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Search term: YDR052C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DBF4
SGD link S000002459
Alternative ID YDR052C
Description Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated
Synonyms YDR052C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4139 --DHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSINGCELLULAR PROCESSES AND SIGNALING Protein kinase essential for the initiation of DNA replication

Species KOG link NCBI link UniProt link
Drosophila melanogaster (Dme) 7298300 GI:7298300
Homo sapiens (Hsa) Hs13376671 GI:13376671 Q8NFT6
Homo sapiens (Hsa) Hs22035682
(DBF4B)		 GI:22035682 Q8NFT6
Homo sapiens (Hsa) Hs5729734_1
(DBF4)		 GI:5729734 Q9UBU7
Saccharomyces cerevisiae (Sce) YDR052c
(S000002459)		 GI:6320258 P32325
Schizosaccharomyces pombe (Spo) SPBC1778.04 GI:19113079 Q9Y7J1
Schizosaccharomyces pombe (Spo) SPCC550.13 GI:19075605 O59836
Encephalitozoon cuniculi (Ecu) ECU05g1330 GI:19173673 Q8SVH2


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SpoSPCC550.13
IDA
SpoSPBC1778.04
SPCC550.13
GO:0005654 nucleoplasm C
EXP
HsaDBF4
ISS
SpoSPBC1778.04
GO:0005816 spindle pole body C
IDA
SpoSPCC550.13
GO:0005829 cytosol C
IDA
SpoSPBC1778.04
GO:0031431 Dbf4-dependent protein kinase complex C
IDA
SpoSPCC550.13
IGI
SceS000002459
IPI
SceS000002459
GO:0003688 DNA replication origin binding F
IDA
SceS000002459
GO:0005515 protein binding F
IPI
HsaDBF4
SpoSPCC550.13
GO:0008047 enzyme activator activity F
TAS
HsaDBF4
GO:0019887 protein kinase regulator activity F
IDA
SpoSPCC550.13
ISS
SpoSPBC1778.04
GO:0043539 protein serine/threonine kinase activator
activity		 F
IGI
SceS000002459
IMP
SceS000002459
IPI
SceS000002459
GO:0046982 protein heterodimerization activity F
IPI
SpoSPCC550.13
GO:0000076 DNA replication checkpoint P
IMP
SpoSPCC550.13
GO:0000077 DNA damage checkpoint P
IMP
SpoSPCC550.13
GO:0000082 G1/S transition of mitotic cell
cycle		 P
TAS
HsaDBF4
GO:0001100 negative regulation of exit from
mitosis		 P
IGI
SceS000002459
IMP
SceS000002459
GO:0006260 DNA replication P
EXP
HsaDBF4
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SpoSPCC550.13
IPI
SceS000002459
GO:0006468 protein amino acid phosphorylation P
ISS
SpoSPBC1778.04
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPCC550.13
GO:0007064 mitotic sister chromatid cohesion P
IGI
SpoSPCC550.13
GO:0007135 meiosis II P
IMP
SpoSPBC1778.04
GO:0007165 signal transduction P
IC
SpoSPBC1778.04
SPCC550.13
GO:0030437 ascospore formation P
IMP
SpoSPBC1778.04
GO:0042325 regulation of phosphorylation P
ISS
SpoSPBC1778.04
GO:0045859 regulation of protein kinase activity P
IDA
SpoSPCC550.13
GO:0045860 positive regulation of protein kinase
activity		 P
IGI
SceS000002459
IMP
SceS000002459
IPI
SceS000002459
GO:0048478 replication fork protection P
TAS
SpoSPCC550.13

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
38657

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) DBF4
(S000002459)		 GI:6320258 P32325
Kluyveromyces lactis (Kla) KLLA0F11660g GI:50311171
Eremothecium gossypii (Ego) AGOS_AGL205C GI:45200892


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0031431 Dbf4-dependent protein kinase complex C
IGI
SceS000002459
IPI
SceS000002459
GO:0003688 DNA replication origin binding F
IDA
SceS000002459
GO:0043539 protein serine/threonine kinase activator
activity		 F
IGI
SceS000002459
IMP
SceS000002459
IPI
SceS000002459
GO:0001100 negative regulation of exit from
mitosis		 P
IGI
SceS000002459
IMP
SceS000002459
GO:0006270 DNA-dependent DNA replication initiation P
IPI
SceS000002459
GO:0045860 positive regulation of protein kinase
activity		 P
IGI
SceS000002459
IMP
SceS000002459
IPI
SceS000002459

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_13172

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago4107 AGL205C
Candida glabrata (Cgl) cgl1140 CAGL0E04576g
Cryptococcus neoformans (Cne) cne2784 183.m01725
Debaryomyces hansenii (Dha) dha1597 DEHA0C03751g
Kluyveromyces lactis (Kla) kla4609 KLLA0F11660g
Saccharomyces cerevisiae (Sce) sce1086 YDR052C
(S000002459)
Schizosaccharomyces pombe (Spo) spo1564 SPBC1778.04 Q9Y7J1
Schizosaccharomyces pombe (Spo) spo3433 SPCC550.13 O59836
Yarrowia lipolytica (Yli) yli1454 YALI0B17006g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SpoSPCC550.13
IDA
SpoSPBC1778.04
SPCC550.13
GO:0005654 nucleoplasm C
ISS
SpoSPBC1778.04
GO:0005816 spindle pole body C
IDA
SpoSPCC550.13
GO:0005829 cytosol C
IDA
SpoSPBC1778.04
GO:0031431 Dbf4-dependent protein kinase complex C
IDA
SpoSPCC550.13
IGI
SceS000002459
IPI
SceS000002459
GO:0003688 DNA replication origin binding F
IDA
SceS000002459
GO:0005515 protein binding F
IPI
SpoSPCC550.13
GO:0019887 protein kinase regulator activity F
IDA
SpoSPCC550.13
ISS
SpoSPBC1778.04
GO:0043539 protein serine/threonine kinase activator
activity		 F
IGI
SceS000002459
IMP
SceS000002459
IPI
SceS000002459
GO:0046982 protein heterodimerization activity F
IPI
SpoSPCC550.13
GO:0000076 DNA replication checkpoint P
IMP
SpoSPCC550.13
GO:0000077 DNA damage checkpoint P
IMP
SpoSPCC550.13
GO:0001100 negative regulation of exit from
mitosis		 P
IGI
SceS000002459
IMP
SceS000002459
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SpoSPCC550.13
IPI
SceS000002459
GO:0006468 protein amino acid phosphorylation P
ISS
SpoSPBC1778.04
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPCC550.13
GO:0007064 mitotic sister chromatid cohesion P
IGI
SpoSPCC550.13
GO:0007135 meiosis II P
IMP
SpoSPBC1778.04
GO:0007165 signal transduction P
IC
SpoSPBC1778.04
SPCC550.13
GO:0030437 ascospore formation P
IMP
SpoSPBC1778.04
GO:0042325 regulation of phosphorylation P
ISS
SpoSPBC1778.04
GO:0045859 regulation of protein kinase activity P
IDA
SpoSPCC550.13
GO:0045860 positive regulation of protein kinase
activity		 P
IGI
SceS000002459
IMP
SceS000002459
IPI
SceS000002459
GO:0048478 replication fork protection P
TAS
SpoSPCC550.13

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1778.04
(Q9Y7J1)		 YDR052C
(S000002459)
SPCC550.13
(O59836)		 YDR052C
(S000002459)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SpoSPCC550.13
IDA
SpoSPBC1778.04
SPCC550.13
GO:0005654 nucleoplasm C
ISS
SpoSPBC1778.04
GO:0005816 spindle pole body C
IDA
SpoSPCC550.13
GO:0005829 cytosol C
IDA
SpoSPBC1778.04
GO:0031431 Dbf4-dependent protein kinase complex C
IDA
SpoSPCC550.13
IGI
SceS000002459
IPI
SceS000002459
GO:0003688 DNA replication origin binding F
IDA
SceS000002459
GO:0005515 protein binding F
IPI
SpoSPCC550.13
GO:0019887 protein kinase regulator activity F
IDA
SpoSPCC550.13
ISS
SpoSPBC1778.04
GO:0043539 protein serine/threonine kinase activator
activity		 F
IGI
SceS000002459
IMP
SceS000002459
IPI
SceS000002459
GO:0046982 protein heterodimerization activity F
IPI
SpoSPCC550.13
GO:0000076 DNA replication checkpoint P
IMP
SpoSPCC550.13
GO:0000077 DNA damage checkpoint P
IMP
SpoSPCC550.13
GO:0001100 negative regulation of exit from
mitosis		 P
IGI
SceS000002459
IMP
SceS000002459
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SpoSPCC550.13
IPI
SceS000002459
GO:0006468 protein amino acid phosphorylation P
ISS
SpoSPBC1778.04
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPCC550.13
GO:0007064 mitotic sister chromatid cohesion P
IGI
SpoSPCC550.13
GO:0007135 meiosis II P
IMP
SpoSPBC1778.04
GO:0007165 signal transduction P
IC
SpoSPBC1778.04
SPCC550.13
GO:0030437 ascospore formation P
IMP
SpoSPBC1778.04
GO:0042325 regulation of phosphorylation P
ISS
SpoSPBC1778.04
GO:0045859 regulation of protein kinase activity P
IDA
SpoSPCC550.13
GO:0045860 positive regulation of protein kinase
activity		 P
IGI
SceS000002459
IMP
SceS000002459
IPI
SceS000002459
GO:0048478 replication fork protection P
TAS
SpoSPCC550.13

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Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk