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Search term: YDL131W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LYS21
SGD link S000002289
Alternative ID YDL131W
Description Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p
Synonyms YDL131W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2367 A---YP-

KOGs classification KOGs description
METABOLISM Alpha-isopropylmalate synthase/homocitrate synthase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g18500 GI:15221794
Arabidopsis thaliana (Ath) At1g74040 GI:15221125
Arabidopsis thaliana (Ath) At5g23010 GI:15237194
Arabidopsis thaliana (Ath) At5g23020 GI:15237196
Saccharomyces cerevisiae (Sce) YDL131w
(S000002289)		 GI:6320071 Q12122
Saccharomyces cerevisiae (Sce) YDL182w
(S000002341)		 GI:6320019 P48570
Saccharomyces cerevisiae (Sce) YNL104c
(S000005048)		 GI:6324225 P06208
Saccharomyces cerevisiae (Sce) YOR108w
(S000005634)		 GI:6324682 Q12166
Schizosaccharomyces pombe (Spo) SPBC1105.02c GI:19113250 Q9Y823
Schizosaccharomyces pombe (Spo) SPBC3E7.16c GI:19112895 O59736


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002341
S000002289
ISS
SpoSPBC1105.02c
GO:0005737 cytoplasm C
IDA
SceS000005048
ISS
SpoSPBC3E7.16c
GO:0005739 mitochondrion C
IDA
SceS000005048
S000005634
S000002341
SpoSPBC3E7.16c
ISS
SpoSPBC3E7.16c
SPBC1105.02c
GO:0005829 cytosol C
IDA
SpoSPBC1105.02c
GO:0009507 chloroplast C
IDA
AthAt5g23020
At1g74040
At5g23010
At1g18500
ISS
AthAt5g23010
GO:0009941 chloroplast envelope C
IDA
AthAt1g74040
GO:0003852 2-isopropylmalate synthase activity F
IDA
AthAt1g74040
At1g18500
SceS000005634
S000005048
IGI
AthAt1g74040
SceS000005634
ISS
AthAt1g74040
SceS000005634
SpoSPBC3E7.16c
NAS
AthAt5g23020
GO:0004410 homocitrate synthase activity F
IEP
SceS000002341
IGI
SceS000002341
IMP
SceS000002341
SpoSPBC1105.02c
ISS
SceS000002341
S000002289
GO:0010177 methylthioalkylmalate synthase
activity		 F
IDA
AthAt5g23010
At5g23020
GO:0006082 organic acid metabolic process P
RCA
SceS000002341
S000005048
S000002289
S000005634
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPBC1105.02c
GO:0006414 translational elongation P
RCA
SceS000002341
S000005048
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000002289
S000002341
S000005048
S000005634
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000002289
S000002341
S000005048
S000005634
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000005048
S000002341
S000002289
S000005634
GO:0009098 leucine biosynthetic process P
IDA
AthAt1g18500
At1g74040
IGI
AthAt1g74040
SceS000005634
IMP
SceS000005048
ISS
SpoSPBC3E7.16c
TAS
AthAt5g23020
GO:0019761 glucosinolate biosynthetic process P
IDA
AthAt5g23010
At5g23020
IGI
AthAt5g23010
At5g23020
IMP
AthAt5g23010
At5g23020
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IGI
SceS000002289
S000002341
IMP
SceS000002289
SpoSPBC1105.02c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5532

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) lys4
(SPBC1105.02c)		 GI:19113250 Q9Y823
Saccharomyces cerevisiae (Sce) LYS21
(S000002289)		 GI:6320071 Q12122
Kluyveromyces lactis (Kla) KLLA0F05489g GI:50310619
Eremothecium gossypii (Ego) AGOS_ADR107W GI:45187980
Magnaporthe grisea (Mgr) MGG_01092 GI:39973523
Arabidopsis thaliana (Ath) IMS1 GI:15221125
Arabidopsis thaliana (Ath) MAML-4 GI:42562149
Oryza sativa (Osa) Os11g0142500 GI:115484117
Oryza sativa (Osa) Os12g0138900 GI:115487258


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002289
ISS
SpoSPBC1105.02c
GO:0005739 mitochondrion C
ISS
SpoSPBC1105.02c
GO:0005829 cytosol C
IDA
SpoSPBC1105.02c
GO:0009507 chloroplast C
IDA
AthIMS1
MAML-4
GO:0009941 chloroplast envelope C
IDA
AthIMS1
GO:0003852 2-isopropylmalate synthase activity F
IDA
AthIMS1
MAML-4
IGI
AthIMS1
ISS
AthIMS1
GO:0004410 homocitrate synthase activity F
IMP
SpoSPBC1105.02c
ISS
SceS000002289
GO:0006082 organic acid metabolic process P
RCA
SceS000002289
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPBC1105.02c
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000002289
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000002289
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000002289
GO:0009098 leucine biosynthetic process P
IDA
AthMAML-4
IMS1
IGI
AthIMS1
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IGI
SceS000002289
IMP
SceS000002289
SpoSPBC1105.02c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1575

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago1848 ADR107W
Arabidopsis thaliana (Ath) ath1983 At1g18500.1
Arabidopsis thaliana (Ath) ath6710 At1g74040.1
Arabidopsis thaliana (Ath) ath24541 At5g23010.1
Arabidopsis thaliana (Ath) ath24542 At5g23020.1
Candida glabrata (Cgl) cgl3270 CAGL0J06402g
Candida glabrata (Cgl) cgl3396 CAGL0J09240g
Cryptococcus neoformans (Cne) cne764 163.m03889
Debaryomyces hansenii (Dha) dha2946 DEHA0D14498g
Debaryomyces hansenii (Dha) dha4801 DEHA0F09405g
Escherichia coli (Eco) eco75 16128068
Kluyveromyces lactis (Kla) kla4021 KLLA0E23782g
Kluyveromyces lactis (Kla) kla4329 KLLA0F05489g
Neurospora crassa (Ncr) ncr5368 NCU05526.2
Oryza sativa (Osa) osa39150 4920.m00155
Oryza sativa (Osa) osa66663 6934.m00149
Oryza sativa (Osa) osa66676 6934.m00193
Oryza sativa (Osa) osa72588 7059.m00135
Saccharomyces cerevisiae (Sce) sce905 YDL131W
(S000002289)
Saccharomyces cerevisiae (Sce) sce960 YDL182W
(S000002341)
Schizosaccharomyces pombe (Spo) spo3662 SPBC1105.02c Q9Y823
Yarrowia lipolytica (Yli) yli6621 YALI0F31075g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002341
S000002289
ISS
SpoSPBC1105.02c
GO:0005739 mitochondrion C
IDA
SceS000002341
ISS
SpoSPBC1105.02c
GO:0005829 cytosol C
IDA
SpoSPBC1105.02c
GO:0009507 chloroplast C
IDA
AthAt5g23020
At1g74040
At5g23010
At1g18500
ISS
AthAt5g23010
GO:0009941 chloroplast envelope C
IDA
AthAt1g74040
GO:0003852 2-isopropylmalate synthase activity F
IDA
AthAt1g74040
At1g18500
IGI
AthAt1g74040
ISS
AthAt1g74040
NAS
AthAt5g23020
GO:0004410 homocitrate synthase activity F
IEP
SceS000002341
IGI
SceS000002341
IMP
SceS000002341
SpoSPBC1105.02c
ISS
SceS000002341
S000002289
GO:0010177 methylthioalkylmalate synthase
activity		 F
IDA
AthAt5g23010
At5g23020
GO:0006082 organic acid metabolic process P
RCA
SceS000002341
S000002289
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPBC1105.02c
GO:0006414 translational elongation P
RCA
SceS000002341
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000002289
S000002341
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000002289
S000002341
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000002341
S000002289
GO:0009098 leucine biosynthetic process P
IDA
AthAt1g18500
At1g74040
IGI
AthAt1g74040
TAS
AthAt5g23020
GO:0019761 glucosinolate biosynthetic process P
IDA
AthAt5g23010
At5g23020
IGI
AthAt5g23010
At5g23020
IMP
AthAt5g23010
At5g23020
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IGI
SceS000002289
S000002341
IMP
SceS000002289
SpoSPBC1105.02c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1105.02c
(Q9Y823)		 YDL131W
(S000002289)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002289
ISS
SpoSPBC1105.02c
GO:0005739 mitochondrion C
ISS
SpoSPBC1105.02c
GO:0005829 cytosol C
IDA
SpoSPBC1105.02c
GO:0004410 homocitrate synthase activity F
IMP
SpoSPBC1105.02c
ISS
SceS000002289
GO:0006082 organic acid metabolic process P
RCA
SceS000002289
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPBC1105.02c
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000002289
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000002289
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000002289
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IGI
SceS000002289
IMP
SceS000002289
SpoSPBC1105.02c

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GO info in one table:

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