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Search term: YDL126C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name CDC48
SGD link S000002284
Alternative ID YDL126C
Description ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
Synonyms YDL126C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0730 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING AAA+-type ATPase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g03670 GI:15227690
Arabidopsis thaliana (Ath) At3g09840 GI:15232776
Arabidopsis thaliana (Ath) At3g24530 GI:15230128
Arabidopsis thaliana (Ath) At3g53230 GI:15231775
Arabidopsis thaliana (Ath) At4g04180 GI:15233417
Arabidopsis thaliana (Ath) At5g03340 GI:11265361
Caenorhabditis elegans (Cel) CE02114
(WBGene00007352)
GI:17531535 P54811
Caenorhabditis elegans (Cel) CE05402
(WBGene00008053)
GI:17532375 P54812
Caenorhabditis elegans (Cel) CE06097
(WBGene00010562)
GI:17508053 Q21222
Drosophila melanogaster (Dme) 7292363 GI:7292363 Q9VZQ0
Drosophila melanogaster (Dme) 7297973
(FBgn0032450)
GI:19921202
Drosophila melanogaster (Dme) 7303816 GI:17137560
Homo sapiens (Hsa) Hs13129040
(SPATA5L1)
GI:13129040
Homo sapiens (Hsa) Hs18583802 GI:18583802
Homo sapiens (Hsa) Hs20532580 GI:20532580
Homo sapiens (Hsa) Hs21624654 GI:19880131 Q8NB90
Homo sapiens (Hsa) Hs6005942
(VCP)
GI:6005942 P55072
Saccharomyces cerevisiae (Sce) YDL126c
(S000002284)
GI:6320077 P25694
Saccharomyces cerevisiae (Sce) YLR397c
(S000004389)
GI:6323429 P32794
Schizosaccharomyces pombe (Spo) SPAC1565.08 GI:19114199 Q9P3A7
Schizosaccharomyces pombe (Spo) SPBC56F2.07c GI:19113502 O60058
Encephalitozoon cuniculi (Ecu) ECU01g1230 GI:19075136
Encephalitozoon cuniculi (Ecu) ECU05g1140 GI:19173654 Q8SRV6
Arabidopsis thaliana (Ath) At2g03670 GI:15227690
Arabidopsis thaliana (Ath) At3g09840 GI:15232776
Arabidopsis thaliana (Ath) At3g24530 GI:15230128
Arabidopsis thaliana (Ath) At3g53230 GI:15231775
Arabidopsis thaliana (Ath) At4g04180 GI:15233417
Arabidopsis thaliana (Ath) At5g03340 GI:11265361
Caenorhabditis elegans (Cel) CE02114
(WBGene00007352)
GI:17531535 P54811
Caenorhabditis elegans (Cel) CE05402
(WBGene00008053)
GI:17532375 P54812
Caenorhabditis elegans (Cel) CE06097
(WBGene00010562)
GI:17508053 Q21222
Drosophila melanogaster (Dme) 7292363 GI:7292363 Q9VZQ0
Drosophila melanogaster (Dme) 7297973
(FBgn0032450)
GI:19921202
Drosophila melanogaster (Dme) 7303816 GI:17137560
Homo sapiens (Hsa) Hs13129040
(SPATA5L1)
GI:13129040
Homo sapiens (Hsa) Hs18583802 GI:18583802
Homo sapiens (Hsa) Hs20532580 GI:20532580
Homo sapiens (Hsa) Hs21624654 GI:19880131 Q8NB90
Homo sapiens (Hsa) Hs6005942
(VCP)
GI:6005942 P55072
Saccharomyces cerevisiae (Sce) YDL126c
(S000002284)
GI:6320077 P25694
Saccharomyces cerevisiae (Sce) YLR397c
(S000004389)
GI:6323429 P32794
Schizosaccharomyces pombe (Spo) SPAC1565.08 GI:19114199 Q9P3A7
Schizosaccharomyces pombe (Spo) SPBC56F2.07c GI:19113502 O60058
Encephalitozoon cuniculi (Ecu) ECU01g1230 GI:19075136
Encephalitozoon cuniculi (Ecu) ECU05g1140 GI:19173654 Q8SRV6


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
IDA
HsaVCP
GO:0000790 nuclear chromatin C
IDA
SpoSPAC1565.08
GO:0000837 Doa10p ubiquitin ligase complex C
IDA
SceS000002284
GO:0005618 cell wall C
IDA
AthAt5g03340
At3g09840
GO:0005622 intracellular C
IDA
SceS000004389
GO:0005634 nucleus C
IDA
AthAt3g09840
CelWBGene00008053
WBGene00007352
HsaVCP
SceS000002284
SpoSPAC1565.08
TAS
HsaVCP
GO:0005635 nuclear envelope C
IDA
AthAt3g09840
GO:0005730 nucleolus C
IDA
AthAt3g53230
At3g09840
GO:0005737 cytoplasm C
IDA
AthAt3g09840
HsaVCP
SpoSPAC1565.08
GO:0005783 endoplasmic reticulum C
IDA
HsaVCP
ISS
DmeFBgn0032450
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000002284
ISS
SpoSPAC1565.08
GO:0005792 microsome C
IDA
SceS000002284
ISS
HsaVCP
GO:0005819 spindle C
IDA
AthAt3g09840
GO:0005829 cytosol C
IDA
AthAt3g53230
HsaVCP
SceS000002284
SpoSPAC1565.08
SPBC56F2.07c
GO:0005886 plasma membrane C
IDA
AthAt3g53230
At3g09840
GO:0009507 chloroplast C
IDA
AthAt3g24530
GO:0009524 phragmoplast C
IDA
AthAt3g09840
GO:0022626 cytosolic ribosome C
IDA
AthAt3g09840
GO:0030687 preribosome, large subunit precursor C
IDA
SceS000004389
IMP
SceS000004389
GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex C
IDA
SceS000002284
IPI
CelWBGene00008053
WBGene00007352
ISS
SpoSPAC1565.08
GO:0043332 mating projection tip C
IDA
SceS000002284
GO:0005515 protein binding F
IPI
AthAt5g03340
HsaVCP
SpoSPAC1565.08
GO:0005524 ATP binding F
ISS
AthAt3g53230
SpoSPBC56F2.07c
GO:0016887 ATPase activity F
IDA
CelWBGene00010562
SceS000002284
S000004389
ISS
AthAt4g04180
At5g03340
At3g09840
At3g24530
At2g03670
DmeFBgn0032450
SpoSPAC1565.08
SPBC56F2.07c
TAS
HsaVCP
GO:0019901 protein kinase binding F
IPI
CelWBGene00010562
GO:0019903 protein phosphatase binding F
IPI
HsaVCP
GO:0019904 protein domain specific binding F
IPI
HsaVCP
GO:0031593 polyubiquitin binding F
IDA
HsaVCP
GO:0042802 identical protein binding F
IPI
AthAt3g09840
GO:0000003 reproduction P
IMP
CelWBGene00007352
WBGene00010562
GO:0000278 mitotic cell cycle P
IMP
SceS000002284
GO:0000910 cytokinesis P
IMP
CelWBGene00007352
WBGene00008053
GO:0002119 nematode larval development P
IMP
CelWBGene00008053
WBGene00007352
WBGene00010562
GO:0006200 ATP catabolic process P
ISS
SpoSPAC1565.08
SPBC56F2.07c
GO:0006281 DNA repair P
NAS
HsaVCP
GO:0006302 double-strand break repair P
IDA
HsaVCP
GO:0006469 negative regulation of protein kinase
activity
P
IDA
CelWBGene00010562
GO:0006508 proteolysis P
RCA
SceS000002284
GO:0006511 ubiquitin-dependent protein catabolic
process
P
IDA
SceS000002284
IGI
SpoSPAC1565.08
IPI
SceS000002284
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00010562
GO:0006906 vesicle fusion P
IDA
SceS000002284
ISS
SpoSPAC1565.08
GO:0006919 activation of caspase activity P
ISS
HsaVCP
GO:0006974 response to DNA damage stimulus P
IDA
HsaVCP
GO:0007052 mitotic spindle organization P
IMP
CelWBGene00010562
GO:0007059 chromosome segregation P
IGI
SpoSPAC1565.08
GO:0007067 mitosis P
IMP
CelWBGene00010562
GO:0007091 mitotic metaphase/anaphase transition P
IMP
CelWBGene00010562
GO:0007126 meiosis P
IMP
CelWBGene00008053
WBGene00007352
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC1565.08
GO:0008219 cell death P
RCA
SceS000002284
GO:0009792 embryo development ending in birth or egg
hatching
P
IGI
CelWBGene00008053
WBGene00007352
IMP
CelWBGene00008053
WBGene00010562
WBGene00007352
GO:0009846 pollen germination P
IMP
AthAt3g09840
GO:0009860 pollen tube growth P
IMP
AthAt3g09840
GO:0015031 protein transport P
IDA
SceS000002284
GO:0016567 protein ubiquitination P
NAS
HsaVCP
GO:0019538 protein metabolic process P
ISS
AthAt3g24530
GO:0030433 ER-associated protein catabolic
process
P
IMP
SceS000002284
ISS
SpoSPAC1565.08
TAS
HsaVCP
GO:0030435 sporulation resulting in formation of a cellular
spore
P
RCA
SceS000002284
GO:0030968 endoplasmic reticulum unfolded protein
response
P
IMP
CelWBGene00008053
WBGene00007352
TAS
HsaVCP
GO:0030970 retrograde protein transport, ER to
cytosol
P
IDA
HsaVCP
ISS
SpoSPAC1565.08
GO:0031134 sister chromatid biorientation P
IMP
SceS000002284
GO:0032436 positive regulation of proteasomal
ubiquitin-dependent protein catabolic
process
P
IDA
HsaVCP
GO:0033554 cellular response to stress P
IGI
SpoSPAC1565.08
GO:0040002 collagen and cuticulin-based cuticle
development
P
IMP
CelWBGene00007352
GO:0040007 growth P
IMP
CelWBGene00010562
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00008053
WBGene00010562
GO:0040011 locomotion P
IMP
CelWBGene00007352
WBGene00008053
GO:0040018 positive regulation of multicellular organism
growth
P
IMP
CelWBGene00007352
GO:0042254 ribosome biogenesis P
ISS
SpoSPBC56F2.07c
GO:0042273 ribosomal large subunit biogenesis P
IMP
SceS000004389
GO:0042493 response to drug P
IMP
SceS000004389
GO:0042981 regulation of apoptosis P
TAS
HsaVCP
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process
P
NAS
HsaVCP
GO:0045184 establishment of protein localization P
TAS
HsaVCP
GO:0045732 positive regulation of protein catabolic
process
P
IDA
HsaVCP
GO:0046686 response to cadmium ion P
IEP
AthAt3g09840
At3g53230
GO:0051230 spindle disassembly P
TAS
SpoSPAC1565.08
GO:0051301 cell division P
IMP
AthAt3g09840
CelWBGene00007352
WBGene00008053
GO:0061166 establishment of endoplasmic reticulum
localization involved in endoplasmic reticulum
polarization at cell division site
P
IMP
SpoSPAC1565.08
GO:0071712 ER-associated misfolded protein catabolic
process
P
IGI
CelWBGene00008053
WBGene00007352

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5168

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) VCP GI:6005942 P55072
Canis familiaris (Cfa) VCP GI:73971230
Mus musculus (Mmu) Vcp
(MGI:99919)
GI:30023842 Q01853
Rattus norvegicus (Rno) Vcp
(RGD:621595)
GI:17865351
Gallus gallus (Gga) VCP GI:113206112
Drosophila melanogaster (Dme) TER94
(FBgn0024923)
GI:161076486
Anopheles gambiae (Aga) AgaP_AGAP005630 GI:158294507
Caenorhabditis elegans (Cel) cdc-48.1
(CE02114;
WBGene00007352)
GI:17531535 P54811
Caenorhabditis elegans (Cel) cdc-48.2
(CE05402;
WBGene00008053)
GI:17532375 P54812
Schizosaccharomyces pombe (Spo) cdc48
(SPAC1565.08)
GI:63054529 Q9P3A7
Saccharomyces cerevisiae (Sce) CDC48
(S000002284)
GI:6320077 P25694
Kluyveromyces lactis (Kla) KLLA0F05676g GI:50310633
Eremothecium gossypii (Ego) AGOS_AFR158W GI:45198676
Magnaporthe grisea (Mgr) MGG_05193 GI:39940094
Neurospora crassa (Ncr) NCU00018.1 GI:32402982
Arabidopsis thaliana (Ath) AT3G53230 GI:15231775
Arabidopsis thaliana (Ath) CDC48 GI:15232776
Arabidopsis thaliana (Ath) AT5G03340 GI:18414193
Oryza sativa (Osa) Os03g0151800 GI:115450773
Plasmodium falciparum (Pfa) PFF0940c GI:86171278