Search term: YDL108W

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0659	ACDHYPE

KOGs classification	KOGs description
CELLULAR PROCESSES AND SIGNALINGINFORMATION STORAGE AND PROCESSINGINFORMATION STORAGE AND PROCESSING	Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g18040	GI:15220917
Arabidopsis thaliana (Ath)	At1g66750	GI:15219730
Arabidopsis thaliana (Ath)	At1g73690	GI:15219522
Caenorhabditis elegans (Cel)	CE11556	GI:17540938
Caenorhabditis elegans (Cel)	CE26988	GI:17509903
Drosophila melanogaster (Dme)	7290565 (FBgn0015617)	GI:17530793
Drosophila melanogaster (Dme)	7300773	GI:7300773	Q9VD82
Homo sapiens (Hsa)	Hs4502743 (CDK7)	GI:4502743	P50613
Homo sapiens (Hsa)	Hs7106269	GI:7106269
Saccharomyces cerevisiae (Sce)	YDL108w (S000002266)	GI:6320095	P06242
Schizosaccharomyces pombe (Spo)	SPBC19F8.07	GI:19113141	Q12126
Encephalitozoon cuniculi (Ecu)	ECU02g1450	GI:19074064	Q8SW92
Arabidopsis thaliana (Ath)	At1g18040	GI:15220917
Arabidopsis thaliana (Ath)	At1g66750	GI:15219730
Arabidopsis thaliana (Ath)	At1g73690	GI:15219522
Caenorhabditis elegans (Cel)	CE11556	GI:17540938
Caenorhabditis elegans (Cel)	CE26988	GI:17509903
Drosophila melanogaster (Dme)	7290565 (FBgn0015617)	GI:17530793
Drosophila melanogaster (Dme)	7300773	GI:7300773	Q9VD82
Homo sapiens (Hsa)	Hs4502743 (CDK7)	GI:4502743	P50613
Homo sapiens (Hsa)	Hs7106269	GI:7106269
Saccharomyces cerevisiae (Sce)	YDL108w (S000002266)	GI:6320095	P06242
Schizosaccharomyces pombe (Spo)	SPBC19F8.07	GI:19113141	Q12126
Encephalitozoon cuniculi (Ecu)	ECU02g1450	GI:19074064	Q8SW92

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005634	nucleus	C	IDA Ath At1g73690 At1g18040 At1g66750 Hsa CDK7 Spo SPBC19F8.07
GO:0005654	nucleoplasm	C	EXP Hsa CDK7
GO:0005675	holo TFIIH complex	C	IDA Hsa CDK7 Sce S000002266 ISS Dme FBgn0015617 Spo SPBC19F8.07
GO:0005737	cytoplasm	C	IDA Ath At1g66750 Hsa CDK7 Spo SPBC19F8.07
GO:0005739	mitochondrion	C	IDA Hsa CDK7
GO:0005829	cytosol	C	IDA Spo SPBC19F8.07
GO:0070985	TFIIK complex	C	IDA Sce S000002266
GO:0003713	transcription coactivator activity	F	NAS Hsa CDK7
GO:0004672	protein kinase activity	F	IDA Hsa CDK7 TAS Ath At1g18040
GO:0004674	protein serine/threonine kinase activity	F	IDA Dme FBgn0015617 NAS Dme FBgn0015617 TAS Ath At1g66750
GO:0004693	cyclin-dependent protein kinase activity	F	ISS Dme FBgn0015617 NAS Spo SPBC19F8.07 TAS Hsa CDK7
GO:0005515	protein binding	F	IPI Ath At1g66750
GO:0008022	protein C-terminus binding	F	IPI Hsa CDK7
GO:0008094	DNA-dependent ATPase activity	F	IDA Hsa CDK7
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	F	IDA Hsa CDK7 Sce S000002266 Spo SPBC19F8.07
GO:0016251	general RNA polymerase II transcription factor activity	F	IDA Sce S000002266 ISS Dme FBgn0015617 Spo SPBC19F8.07
GO:0016301	kinase activity	F	ISS Ath At1g66750 At1g73690 At1g18040
GO:0019912	cyclin-dependent protein kinase activating kinase activity	F	IGI Spo SPBC19F8.07
GO:0050681	androgen receptor binding	F	NAS Hsa CDK7
GO:0000079	regulation of cyclin-dependent protein kinase activity	P	IDA Dme FBgn0015617 TAS Ath At1g66750 Hsa CDK7
GO:0000718	nucleotide-excision repair, DNA damage removal	P	EXP Hsa CDK7
GO:0006366	transcription from RNA polymerase II promoter	P	IDA Hsa CDK7
GO:0006367	transcription initiation from RNA polymerase II promoter	P	EXP Hsa CDK7 ISS Dme FBgn0015617
GO:0006368	RNA elongation from RNA polymerase II promoter	P	EXP Hsa CDK7
GO:0006468	protein amino acid phosphorylation	P	IC Spo SPBC19F8.07 IDA Dme FBgn0015617 NAS Dme FBgn0015617
GO:0007067	mitosis	P	IMP Dme FBgn0015617
GO:0007346	regulation of mitotic cell cycle	P	IGI Spo SPBC19F8.07
GO:0008283	cell proliferation	P	TAS Hsa CDK7
GO:0030154	cell differentiation	P	TAS Ath At1g73690
GO:0030521	androgen receptor signaling pathway	P	NAS Hsa CDK7
GO:0032568	general transcription from RNA polymerase II promoter	P	IDA Sce S000002266 IMP Sce S000002266
GO:0042327	positive regulation of phosphorylation	P	IGI Spo SPBC19F8.07
GO:0045893	positive regulation of transcription, DNA-dependent	P	NAS Hsa CDK7
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	P	IDA Hsa CDK7 ISS Spo SPBC19F8.07
GO:0051726	regulation of cell cycle	P	TAS Ath At1g73690 At1g18040
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	P	IDA Sce S000002266 IMP Spo SPBC19F8.07
GO:0070817	P-TEFb-cap methyltransferase complex localization	P	IMP Spo SPBC19F8.07
GO:0090039	regulation of gene-specific transcription elongation from RNA polymerase II promoter	P	IMP Spo SPBC19F8.07

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
1363

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	CDK7	GI:4502743	P50613
Pan troglodytes (Ptr)	CDK7	GI:114599911
Canis familiaris (Cfa)	CDK7	GI:73949665
Mus musculus (Mmu)	Cdk7 (MGI:102956)	GI:33859522	Q03147
Rattus norvegicus (Rno)	Cdk7 (RGD:621124)	GI:34853514
Drosophila melanogaster (Dme)	Cdk7 (FBgn0015617)	GI:17530793
Anopheles gambiae (Aga)	AgaP_AGAP002646	GI:158290711
Caenorhabditis elegans (Cel)	cdk-7 (CE30320; WBGene00000408)	GI:25145738
Schizosaccharomyces pombe (Spo)	crk1	GI:19113141
Saccharomyces cerevisiae (Sce)	KIN28 (S000002266)	GI:6320095	P06242
Kluyveromyces lactis (Kla)	KLLA0E14828g	GI:50309219
Eremothecium gossypii (Ego)	AGOS_ADL283W	GI:45187590
Magnaporthe grisea (Mgr)	MGG_13401	GI:145609287
Neurospora crassa (Ncr)	NCU03659.1	GI:32404696
Arabidopsis thaliana (Ath)	CAK4	GI:15219730

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005575	cellular_component	C	ND Cel WBGene00000408
GO:0005624	membrane fraction	C	ISO Mmu MGI:102956
GO:0005634	nucleus	C	IDA Ath CAK4 Hsa CDK7 Mmu MGI:102956 ISO Mmu MGI:102956
GO:0005654	nucleoplasm	C	EXP Hsa CDK7
GO:0005675	holo TFIIH complex	C	IDA Hsa CDK7 Sce S000002266 ISS Dme FBgn0015617
GO:0005737	cytoplasm	C	IDA Ath CAK4 Hsa CDK7
GO:0005739	mitochondrion	C	IDA Hsa CDK7
GO:0005829	cytosol	C	ISO Mmu MGI:102956
GO:0005856	cytoskeleton	C	ISO Mmu MGI:102956
GO:0070985	TFIIK complex	C	IDA Sce S000002266
GO:0003713	transcription coactivator activity	F	NAS Hsa CDK7
GO:0004672	protein kinase activity	F	IDA Hsa CDK7 Mmu MGI:102956
GO:0004674	protein serine/threonine kinase activity	F	IDA Dme FBgn0015617 NAS Dme FBgn0015617 TAS Ath CAK4
GO:0004693	cyclin-dependent protein kinase activity	F	ISO Mmu MGI:102956 ISS Cel WBGene00000408 Dme FBgn0015617 Mmu MGI:102956 TAS Hsa CDK7
GO:0005515	protein binding	F	IPI Ath CAK4 Mmu MGI:102956
GO:0008022	protein C-terminus binding	F	IPI Hsa CDK7
GO:0008094	DNA-dependent ATPase activity	F	IDA Hsa CDK7
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	F	IDA Hsa CDK7 Sce S000002266
GO:0016251	general RNA polymerase II transcription factor activity	F	IDA Sce S000002266 ISS Dme FBgn0015617
GO:0016301	kinase activity	F	IDA Mmu MGI:102956 ISS Ath CAK4
GO:0032403	protein complex binding	F	ISO Mmu MGI:102956
GO:0050681	androgen receptor binding	F	NAS Hsa CDK7
GO:0000079	regulation of cyclin-dependent protein kinase activity	P	IDA Dme FBgn0015617 TAS Ath CAK4 Hsa CDK7
GO:0000718	nucleotide-excision repair, DNA damage removal	P	EXP Hsa CDK7
GO:0006366	transcription from RNA polymerase II promoter	P	IDA Hsa CDK7
GO:0006367	transcription initiation from RNA polymerase II promoter	P	EXP Hsa CDK7 ISS Dme FBgn0015617
GO:0006368	RNA elongation from RNA polymerase II promoter	P	EXP Hsa CDK7
GO:0006468	protein amino acid phosphorylation	P	IDA Dme FBgn0015617 ISO Mmu MGI:102956 ISS Cel WBGene00000408 NAS Dme FBgn0015617
GO:0007049	cell cycle	P	ISS Mmu MGI:102956
GO:0007067	mitosis	P	IMP Dme FBgn0015617
GO:0008283	cell proliferation	P	TAS Hsa CDK7
GO:0009299	mRNA transcription	P	IDA Cel WBGene00000408
GO:0009792	embryo development ending in birth or egg hatching	P	IMP Cel WBGene00000408
GO:0016310	phosphorylation	P	IDA Mmu MGI:102956 ISS Mmu MGI:102956
GO:0030521	androgen receptor signaling pathway	P	NAS Hsa CDK7
GO:0032568	general transcription from RNA polymerase II promoter	P	IDA Sce S000002266 IMP Sce S000002266
GO:0045448	mitotic cell cycle, embryonic	P	IMP Cel WBGene00000408
GO:0045893	positive regulation of transcription, DNA-dependent	P	NAS Hsa CDK7
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	P	IDA Hsa CDK7
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	P	IDA Sce S000002266

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_2769

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga4861	ENSANGP00000002848
Ashbya gossypii (Ago)	ago1458	ADL283W
Arabidopsis thaliana (Ath)	ath1935	At1g18040.1
Arabidopsis thaliana (Ath)	ath5905	At1g66750.1
Arabidopsis thaliana (Ath)	ath6671	At1g73690.1
Caenorhabditis elegans (Cel)	cel18578	Y39G10AL.3 (CE30320; WBGene00000408)
Candida glabrata (Cgl)	cgl2513	CAGL0H10318g
Cryptococcus neoformans (Cne)	cne2876	183.m01889
Cryptococcus neoformans (Cne)	cne2877	183.m01890
Dictyostelium discoideum (Ddi)	ddi12974	DDB0191429
Debaryomyces hansenii (Dha)	dha6705	DEHA0G22528g
Drosophila melanogaster (Dme)	dme16552	CG3319-PA (FBgn0015617)
Danio rerio (Dre)	dre31290	ENSDARP00000007199
Danio rerio (Dre)	dre19827	ENSDARP00000042043
Encephalitozoon cuniculi (Ecu)	ecu143	19074064
Takifugu rubripes (Fru)	fru14601	SINFRUP00000151161
Gallus gallus (Gga)	gga27600	ENSGALP00000023830 (CDK7)
Homo sapiens (Hsa)	hsa25323	ENSP00000256443 (CDK7)	P50613
Kluyveromyces lactis (Kla)	kla3615	KLLA0E14828g
Mus musculus (Mmu)	mmu31484	ENSMUSP00000073298
Mus musculus (Mmu)	mmu7473	ENSMUSP00000078328
Neurospora crassa (Ncr)	ncr3550	NCU03659.2
Oryza sativa (Osa)	osa26090	3916.m00171
Oryza sativa (Osa)	osa26758	3954.m00117
Rattus norvegicus (Rno)	rno15438	ENSRNOP00000025026 (RGD:621124)	P51952
Saccharomyces cerevisiae (Sce)	sce880	YDL108W (S000002266)
Schizosaccharomyces pombe (Spo)	spo1333	SPBC19F8.07	Q12126
Yarrowia lipolytica (Yli)	yli2884	YALI0D04334g

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005575	cellular_component	C	ND Cel WBGene00000408
GO:0005634	nucleus	C	IDA Ath At1g73690 At1g18040 At1g66750 Spo SPBC19F8.07
GO:0005675	holo TFIIH complex	C	IDA Sce S000002266 ISS Dme FBgn0015617 Spo SPBC19F8.07
GO:0005737	cytoplasm	C	IDA Ath At1g66750 Spo SPBC19F8.07
GO:0005829	cytosol	C	IDA Spo SPBC19F8.07
GO:0070985	TFIIK complex	C	IDA Sce S000002266
GO:0004672	protein kinase activity	F	TAS Ath At1g18040
GO:0004674	protein serine/threonine kinase activity	F	IDA Dme FBgn0015617 NAS Dme FBgn0015617 TAS Ath At1g66750
GO:0004693	cyclin-dependent protein kinase activity	F	ISS Cel WBGene00000408 Dme FBgn0015617 NAS Spo SPBC19F8.07
GO:0005515	protein binding	F	IPI Ath At1g66750
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	F	IDA Sce S000002266 Spo SPBC19F8.07
GO:0016251	general RNA polymerase II transcription factor activity	F	IDA Sce S000002266 ISS Dme FBgn0015617 Spo SPBC19F8.07
GO:0016301	kinase activity	F	ISS Ath At1g66750 At1g73690 At1g18040
GO:0019912	cyclin-dependent protein kinase activating kinase activity	F	IGI Spo SPBC19F8.07
GO:0000079	regulation of cyclin-dependent protein kinase activity	P	IDA Dme FBgn0015617 TAS Ath At1g66750
GO:0006367	transcription initiation from RNA polymerase II promoter	P	ISS Dme FBgn0015617
GO:0006468	protein amino acid phosphorylation	P	IC Spo SPBC19F8.07 IDA Dme FBgn0015617 ISS Cel WBGene00000408 NAS Dme FBgn0015617
GO:0007067	mitosis	P	IMP Dme FBgn0015617
GO:0007346	regulation of mitotic cell cycle	P	IGI Spo SPBC19F8.07
GO:0009299	mRNA transcription	P	IDA Cel WBGene00000408
GO:0009792	embryo development ending in birth or egg hatching	P	IMP Cel WBGene00000408
GO:0030154	cell differentiation	P	TAS Ath At1g73690
GO:0032568	general transcription from RNA polymerase II promoter	P	IDA Sce S000002266 IMP Sce S000002266
GO:0042327	positive regulation of phosphorylation	P	IGI Spo SPBC19F8.07
GO:0045448	mitotic cell cycle, embryonic	P	IMP Cel WBGene00000408
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	P	ISS Spo SPBC19F8.07
GO:0051726	regulation of cell cycle	P	TAS Ath At1g73690 At1g18040
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	P	IDA Sce S000002266 IMP Spo SPBC19F8.07
GO:0070817	P-TEFb-cap methyltransferase complex localization	P	IMP Spo SPBC19F8.07
GO:0090039	regulation of gene-specific transcription elongation from RNA polymerase II promoter	P	IMP Spo SPBC19F8.07

Curated yeast ortholog results:

S. pombe systematic ID	S. cerevisiae systematic ID
SPBC19F8.07 (Q12126)	YDL108W (S000002266)

GO terms for curated homolog results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005634	nucleus	C	IDA Spo SPBC19F8.07
GO:0005675	holo TFIIH complex	C	IDA Sce S000002266 ISS Spo SPBC19F8.07
GO:0005737	cytoplasm	C	IDA Spo SPBC19F8.07
GO:0005829	cytosol	C	IDA Spo SPBC19F8.07
GO:0070985	TFIIK complex	C	IDA Sce S000002266
GO:0004693	cyclin-dependent protein kinase activity	F	NAS Spo SPBC19F8.07
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	F	IDA Sce S000002266 Spo SPBC19F8.07
GO:0016251	general RNA polymerase II transcription factor activity	F	IDA Sce S000002266 ISS Spo SPBC19F8.07
GO:0019912	cyclin-dependent protein kinase activating kinase activity	F	IGI Spo SPBC19F8.07
GO:0006468	protein amino acid phosphorylation	P	IC Spo SPBC19F8.07
GO:0007346	regulation of mitotic cell cycle	P	IGI Spo SPBC19F8.07
GO:0032568	general transcription from RNA polymerase II promoter	P	IDA Sce S000002266 IMP Sce S000002266
GO:0042327	positive regulation of phosphorylation	P	IGI Spo SPBC19F8.07
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	P	ISS Spo SPBC19F8.07
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	P	IDA Sce S000002266 IMP Spo SPBC19F8.07
GO:0070817	P-TEFb-cap methyltransferase complex localization	P	IMP Spo SPBC19F8.07
GO:0090039	regulation of gene-specific transcription elongation from RNA polymerase II promoter	P	IMP Spo SPBC19F8.07