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Search term: YDR164C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SEC1
SGD link S000002571
Alternative ID YDR164C
Description Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
Synonyms YDR164C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1300 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Vesicle trafficking protein Sec1

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g02010 GI:15220920
Arabidopsis thaliana (Ath) At1g12360 GI:15221288
Arabidopsis thaliana (Ath) At4g12120 GI:7485573
Caenorhabditis elegans (Cel) CE17219
(WBGene00020298)		 GI:17542248 O44412
Caenorhabditis elegans (Cel) CE24927
(WBGene00006757)		 GI:17570171
Drosophila melanogaster (Dme) 7292440 GI:12644024
Homo sapiens (Hsa) Hs6005886 GI:6005886
Homo sapiens (Hsa) Hs5902128 GI:5902128
Homo sapiens (Hsa) Hs4507297 GI:4507297 P61764
Saccharomyces cerevisiae (Sce) YDR164c
(S000002571)		 GI:6320368 P30619
Schizosaccharomyces pombe (Spo) SPCC584.05 GI:19075726 O94590
Encephalitozoon cuniculi (Ecu) ECU02g0430 GI:19073964 Q8SSH8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000300 peripheral to membrane of membrane
fraction		 C
IDA
AthAt1g12360
GO:0005575 cellular_component C
ND
AthAt1g02010
GO:0005634 nucleus C
IDA
SpoSPCC584.05
GO:0005773 vacuole C
IDA
AthAt1g12360
GO:0005829 cytosol C
IDA
AthAt1g12360
SpoSPCC584.05
GO:0005886 plasma membrane C
IDA
AthAt4g12120
At1g12360
SceS000002571
GO:0005934 cellular bud tip C
IDA
SceS000002571
GO:0005935 cellular bud neck C
IDA
SceS000002571
GO:0030424 axon C
IDA
CelWBGene00006757
GO:0032153 cell division site C
IDA
SpoSPCC584.05
GO:0051286 cell tip C
IDA
SpoSPCC584.05
GO:0000149 SNARE binding F
IDA
SceS000002571
ISS
SpoSPCC584.05
GO:0008565 protein transporter activity F
ISS
AthAt4g12120
At1g02010
At1g12360
GO:0000003 reproduction P
IMP
CelWBGene00006757
RCA
SceS000002571
GO:0001956 positive regulation of neurotransmitter
secretion		 P
IMP
CelWBGene00006757
GO:0006887 exocytosis P
IMP
SceS000002571
IPI
SceS000002571
GO:0006904 vesicle docking involved in exocytosis P
IPI
SceS000002571
ISS
SpoSPCC584.05
GO:0006906 vesicle fusion P
IDA
SceS000002571
IMP
SceS000002571
ISS
SpoSPCC584.05
GO:0007271 synaptic transmission, cholinergic P
IMP
CelWBGene00006757
GO:0009306 protein secretion P
ISS
AthAt4g12120
At1g02010
At1g12360
GO:0016050 vesicle organization P
RCA
SceS000002571
GO:0016081 synaptic vesicle docking involved in
exocytosis		 P
IMP
CelWBGene00006757
GO:0040011 locomotion P
IMP
CelWBGene00006757
GO:0048284 organelle fusion P
RCA
SceS000002571
GO:0051301 cell division P
RCA
SceS000002571

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
55530

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) STXBP2 GI:188528689
Pan troglodytes (Ptr) STXBP2 GI:114674993
Canis familiaris (Cfa) STXBP2 GI:50978986
Mus musculus (Mmu) Stxbp2
(MGI:107370)		 GI:6755688 Q548T0
Rattus norvegicus (Rno) Stxbp2
(RGD:619967)		 GI:13592101
Schizosaccharomyces pombe (Spo) sec1
(SPCC584.05)		 GI:19075726 O94590
Saccharomyces cerevisiae (Sce) SEC1
(S000002571)		 GI:6320368 P30619
Kluyveromyces lactis (Kla) KLLA0D17028g GI:50307667
Eremothecium gossypii (Ego) AGOS_AGL162C GI:45200935
Magnaporthe grisea (Mgr) MGG_12345 GI:145612411
Neurospora crassa (Ncr) NCU08312.1 GI:32417080


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPCC584.05
GO:0005737 cytoplasm C
ISO
MmuMGI:107370
GO:0005829 cytosol C
IDA
HsaSTXBP2
SpoSPCC584.05
GO:0005886 plasma membrane C
IDA
HsaSTXBP2
SceS000002571
ISO
MmuMGI:107370
GO:0005934 cellular bud tip C
IDA
SceS000002571
GO:0005935 cellular bud neck C
IDA
SceS000002571
GO:0016324 apical plasma membrane C
IDA
MmuMGI:107370
GO:0030027 lamellipodium C
ISO
MmuMGI:107370
GO:0030141 stored secretory granule C
ISO
MmuMGI:107370
GO:0031201 SNARE complex C
IDA
HsaSTXBP2
GO:0032153 cell division site C
IDA
SpoSPCC584.05
GO:0042581 specific granule C
IDA
HsaSTXBP2
GO:0042582 azurophil granule C
IDA
HsaSTXBP2
GO:0043234 protein complex C
ISO
MmuMGI:107370
GO:0051286 cell tip C
IDA
SpoSPCC584.05
GO:0070820 tertiary granule C
IDA
HsaSTXBP2
GO:0000149 SNARE binding F
IDA
SceS000002571
ISS
SpoSPCC584.05
GO:0017075 syntaxin-1 binding F
IPI
MmuMGI:107370
GO:0019905 syntaxin binding F
ISO
MmuMGI:107370
TAS
MmuMGI:107370
GO:0030348 syntaxin-3 binding F
IPI
HsaSTXBP2
MmuMGI:107370
GO:0000003 reproduction P
RCA
SceS000002571
GO:0006887 exocytosis P
IMP
MmuMGI:107370
SceS000002571
IPI
SceS000002571
GO:0006904 vesicle docking involved in exocytosis P
IPI
SceS000002571
ISS
SpoSPCC584.05
GO:0006906 vesicle fusion P
IDA
SceS000002571
IMP
SceS000002571
ISS
SpoSPCC584.05
GO:0016050 vesicle organization P
RCA
SceS000002571
GO:0043304 regulation of mast cell degranulation P
ISO
MmuMGI:107370
ISS
HsaSTXBP2
GO:0043312 neutrophil degranulation P
IEP
HsaSTXBP2
GO:0048284 organelle fusion P
RCA
SceS000002571
GO:0051301 cell division P
RCA
SceS000002571

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_702

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5291 ENSANGP00000017600
Ashbya gossypii (Ago) ago4150 AGL162C
Arabidopsis thaliana (Ath) ath109 At1g02010.1
Arabidopsis thaliana (Ath) ath1301 At1g12360.1
Arabidopsis thaliana (Ath) ath18961 At4g12120.1
Caenorhabditis elegans (Cel) cel7484 F27D9.1a
(CE24927;
WBGene00006757)
Caenorhabditis elegans (Cel) cel7486 F27D9.1c
(CE04449)
Candida glabrata (Cgl) cgl984 CAGL0E01001g
Dictyostelium discoideum (Ddi) ddi13324 DDB0231656
Debaryomyces hansenii (Dha) dha4054 DEHA0E18370g
Drosophila melanogaster (Dme) dme7906 CG15811-PA
(FBgn0004574)
Danio rerio (Dre) dre297 ENSDARP00000012776
(zgc:114171)		 Q4QRD0
Danio rerio (Dre) dre296 ENSDARP00000023395
Danio rerio (Dre) dre31091 ENSDARP00000044188
Danio rerio (Dre) dre4608 ENSDARP00000044775
(stxbp3)		 Q6PD84
Encephalitozoon cuniculi (Ecu) ecu43 19073964
Takifugu rubripes (Fru) fru30052 SINFRUP00000144450
Takifugu rubripes (Fru) fru30789 SINFRUP00000150657
Takifugu rubripes (Fru) fru7380 SINFRUP00000157639
Gallus gallus (Gga) gga22080 ENSGALP00000003109
(STXBP3)		 Q5ZIM9
Gallus gallus (Gga) gga22079 ENSGALP00000003111
(STXBP3)
Gallus gallus (Gga) gga8150 ENSGALP00000011635
(STXBP1)		 Q6R748
Homo sapiens (Hsa) hsa15486 ENSP00000221283
(STXBP2)		 Q15833
Homo sapiens (Hsa) hsa31938 ENSP00000259377
Homo sapiens (Hsa) hsa1613 ENSP00000264125
Homo sapiens (Hsa) hsa31939 ENSP00000344525
Kluyveromyces lactis (Kla) kla2812 KLLA0D17028g
Mus musculus (Mmu) mmu25533 ENSMUSP00000004745
(MGI:107370)		 Q64324
Mus musculus (Mmu) mmu17408 ENSMUSP00000029481
(MGI:107362)		 Q60770-2
Mus musculus (Mmu) mmu14463 ENSMUSP00000052440
(MGI:107363)		 O08599-1
Mus musculus (Mmu) mmu14464 ENSMUSP00000073266
Neurospora crassa (Ncr) ncr8101 NCU08312.2
Oryza sativa (Osa) osa27884 4184.m00196
Oryza sativa (Osa) osa28065 4223.m00157
Oryza sativa (Osa) osa84237 8265.m00096
Plasmodium falciparum (Pfa) pfa3098 PFF0665c
Rattus norvegicus (Rno) rno7935 ENSRNOP00000001322
(RGD:619967)		 Q62753
Rattus norvegicus (Rno) rno18432 ENSRNOP00000021178
(RGD:3785)		 P61765-1
Rattus norvegicus (Rno) rno18433 ENSRNOP00000021189
(RGD:3785)		 P61765-2
Rattus norvegicus (Rno) rno16867 ENSRNOP00000027666
(RGD:619968)		 Q99PV2
Saccharomyces cerevisiae (Sce) sce1202 YDR164C
(S000002571)
Schizosaccharomyces pombe (Spo) spo3431 SPCC584.05 O94590
Yarrowia lipolytica (Yli) yli4772 YALI0E22044g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000300 peripheral to membrane of membrane
fraction		 C
IDA
AthAt1g12360
DmeFBgn0004574
GO:0005575 cellular_component C
ND
AthAt1g02010
GO:0005634 nucleus C
IDA
SpoSPCC584.05
GO:0005737 cytoplasm C
ISO
MmuMGI:107370
MGI:107363
NAS
DmeFBgn0004574
GO:0005739 mitochondrion C
IDA
MmuMGI:107363
GO:0005773 vacuole C
IDA
AthAt1g12360
GO:0005829 cytosol C
IDA
AthAt1g12360
DmeFBgn0004574
MmuMGI:107362
SpoSPCC584.05
TAS
DmeFBgn0004574
GO:0005886 plasma membrane C
IDA
AthAt4g12120
At1g12360
MmuMGI:107362
SceS000002571
ISO
MmuMGI:107370
MGI:107363
GO:0005934 cellular bud tip C
IDA
SceS000002571
GO:0005935 cellular bud neck C
IDA
SceS000002571
GO:0012506 vesicle membrane C
NAS
DmeFBgn0004574
GO:0016020 membrane C
TAS
DmeFBgn0004574
GO:0016323 basolateral plasma membrane C
ISO
MmuMGI:107362
GO:0016324 apical plasma membrane C
IDA
MmuMGI:107370
MGI:107362
ISO
MmuMGI:107362
GO:0030027 lamellipodium C
ISO
MmuMGI:107370
GO:0030141 stored secretory granule C
ISO
MmuMGI:107370
GO:0030424 axon C
IDA
CelWBGene00006757
GO:0032153 cell division site C
IDA
SpoSPCC584.05
GO:0043195 terminal button C
IDA
DmeFBgn0004574
GO:0043234 protein complex C
ISO
MmuMGI:107370
MGI:107363
GO:0051286 cell tip C
IDA
SpoSPCC584.05
GO:0000149 SNARE binding F
IDA
SceS000002571
ISO
MmuMGI:107363
ISS
DmeFBgn0004574
SpoSPCC584.05
GO:0005515 protein binding F
IPI
MmuMGI:107363
MGI:107362
GO:0008565 protein transporter activity F
ISS
AthAt4g12120
At1g02010
At1g12360
PfaPFF0665c
GO:0017075 syntaxin-1 binding F
IPI
MmuMGI:107370
MGI:107363
ISO
MmuMGI:107363
MGI:107362
GO:0019904 protein domain specific binding F
ISO
MmuMGI:107363
GO:0019905 syntaxin binding F
IDA
MmuMGI:107362
IPI
MmuMGI:107362
ISO
MmuMGI:107362
MGI:107370
MGI:107363
NAS
DmeFBgn0004574
TAS
MmuMGI:107370
GO:0030348 syntaxin-3 binding F
IPI
MmuMGI:107370
GO:0042802 identical protein binding F
ISO
MmuMGI:107363
GO:0047485 protein N-terminus binding F
ISO
MmuMGI:107363
GO:0000003 reproduction P
IMP
CelWBGene00006757
RCA
SceS000002571
GO:0000910 cytokinesis P
IMP
DmeFBgn0004574
GO:0001956 positive regulation of neurotransmitter
secretion		 P
IMP
CelWBGene00006757
GO:0006887 exocytosis P
IMP
MmuMGI:107370
MGI:107363
MGI:107362
SceS000002571
IPI
SceS000002571
NAS
DmeFBgn0004574
TAS
DmeFBgn0004574
GO:0006904 vesicle docking involved in exocytosis P
IMP
MmuMGI:107363
IPI
SceS000002571
ISS
SpoSPCC584.05
GO:0006906 vesicle fusion P
IDA
SceS000002571
IMP
SceS000002571
ISS
SpoSPCC584.05
GO:0006944 cellular membrane fusion P
ISO
MmuMGI:107363
GO:0007268 synaptic transmission P
IDA
DmeFBgn0004574
NAS
DmeFBgn0004574
TAS
DmeFBgn0004574
GO:0007269 neurotransmitter secretion P
IMP
DmeFBgn0004574
MmuMGI:107363
NAS
DmeFBgn0004574
TAS
DmeFBgn0004574
GO:0007271 synaptic transmission, cholinergic P
IMP
CelWBGene00006757
GO:0007274 neuromuscular synaptic transmission P
IMP
MmuMGI:107363
GO:0007317 regulation of pole plasm oskar mRNA
localization		 P
IMP
DmeFBgn0004574
GO:0007412 axon target recognition P
IMP
MmuMGI:107363
GO:0007420 brain development P
IMP
MmuMGI:107362
GO:0009306 protein secretion P
ISS
AthAt4g12120
At1g02010
At1g12360
PfaPFF0665c
GO:0009416 response to light stimulus P
IMP
DmeFBgn0004574
GO:0010807 regulation of synaptic vesicle
priming		 P
ISO
MmuMGI:107363
GO:0015758 glucose transport P
IDA
MmuMGI:107362
GO:0016050 vesicle organization P
RCA
SceS000002571
GO:0016081 synaptic vesicle docking involved in
exocytosis		 P
IMP
CelWBGene00006757
GO:0016082 synaptic vesicle priming P
NAS
DmeFBgn0004574
GO:0016188 synaptic vesicle maturation P
IMP
MmuMGI:107363
GO:0016192 vesicle-mediated transport P
ISS
DmeFBgn0004574
NAS
DmeFBgn0004574
GO:0022615 protein to membrane docking P
IMP
MmuMGI:107362
GO:0030073 insulin secretion P
IMP
MmuMGI:107362
GO:0032229 negative regulation of synaptic transmission,
GABAergic		 P
IDA
MmuMGI:107363
GO:0032868 response to insulin stimulus P
IMP
MmuMGI:107362
GO:0032940 secretion by cell P
IDA
DmeFBgn0004574
GO:0040011 locomotion P
IMP
CelWBGene00006757
GO:0043304 regulation of mast cell degranulation P
ISO
MmuMGI:107370
GO:0043524 negative regulation of neuron apoptosis P
IMP
MmuMGI:107363
GO:0048284 organelle fusion P
RCA
SceS000002571
GO:0048489 synaptic vesicle transport P
TAS
DmeFBgn0004574
GO:0050821 protein stabilization P
ISO
MmuMGI:107363
GO:0051291 protein heterooligomerization P
ISO
MmuMGI:107362
GO:0051301 cell division P
RCA
SceS000002571
GO:0060292 long term synaptic depression P
IMP
MmuMGI:107363

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC584.05
(O94590)		 YDR164C
(S000002571)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPCC584.05
GO:0005829 cytosol C
IDA
SpoSPCC584.05
GO:0005886 plasma membrane C
IDA
SceS000002571
GO:0005934 cellular bud tip C
IDA
SceS000002571
GO:0005935 cellular bud neck C
IDA
SceS000002571
GO:0032153 cell division site C
IDA
SpoSPCC584.05
GO:0051286 cell tip C
IDA
SpoSPCC584.05
GO:0000149 SNARE binding F
IDA
SceS000002571
ISS
SpoSPCC584.05
GO:0000003 reproduction P
RCA
SceS000002571
GO:0006887 exocytosis P
IMP
SceS000002571
IPI
SceS000002571
GO:0006904 vesicle docking involved in exocytosis P
IPI
SceS000002571
ISS
SpoSPCC584.05
GO:0006906 vesicle fusion P
IDA
SceS000002571
IMP
SceS000002571
ISS
SpoSPCC584.05
GO:0016050 vesicle organization P
RCA
SceS000002571
GO:0048284 organelle fusion P
RCA
SceS000002571
GO:0051301 cell division P
RCA
SceS000002571

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