromatin silencing	P	IDA Hsa SIRT1
GO:0006344	maintenance of chromatin silencing	P	IMP Hsa SIRT1
GO:0006348	chromatin silencing at telomere	P	IGI Sce S000002599 S000005551 IMP Sce S000002200 Spo SPAC1783.04c SPBC16D10.07c IPI Sce S000002200
GO:0006357	regulation of transcription from RNA polymerase II promoter	P	IEP Spo SPBC16D10.07c
GO:0006476	protein amino acid deacetylation	P	IDA Cel WBGene00004800 Hsa SIRT1 IMP Hsa SIRT1
GO:0006642	triglyceride mobilization	P	ISS Hsa SIRT1
GO:0006974	response to DNA damage stimulus	P	IDA Hsa SIRT1 IMP Spo SPAC1783.04c
GO:0007059	chromosome segregation	P	IMP Spo SPBC16D10.07c
GO:0007568	aging	P	RCA Sce S000002200
GO:0007569	cell aging	P	TAS Hsa SIRT1
GO:0007584	response to nutrient	P	IMP Dme FBgn0024291
GO:0008156	negative regulation of DNA replication	P	IMP Sce S000002200
GO:0008340	determination of adult lifespan	P	IMP Cel WBGene00004800 Dme FBgn0024291
GO:0009267	cellular response to starvation	P	ISS Hsa SIRT1
GO:0009890	negative regulation of biosynthetic process	P	RCA Sce S000002200
GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter	P	IEP Spo SPAC1783.04c SPBC16D10.07c
GO:0016458	gene silencing	P	RCA Sce S000002200
GO:0016481	negative regulation of transcription	P	IDA Hsa SIRT1 RCA Sce S000002200
GO:0016575	histone deacetylation	P	IDA Dme FBgn0024291 Hsa SIRT1 Sce S000005429 Spo SPBC16D10.07c IMP Sce S000002599 S000005551 Spo SPAC1783.04c
GO:0030466	chromatin silencing at silent mating-type cassette	P	IGI Spo SPBC16D10.07c IMP Sce S000002200 Spo SPBC16D10.07c
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPAC1783.04c SPBC16D10.07c
GO:0031937	positive regulation of chromatin silencing	P	IMP Hsa SIRT1
GO:0033158	regulation of protein import into nucleus, translocation	P	IMP Hsa SIRT1
GO:0034339	regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	P	ISS Hsa SIRT1
GO:0034983	peptidyl-lysine deacetylation	P	IDA Hsa SIRT1
GO:0035065	regulation of histone acetylation	P	IMP Dme FBgn0024291
GO:0040024	dauer larval development	P	IGI Cel WBGene00004800
GO:0040029	regulation of gene expression, epigenetic	P	RCA Sce S000002200
GO:0042127	regulation of cell proliferation	P	IMP Hsa SIRT1
GO:0042981	regulation of apoptosis	P	IMP Dme FBgn0024291 ISS Hsa SIRT1
GO:0043433	negative regulation of transcription factor activity	P	IDA Hsa SIRT1
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	P	IDA Hsa SIRT1
GO:0045449	regulation of transcription	P	IDA Dme FBgn0024291
GO:0045599	negative regulation of fat cell differentiation	P	ISS Hsa SIRT1
GO:0045768	positive regulation of anti-apoptosis	P	TAS Hsa SIRT1
GO:0045910	negative regulation of DNA recombination	P	IGI Sce S000002200
GO:0045950	negative regulation of mitotic recombination	P	IMP Sce S000005429
GO:0046459	short-chain fatty acid metabolic process	P	IMP Sce S000002599 S000005551
GO:0050872	white fat cell differentiation	P	ISS Hsa SIRT1
GO:0051097	negative regulation of helicase activity	P	IDA Hsa SIRT1
GO:0051570	regulation of histone H3-K9 methylation	P	IMP Spo SPBC16D10.07c
GO:0060303	regulation of nucleosome density	P	IEP Spo SPAC1783.04c SPBC16D10.07c
GO:0070198	protein localization to chromosome, telomeric region	P	IGI Spo SPBC16D10.07c
GO:0070932	histone H3 deacetylation	P	IMP Spo SPAC1783.04c
GO:0071572	histone H3-K56 deacetylation	P	IMP Spo SPAC1783.04c

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
48604

Species	Gene ID	NCBI link	UniProt link
Saccharomyces cerevisiae (Sce)	SIR2 (S000002200)	GI:6320163	P06700
Saccharomyces cerevisiae (Sce)	HST1 (S000005429)	GI:6324504	P53685
Kluyveromyces lactis (Kla)	SIR2_KLULA	GI:50311429
Eremothecium gossypii (Ego)	AGOS_AEL013C	GI:45190594