Bahler Lab

Search term: YDL078C

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name MDH3

SGD link S000002236

Alternative ID YDL078C

Description Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle

Synonyms YDL078C

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG1494 ACDHYP-

KOGs classification KOGs description

METABOLISM NAD-dependent malate dehydrogenase

Species KOG link NCBI link UniProt link

Arabidopsis thaliana (Ath) At1g53240 GI:7769871

Arabidopsis thaliana (Ath) At2g22780 GI:15227752

Arabidopsis thaliana (Ath) At3g15020 GI:15232468

Arabidopsis thaliana (Ath) At3g47520 GI:15232820

Arabidopsis thaliana (Ath) At3g53910 GI:15232361

Arabidopsis thaliana (Ath) At5g09660 GI:15242466

Caenorhabditis elegans (Cel) CE09512
(WBGene00003162) GI:17554310 O02640

Drosophila melanogaster (Dme) 7294520 GI:7294520

Drosophila melanogaster (Dme) 7294521 GI:7294521 Q9VU28

Drosophila melanogaster (Dme) 7300357 GI:7300357

Homo sapiens (Hsa) Hs21735621
(MDH2) GI:21735621 P40926

Homo sapiens (Hsa) HsM5174541 GI:5174541

Saccharomyces cerevisiae (Sce) YDL078c
(S000002236) GI:6320125 P32419

Saccharomyces cerevisiae (Sce) YKL085w
(S000001568) GI:6322765 P17505

Saccharomyces cerevisiae (Sce) YOL126c
(S000005486) GI:6324446

Schizosaccharomyces pombe (Spo) SPCC306.08c GI:19075316 Q9Y7R8

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005618 cell wall C
IDA
Ath At1g53240

GO:0005737 cytoplasm C
IDA
Sce S000005486

GO:0005739 mitochondrion C
IDA
Ath At3g47520
At3g15020
At1g53240
Hsa MDH2
Sce S000001568
Spo SPCC306.08c
IMP
Sce S000001568
IPI
Sce S000001568
ISS
Cel WBGene00003162

GO:0005759 mitochondrial matrix C
EXP
Hsa MDH2
IDA
Sce S000001568
ISS
Spo SPCC306.08c

GO:0005773 vacuole C
IDA
Ath At5g09660

GO:0005777 peroxisome C
IDA
Ath At5g09660
At2g22780
Sce S000002236

GO:0005782 peroxisomal matrix C
TAS
Sce S000002236

GO:0005829 cytosol C
IDA
Sce S000005486

GO:0005886 plasma membrane C
IDA
Ath At3g47520

GO:0009507 chloroplast C
IDA
Ath At5g09660
At2g22780
At3g47520
At1g53240

GO:0009570 chloroplast stroma C
IDA
Ath At3g47520

GO:0009941 chloroplast envelope C
IDA
Ath At3g47520
At5g09660

GO:0010319 stromule C
IDA
Ath At3g47520

GO:0016020 membrane C
IDA
Ath At3g47520
At3g15020

GO:0042579 microbody C
ISS
Ath At5g09660

GO:0048046 apoplast C
IDA
Ath At3g47520
At3g15020
At5g09660

GO:0005507 copper ion binding F
IDA
Ath At3g15020
At1g53240

GO:0016615 malate dehydrogenase activity F
IDA
Ath At1g53240
ISS
Ath At5g09660
At2g22780
At3g47520
At3g15020

GO:0030060 L-malate dehydrogenase activity F
EXP
Hsa MDH2
IDA
Hsa MDH2
Sce S000005486
S000001568
IMP
Hsa MDH2
Sce S000002236
S000001568
S000005486
ISS
Cel WBGene00003162
Spo SPCC306.08c
TAS
Sce S000002236

GO:0001300 chronological cell aging P
IMP
Sce S000001568

GO:0001302 replicative cell aging P
IMP
Sce S000001568

GO:0006094 gluconeogenesis P
IEP
Sce S000005486
IMP
Sce S000005486

GO:0006097 glyoxylate cycle P
TAS
Sce S000002236

GO:0006099 tricarboxylic acid cycle P
IMP
Sce S000001568
ISS
Spo SPCC306.08c

GO:0006108 malate metabolic process P
IDA
Hsa MDH2
IMP
Hsa MDH2
ISS
Cel WBGene00003162
Spo SPCC306.08c
TAS
Sce S000002236
S000005486

GO:0006635 fatty acid beta-oxidation P
TAS
Sce S000002236

GO:0006735 NADH regeneration P
TAS
Sce S000002236

GO:0006793 phosphorus metabolic process P
RCA
Sce S000001568

GO:0006811 ion transport P
RCA
Sce S000001568

GO:0006898 receptor-mediated endocytosis P
IMP
Cel WBGene00003162

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00003162

GO:0009060 aerobic respiration P
IMP
Sce S000001568

GO:0009117 nucleotide metabolic process P
RCA
Sce S000001568

GO:0009409 response to cold P
IEP
Ath At1g53240
At3g47520

GO:0009651 response to salt stress P
IEP
Ath At1g53240

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00003162

GO:0016558 protein import into peroxisome
matrix P
IMP
Sce S000005486

GO:0031998 regulation of fatty acid beta-oxidation P
IGI
Ath At2g22780
At5g09660
IMP
Ath At5g09660
At2g22780

GO:0033554 cellular response to stress P
IEP
Spo SPCC306.08c

GO:0040010 positive regulation of growth rate P
IMP
Cel WBGene00003162

GO:0042742 defense response to bacterium P
IEP
Ath At1g53240
At3g15020

GO:0046686 response to cadmium ion P
IEP
Ath At1g53240

GO:0051186 cofactor metabolic process P
RCA
Sce S000001568

GO:0055114 oxidation reduction P
RCA
Sce S000001568

GO:0080093 regulation of photorespiration P
IMP
Ath At2g22780
At5g09660

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

81764

Species Gene ID NCBI link UniProt link

Saccharomyces cerevisiae (Sce) MDH3
(S000002236) GI:6320125 P32419

Kluyveromyces lactis (Kla) KLLA0F17050g GI:50311639

Eremothecium gossypii (Ego) AGOS_ADR252W GI:45188125

Magnaporthe grisea (Mgr) MGG_08835 GI:39953501

Neurospora crassa (Ncr) NCU06211.1 GI:32411171

Arabidopsis thaliana (Ath) MDH GI:15232820

Oryza sativa (Osa) Os01g0829800 GI:115440823

Oryza sativa (Osa) Os08g0434300 GI:115476564

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Ath MDH

GO:0005739 mitochondrion C
IDA
Ath MDH

GO:0005777 peroxisome C
IDA
Ath MDH
Sce S000002236

GO:0005782 peroxisomal matrix C
TAS
Sce S000002236

GO:0005829 cytosol C
IDA
Ath MDH

GO:0005886 plasma membrane C
IDA
Ath MDH

GO:0009507 chloroplast C
IDA
Ath MDH

GO:0009570 chloroplast stroma C
IDA
Ath MDH

GO:0009941 chloroplast envelope C
IDA
Ath MDH

GO:0010319 stromule C
IDA
Ath MDH

GO:0016020 membrane C
IDA
Ath MDH
ISS
Ath MDH

GO:0042579 microbody C
ISS
Ath MDH

GO:0048046 apoplast C
IDA
Ath MDH

GO:0003674 molecular_function F
ND
Ath MDH

GO:0003777 microtubule motor activity F
ISS
Ath MDH

GO:0004222 metalloendopeptidase activity F
ISS
Ath MDH

GO:0016301 kinase activity F
ISS
Ath MDH

GO:0016615 malate dehydrogenase activity F
ISS
Ath MDH

GO:0016656 monodehydroascorbate reductase (NADH)
activity F
ISS
Ath MDH

GO:0030060 L-malate dehydrogenase activity F
IMP
Sce S000002236
TAS
Sce S000002236

GO:0006097 glyoxylate cycle P
TAS
Sce S000002236

GO:0006108 malate metabolic process P
TAS
Sce S000002236

GO:0006508 proteolysis P
ISS
Ath MDH

GO:0006635 fatty acid beta-oxidation P
TAS
Sce S000002236

GO:0006735 NADH regeneration P
TAS
Sce S000002236

GO:0006952 defense response P
ISS
Ath MDH

GO:0008150 biological_process P
ND
Ath MDH

GO:0009409 response to cold P
IEP
Ath MDH

GO:0009414 response to water deprivation P
IEP
Ath MDH

GO:0009610 response to symbiotic fungus P
IEP
Ath MDH

GO:0009733 response to auxin stimulus P
ISS
Ath MDH

GO:0009753 response to jasmonic acid stimulus P
IEP
Ath MDH

GO:0031998 regulation of fatty acid beta-oxidation P
IGI
Ath MDH
IMP
Ath MDH

GO:0043903 regulation of symbiosis, encompassing mutualism
through parasitism P
IMP
Ath MDH

GO:0080093 regulation of photorespiration P
IMP
Ath MDH

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_31657

Species OrthoMCL
sequence Model organism
protein page UniProt link

Ashbya gossypii (Ago) ago1993 ADR252W

Candida glabrata (Cgl) cgl4376 CAGL0L06798g

Kluyveromyces lactis (Kla) kla4846 KLLA0F17050g

Saccharomyces cerevisiae (Sce) sce848 YDL078C
(S000002236)

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005777 peroxisome C
IDA
Sce S000002236

GO:0005782 peroxisomal matrix C
TAS
Sce S000002236

GO:0030060 L-malate dehydrogenase activity F
IMP
Sce S000002236
TAS
Sce S000002236

GO:0006097 glyoxylate cycle P
TAS
Sce S000002236

GO:0006108 malate metabolic process P
TAS
Sce S000002236

GO:0006635 fatty acid beta-oxidation P
TAS
Sce S000002236

GO:0006735 NADH regeneration P
TAS
Sce S000002236

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1494	ACDHYP-

KOGs classification	KOGs description
METABOLISM	NAD-dependent malate dehydrogenase

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g53240	GI:7769871
Arabidopsis thaliana (Ath)	At2g22780	GI:15227752
Arabidopsis thaliana (Ath)	At3g15020	GI:15232468
Arabidopsis thaliana (Ath)	At3g47520	GI:15232820
Arabidopsis thaliana (Ath)	At3g53910	GI:15232361
Arabidopsis thaliana (Ath)	At5g09660	GI:15242466
Caenorhabditis elegans (Cel)	CE09512 (WBGene00003162)	GI:17554310	O02640
Drosophila melanogaster (Dme)	7294520	GI:7294520
Drosophila melanogaster (Dme)	7294521	GI:7294521	Q9VU28
Drosophila melanogaster (Dme)	7300357	GI:7300357
Homo sapiens (Hsa)	Hs21735621 (MDH2)	GI:21735621	P40926
Homo sapiens (Hsa)	HsM5174541	GI:5174541
Saccharomyces cerevisiae (Sce)	YDL078c (S000002236)	GI:6320125	P32419
Saccharomyces cerevisiae (Sce)	YKL085w (S000001568)	GI:6322765	P17505
Saccharomyces cerevisiae (Sce)	YOL126c (S000005486)	GI:6324446
Schizosaccharomyces pombe (Spo)	SPCC306.08c	GI:19075316	Q9Y7R8

Species	Gene ID	NCBI link	UniProt link
Saccharomyces cerevisiae (Sce)	MDH3 (S000002236)	GI:6320125	P32419
Kluyveromyces lactis (Kla)	KLLA0F17050g	GI:50311639
Eremothecium gossypii (Ego)	AGOS_ADR252W	GI:45188125
Magnaporthe grisea (Mgr)	MGG_08835	GI:39953501
Neurospora crassa (Ncr)	NCU06211.1	GI:32411171
Arabidopsis thaliana (Ath)	MDH	GI:15232820
Oryza sativa (Osa)	Os01g0829800	GI:115440823
Oryza sativa (Osa)	Os08g0434300	GI:115476564

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago1993	ADR252W
Candida glabrata (Cgl)	cgl4376	CAGL0L06798g
Kluyveromyces lactis (Kla)	kla4846	KLLA0F17050g
Saccharomyces cerevisiae (Sce)	sce848	YDL078C (S000002236)