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Search term: YDL205C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HEM3
SGD link S000002364
Alternative ID YDL205C
Description Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
Synonyms YDL205C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2892 A-DHYP-

KOGs classification KOGs description
METABOLISM Porphobilinogen deaminase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g08280 GI:15241573
Drosophila melanogaster (Dme) 7292071
(FBgn0010786)		 GI:20130425
Homo sapiens (Hsa) Hs20149500
(HMBS)		 GI:20149500 P08397
Saccharomyces cerevisiae (Sce) YDL205c
(S000002364)		 GI:6319996 P28789
Schizosaccharomyces pombe (Spo) SPAC24B11.13 GI:19113763 Q09899


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002364
ISS
SpoSPAC24B11.13
GO:0005737 cytoplasm C
IDA
HsaHMBS
SceS000002364
SpoSPAC24B11.13
ISS
SpoSPAC24B11.13
GO:0005739 mitochondrion C
IDA
HsaHMBS
GO:0009507 chloroplast C
IDA
AthAt5g08280
GO:0009570 chloroplast stroma C
IDA
AthAt5g08280
GO:0009941 chloroplast envelope C
IDA
AthAt5g08280
GO:0048046 apoplast C
IDA
AthAt5g08280
GO:0004418 hydroxymethylbilane synthase activity F
IDA
AthAt5g08280
HsaHMBS
IMP
SceS000002364
ISS
DmeFBgn0010786
SpoSPAC24B11.13
GO:0006779 porphyrin biosynthetic process P
TAS
AthAt5g08280
GO:0006783 heme biosynthetic process P
IC
HsaHMBS
IMP
SceS000002364
ISS
SpoSPAC24B11.13
GO:0015995 chlorophyll biosynthetic process P
TAS
AthAt5g08280
GO:0042742 defense response to bacterium P
IEP
AthAt5g08280

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
158

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) HMBS GI:20149500 P08397
Pan troglodytes (Ptr) HMBS GI:114640812
Canis familiaris (Cfa) HMBS GI:73955044
Mus musculus (Mmu) Hmbs
(MGI:96112)		 GI:30794512 P22907
Rattus norvegicus (Rno) Hmbs
(RGD:2801)		 GI:78214363 44446
Gallus gallus (Gga) HMBS GI:118101810
Drosophila melanogaster (Dme) l(3)02640
(FBgn0010786)		 GI:20130425
Anopheles gambiae (Aga) AgaP_AGAP011080 GI:158287571
Schizosaccharomyces pombe (Spo) hem3
(SPAC24B11.13)		 GI:67989478 Q09899
Saccharomyces cerevisiae (Sce) HEM3
(S000002364)		 GI:6319996 P28789
Kluyveromyces lactis (Kla) KLLA0C15147g GI:50305837
Eremothecium gossypii (Ego) AGOS_ABL107C GI:45185123
Magnaporthe grisea (Mgr) MGG_04860 GI:39940760
Neurospora crassa (Ncr) NCU08876.1 GI:32421649
Arabidopsis thaliana (Ath) HEMC GI:15241573
Oryza sativa (Osa) Os02g0168800 GI:115444475


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000793 condensed chromosome C
ISO
MmuMGI:96112
GO:0005634 nucleus C
IDA
SceS000002364
ISO
MmuMGI:96112
ISS
SpoSPAC24B11.13
GO:0005737 cytoplasm C
IDA
HsaHMBS
SceS000002364
SpoSPAC24B11.13
ISO
MmuMGI:96112
ISS
SpoSPAC24B11.13
GO:0005739 mitochondrion C
IDA
HsaHMBS
GO:0009507 chloroplast C
IDA
AthHEMC
GO:0009570 chloroplast stroma C
IDA
AthHEMC
GO:0009941 chloroplast envelope C
IDA
AthHEMC
GO:0048046 apoplast C
IDA
AthHEMC
GO:0004418 hydroxymethylbilane synthase activity F
IDA
AthHEMC
HsaHMBS
IMP
SceS000002364
ISO
MmuMGI:96112
ISS
DmeFBgn0010786
SpoSPAC24B11.13
GO:0031406 carboxylic acid binding F
ISO
MmuMGI:96112
GO:0043176 amine binding F
ISO
MmuMGI:96112
GO:0050662 coenzyme binding F
ISO
MmuMGI:96112
GO:0006779 porphyrin biosynthetic process P
TAS
AthHEMC
GO:0006783 heme biosynthetic process P
IC
HsaHMBS
IMP
SceS000002364
ISS
SpoSPAC24B11.13
GO:0015995 chlorophyll biosynthetic process P
TAS
AthHEMC
GO:0033014 tetrapyrrole biosynthetic process P
ISO
MmuMGI:96112
GO:0042742 defense response to bacterium P
IEP
AthHEMC

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_912

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga8087 ENSANGP00000003954
Ashbya gossypii (Ago) ago485 ABL107C
Arabidopsis thaliana (Ath) ath23045 At5g08280.1
Candida glabrata (Cgl) cgl3415 CAGL0J09680g
Cryptococcus neoformans (Cne) cne5357 179.m00209
Dictyostelium discoideum (Ddi) ddi13203 DDB0231417
Debaryomyces hansenii (Dha) dha4818 DEHA0F09779g
Drosophila melanogaster (Dme) dme7382 CG9165-PA
(FBgn0010786)
Danio rerio (Dre) dre6384 ENSDARP00000006663
Danio rerio (Dre) dre19290 ENSDARP00000023322
(hmbs)		 Q7T336
Danio rerio (Dre) dre19314 ENSDARP00000039562
Danio rerio (Dre) dre6383 ENSDARP00000045639
Danio rerio (Dre) dre19289 ENSDARP00000045648
Escherichia coli (Eco) eco3672 49176416
Takifugu rubripes (Fru) fru2845 SINFRUP00000128973
Gallus gallus (Gga) gga13062 ENSGALP00000000379
(HMBS)
Gallus gallus (Gga) gga13063 ENSGALP00000000380
Homo sapiens (Hsa) hsa6665 ENSP00000278715
(HMBS)		 P08397-1
Kluyveromyces lactis (Kla) kla1878 KLLA0C15147g
Mus musculus (Mmu) mmu27478 ENSMUSP00000076575
(MGI:96112)		 Q3TIV0
Neurospora crassa (Ncr) ncr9965 NCU10292.2
Oryza sativa (Osa) osa31155 4363.m00206
Oryza sativa (Osa) osa31178 4363.m00244
Oryza sativa (Osa) osa31196 4363.m00248
Plasmodium falciparum (Pfa) pfa4882 PFL0480w
Rattus norvegicus (Rno) rno28449 ENSRNOP00000014128
(RGD:2801)		 P19356-2
Saccharomyces cerevisiae (Sce) sce984 YDL205C
(S000002364)
Schizosaccharomyces pombe (Spo) spo2762 SPAC24B11.13 Q09899
Yarrowia lipolytica (Yli) yli6456 YALI0F26609g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000793 condensed chromosome C
ISO
MmuMGI:96112
GO:0005634 nucleus C
IDA
SceS000002364
ISO
MmuMGI:96112
ISS
SpoSPAC24B11.13
GO:0005737 cytoplasm C
IDA
SceS000002364
SpoSPAC24B11.13
ISO
MmuMGI:96112
ISS
SpoSPAC24B11.13
GO:0009507 chloroplast C
IDA
AthAt5g08280
GO:0009570 chloroplast stroma C
IDA
AthAt5g08280
GO:0009941 chloroplast envelope C
IDA
AthAt5g08280
GO:0020011 apicoplast C
IDA
PfaPFL0480w
GO:0048046 apoplast C
IDA
AthAt5g08280
GO:0004418 hydroxymethylbilane synthase activity F
IDA
AthAt5g08280
IMP
SceS000002364
ISO
MmuMGI:96112
ISS
DmeFBgn0010786
SpoSPAC24B11.13
GO:0031406 carboxylic acid binding F
ISO
MmuMGI:96112
GO:0043176 amine binding F
ISO
MmuMGI:96112
GO:0050662 coenzyme binding F
ISO
MmuMGI:96112
GO:0006779 porphyrin biosynthetic process P
TAS
AthAt5g08280
GO:0006783 heme biosynthetic process P
IMP
SceS000002364
ISS
SpoSPAC24B11.13
GO:0015995 chlorophyll biosynthetic process P
TAS
AthAt5g08280
GO:0033014 tetrapyrrole biosynthetic process P
ISO
MmuMGI:96112
GO:0042742 defense response to bacterium P
IEP
AthAt5g08280

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC24B11.13
(Q09899)		 YDL205C
(S000002364)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002364
ISS
SpoSPAC24B11.13
GO:0005737 cytoplasm C
IDA
SceS000002364
SpoSPAC24B11.13
ISS
SpoSPAC24B11.13
GO:0004418 hydroxymethylbilane synthase activity F
IMP
SceS000002364
ISS
SpoSPAC24B11.13
GO:0006783 heme biosynthetic process P
IMP
SceS000002364
ISS
SpoSPAC24B11.13

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GO info in one table:

s.khadayate@ucl.ac.uk