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Search term: YDL080C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name THI3
SGD link S000002238
Alternative ID YDL080C
Description Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
Synonyms YDL080C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1184 A---YP-

KOGs classification KOGs description
METABOLISMMETABOLISM Thiamine pyrophosphate-requiring enzyme

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g33070 GI:15234062
Arabidopsis thaliana (Ath) At5g01320 GI:15240950
Arabidopsis thaliana (Ath) At5g01330 GI:15240952
Arabidopsis thaliana (Ath) At5g54960 GI:15240423
Saccharomyces cerevisiae (Sce) YDL080c
(S000002238)
GI:6320123 Q07471
Saccharomyces cerevisiae (Sce) YDR380w
(S000002788)
GI:6320588 Q06408
Saccharomyces cerevisiae (Sce) YGR087c
(S000003319)
GI:6321524 P26263
Saccharomyces cerevisiae (Sce) YLR044c
(S000004034)
GI:6323073 P06169
Saccharomyces cerevisiae (Sce) YLR134w
(S000004124)
GI:6323163 P16467
Schizosaccharomyces pombe (Spo) SPAC13A11.06 GI:19113906 Q09737
Schizosaccharomyces pombe (Spo) SPAC186.09 GI:19115939 Q9P7P6
Schizosaccharomyces pombe (Spo) SPAC1F8.07c GI:19113708 Q92345
Schizosaccharomyces pombe (Spo) SPAC3G9.11c GI:19114995 O42873
Arabidopsis thaliana (Ath) At4g33070 GI:15234062
Arabidopsis thaliana (Ath) At5g01320 GI:15240950
Arabidopsis thaliana (Ath) At5g01330 GI:15240952
Arabidopsis thaliana (Ath) At5g54960 GI:15240423
Saccharomyces cerevisiae (Sce) YDL080c
(S000002238)
GI:6320123 Q07471
Saccharomyces cerevisiae (Sce) YDR380w
(S000002788)
GI:6320588 Q06408
Saccharomyces cerevisiae (Sce) YGR087c
(S000003319)
GI:6321524 P26263
Saccharomyces cerevisiae (Sce) YLR044c
(S000004034)
GI:6323073 P06169
Saccharomyces cerevisiae (Sce) YLR134w
(S000004124)
GI:6323163 P16467
Schizosaccharomyces pombe (Spo) SPAC13A11.06 GI:19113906 Q09737
Schizosaccharomyces pombe (Spo) SPAC186.09 GI:19115939 Q9P7P6
Schizosaccharomyces pombe (Spo) SPAC1F8.07c GI:19113708 Q92345
Schizosaccharomyces pombe (Spo) SPAC3G9.11c GI:19114995 O42873


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g01320
At5g54960
SpoSPAC1F8.07c
GO:0005634 nucleus C
IDA
SceS000004034
S000002238
S000004124
SpoSPAC3G9.11c
SPAC13A11.06
SPAC186.09
GO:0005737 cytoplasm C
IDA
SceS000003319
S000004124
S000004034
S000002788
GO:0005829 cytosol C
IDA
SceS000002238
S000004034
SpoSPAC3G9.11c
SPAC13A11.06
SPAC186.09
GO:0016020 membrane C
IDA
AthAt4g33070
GO:0004737 pyruvate decarboxylase activity F
IDA
SceS000004034
S000004124
IGI
SceS000004124
IMP
SceS000003319
ISS
AthAt5g01320
At5g01330
At4g33070
At5g54960
SceS000002788
SpoSPAC1F8.07c
SPAC13A11.06
SPAC186.09
GO:0016831 carboxy-lyase activity F
IMP
SceS000002788
S000002238
ISS
SceS000002238
S000002788
GO:0050177 phenylpyruvate decarboxylase activity F
IDA
SceS000002788
GO:0000949 aromatic amino acid family catabolic process to
alcohol via Ehrlich pathway
P
IGI
SceS000003319
S000002788
S000004034
S000004124
ISS
SpoSPAC13A11.06
GO:0000950 branched chain family amino acid catabolic process
to alcohol via Ehrlich pathway
P
IGI
SceS000002238
S000002788
GO:0000951 methionine catabolic process to
3-methylthiopropanol
P
IMP
SceS000002788
GO:0001666 response to hypoxia P
IEP
AthAt5g54960
GO:0006066 alcohol metabolic process P
RCA
SceS000004034
GO:0006067 ethanol metabolic process P
IMP
SceS000003319
GO:0006082 organic acid metabolic process P
RCA
SceS000004034
GO:0006090 pyruvate metabolic process P
IDA
SceS000004124
S000004034
IGI
SceS000004124
ISS
SpoSPAC1F8.07c
SPAC13A11.06
SPAC186.09
NAS
SpoSPAC3G9.11c
GO:0006091 generation of precursor metabolites and
energy
P
NAS
SpoSPAC3G9.11c
SPAC186.09
SPAC1F8.07c
GO:0006417 regulation of translation P
RCA
SceS000004034
GO:0006552 leucine catabolic process P
IGI
SceS000002238
S000002788
IMP
SceS000002788
GO:0006559 L-phenylalanine catabolic process P
IDA
SceS000002788
IGI
SceS000002788
S000003319
S000004034
S000004124
GO:0006569 tryptophan catabolic process P
IGI
SceS000002788
S000004034
S000003319
S000004124
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000003319
GO:0008152 metabolic process P
NAS
SpoSPAC1F8.07c
GO:0009063 cellular amino acid catabolic process P
ISS
SpoSPAC186.09
SPAC3G9.11c
SPAC1F8.07c
GO:0019655 glucose catabolic process to ethanol P
IDA
SceS000004034
S000004124
IGI
SceS000004124
ISS
SpoSPAC13A11.06
GO:0044237 cellular metabolic process P
NAS
SpoSPAC1F8.07c
GO:0044238 primary metabolic process P
NAS
SpoSPAC1F8.07c
GO:0044262 cellular carbohydrate metabolic
process
P
RCA
SceS000004034
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter
P
IMP
SceS000002238
GO:0070623 regulation of thiamin biosynthetic
process
P
IMP
SceS000002238
IPI
SceS000002238

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_59994

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Candida glabrata (Cgl) cgl4378 CAGL0L06842g
Saccharomyces cerevisiae (Sce) sce850 YDL080C
(S000002238)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002238
GO:0005829 cytosol C
IDA
SceS000002238
GO:0016831 carboxy-lyase activity F
IMP
SceS000002238
ISS
SceS000002238
GO:0000950 branched chain family amino acid catabolic process
to alcohol via Ehrlich pathway
P
IGI
SceS000002238
GO:0006552 leucine catabolic process P
IGI
SceS000002238
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter
P
IMP
SceS000002238
GO:0070623 regulation of thiamin biosynthetic
process
P
IMP
SceS000002238
IPI
SceS000002238

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPAC3G9.11c
(O42873)
YDL080C
(S000002238)
SPAC13A11.06
(Q09737)
YDL080C
(S000002238)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002238
SpoSPAC3G9.11c
SPAC13A11.06
GO:0005829 cytosol C
IDA
SceS000002238
SpoSPAC3G9.11c
SPAC13A11.06
GO:0004737 pyruvate decarboxylase activity F
ISS
SpoSPAC13A11.06
GO:0016831 carboxy-lyase activity F
IMP
SceS000002238
ISS
SceS000002238
GO:0000949 aromatic amino acid family catabolic process to
alcohol via Ehrlich pathway
P
ISS
SpoSPAC13A11.06
GO:0000950 branched chain family amino acid catabolic process
to alcohol via Ehrlich pathway
P
IGI
SceS000002238
GO:0006090 pyruvate metabolic process P
ISS
SpoSPAC13A11.06
NAS
SpoSPAC3G9.11c
GO:0006091 generation of precursor metabolites and
energy
P
NAS
SpoSPAC3G9.11c
GO:0006552 leucine catabolic process P
IGI
SceS000002238
GO:0009063 cellular amino acid catabolic process P
ISS
SpoSPAC3G9.11c
GO:0019655 glucose catabolic process to ethanol P
ISS
SpoSPAC13A11.06
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter
P
IMP
SceS000002238
GO:0070623 regulation of thiamin biosynthetic
process
P
IMP
SceS000002238
IPI
SceS000002238

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s.khadayate@ucl.ac.uk