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Search term: YDL046W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NPC2
SGD link S000002204
Alternative ID YDL046W
Description Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
Synonyms YDL046W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4680 A---YP-

KOGs classification KOGs description
POORLY CHARACTERIZED Uncharacterized conserved protein, contains ML domain

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g11780 GI:18399355
Arabidopsis thaliana (Ath) At3g44100 GI:15229872
Arabidopsis thaliana (Ath) At5g06480 GI:15240063
Saccharomyces cerevisiae (Sce) YDL046w
(S000002204)		 GI:6320157 Q12408
Schizosaccharomyces pombe (Spo) SPAPB8E5.04c GI:19115690 Q9C0X9


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000002204
GO:0000328 fungal-type vacuole lumen C
IDA
SceS000002204
ISS
SpoSPAPB8E5.04c
GO:0005618 cell wall C
IDA
AthAt3g44100
GO:0005773 vacuole C
IDA
AthAt3g44100
At3g11780
GO:0031225 anchored to membrane C
TAS
AthAt3g44100
GO:0003674 molecular_function F
ND
AthAt3g44100
At5g06480
At3g11780
SceS000002204
SpoSPAPB8E5.04c
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000002204
GO:0008150 biological_process P
ND
AthAt5g06480
At3g11780
At3g44100
GO:0032366 intracellular sterol transport P
IGI
SceS000002204
ISS
SceS000002204
SpoSPAPB8E5.04c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5582

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) SPAPB8E5.04c GI:19115690 Q9C0X9
Saccharomyces cerevisiae (Sce) NPC2
(S000002204)		 GI:6320157 Q12408
Kluyveromyces lactis (Kla) KLLA0E13321g GI:50309087
Eremothecium gossypii (Ego) AGOS_AER201C GI:45190804
Magnaporthe grisea (Mgr) MGG_01557 GI:145613536
Neurospora crassa (Ncr) NCU04388.1 GI:32406256


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000002204
GO:0000328 fungal-type vacuole lumen C
IDA
SceS000002204
ISS
SpoSPAPB8E5.04c
GO:0003674 molecular_function F
ND
SceS000002204
SpoSPAPB8E5.04c
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000002204
GO:0032366 intracellular sterol transport P
IGI
SceS000002204
ISS
SceS000002204
SpoSPAPB8E5.04c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3931

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago2703 AER201C
Arabidopsis thaliana (Ath) ath13302 At3g11780.1
Arabidopsis thaliana (Ath) ath15676 At3g44100.1
Arabidopsis thaliana (Ath) ath22845 At5g06480.1
Candida glabrata (Cgl) cgl3578 CAGL0K01353g
Cryptococcus neoformans (Cne) cne647 163.m06171
Dictyostelium discoideum (Ddi) ddi9434 DDB0186632
Dictyostelium discoideum (Ddi) ddi4184 DDB0191075
Dictyostelium discoideum (Ddi) ddi11250 DDB0192231
Dictyostelium discoideum (Ddi) ddi5388 DDB0205137
Dictyostelium discoideum (Ddi) ddi5152 DDB0205354
Dictyostelium discoideum (Ddi) ddi10518 DDB0215605
Dictyostelium discoideum (Ddi) ddi7743 DDB0215771
Dictyostelium discoideum (Ddi) ddi11257 DDB0219920
Dictyostelium discoideum (Ddi) ddi12403 DDB0230194
Debaryomyces hansenii (Dha) dha1710 DEHA0C06248g
Kluyveromyces lactis (Kla) kla3548 KLLA0E13321g
Neurospora crassa (Ncr) ncr4261 NCU04388.2
Oryza sativa (Osa) osa4811 2118.m00074
Oryza sativa (Osa) osa20399 3545.m00140
Oryza sativa (Osa) osa52143 5997.m00168
Oryza sativa (Osa) osa86447 9202.m00144
Saccharomyces cerevisiae (Sce) sce816 YDL046W
(S000002204)
Schizosaccharomyces pombe (Spo) spo1648 SPAPB8E5.04c Q9C0X9
Yarrowia lipolytica (Yli) yli169 YALI0A04895g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000002204
GO:0000328 fungal-type vacuole lumen C
IDA
SceS000002204
ISS
SpoSPAPB8E5.04c
GO:0005618 cell wall C
IDA
AthAt3g44100
GO:0005773 vacuole C
IDA
AthAt3g44100
At3g11780
GO:0031225 anchored to membrane C
TAS
AthAt3g44100
GO:0003674 molecular_function F
ND
AthAt3g44100
At5g06480
At3g11780
SceS000002204
SpoSPAPB8E5.04c
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000002204
GO:0008150 biological_process P
ND
AthAt5g06480
At3g11780
At3g44100
GO:0032366 intracellular sterol transport P
IGI
SceS000002204
ISS
SceS000002204
SpoSPAPB8E5.04c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAPB8E5.04c
(Q9C0X9)		 YDL046W
(S000002204)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000002204
GO:0000328 fungal-type vacuole lumen C
IDA
SceS000002204
ISS
SpoSPAPB8E5.04c
GO:0003674 molecular_function F
ND
SceS000002204
SpoSPAPB8E5.04c
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000002204
GO:0032366 intracellular sterol transport P
IGI
SceS000002204
ISS
SceS000002204
SpoSPAPB8E5.04c

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