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Search term: YDR097C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MSH6
SGD link S000002504
Alternative ID YDR097C
Description Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
Synonyms YDR097C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0217 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Mismatch repair ATPase MSH6 (MutS family)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g24320 GI:15230096
Arabidopsis thaliana (Ath) At4g02070 GI:15235223
Caenorhabditis elegans (Cel) CE28985
(WBGene00003422)
GI:17508447 Q9N3T8
Drosophila melanogaster (Dme) 7294307 GI:7294307
Homo sapiens (Hsa) Hs4504191
(MSH6)
GI:4504191 P52701
Saccharomyces cerevisiae (Sce) YDR097c
(S000002504)
GI:6320302 Q03834
Schizosaccharomyces pombe (Spo) SPCC285.16c GI:19075844 O74502
Encephalitozoon cuniculi (Ecu) ECU10g0710 GI:19074680 Q8SR47
Arabidopsis thaliana (Ath) At3g24320 GI:15230096
Arabidopsis thaliana (Ath) At4g02070 GI:15235223
Caenorhabditis elegans (Cel) CE28985
(WBGene00003422)
GI:17508447 Q9N3T8
Drosophila melanogaster (Dme) 7294307 GI:7294307
Homo sapiens (Hsa) Hs4504191
(MSH6)
GI:4504191 P52701
Saccharomyces cerevisiae (Sce) YDR097c
(S000002504)
GI:6320302 Q03834
Schizosaccharomyces pombe (Spo) SPCC285.16c GI:19075844 O74502
Encephalitozoon cuniculi (Ecu) ECU10g0710 GI:19074680 Q8SR47
Arabidopsis thaliana (Ath) At3g24320 GI:15230096
Arabidopsis thaliana (Ath) At4g02070 GI:15235223
Caenorhabditis elegans (Cel) CE28985
(WBGene00003422)
GI:17508447 Q9N3T8
Drosophila melanogaster (Dme) 7294307 GI:7294307
Homo sapiens (Hsa) Hs4504191
(MSH6)
GI:4504191 P52701
Saccharomyces cerevisiae (Sce) YDR097c
(S000002504)
GI:6320302 Q03834
Schizosaccharomyces pombe (Spo) SPCC285.16c GI:19075844 O74502
Encephalitozoon cuniculi (Ecu) ECU10g0710 GI:19074680 Q8SR47


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
ISS
SpoSPCC285.16c
GO:0005634 nucleus C
IDA
SceS000002504
SpoSPCC285.16c
GO:0005739 mitochondrion C
IDA
AthAt3g24320
GO:0005829 cytosol C
IDA
SpoSPCC285.16c
GO:0009507 chloroplast C
IDA
AthAt3g24320
GO:0032301 MutSalpha complex C
IDA
HsaMSH6
IPI
SceS000002504
ISS
CelWBGene00003422
SpoSPCC285.16c
GO:0000287 magnesium ion binding F
IDA
HsaMSH6
GO:0000400 four-way junction DNA binding F
IDA
HsaMSH6
SceS000002504
ISS
SpoSPCC285.16c
GO:0000403 Y-form DNA binding F
RCA
SceS000002504
GO:0000404 loop DNA binding F
RCA
SceS000002504
GO:0003677 DNA binding F
ISS
CelWBGene00003422
GO:0003684 damaged DNA binding F
IDA
AthAt4g02070
ISS
AthAt3g24320
SpoSPCC285.16c
GO:0003690 double-stranded DNA binding F
IDA
HsaMSH6
GO:0005515 protein binding F
IPI
HsaMSH6
MSH6
GO:0005524 ATP binding F
IDA
HsaMSH6
SceS000002504
ISS
AthAt3g24320
SpoSPCC285.16c
GO:0008094 DNA-dependent ATPase activity F
ISS
SpoSPCC285.16c
GO:0016887 ATPase activity F
IDA
HsaMSH6
SceS000002504
GO:0030983 mismatched DNA binding F
IDA
HsaMSH6
GO:0032137 guanine/thymine mispair binding F
IDA
HsaMSH6
SceS000002504
ISS
SpoSPCC285.16c
GO:0032138 single base insertion or deletion
binding
F
IDA
SceS000002504
IMP
SceS000002504
ISS
SpoSPCC285.16c
GO:0032142 single guanine insertion binding F
IDA
HsaMSH6
GO:0032143 single thymine insertion binding F
IDA
HsaMSH6
GO:0032357 oxidized purine DNA binding F
IDA
HsaMSH6
GO:0032405 MutLalpha complex binding F
IDA
HsaMSH6
GO:0043531 ADP binding F
IDA
HsaMSH6
GO:0000002 mitochondrial genome maintenance P
IMP
AthAt3g24320
GO:0000710 meiotic mismatch repair P
IMP
SceS000002504
ISS
HsaMSH6
SpoSPCC285.16c
GO:0000737 DNA catabolic process, endonucleolytic P
RCA
SceS000002504
GO:0003006 reproductive developmental process P
RCA
SceS000002504
GO:0006260 DNA replication P
RCA
SceS000002504
GO:0006281 DNA repair P
IDA
HsaMSH6
RCA
SceS000002504
GO:0006298 mismatch repair P
IDA
HsaMSH6
SceS000002504
IMP
CelWBGene00003422
HsaMSH6
SceS000002504
SpoSPCC285.16c
ISS
AthAt4g02070
At3g24320
GO:0006308 DNA catabolic process P
RCA
SceS000002504
GO:0006310 DNA recombination P
RCA
SceS000002504
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00003422
RCA
SceS000002504
GO:0007131 reciprocal meiotic recombination P
ISS
SpoSPCC285.16c
GO:0007530 sex determination P
RCA
SceS000002504
GO:0007531 mating type determination P
RCA
SceS000002504
GO:0007533 mating type switching P
RCA
SceS000002504
GO:0008340 determination of adult lifespan P
ISS
HsaMSH6
GO:0008629 induction of apoptosis by intracellular
signals
P
ISS
HsaMSH6
GO:0008630 DNA damage response, signal transduction resulting
in induction of apoptosis
P
ISS
HsaMSH6
SpoSPCC285.16c
GO:0009411 response to UV P
ISS
HsaMSH6
SpoSPCC285.16c
GO:0016446 somatic hypermutation of immunoglobulin
genes
P
ISS
HsaMSH6
GO:0016447 somatic recombination of immunoglobulin gene
segments
P
ISS
HsaMSH6
GO:0032042 mitochondrial DNA metabolic process P
IMP
AthAt3g24320
GO:0043570 maintenance of DNA repeat elements P
IMP
CelWBGene00003422
SpoSPCC285.16c
GO:0045190 isotype switching P
ISS
HsaMSH6
GO:0045910 negative regulation of DNA recombination P
IDA
HsaMSH6
ISS
SpoSPCC285.16c
GO:0051096 positive regulation of helicase
activity
P
IDA
HsaMSH6
GO:0051321 meiotic cell cycle P
RCA
SceS000002504

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
149

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) MSH6 GI:4504191 P52701
Canis familiaris (Cfa) MSH6 GI:73970143
Mus musculus (Mmu) Msh6
(MGI:1343961)
GI:6754744 P54276
Gallus gallus (Gga) MSH6 GI:118087634
Drosophila melanogaster (Dme) Msh6 GI:24664545
Anopheles gambiae (Aga) AgaP_AGAP003190 GI:158291378
Caenorhabditis elegans (Cel) msh-6
(CE28985;
WBGene00003422)
GI:17508447 Q9N3T8
Schizosaccharomyces pombe (Spo) msh6
(SPCC285.16c)
GI:19075844 O74502
Saccharomyces cerevisiae (Sce) MSH6
(S000002504)
GI:6320302 Q03834
Kluyveromyces lactis (Kla) KLLA0C17732g GI:50306061
Eremothecium gossypii (Ego) AGOS_AGR116W GI:45201212
Magnaporthe grisea (Mgr) MGG_00704 GI:39974299
Neurospora crassa (Ncr) NCU08135.1 GI:32416726
Arabidopsis thaliana (Ath) MSH6 GI:15235223
Oryza sativa (Osa) Os09g0407600 GI:115479085
Plasmodium falciparum (Pfa) PFE0270c GI:124506031


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
ISS
SpoSPCC285.16c
GO:0000790 nuclear chromatin C
IDA
MmuMGI:1343961
GO:0005634 nucleus C
IDA
SceS000002504
SpoSPCC285.16c
GO:0005829 cytosol C
IDA
SpoSPCC285.16c
GO:0032301 MutSalpha complex C
IDA
HsaMSH6
MmuMGI:1343961
IPI
SceS000002504
ISS
CelWBGene00003422
SpoSPCC285.16c
GO:0000287 magnesium ion binding F
IDA
HsaMSH6
GO:0000400 four-way junction DNA binding F
IDA
HsaMSH6
SceS000002504
ISS
SpoSPCC285.16c
GO:0000403 Y-form DNA binding F
RCA
SceS000002504
GO:0000404 loop DNA binding F
RCA
SceS000002504
GO:0003677 DNA binding F </
IGI
MmuMGI:1343961
IMP
MmuMGI:1343961
ISS
CelWBGene00003422