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Search term: YDR110W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name FOB1
SGD link S000002517
Alternative ID YDR110W
Description Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
Synonyms YDR110W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
38675

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) FOB1
(S000002517)		 GI:6320315
Kluyveromyces lactis (Kla) KLLA0F19140g GI:50311817
Eremothecium gossypii (Ego) AGOS_AGR086C GI:45201181


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005730 nucleolus C
IDA
SceS000002517
GO:0043110 rDNA spacer replication fork barrier
binding		 F
IDA
SceS000002517
GO:0000183 chromatin silencing at rDNA P
IDA
SceS000002517
GO:0001302 replicative cell aging P
IMP
SceS000002517
GO:0006310 DNA recombination P
IMP
SceS000002517
GO:0006364 rRNA processing P
RCA
SceS000002517
GO:0007580 extrachromosomal circular DNA accumulation
involved in cell aging		 P
IMP
SceS000002517
GO:0008156 negative regulation of DNA replication P
IDA
SceS000002517
GO:0034503 protein localization to nucleolar rDNA
repeats		 P
IMP
SceS000002517
GO:0070550 rDNA condensation P
IMP
SceS000002517

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_31448

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago4396 AGR086C
Candida glabrata (Cgl) cgl280 CAGL0B01771g
Kluyveromyces lactis (Kla) kla4939 KLLA0F19140g
Saccharomyces cerevisiae (Sce) sce1147 YDR110W
(S000002517)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005730 nucleolus C
IDA
SceS000002517
GO:0043110 rDNA spacer replication fork barrier
binding		 F
IDA
SceS000002517
GO:0000183 chromatin silencing at rDNA P
IDA
SceS000002517
GO:0001302 replicative cell aging P
IMP
SceS000002517
GO:0006310 DNA recombination P
IMP
SceS000002517
GO:0006364 rRNA processing P
RCA
SceS000002517
GO:0007580 extrachromosomal circular DNA accumulation
involved in cell aging		 P
IMP
SceS000002517
GO:0008156 negative regulation of DNA replication P
IDA
SceS000002517
GO:0034503 protein localization to nucleolar rDNA
repeats		 P
IMP
SceS000002517
GO:0070550 rDNA condensation P
IMP
SceS000002517

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