YOGY Home YOGY Help

Search term: YDR047W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HEM12
SGD link S000002454
Alternative ID YDR047W
Description Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
Synonyms YDR047W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2872 A-DHYP-

KOGs classification KOGs description
METABOLISM Uroporphyrinogen decarboxylase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g40490 GI:15226690
Arabidopsis thaliana (Ath) At3g14930 GI:8777476
Drosophila melanogaster (Dme) 7303877
(FBgn0033428)		 GI:19921920 Q9V595
Homo sapiens (Hsa) Hs14742907 GI:14742907
Homo sapiens (Hsa) Hs9845522 GI:9845522
Saccharomyces cerevisiae (Sce) YDR047w
(S000002454)		 GI:6320252 P32347
Schizosaccharomyces pombe (Spo) SPCC4B3.05c GI:19075585 Q9USJ5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002454
SpoSPCC4B3.05c
ISS
SpoSPCC4B3.05c
GO:0005737 cytoplasm C
IDA
SceS000002454
ISS
SpoSPCC4B3.05c
NAS
DmeFBgn0033428
GO:0005829 cytosol C
IDA
SpoSPCC4B3.05c
GO:0009507 chloroplast C
IDA
AthAt3g14930
At2g40490
GO:0009570 chloroplast stroma C
IDA
AthAt3g14930
At2g40490
GO:0009941 chloroplast envelope C
IDA
AthAt2g40490
GO:0004853 uroporphyrinogen decarboxylase
activity		 F
IDA
SceS000002454
IMP
SceS000002454
ISS
AthAt3g14930
At2g40490
DmeFBgn0033428
SpoSPCC4B3.05c
GO:0006779 porphyrin biosynthetic process P
NAS
DmeFBgn0033428
GO:0006783 heme biosynthetic process P
IMP
SceS000002454
ISS
SpoSPCC4B3.05c
NAS
DmeFBgn0033428
GO:0046686 response to cadmium ion P
IEP
AthAt3g14930

Back to the top

HomoloGene results:

HomoloGene cluster Phylogenetic pattern
320

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) UROD GI:71051616
Pan troglodytes (Ptr) UROD GI:114556193
Canis familiaris (Cfa) UROD GI:73977150
Mus musculus (Mmu) Urod
(MGI:98916)		 GI:110347606 P70697
Rattus norvegicus (Rno) Urod
(RGD:3946)		 GI:62649478
Gallus gallus (Gga) UROD GI:118094545
Drosophila melanogaster (Dme) Updo
(FBgn0033428)		 GI:19921920 Q9V595
Anopheles gambiae (Aga) AgaP_AGAP011895 GI:158300799
Schizosaccharomyces pombe (Spo) hem12
(SPCC4B3.05c)		 GI:19075585 Q9USJ5
Saccharomyces cerevisiae (Sce) HEM12
(S000002454)		 GI:6320252 P32347
Kluyveromyces lactis (Kla) KLLA0F11770g GI:50311181
Eremothecium gossypii (Ego) AGOS_AGL210C GI:45200887
Magnaporthe grisea (Mgr) MGG_01622 GI:145613461
Neurospora crassa (Ncr) NCU02771.1 GI:32418962
Arabidopsis thaliana (Ath) HEME1 GI:18400577
Oryza sativa (Osa) Os01g0622300 GI:115438661
Plasmodium falciparum (Pfa) PFF0360w GI:86170683


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002454
SpoSPCC4B3.05c
ISS
SpoSPCC4B3.05c
GO:0005737 cytoplasm C
IDA
SceS000002454
ISS
SpoSPCC4B3.05c
NAS
DmeFBgn0033428
GO:0005829 cytosol C
IDA
MmuMGI:98916
SpoSPCC4B3.05c
ISO
MmuMGI:98916
GO:0009507 chloroplast C
IDA
AthHEME1
GO:0009570 chloroplast stroma C
IDA
AthHEME1
GO:0020011 apicoplast C
IDA
PfaPFF0360w
GO:0004853 uroporphyrinogen decarboxylase
activity		 F
IDA
HsaUROD
MmuMGI:98916
SceS000002454
IMP
MmuMGI:98916
SceS000002454
ISO
MmuMGI:98916
ISS
AthHEME1
DmeFBgn0033428
SpoSPCC4B3.05c
GO:0006779 porphyrin biosynthetic process P
ISO
MmuMGI:98916
NAS
DmeFBgn0033428
GO:0006783 heme biosynthetic process P
IC
HsaUROD
IMP
MmuMGI:98916
SceS000002454
ISS
SpoSPCC4B3.05c
NAS
DmeFBgn0033428
GO:0008152 metabolic process P
IDA
MmuMGI:98916
GO:0042168 heme metabolic process P
IMP
MmuMGI:98916
GO:0046502 uroporphyrinogen III metabolic
process		 P
ISO
MmuMGI:98916
GO:0046686 response to cadmium ion P
IEP
AthHEME1

Back to the top

OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1393

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9039 ENSANGP00000021292
Ashbya gossypii (Ago) ago4102 AGL210C
Arabidopsis thaliana (Ath) ath11189 At2g40490.1
Candida glabrata (Cgl) cgl2430 CAGL0H08371g
Cryptococcus neoformans (Cne) cne4577 186.m03417
Dictyostelium discoideum (Ddi) ddi13626 DDB0231418
Debaryomyces hansenii (Dha) dha4697 DEHA0F07062g
Drosophila melanogaster (Dme) dme4102 CG1818-PA
(FBgn0033428)
Danio rerio (Dre) dre26708 ENSDARP00000023867
(urod)		 Q9PTS2
Escherichia coli (Eco) eco3846 16131827
Takifugu rubripes (Fru) fru17446 SINFRUP00000141061
Gallus gallus (Gga) gga22684 ENSGALP00000016593
(UROD)
Gallus gallus (Gga) gga22685 ENSGALP00000016594
Gallus gallus (Gga) gga22686 ENSGALP00000016595
Homo sapiens (Hsa) hsa1054 ENSP00000246337
(UROD)		 P06132
Kluyveromyces lactis (Kla) kla4614 KLLA0F11770g
Mus musculus (Mmu) mmu18707 ENSMUSP00000030446
(MGI:98916)		 P70697
Neurospora crassa (Ncr) ncr2683 NCU02771.2
Oryza sativa (Osa) osa53476 6133.m00115
Plasmodium falciparum (Pfa) pfa3037 PFF0360w
Rattus norvegicus (Rno) rno23730 ENSRNOP00000024719
(RGD:3946)		 B0BN55
Saccharomyces cerevisiae (Sce) sce1081 YDR047W
(S000002454)
Schizosaccharomyces pombe (Spo) spo2037 SPCC4B3.05c Q9USJ5
Yarrowia lipolytica (Yli) yli1796 YALI0C01716g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002454
SpoSPCC4B3.05c
ISS
SpoSPCC4B3.05c
GO:0005737 cytoplasm C
IDA
SceS000002454
ISS
SpoSPCC4B3.05c
NAS
DmeFBgn0033428
GO:0005829 cytosol C
IDA
MmuMGI:98916
SpoSPCC4B3.05c
ISO
MmuMGI:98916
GO:0009507 chloroplast C
IDA
AthAt2g40490
GO:0009570 chloroplast stroma C
IDA
AthAt2g40490
GO:0009941 chloroplast envelope C
IDA
AthAt2g40490
GO:0020011 apicoplast C
IDA
PfaPFF0360w
GO:0004853 uroporphyrinogen decarboxylase
activity		 F
IDA
MmuMGI:98916
SceS000002454
IMP
MmuMGI:98916
SceS000002454
ISO
MmuMGI:98916
ISS
AthAt2g40490
DmeFBgn0033428
SpoSPCC4B3.05c
GO:0006779 porphyrin biosynthetic process P
ISO
MmuMGI:98916
NAS
DmeFBgn0033428
GO:0006783 heme biosynthetic process P
IMP
MmuMGI:98916
SceS000002454
ISS
SpoSPCC4B3.05c
NAS
DmeFBgn0033428
GO:0008152 metabolic process P
IDA
MmuMGI:98916
GO:0042168 heme metabolic process P
IMP
MmuMGI:98916
GO:0046502 uroporphyrinogen III metabolic
process		 P
ISO
MmuMGI:98916

Back to the top

Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC4B3.05c
(Q9USJ5)		 YDR047W
(S000002454)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002454
SpoSPCC4B3.05c
ISS
SpoSPCC4B3.05c
GO:0005737 cytoplasm C
IDA
SceS000002454
ISS
SpoSPCC4B3.05c
GO:0005829 cytosol C
IDA
SpoSPCC4B3.05c
GO:0004853 uroporphyrinogen decarboxylase
activity		 F
IDA
SceS000002454
IMP
SceS000002454
ISS
SpoSPCC4B3.05c
GO:0006783 heme biosynthetic process P
IMP
SceS000002454
ISS
SpoSPCC4B3.05c

Back to the top
YOGY Home YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk