Bahler Lab

Search term: YDR050C

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name TPI1

SGD link S000002457

Alternative ID YDR050C

Description Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region

Synonyms YDR050C

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG1643 ACDHYPE

KOGs classification KOGs description

METABOLISM Triosephosphate isomerase

Species KOG link NCBI link UniProt link

Arabidopsis thaliana (Ath) At2g21170 GI:15226479

Arabidopsis thaliana (Ath) At3g55440 GI:15233272

Caenorhabditis elegans (Cel) CE19040
(WBGene00006601) GI:17536593 Q10657

Drosophila melanogaster (Dme) 7301903 GI:17864112

Homo sapiens (Hsa) Hs17449158 GI:17449158

Homo sapiens (Hsa) Hs22043461 GI:22043461

Homo sapiens (Hsa) Hs4507645
(TPI1) GI:4507645 P60174

Saccharomyces cerevisiae (Sce) YDR050c
(S000002457) GI:6320255 P00942

Schizosaccharomyces pombe (Spo) SPCC24B10.21 GI:19075524 P07669

Encephalitozoon cuniculi (Ecu) ECU11g0230 GI:19074823 Q8SQZ1

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0001950 plasma membrane enriched fraction C
IDA
Sce S000002457

GO:0005618 cell wall C
IDA
Ath At3g55440

GO:0005622 intracellular C
IDA
Cel WBGene00006601

GO:0005634 nucleus C
IDA
Spo SPCC24B10.21

GO:0005737 cytoplasm C
IDA
Sce S000002457

GO:0005739 mitochondrion C
IDA
Ath At2g21170
At3g55440
Sce S000002457

GO:0005773 vacuole C
IDA
Ath At3g55440

GO:0005829 cytosol C
IDA
Spo SPCC24B10.21
ISS
Ath At3g55440
Spo SPCC24B10.21

GO:0005886 plasma membrane C
IDA
Ath At3g55440

GO:0009507 chloroplast C
IDA
Ath At2g21170
At3g55440
ISS
Ath At2g21170

GO:0009570 chloroplast stroma C
IDA
Ath At2g21170
At3g55440

GO:0009579 thylakoid C
IDA
Ath At2g21170

GO:0009941 chloroplast envelope C
IDA
Ath At2g21170

GO:0048046 apoplast C
IDA
Ath At2g21170
At3g55440

GO:0004807 triose-phosphate isomerase activity F
IDA
Ath At3g55440
At2g21170
Sce S000002457
IGI
Spo SPCC24B10.21
ISS
Ath At3g55440
At2g21170
NAS
Hsa TPI1
TAS
Hsa TPI1

GO:0005507 copper ion binding F
IDA
Ath At3g55440

GO:0006066 alcohol metabolic process P
RCA
Sce S000002457

GO:0006094 gluconeogenesis P
IC
Spo SPCC24B10.21

GO:0006096 glycolysis P
IC
Ath At3g55440
Spo SPCC24B10.21
IMP
Sce S000002457

GO:0006414 translational elongation P
RCA
Sce S000002457

GO:0006642 triglyceride mobilization P
IMP
Ath At2g21170

GO:0008152 metabolic process P
ISS
Ath At3g55440

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00006601

GO:0009651 response to salt stress P
IEP
Ath At3g55440

GO:0009658 chloroplast organization P
IMP
Ath At2g21170

GO:0010043 response to zinc ion P
IEP
Ath At3g55440

GO:0019253 reductive pentose-phosphate cycle P
ISS
Ath At2g21170

GO:0019563 glycerol catabolic process P
IMP
Ath At2g21170

GO:0032504 multicellular organism reproduction P
IMP
Ath At2g21170

GO:0044262 cellular carbohydrate metabolic
process P
IDA
Ath At3g55440

GO:0045454 cell redox homeostasis P
IMP
Cel WBGene00006601

GO:0046166 glyceraldehyde-3-phosphate biosynthetic
process P
IDA
Ath At2g21170

GO:0046686 response to cadmium ion P
IEP
Ath At3g55440

GO:0080022 primary root development P
IMP
Ath At2g21170

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

311

Species Gene ID NCBI link UniProt link

Homo sapiens (Hsa) TPI1 GI:4507645 P60174

Pan troglodytes (Ptr) TPI1 GI:114643113

Canis familiaris (Cfa) TPI1 GI:57106546

Mus musculus (Mmu) Tpi1
(MGI:98797) GI:6678413 P17751

Rattus norvegicus (Rno) RGD1563601 GI:62663437

Rattus norvegicus (Rno) Tpi1
(RGD:3896) GI:12621074 34507

Rattus norvegicus (Rno) LOC500959
(RGD:1560534) GI:109483205

Gallus gallus (Gga) TPI1 GI:45382061

Drosophila melanogaster (Dme) Tpi
(FBgn0003738) GI:28572004

Anopheles gambiae (Aga) AgaP_AGAP001630 GI:118794416

Schizosaccharomyces pombe (Spo) tpi GI:19075524

Saccharomyces cerevisiae (Sce) TPI1
(S000002457) GI:6320255 P00942

Kluyveromyces lactis (Kla) KLLA0F18832g GI:50312993

Eremothecium gossypii (Ego) AGOS_AGL201C GI:45200896

Magnaporthe grisea (Mgr) MGG_08905 GI:145614206

Neurospora crassa (Ncr) NCU07550.1 GI:32414713

Arabidopsis thaliana (Ath) TIM GI:15226479

Oryza sativa (Osa) Os09g0535000 GI:115480367

Plasmodium falciparum (Pfa) PF14_0378 GI:124809349

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0001950 plasma membrane enriched fraction C
IDA
Sce S000002457

GO:0005575 cellular_component C
ND
Pfa PF14_0378

GO:0005618 cell wall C
IDA
Ath TIM

GO:0005625 soluble fraction C
ISO
Mmu MGI:98797

GO:0005634 nucleus C
ISO
Mmu MGI:98797
NAS
Ath TIM

GO:0005737 cytoplasm C
IDA
Sce S000002457

GO:0005739 mitochondrion C
IDA
Ath TIM
Sce S000002457

GO:0005741 mitochondrial outer membrane C
IDA
Ath TIM

GO:0005743 mitochondrial inner membrane C
IDA
Ath TIM
ISS
Ath TIM

GO:0005744 mitochondrial inner membrane presequence
translocase complex C
ISS
Ath TIM
TAS
Ath TIM

GO:0005758 mitochondrial intermembrane space C
IDA
Ath TIM

GO:0005773 vacuole C
IDA
Ath TIM

GO:0005829 cytosol C
ISO
Mmu MGI:98797
ISS
Ath TIM

GO:0005886 plasma membrane C
IDA
Ath TIM

GO:0009507 chloroplast C
IDA
Ath TIM
ISS
Ath TIM

GO:0009536 plastid C
IDA
Ath TIM
ISS
Ath TIM

GO:0009570 chloroplast stroma C
IDA
Ath TIM

GO:0009579 thylakoid C
IDA
Ath TIM

GO:0009941 chloroplast envelope C
IDA
Ath TIM

GO:0048046 apoplast C
IDA
Ath TIM

GO:0003674 molecular_function F
ND
Ath TIM

GO:0003862 3-isopropylmalate dehydrogenase
activity F
IGI
Ath TIM
ISS
Ath TIM

GO:0004807 triose-phosphate isomerase activity F
IDA
Ath TIM
Mmu MGI:98797
Sce S000002457
IMP
Mmu MGI:98797
ISO
Mmu MGI:98797
ISS
Ath TIM
NAS
Hsa TPI1
TAS
Hsa TPI1

GO:0005507 copper ion binding F
IDA
Ath TIM

GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane
transporter activity F
ISS
Ath TIM
TAS
Ath TIM

GO:0015462 protein-transmembrane transporting ATPase
activity F
TAS
Ath TIM

GO:0016853 isomerase activity F
IDA
Mmu MGI:98797

GO:0005975 carbohydrate metabolic process P
ISO
Mmu MGI:98797

GO:0006006 glucose metabolic process P
IDA
Mmu MGI:98797

GO:0006066 alcohol metabolic process P
RCA
Sce S000002457

GO:0006094 gluconeogenesis P
ISS
Pfa PF14_0378

GO:0006096 glycolysis P
IC
Ath TIM
IMP
Sce S000002457
ISS
Pfa PF14_0378

GO:0006098 pentose-phosphate shunt P
ISS
Pfa PF14_0378

GO:0006414 translational elongation P
RCA
Sce S000002457

GO:0006626 protein targeting to mitochondrion P
ISS
Ath TIM
TAS
Ath TIM

GO:0006633 fatty acid biosynthetic process P
ISS
Pfa PF14_0378

GO:0006642 triglyceride mobilization P
IMP
Ath TIM

GO:0007275 multicellular organismal development P
IMP
Mmu MGI:98797

GO:0008152 metabolic process P
IMP
Mmu MGI:98797
ISS
Ath TIM

GO:0009098 leucine biosynthetic process P
IGI
Ath TIM
ISS
Ath TIM

GO:0009651 response to salt stress P
IEP
Ath TIM

GO:0009658 chloroplast organization P
IMP
Ath TIM

GO:0009790 embryo development P
IMP
Mmu MGI:98797

GO:0009793 embryo development ending in seed
dormancy P
NAS
Ath TIM

GO:0010043 response to zinc ion P
IEP
Ath TIM

GO:0015031 protein transport P
ISS
Ath TIM

GO:0019253 reductive pentose-phosphate cycle P
ISS
Ath TIM

GO:0019563 glycerol catabolic process P
IMP
Ath TIM

GO:0019682 glyceraldehyde-3-phosphate metabolic
process P
IDA
Mmu MGI:98797

GO:0019761 glucosinolate biosynthetic process P
IMP
Ath TIM

GO:0032504 multicellular organism reproduction P
IMP
Ath TIM

GO:0042752 regulation of circadian rhythm P
NAS
Ath TIM

GO:0044262 cellular carbohydrate metabolic
process P
IDA
Ath TIM

GO:0046166 glyceraldehyde-3-phosphate biosynthetic
process P
IDA
Ath TIM

GO:0046686 response to cadmium ion P
IEP
Ath TIM

GO:0080022 primary root development P
IMP
Ath TIM

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_500

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0001950 plasma membrane enriched fraction C
IDA
Sce S000002457

GO:0005575 cellular_component C
ND
Pfa PF14_0378

GO:0005618 cell wall C
IDA
Ath At3g55440

GO:0005622 intracellular C
IDA
Cel WBGene00006601

GO:0005625 soluble fraction C
ISO
Mmu MGI:98797

GO:0005634 nucleus C
IDA
Spo SPCC24B10.21
ISO
Mmu MGI:98797

GO:0005737 cytoplasm C
IDA
Sce S000002457

GO:0005739 mitochondrion C
IDA
Ath At2g21170
At3g55440
Sce S000002457

GO:0005773 vacuole C
IDA
Ath At3g55440

GO:0005829 cytosol C
IDA
Spo SPCC24B10.21
ISO
Mmu MGI:98797
ISS
Ath At3g55440
Spo SPCC24B10.21

GO:0005886 plasma membrane C
IDA
Ath At3g55440

GO:0009507 chloroplast C
IDA
Ath At2g21170
At3g55440
ISS
Ath At2g21170

GO:0009570 chloroplast stroma C
IDA
Ath At2g21170
At3g55440

GO:0009579 thylakoid C
IDA
Ath At2g21170

GO:0009941 chloroplast envelope C
IDA
Ath At2g21170

GO:0048046 apoplast C
IDA
Ath At2g21170
At3g55440

GO:0004807 triose-phosphate isomerase activity F
IDA
Ath At3g55440
At2g21170
Mmu MGI:98797
Sce S000002457
IGI
Spo SPCC24B10.21
IMP
Mmu MGI:98797
ISO
Mmu MGI:98797
ISS
Ath At3g55440
At2g21170

GO:0005507 copper ion binding F
IDA
Ath At3g55440

GO:0016853 isomerase activity F
IDA
Mmu MGI:98797

GO:0005975 carbohydrate metabolic process P
ISO
Mmu MGI:98797

GO:0006006 glucose metabolic process P
IDA
Mmu MGI:98797

GO:0006066 alcohol metabolic process P
RCA
Sce S000002457

GO:0006094 gluconeogenesis P
IC
Spo SPCC24B10.21
ISS
Pfa PF14_0378

GO:0006096 glycolysis P
IC
Ath At3g55440
Spo SPCC24B10.21
IMP
Sce S000002457
ISS
Pfa PF14_0378

GO:0006098 pentose-phosphate shunt P
ISS
Pfa PF14_0378

GO:0006414 translational elongation P
RCA
Sce S000002457

GO:0006633 fatty acid biosynthetic process P
ISS
Pfa PF14_0378

GO:0006642 triglyceride mobilization P
IMP
Ath At2g21170

GO:0007275 multicellular organismal development P
IMP
Mmu MGI:98797

GO:0008152 metabolic process P
IMP
Mmu MGI:98797
ISS
Ath At3g55440

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00006601

GO:0009651 response to salt stress P
IEP
Ath At3g55440

GO:0009658 chloroplast organization P
IMP
Ath At2g21170

GO:0009790 embryo development P
IMP
Mmu MGI:98797

GO:0010043 response to zinc ion P
IEP
Ath At3g55440

GO:0019253 reductive pentose-phosphate cycle P
ISS
Ath At2g21170

GO:0019563 glycerol catabolic process P
IMP
Ath At2g21170

GO:0019682 glyceraldehyde-3-phosphate metabolic
process P
IDA
Mmu MGI:98797

GO:0032504 multicellular organism reproduction P
IMP
Ath At2g21170

GO:0044262 cellular carbohydrate metabolic
process P
IDA
Ath At3g55440

GO:0045454 cell redox homeostasis P
IMP
Cel WBGene00006601

GO:0046166 glyceraldehyde-3-phosphate biosynthetic
process P
IDA
Ath At2g21170

GO:0046686 response to cadmium ion P
IEP
Ath At3g55440

GO:0080022 primary root development P
IMP
Ath At2g21170

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPCC24B10.21
(P07669) YDR050C
(S000002457)

GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations

GO:0001950 plasma membrane enriched fraction C
IDA
Sce S000002457

GO:0005634 nucleus C
IDA
Spo SPCC24B10.21

GO:0005737 cytoplasm C
IDA
Sce S000002457

GO:0005739 mitochondrion C
IDA
Sce S000002457

GO:0005829 cytosol C
IDA
Spo SPCC24B10.21
ISS
Spo SPCC24B10.21

GO:0004807 triose-phosphate isomerase activity F
IDA
Sce S000002457
IGI
Spo SPCC24B10.21

GO:0006066 alcohol metabolic process P
RCA
Sce S000002457

GO:0006094 gluconeogenesis P
IC
Spo SPCC24B10.21

GO:0006096 glycolysis P
IC
Spo SPCC24B10.21
IMP
Sce S000002457

GO:0006414 translational elongation P
RCA
Sce S000002457

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1643	ACDHYPE

KOGs classification	KOGs description
METABOLISM	Triosephosphate isomerase

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At2g21170	GI:15226479
Arabidopsis thaliana (Ath)	At3g55440	GI:15233272
Caenorhabditis elegans (Cel)	CE19040 (WBGene00006601)	GI:17536593	Q10657
Drosophila melanogaster (Dme)	7301903	GI:17864112
Homo sapiens (Hsa)	Hs17449158	GI:17449158
Homo sapiens (Hsa)	Hs22043461	GI:22043461
Homo sapiens (Hsa)	Hs4507645 (TPI1)	GI:4507645	P60174
Saccharomyces cerevisiae (Sce)	YDR050c (S000002457)	GI:6320255	P00942
Schizosaccharomyces pombe (Spo)	SPCC24B10.21	GI:19075524	P07669
Encephalitozoon cuniculi (Ecu)	ECU11g0230	GI:19074823	Q8SQZ1

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	TPI1	GI:4507645	P60174
Pan troglodytes (Ptr)	TPI1	GI:114643113
Canis familiaris (Cfa)	TPI1	GI:57106546
Mus musculus (Mmu)	Tpi1 (MGI:98797)	GI:6678413	P17751
Rattus norvegicus (Rno)	RGD1563601	GI:62663437
Rattus norvegicus (Rno)	Tpi1 (RGD:3896)	GI:12621074	34507
Rattus norvegicus (Rno)	LOC500959 (RGD:1560534)	GI:109483205
Gallus gallus (Gga)	TPI1	GI:45382061
Drosophila melanogaster (Dme)	Tpi (FBgn0003738)	GI:28572004
Anopheles gambiae (Aga)	AgaP_AGAP001630	GI:118794416
Schizosaccharomyces pombe (Spo)	tpi	GI:19075524
Saccharomyces cerevisiae (Sce)	TPI1 (S000002457)	GI:6320255	P00942
Kluyveromyces lactis (Kla)	KLLA0F18832g	GI:50312993
Eremothecium gossypii (Ego)	AGOS_AGL201C	GI:45200896
Magnaporthe grisea (Mgr)	MGG_08905	GI:145614206
Neurospora crassa (Ncr)	NCU07550.1	GI:32414713
Arabidopsis thaliana (Ath)	TIM	GI:15226479
Oryza sativa (Osa)	Os09g0535000	GI:115480367
Plasmodium falciparum (Pfa)	PF14_0378	GI:124809349

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga3736	ENSANGP00000018152
Ashbya gossypii (Ago)	ago4111	AGL201C
Arabidopsis thaliana (Ath)	ath9004	At2g21170.1
Arabidopsis thaliana (Ath)	ath16926	At3g55440.1
Caenorhabditis elegans (Cel)	cel17878	Y17G7B.7 (CE19040; WBGene00006601)
Candida glabrata (Cgl)	cgl2428	CAGL0H08327g
Cryptococcus neoformans (Cne)	cne3281	167.m03634
Dictyostelium discoideum (Ddi)	ddi12074	DDB0231425
Debaryomyces hansenii (Dha)	dha4714	DEHA0F07436g
Drosophila melanogaster (Dme)	dme15173	CG2171-PA (FBgn0003738)
Drosophila melanogaster (Dme)	dme15174	CG2171-PB (FBgn0003738)
Drosophila melanogaster (Dme)	dme15175	CG2171-PC (FBgn0003738)
Danio rerio (Dre)	dre6924	ENSDARP00000008240
Danio rerio (Dre)	dre9647	ENSDARP00000033907 (tpi1a)	Q1MTI4
Danio rerio (Dre)	dre8524	ENSDARP00000050357
Escherichia coli (Eco)	eco3776	16131757
Encephalitozoon cuniculi (Ecu)	ecu911	19074823
Takifugu rubripes (Fru)	fru10775	SINFRUP00000156180
Gallus gallus (Gga)	gga1574	ENSGALP00000023396 (TPI1)	P00940
Homo sapiens (Hsa)	hsa6991	ENSP00000229270 (TPI1)	Q53HE2
Homo sapiens (Hsa)	hsa1374	ENSP00000334713
Kluyveromyces lactis (Kla)	kla4924	KLLA0F18832g
Mus musculus (Mmu)	mmu22722	ENSMUSP00000024223 (MGI:98797)	P17751
Neurospora crassa (Ncr)	ncr7351	NCU07550.2
Oryza sativa (Osa)	osa8778	2684.m00175
Oryza sativa (Osa)	osa10816	2784.m00142
Oryza sativa (Osa)	osa13320	2927.m00124
Oryza sativa (Osa)	osa31317	4407.m00136
Oryza sativa (Osa)	osa35200	4772.m00160
Oryza sativa (Osa)	osa35204	4772.m00195
Oryza sativa (Osa)	osa48341	5664.m00149
Oryza sativa (Osa)	osa60385	6568.m00153
Plasmodium falciparum (Pfa)	pfa1829	PF14_0378
Rattus norvegicus (Rno)	rno22207	ENSRNOP00000020647 (RGD:3896)	P48500
Rattus norvegicus (Rno)	rno28170	ENSRNOP00000039702
Rattus norvegicus (Rno)	rno13208	ENSRNOP00000048631
Saccharomyces cerevisiae (Sce)	sce1084	YDR050C (S000002457)
Schizosaccharomyces pombe (Spo)	spo2836	SPCC24B10.21	P07669
Yarrowia lipolytica (Yli)	yli5559	YALI0F05214g

S. pombe systematic ID	S. cerevisiae systematic ID
SPCC24B10.21 (P07669)	YDR050C (S000002457)