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Search term: YDR062W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LCB2
SGD link S000002469
Alternative ID YDR062W
Description Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
Synonyms YDR062W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1357 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Serine palmitoyltransferase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g48780 GI:15229023
Arabidopsis thaliana (Ath) At3g48790 GI:15229024
Arabidopsis thaliana (Ath) At5g23670 GI:15237805
Caenorhabditis elegans (Cel) CE07246
(WBGene00018398)		 GI:17560914 Q20375
Caenorhabditis elegans (Cel) CE13990 GI:17564570
Caenorhabditis elegans (Cel) CE27380 GI:17560912 Q20375
Drosophila melanogaster (Dme) 7298232
(FBgn0002524)		 GI:17136286
Homo sapiens (Hsa) Hs4758668
(SPTLC2)		 GI:4758668 O15270
Homo sapiens (Hsa) Hs17454892 GI:17454892
Homo sapiens (Hsa) Hs20559517 GI:20559517
Homo sapiens (Hsa) Hs22063303 GI:22063303
Saccharomyces cerevisiae (Sce) YDR062w
(S000002469)		 GI:6320267 P40970
Schizosaccharomyces pombe (Spo) SPAC21E11.08 GI:19115417 Q09925
Encephalitozoon cuniculi (Ecu) ECU05g0730 GI:19173612 Q8SRX7


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g48790
GO:0005624 membrane fraction C
IDA
SceS000002469
GO:0005773 vacuole C
IDA
AthAt5g23670
GO:0005783 endoplasmic reticulum C
IDA
AthAt5g23670
SpoSPAC21E11.08
GO:0005792 microsome C
IPI
SceS000002469
GO:0016020 membrane C
IDA
AthAt5g23670
GO:0017059 serine C-palmitoyltransferase complex C
IDA
HsaSPTLC2
IMP
SceS000002469
ISS
SpoSPAC21E11.08
GO:0004758 serine C-palmitoyltransferase activity F
IDA
AthAt5g23670
HsaSPTLC2
IGI
AthAt3g48780
SceS000002469
IMP
SceS000002469
ISS
AthAt5g23670
At3g48790
At3g48780
DmeFBgn0002524
SpoSPAC21E11.08
NAS
DmeFBgn0002524
GO:0005515 protein binding F
IPI
AthAt5g23670
GO:0009555 pollen development P
IMP
AthAt5g23670
At3g48780
GO:0009640 photomorphogenesis P
IMP
AthAt5g23670
At3g48780
GO:0019915 lipid storage P
IMP
CelWBGene00018398
GO:0030148 sphingolipid biosynthetic process P
IMP
AthAt3g48780
SceS000002469
ISS
AthAt5g23670
At3g48780
At3g48790
SpoSPAC21E11.08
TAS
HsaSPTLC2
GO:0046512 sphingosine biosynthetic process P
IDA
AthAt5g23670

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
21610

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SPTLC2 GI:4758668 O15270
Pan troglodytes (Ptr) SPTLC2 GI:114654128
Canis familiaris (Cfa) SPTLC2 GI:73964352
Mus musculus (Mmu) Sptlc2
(MGI:108074)		 GI:6755656 P97363
Rattus norvegicus (Rno) Sptlc2 GI:79749411
Gallus gallus (Gga) SPTLC2 GI:57529939
Drosophila melanogaster (Dme) lace
(FBgn0002524)		 GI:17136286
Anopheles gambiae (Aga) AgaP_AGAP007941 GI:158297271
Caenorhabditis elegans (Cel) sptl-2
(CE07246;
WBGene00018398)		 GI:17560912 Q20375
Schizosaccharomyces pombe (Spo) lcb2
(SPAC21E11.08)		 GI:68000890 Q09925
Saccharomyces cerevisiae (Sce) LCB2
(S000002469)		 GI:6320267 P40970
Kluyveromyces lactis (Kla) LCB2_KLULA GI:50306379
Eremothecium gossypii (Ego) AGOS_AGR127C GI:45201223
Magnaporthe grisea (Mgr) MGG_05197 GI:145602091
Neurospora crassa (Ncr) NCU00447.1 GI:32403840


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000002469
GO:0005739 mitochondrion C
IDA
MmuMGI:108074
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC21E11.08
GO:0005792 microsome C
IPI
SceS000002469
GO:0017059 serine C-palmitoyltransferase complex C
IDA
HsaSPTLC2
IMP
SceS000002469
ISA
MmuMGI:108074
ISS
SpoSPAC21E11.08
GO:0004758 serine C-palmitoyltransferase activity F
IDA
HsaSPTLC2
MmuMGI:108074
IGI
SceS000002469
IMP
SceS000002469
ISS
DmeFBgn0002524
SpoSPAC21E11.08
NAS
DmeFBgn0002524
GO:0006686 sphingomyelin biosynthetic process P
IMP
MmuMGI:108074
GO:0019915 lipid storage P
IMP
CelWBGene00018398
GO:0030148 sphingolipid biosynthetic process P
IMP
SceS000002469
ISS
SpoSPAC21E11.08
TAS
HsaSPTLC2
GO:0046511 sphinganine biosynthetic process P
IDA
MmuMGI:108074
GO:0046512 sphingosine biosynthetic process P
IMP
MmuMGI:108074
GO:0046513 ceramide biosynthetic process P
IMP
MmuMGI:108074

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1032

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9905 ENSANGP00000010113
Ashbya gossypii (Ago) ago4438 AGR127C
Arabidopsis thaliana (Ath) ath16183 At3g48780.1
Arabidopsis thaliana (Ath) ath24616 At5g23670.1
Caenorhabditis elegans (Cel) cel9047 F43H9.2a
(CE07246;
WBGene00018398)
Caenorhabditis elegans (Cel) cel9048 F43H9.2b
(CE27380)
Caenorhabditis elegans (Cel) cel16051 T22G5.5
(CE31996;
WBGene00011932)
Candida glabrata (Cgl) cgl1842 CAGL0G05071g
Cryptococcus neoformans (Cne) cne5750 179.m00624
Cryptococcus neoformans (Cne) cne5751 179.m00625
Dictyostelium discoideum (Ddi) ddi10559 DDB0183793
Debaryomyces hansenii (Dha) dha5567 DEHA0F26444g
Drosophila melanogaster (Dme) dme2515 CG4162-PA
(FBgn0002524)
Danio rerio (Dre) dre15251 ENSDARP00000015045
(zgc:110661)		 Q503F0
Danio rerio (Dre) dre15252 ENSDARP00000047735
Encephalitozoon cuniculi (Ecu) ecu1174 19173612
Takifugu rubripes (Fru) fru10271 SINFRUP00000128825
Takifugu rubripes (Fru) fru14911 SINFRUP00000140018
Gallus gallus (Gga) gga19616 ENSGALP00000017050
(SPTLC2)		 Q5ZJ96
Homo sapiens (Hsa) hsa9884 ENSP00000216484
(SPTLC2)		 O15270
Homo sapiens (Hsa) hsa19839 ENSP00000217206
Kluyveromyces lactis (Kla) kla2162 KLLA0D02134g
Mus musculus (Mmu) mmu6044 ENSMUSP00000021424
(MGI:108074)		 P97363
Mus musculus (Mmu) mmu15592 ENSMUSP00000048313
(MGI:2444678)		 Q8BG54
Neurospora crassa (Ncr) ncr433 NCU00447.2
Oryza sativa (Osa) osa31505 4385.m00149
Oryza sativa (Osa) osa31506 4385.m00150
Oryza sativa (Osa) osa31507 4385.m00151
Oryza sativa (Osa) osa70922 7152.m00147
Plasmodium falciparum (Pfa) pfa1518 PF14_0155
Rattus norvegicus (Rno) rno19827 ENSRNOP00000005920
(RGD:1310030)
Rattus norvegicus (Rno) rno25474 ENSRNOP00000016324
(RGD:1305447)		 Q3B7D2
Saccharomyces cerevisiae (Sce) sce1096 YDR062W
(S000002469)
Schizosaccharomyces pombe (Spo) spo591 SPAC21E11.08 Q09925
Yarrowia lipolytica (Yli) yli5991 YALI0F15345g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000002469
GO:0005739 mitochondrion C
IDA
MmuMGI:108074
GO:0005773 vacuole C
IDA
AthAt5g23670
GO:0005783 endoplasmic reticulum C
IDA
AthAt5g23670
SpoSPAC21E11.08
GO:0005792 microsome C
IPI
SceS000002469
GO:0016020 membrane C
IDA
AthAt5g23670
GO:0017059 serine C-palmitoyltransferase complex C
IMP
SceS000002469
ISA
MmuMGI:108074
ISO
MmuMGI:2444678
ISS
SpoSPAC21E11.08
GO:0020011 apicoplast C
IDA
PfaPF14_0155
GO:0004758 serine C-palmitoyltransferase activity F
IDA
AthAt5g23670
MmuMGI:108074
IGI
AthAt3g48780
SceS000002469
IMP
SceS000002469
ISO
MmuMGI:2444678
ISS
AthAt5g23670
At3g48780
DmeFBgn0002524
SpoSPAC21E11.08
NAS
DmeFBgn0002524
GO:0005515 protein binding F
IPI
AthAt5g23670
GO:0000003 reproduction P
IMP
CelWBGene00011932
GO:0006686 sphingomyelin biosynthetic process P
IMP
MmuMGI:108074
GO:0009555 pollen development P
IMP
AthAt5g23670
At3g48780
GO:0009640 photomorphogenesis P
IMP
AthAt5g23670
At3g48780
GO:0019915 lipid storage P
IMP
CelWBGene00018398
GO:0030148 sphingolipid biosynthetic process P
IMP
AthAt3g48780
SceS000002469
ISS
AthAt5g23670
At3g48780
SpoSPAC21E11.08
GO:0046511 sphinganine biosynthetic process P
IDA
MmuMGI:108074
GO:0046512 sphingosine biosynthetic process P
IDA
AthAt5g23670
IMP
MmuMGI:108074
GO:0046513 ceramide biosynthetic process P
IMP
MmuMGI:108074
GO:0046520 sphingoid biosynthetic process P
ISO
MmuMGI:2444678

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC21E11.08
(Q09925)		 YDR062W
(S000002469)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000002469
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC21E11.08
GO:0005792 microsome C
IPI
SceS000002469
GO:0017059 serine C-palmitoyltransferase complex C
IMP
SceS000002469
ISS
SpoSPAC21E11.08
GO:0004758 serine C-palmitoyltransferase activity F
IGI
SceS000002469
IMP
SceS000002469
ISS
SpoSPAC21E11.08
GO:0030148 sphingolipid biosynthetic process P
IMP
SceS000002469
ISS
SpoSPAC21E11.08

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Search for gene by ID or name:

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Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk