Bahler Lab

Search term: YDL246C

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name SOR2

SGD link S000002405

Alternative ID YDL246C

Description Protein of unknown function; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase; computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism

Synonyms YDL246C

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0024 ACDHYP-

KOGs classification KOGs description

METABOLISM Sorbitol dehydrogenase

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000003920
S000002405
S000004060

GO:0005634 nucleus C
IDA
Sce S000000057

GO:0005737 cytoplasm C
IDA
Sce S000000056
S000000057

GO:0005794 Golgi apparatus C
IDA
Spo SPBC1198.01

GO:0005829 cytosol C
IDA
Spo SPBC1773.05c

GO:0000721 (R,R)-butanediol dehydrogenase
activity F
IDA
Sce S000000056

GO:0003939 L-iditol 2-dehydrogenase activity F
IDA
Sce S000003920
ISS
Dme FBgn0022359
Sce S000003920
S000002405
Spo SPBC1773.05c
NAS
Dme FBgn0024289
TAS
Dme FBgn0022359

GO:0016616 oxidoreductase activity, acting on the CH-OH group
of donors, NAD or NADP as acceptor F
ISS
Sce S000000057

GO:0046526 D-xylulose reductase activity F
IDA
Sce S000004060
ISS
Spo SPBC1773.05c

GO:0005999 xylulose biosynthetic process P
IDA
Sce S000004060
IEP
Sce S000004060

GO:0006066 alcohol metabolic process P
IMP
Sce S000000056

GO:0007039 vacuolar protein catabolic process P
RCA
Sce S000000057

GO:0008150 biological_process P
ND
Sce S000000057
Spo SPBC1198.01

GO:0009266 response to temperature stimulus P
RCA
Sce S000000057

GO:0009636 response to toxin P
RCA
Sce S000003920

GO:0019318 hexose metabolic process P
IEP
Sce S000003920
ISS
Sce S000002405

GO:0019407 hexitol catabolic process P
IC
Spo SPBC1773.05c

GO:0033554 cellular response to stress P
IEP
Spo SPBC1773.05c

GO:0034079 butanediol biosynthetic process P
IMP
Sce S000000056

GO:0051098 regulation of binding P
RCA
Sce S000003920
S000002405

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

56080

Species Gene ID NCBI link UniProt link

Homo sapiens (Hsa) SORD GI:156627571

Pan troglodytes (Ptr) SORD GI:114656772

Canis familiaris (Cfa) SORD GI:74000494

Mus musculus (Mmu) Sord
(MGI:98266) GI:22128627 Q64442

Rattus norvegicus (Rno) Sord
(RGD:3734) GI:77404286 34444

Gallus gallus (Gga) SORD GI:50752703

Drosophila melanogaster (Dme) Sodh-1
(FBgn0024289) GI:17137530

Drosophila melanogaster (Dme) Sodh-2
(FBgn0022359) GI:17737897

Anopheles gambiae (Aga) AgaP_AGAP003584 GI:158291803

Caenorhabditis elegans (Cel) R04B5.6
(CE06216;
WBGene00011004) GI:17562878 Q21703

Caenorhabditis elegans (Cel) R04B5.5
(CE06215;
WBGene00011003) GI:17562876 Q21702

Schizosaccharomyces pombe (Spo) tms1
(SPBC1773.05c) GI:19111912 P36624

Saccharomyces cerevisiae (Sce) SOR2
(S000002405) GI:6319955 Q07786

Saccharomyces cerevisiae (Sce) SOR1
(S000003920) GI:6322619 P35497

Kluyveromyces lactis (Kla) KLLA0D05511g GI:50306665

Eremothecium gossypii (Ego) AGOS_ABR229C GI:45185461

Magnaporthe grisea (Mgr) MGG_01176 GI:145614058

Neurospora crassa (Ncr) NCU00891.1 GI:32409181

Arabidopsis thaliana (Ath) AT5G51970 GI:15242240

Oryza sativa (Osa) Os08g0545200 GI:115477633

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000003920
S000002405

GO:0005615 extracellular space C
TAS
Hsa SORD

GO:0005624 membrane fraction C
IDA
Hsa SORD

GO:0005625 soluble fraction C
IDA
Hsa SORD
Mmu MGI:98266
ISS
Hsa SORD

GO:0005829 cytosol C
IDA
Spo SPBC1773.05c

GO:0003939 L-iditol 2-dehydrogenase activity F
IDA
Hsa SORD
Mmu MGI:98266
Sce S000003920
ISS
Dme FBgn0022359
Hsa SORD
Sce S000003920
S000002405
Spo SPBC1773.05c
NAS
Dme FBgn0024289
TAS
Dme FBgn0022359

GO:0005529 sugar binding F
NAS
Hsa SORD

GO:0008270 zinc ion binding F
IDA
Hsa SORD
ISO
Mmu MGI:98266
ISS
Hsa SORD

GO:0042802 identical protein binding F
ISO
Mmu MGI:98266

GO:0046526 D-xylulose reductase activity F
ISS
Spo SPBC1773.05c

GO:0051287 NAD or NADH binding F
IDA
Hsa SORD

GO:0006006 glucose metabolic process P
TAS
Hsa SORD

GO:0006060 sorbitol metabolic process P
IDA
Mmu MGI:98266

GO:0006062 sorbitol catabolic process P
IDA
Hsa SORD

GO:0009636 response to toxin P
RCA
Sce S000003920

GO:0009725 response to hormone stimulus P
ISO
Mmu MGI:98266

GO:0019318 hexose metabolic process P
IEP
Sce S000003920
ISS
Sce S000002405

GO:0019407 hexitol catabolic process P
IC
Spo SPBC1773.05c

GO:0030317 sperm motility P
NAS
Hsa SORD

GO:0033554 cellular response to stress P
IEP
Spo SPBC1773.05c

GO:0046370 fructose biosynthetic process P
IDA
Hsa SORD

GO:0046686 response to cadmium ion P
ISO
Mmu MGI:98266

GO:0046688 response to copper ion P
ISO
Mmu MGI:98266

GO:0051098 regulation of binding P
RCA
Sce S000003920
S000002405

GO:0051160 L-xylitol catabolic process P
IDA
Hsa SORD

GO:0051164 L-xylitol metabolic process P
IDA
Hsa SORD

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_355

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga6028 ENSANGP00000011284

Anopheles gambiae (Aga) aga6029 ENSANGP00000011286

Anopheles gambiae (Aga) aga6031 ENSANGP00000011358

Ashbya gossypii (Ago) ago823 ABR229C

Arabidopsis thaliana (Ath) ath27144 At5g51970.1

Arabidopsis thaliana (Ath) ath27145 At5g51970.2

Caenorhabditis elegans (Cel) cel13286 R04B5.5
(CE06215;
WBGene00011003)

Caenorhabditis elegans (Cel) cel13287 R04B5.6
(CE06216;
WBGene00011004)

Candida glabrata (Cgl) cgl667 CAGL0D00198g

Cryptococcus neoformans (Cne) cne3682 176.m02422

Cryptococcus neoformans (Cne) cne4105 177.m02864

Cryptococcus neoformans (Cne) cne5677 179.m00539

Cryptococcus neoformans (Cne) cne5709 179.m00574

Cryptococcus neoformans (Cne) cne2036 181.m08019

Cryptococcus neoformans (Cne) cne1914 181.m08701

Debaryomyces hansenii (Dha) dha645 DEHA0A14410g

Debaryomyces hansenii (Dha) dha704 DEHA0B00583g

Debaryomyces hansenii (Dha) dha1242 DEHA0B12980g

Debaryomyces hansenii (Dha) dha5206 DEHA0F18337g

Debaryomyces hansenii (Dha) dha5207 DEHA0F18359g

Drosophila melanogaster (Dme) dme11299 CG1982-PA
(FBgn0024289)

Drosophila melanogaster (Dme) dme11968 CG4649-PA
(FBgn0022359)

Danio rerio (Dre) dre21446 ENSDARP00000041702

Danio rerio (Dre) dre31673 ENSDARP00000042422

Danio rerio (Dre) dre31672 ENSDARP00000043943

Escherichia coli (Eco) eco1730 16129728

Escherichia coli (Eco) eco2466 16130470

Escherichia coli (Eco) eco3496 16131487

Takifugu rubripes (Fru) fru22149 SINFRUP00000144094

Gallus gallus (Gga) gga3646 ENSGALP00000003636

Gallus gallus (Gga) gga3645 ENSGALP00000003637
(SORD)

Gallus gallus (Gga) gga3644 ENSGALP00000003641

Homo sapiens (Hsa) hsa10588 ENSP00000267814
(SORD) Q00796

Kluyveromyces lactis (Kla) kla2305 KLLA0D05511g

Kluyveromyces lactis (Kla) kla4101 KLLA0F00506g

Kluyveromyces lactis (Kla) kla4102 KLLA0F00528g

Mus musculus (Mmu) mmu15382 ENSMUSP00000028657
(MGI:98266)

Neurospora crassa (Ncr) ncr624 NCU00643.2

Neurospora crassa (Ncr) ncr867 NCU00891.2

Oryza sativa (Osa) osa25993 3908.m00133

Oryza sativa (Osa) osa26031 3908.m00180

Oryza sativa (Osa) osa74524 7300.m00081

Rattus norvegicus (Rno) rno19584 ENSRNOP00000023350
(RGD:3734) P27867

Saccharomyces cerevisiae (Sce) sce71 YAL061W
(S000000057)

Saccharomyces cerevisiae (Sce) sce1026 YDL246C
(S000002405)

Saccharomyces cerevisiae (Sce) sce3658 YJR159W
(S000003920)

Saccharomyces cerevisiae (Sce) sce4151 YLR070C
(S000004060)

Schizosaccharomyces pombe (Spo) spo3675 SPBC1773.05c P36624

Yarrowia lipolytica (Yli) yli4380 YALI0E12463g

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000003920
S000002405
S000004060

GO:0005625 soluble fraction C
IDA
Mmu MGI:98266

GO:0005634 nucleus C
IDA
Sce S000000057

GO:0005737 cytoplasm C
IDA
Sce S000000057

GO:0005829 cytosol C
IDA
Spo SPBC1773.05c

GO:0003939 L-iditol 2-dehydrogenase activity F
IDA
Mmu MGI:98266
Sce S000003920
ISS
Dme FBgn0022359
Sce S000003920
S000002405
Spo SPBC1773.05c
NAS
Dme FBgn0024289
TAS
Dme FBgn0022359

GO:0008270 zinc ion binding F
ISO
Mmu MGI:98266

GO:0016616 oxidoreductase activity, acting on the CH-OH group
of donors, NAD or NADP as acceptor F
ISS
Sce S000000057

GO:0042802 identical protein binding F
ISO
Mmu MGI:98266

GO:0046526 D-xylulose reductase activity F
IDA
Sce S000004060
ISS
Spo SPBC1773.05c

GO:0005999 xylulose biosynthetic process P
IDA
Sce S000004060
IEP
Sce S000004060

GO:0006060 sorbitol metabolic process P
IDA
Mmu MGI:98266

GO:0007039 vacuolar protein catabolic process P
RCA
Sce S000000057

GO:0008150 biological_process P
ND
Sce S000000057

GO:0009266 response to temperature stimulus P
RCA
Sce S000000057

GO:0009636 response to toxin P
RCA
Sce S000003920

GO:0009725 response to hormone stimulus P
ISO
Mmu MGI:98266

GO:0019318 hexose metabolic process P
IEP
Sce S000003920
ISS
Sce S000002405

GO:0019407 hexitol catabolic process P
IC
Spo SPBC1773.05c

GO:0033554 cellular response to stress P
IEP
Spo SPBC1773.05c

GO:0046686 response to cadmium ion P
ISO
Mmu MGI:98266

GO:0046688 response to copper ion P
ISO
Mmu MGI:98266

GO:0051098 regulation of binding P
RCA
Sce S000003920
S000002405

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPBC1773.05c
(P36624) YDL246C
(S000002405)

GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000002405

GO:0005829 cytosol C
IDA
Spo SPBC1773.05c

GO:0003939 L-iditol 2-dehydrogenase activity F
ISS
Sce S000002405
Spo SPBC1773.05c

GO:0046526 D-xylulose reductase activity F
ISS
Spo SPBC1773.05c

GO:0019318 hexose metabolic process P
ISS
Sce S000002405

GO:0019407 hexitol catabolic process P
IC
Spo SPBC1773.05c

GO:0033554 cellular response to stress P
IEP
Spo SPBC1773.05c

GO:0051098 regulation of binding P
RCA
Sce S000002405

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0024	ACDHYP-

KOGs classification	KOGs description
METABOLISM	Sorbitol dehydrogenase

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At5g51970	GI:15242240
Caenorhabditis elegans (Cel)	CE06215 (WBGene00011003)	GI:17562876	Q21702
Caenorhabditis elegans (Cel)	CE06216 (WBGene00011004)	GI:17562878	Q21703
Drosophila melanogaster (Dme)	7298873 (FBgn0024289)	GI:17137530
Drosophila melanogaster (Dme)	7299382 (FBgn0022359)	GI:17737897
Drosophila melanogaster (Dme)	7300579	GI:7300579
Homo sapiens (Hsa)	Hs18583841	GI:18583841
Homo sapiens (Hsa)	Hs20549232	GI:20549232
Homo sapiens (Hsa)	Hs4507155	GI:4507155
Saccharomyces cerevisiae (Sce)	YAL060w (S000000056)	GI:6319258	P39714
Saccharomyces cerevisiae (Sce)	YAL061w (S000000057)	GI:6319257	P39713
Saccharomyces cerevisiae (Sce)	YDL246c (S000002405)	GI:6319955	Q07786
Saccharomyces cerevisiae (Sce)	YJR159w (S000003920)	GI:6322619	P35497
Saccharomyces cerevisiae (Sce)	YLR070c (S000004060)	GI:6323099	Q07993
Schizosaccharomyces pombe (Spo)	SPBC1198.01	GI:19111862	Q9P6I8
Schizosaccharomyces pombe (Spo)	SPBC1773.05c	GI:19111912	P36624
Arabidopsis thaliana (Ath)	At5g51970	GI:15242240
Caenorhabditis elegans (Cel)	CE06215 (WBGene00011003)	GI:17562876	Q21702
Caenorhabditis elegans (Cel)	CE06216 (WBGene00011004)	GI:17562878	Q21703
Drosophila melanogaster (Dme)	7298873 (FBgn0024289)	GI:17137530
Drosophila melanogaster (Dme)	7299382 (FBgn0022359)	GI:17737897
Drosophila melanogaster (Dme)	7300579	GI:7300579
Homo sapiens (Hsa)	Hs18583841	GI:18583841
Homo sapiens (Hsa)	Hs20549232	GI:20549232
Homo sapiens (Hsa)	Hs4507155	GI:4507155
Saccharomyces cerevisiae (Sce)	YAL060w (S000000056)	GI:6319258	P39714
Saccharomyces cerevisiae (Sce)	YAL061w (S000000057)	GI:6319257	P39713
Saccharomyces cerevisiae (Sce)	YDL246c (S000002405)	GI:6319955	Q07786
Saccharomyces cerevisiae (Sce)	YJR159w (S000003920)	GI:6322619	P35497
Saccharomyces cerevisiae (Sce)	YLR070c (S000004060)	GI:6323099	Q07993
Schizosaccharomyces pombe (Spo)	SPBC1198.01	GI:19111862	Q9P6I8
Schizosaccharomyces pombe (Spo)	SPBC1773.05c	GI:19111912	P36624
Arabidopsis thaliana (Ath)	At5g51970	GI:15242240
Caenorhabditis elegans (Cel)	CE06215 (WBGene00011003)	GI:17562876	Q21702
Caenorhabditis elegans (Cel)	CE06216 (WBGene00011004)	GI:17562878	Q21703
Drosophila melanogaster (Dme)	7298873 (FBgn0024289)	GI:17137530
Drosophila melanogaster (Dme)	7299382 (FBgn0022359)	GI:17737897
Drosophila melanogaster (Dme)	7300579	GI:7300579
Homo sapiens (Hsa)	Hs18583841	GI:18583841
Homo sapiens (Hsa)	Hs20549232	GI:20549232
Homo sapiens (Hsa)	Hs4507155	GI:4507155
Saccharomyces cerevisiae (Sce)	YAL060w (S000000056)	GI:6319258	P39714
Saccharomyces cerevisiae (Sce)	YAL061w (S000000057)	GI:6319257	P39713
Saccharomyces cerevisiae (Sce)	YDL246c (S000002405)	GI:6319955	Q07786
Saccharomyces cerevisiae (Sce)	YJR159w (S000003920)	GI:6322619	P35497
Saccharomyces cerevisiae (Sce)	YLR070c (S000004060)	GI:6323099	Q07993
Schizosaccharomyces pombe (Spo)	SPBC1198.01	GI:19111862	Q9P6I8
Schizosaccharomyces pombe (Spo)	SPBC1773.05c	GI:19111912	P36624

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	SORD	GI:156627571
Pan troglodytes (Ptr)	SORD	GI:114656772
Canis familiaris (Cfa)	SORD	GI:74000494
Mus musculus (Mmu)	Sord (MGI:98266)	GI:22128627	Q64442
Rattus norvegicus (Rno)	Sord (RGD:3734)	GI:77404286	34444
Gallus gallus (Gga)	SORD	GI:50752703
Drosophila melanogaster (Dme)	Sodh-1 (FBgn0024289)	GI:17137530
Drosophila melanogaster (Dme)	Sodh-2 (FBgn0022359)	GI:17737897
Anopheles gambiae (Aga)	AgaP_AGAP003584	GI:158291803
Caenorhabditis elegans (Cel)	R04B5.6 (CE06216; WBGene00011004)	GI:17562878	Q21703
Caenorhabditis elegans (Cel)	R04B5.5 (CE06215; WBGene00011003)	GI:17562876	Q21702
Schizosaccharomyces pombe (Spo)	tms1 (SPBC1773.05c)	GI:19111912	P36624
Saccharomyces cerevisiae (Sce)	SOR2 (S000002405)	GI:6319955	Q07786
Saccharomyces cerevisiae (Sce)	SOR1 (S000003920)	GI:6322619	P35497
Kluyveromyces lactis (Kla)	KLLA0D05511g	GI:50306665
Eremothecium gossypii (Ego)	AGOS_ABR229C	GI:45185461
Magnaporthe grisea (Mgr)	MGG_01176	GI:145614058
Neurospora crassa (Ncr)	NCU00891.1	GI:32409181
Arabidopsis thaliana (Ath)	AT5G51970	GI:15242240
Oryza sativa (Osa)	Os08g0545200	GI:115477633

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga6028	ENSANGP00000011284
Anopheles gambiae (Aga)	aga6029	ENSANGP00000011286
Anopheles gambiae (Aga)	aga6031	ENSANGP00000011358
Ashbya gossypii (Ago)	ago823	ABR229C
Arabidopsis thaliana (Ath)	ath27144	At5g51970.1
Arabidopsis thaliana (Ath)	ath27145	At5g51970.2
Caenorhabditis elegans (Cel)	cel13286	R04B5.5 (CE06215; WBGene00011003)
Caenorhabditis elegans (Cel)	cel13287	R04B5.6 (CE06216; WBGene00011004)
Candida glabrata (Cgl)	cgl667	CAGL0D00198g
Cryptococcus neoformans (Cne)	cne3682	176.m02422
Cryptococcus neoformans (Cne)	cne4105	177.m02864
Cryptococcus neoformans (Cne)	cne5677	179.m00539
Cryptococcus neoformans (Cne)	cne5709	179.m00574
Cryptococcus neoformans (Cne)	cne2036	181.m08019
Cryptococcus neoformans (Cne)	cne1914	181.m08701
Debaryomyces hansenii (Dha)	dha645	DEHA0A14410g
Debaryomyces hansenii (Dha)	dha704	DEHA0B00583g
Debaryomyces hansenii (Dha)	dha1242	DEHA0B12980g
Debaryomyces hansenii (Dha)	dha5206	DEHA0F18337g
Debaryomyces hansenii (Dha)	dha5207	DEHA0F18359g
Drosophila melanogaster (Dme)	dme11299	CG1982-PA (FBgn0024289)
Drosophila melanogaster (Dme)	dme11968	CG4649-PA (FBgn0022359)
Danio rerio (Dre)	dre21446	ENSDARP00000041702
Danio rerio (Dre)	dre31673	ENSDARP00000042422
Danio rerio (Dre)	dre31672	ENSDARP00000043943
Escherichia coli (Eco)	eco1730	16129728
Escherichia coli (Eco)	eco2466	16130470
Escherichia coli (Eco)	eco3496	16131487
Takifugu rubripes (Fru)	fru22149	SINFRUP00000144094
Gallus gallus (Gga)	gga3646	ENSGALP00000003636
Gallus gallus (Gga)	gga3645	ENSGALP00000003637 (SORD)
Gallus gallus (Gga)	gga3644	ENSGALP00000003641
Homo sapiens (Hsa)	hsa10588	ENSP00000267814 (SORD)	Q00796
Kluyveromyces lactis (Kla)	kla2305	KLLA0D05511g
Kluyveromyces lactis (Kla)	kla4101	KLLA0F00506g
Kluyveromyces lactis (Kla)	kla4102	KLLA0F00528g
Mus musculus (Mmu)	mmu15382	ENSMUSP00000028657 (MGI:98266)
Neurospora crassa (Ncr)	ncr624	NCU00643.2
Neurospora crassa (Ncr)	ncr867	NCU00891.2
Oryza sativa (Osa)	osa25993	3908.m00133
Oryza sativa (Osa)	osa26031	3908.m00180
Oryza sativa (Osa)	osa74524	7300.m00081
Rattus norvegicus (Rno)	rno19584	ENSRNOP00000023350 (RGD:3734)	P27867
Saccharomyces cerevisiae (Sce)	sce71	YAL061W (S000000057)
Saccharomyces cerevisiae (Sce)	sce1026	YDL246C (S000002405)
Saccharomyces cerevisiae (Sce)	sce3658	YJR159W (S000003920)
Saccharomyces cerevisiae (Sce)	sce4151	YLR070C (S000004060)
Schizosaccharomyces pombe (Spo)	spo3675	SPBC1773.05c	P36624
Yarrowia lipolytica (Yli)	yli4380	YALI0E12463g

S. pombe systematic ID	S. cerevisiae systematic ID
SPBC1773.05c (P36624)	YDL246C (S000002405)