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Search term: YDR057W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name YOS9
SGD link S000002464
Alternative ID YDR057W
Description ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
Synonyms YDR057W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3394 ACDHYP-

KOGs classification KOGs description
POORLY CHARACTERIZED Protein OS-9

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g35080 GI:15238373
Caenorhabditis elegans (Cel) CE02757 GI:17553502
Caenorhabditis elegans (Cel) CE25700 GI:17510745
Drosophila melanogaster (Dme) 7297903 GI:7297903
Homo sapiens (Hsa) Hs5803109
(OS9)		 GI:5803109 Q13438
Homo sapiens (Hsa) Hs20070264
(C2orf30)		 GI:20070264 Q96DZ1
Saccharomyces cerevisiae (Sce) YDR057w
(S000002464)		 GI:6320262 Q99220
Schizosaccharomyces pombe (Spo) SPAC227.11c GI:19113877 Q9UTC8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000836 Hrd1p ubiquitin ligase complex C
NAS
HsaOS9
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IPI
SceS000002464
GO:0005783 endoplasmic reticulum C
ISS
SpoSPAC227.11c
GO:0005788 endoplasmic reticulum lumen C
IDA
HsaOS9
SceS000002464
GO:0016020 membrane C
NAS
SpoSPAC227.11c
GO:0034099 luminal surveillance complex C
IDA
SceS000002464
GO:0001948 glycoprotein binding F
IDA
HsaOS9
ISS
SpoSPAC227.11c
GO:0005515 protein binding F
IPI
HsaOS9
GO:0005529 sugar binding F
IMP
SceS000002464
ISS
SceS000002464
SpoSPAC227.11c
GO:0070492 oligosaccharide binding F
IDA
SceS000002464
GO:0006621 protein retention in ER lumen P
IDA
HsaOS9
GO:0008150 biological_process P
ND
AthAt5g35080
GO:0016567 protein ubiquitination P
IMP
HsaOS9
GO:0030433 ER-associated protein catabolic
process		 P
IMP
HsaOS9
SceS000002464
ISS
SpoSPAC227.11c
GO:0034976 response to endoplasmic reticulum
stress		 P
IDA
HsaOS9
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
HsaOS9

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_24710

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago2674 AER171W
Candida glabrata (Cgl) cgl1145 CAGL0E04686g
Debaryomyces hansenii (Dha) dha6003 DEHA0G06787g
Kluyveromyces lactis (Kla) kla3517 KLLA0E12639g
Saccharomyces cerevisiae (Sce) sce1091 YDR057W
(S000002464)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IPI
SceS000002464
GO:0005788 endoplasmic reticulum lumen C
IDA
SceS000002464
GO:0034099 luminal surveillance complex C
IDA
SceS000002464
GO:0005529 sugar binding F
IMP
SceS000002464
ISS
SceS000002464
GO:0070492 oligosaccharide binding F
IDA
SceS000002464
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000002464

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC227.11c
(Q9UTC8)		 YDR057W
(S000002464)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IPI
SceS000002464
GO:0005783 endoplasmic reticulum C
ISS
SpoSPAC227.11c
GO:0005788 endoplasmic reticulum lumen C
IDA
SceS000002464
GO:0016020 membrane C
NAS
SpoSPAC227.11c
GO:0034099 luminal surveillance complex C
IDA
SceS000002464
GO:0001948 glycoprotein binding F
ISS
SpoSPAC227.11c
GO:0005529 sugar binding F
IMP
SceS000002464
ISS
SceS000002464
SpoSPAC227.11c
GO:0070492 oligosaccharide binding F
IDA
SceS000002464
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000002464
ISS
SpoSPAC227.11c

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