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Search term: YDR170C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SEC7
SGD link S000002577
Alternative ID YDR170C
Description Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
Synonyms YDR170C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0929 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Guanine nucleotide exchange factor

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g01960 GI:15217579
Arabidopsis thaliana (Ath) At3g43300 GI:15229258
Arabidopsis thaliana (Ath) At3g60860 GI:15232969
Arabidopsis thaliana (Ath) At4g35380 GI:15236976
Arabidopsis thaliana (Ath) At4g38200 GI:15233734
Caenorhabditis elegans (Cel) CE24576 GI:17509689
Drosophila melanogaster (Dme) 7298092 GI:19921290
Homo sapiens (Hsa) Hs5453571 GI:5453571
Homo sapiens (Hsa) Hs5453573 GI:5453573
Homo sapiens (Hsa) Hs15812208 GI:15812208
Saccharomyces cerevisiae (Sce) YBL060w
(S000000156)		 GI:6319411 P34225
Saccharomyces cerevisiae (Sce) YDR170c
(S000002577)		 GI:6320374 P11075
Saccharomyces cerevisiae (Sce) YPR095c
(S000006299)		 GI:6325352 Q06836
Schizosaccharomyces pombe (Spo) SPAC11E3.11c GI:19115848 O13690
Schizosaccharomyces pombe (Spo) SPAC26F1.01 GI:19115806 Q10491
Schizosaccharomyces pombe (Spo) SPAC30.01c GI:19115467 Q9P7V5
Schizosaccharomyces pombe (Spo) SPAC4D7.01c GI:19115866 Q9UT02
Arabidopsis thaliana (Ath) At1g01960 GI:15217579
Arabidopsis thaliana (Ath) At3g43300 GI:15229258
Arabidopsis thaliana (Ath) At3g60860 GI:15232969
Arabidopsis thaliana (Ath) At4g35380 GI:15236976
Arabidopsis thaliana (Ath) At4g38200 GI:15233734
Caenorhabditis elegans (Cel) CE24576 GI:17509689
Drosophila melanogaster (Dme) 7298092 GI:19921290
Homo sapiens (Hsa) Hs5453571 GI:5453571
Homo sapiens (Hsa) Hs5453573 GI:5453573
Homo sapiens (Hsa) Hs15812208 GI:15812208
Saccharomyces cerevisiae (Sce) YBL060w
(S000000156)		 GI:6319411 P34225
Saccharomyces cerevisiae (Sce) YDR170c
(S000002577)		 GI:6320374 P11075
Saccharomyces cerevisiae (Sce) YPR095c
(S000006299)		 GI:6325352 Q06836
Schizosaccharomyces pombe (Spo) SPAC11E3.11c GI:19115848 O13690
Schizosaccharomyces pombe (Spo) SPAC26F1.01 GI:19115806 Q10491
Schizosaccharomyces pombe (Spo) SPAC30.01c GI:19115467 Q9P7V5
Schizosaccharomyces pombe (Spo) SPAC4D7.01c GI:19115866 Q9UT02


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000137 Golgi cis cisterna C
IDA
SpoSPAC30.01c
GO:0000138 Golgi trans cisterna C
IDA
SpoSPAC30.01c
GO:0005575 cellular_component C
ND
SpoSPAC11E3.11c
GO:0005634 nucleus C
IDA
AthAt1g01960
GO:0005635 nuclear envelope C
IDA
SpoSPAC30.01c
GO:0005737 cytoplasm C
IDA
SceS000000156
SpoSPAC30.01c
GO:0005739 mitochondrion C
IDA
SceS000006299
GO:0005769 early endosome C
IDA
AthAt3g43300
GO:0005770 late endosome C
IDA
SceS000002577
GO:0005794 Golgi apparatus C
IDA
SpoSPAC4D7.01c
GO:0005798 Golgi-associated vesicle C
IDA
SceS000002577
ISS
SpoSPAC30.01c
SPAC4D7.01c
GO:0005802 trans-Golgi network C
IDA
AthAt3g43300
SceS000002577
GO:0005829 cytosol C
IDA
AthAt1g01960
SceS000002577
SpoSPAC26F1.01
GO:0005934 cellular bud tip C
IDA
SceS000000156
GO:0005935 cellular bud neck C
IDA
SceS000000156
GO:0005938 cell cortex C
IDA
SpoSPAC30.01c
GO:0009507 chloroplast C
IDA
AthAt4g38200
GO:0030135 coated vesicle C
RCA
SceS000002577
GO:0032153 cell division site C
IDA
SpoSPAC26F1.01
GO:0051286 cell tip C
IDA
SpoSPAC26F1.01
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
ISS
AthAt3g43300
At3g60860
At4g35380
At1g01960
At4g38200
SpoSPAC11E3.11c
GO:0005086 ARF guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000002577
S000006299
S000000156
ISS
SceS000000156
SpoSPAC26F1.01
SPAC30.01c
SPAC4D7.01c
GO:0005515 protein binding F
IPI
AthAt3g43300
GO:0000045 autophagic vacuole assembly P
IMP
SceS000002577
GO:0006886 intracellular protein transport P
IC
SpoSPAC26F1.01
ISS
SpoSPAC4D7.01c
SPAC11E3.11c
SPAC30.01c
GO:0006887 exocytosis P
IGI
SceS000006299
ISS
SpoSPAC26F1.01
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SceS000002577
ISS
SpoSPAC4D7.01c
SPAC30.01c
GO:0006891 intra-Golgi vesicle-mediated transport P
IMP
SceS000002577
GO:0008104 protein localization P
IMP
SceS000000156
GO:0009561 megagametogenesis P
IMP
AthAt1g01960
GO:0010513 positive regulation of phosphatidylinositol
biosynthetic process		 P
IMP
SceS000000156
GO:0016192 vesicle-mediated transport P
IGI
SceS000006299
IMP
AthAt3g43300
ISS
SpoSPAC11E3.11c
SPAC26F1.01
GO:0040007 growth P
IMP
AthAt3g43300
GO:0042742 defense response to bacterium P
IMP
AthAt3g43300
GO:0051666 actin cortical patch localization P
IMP
SceS000000156

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
111880

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ARFGEF2 GI:150417986
Pan troglodytes (Ptr) ARFGEF2 GI:114682531
Canis familiaris (Cfa) ARFGEF2 GI:57104270
Mus musculus (Mmu) Arfgef2
(MGI:2139354)		 GI:82887368 A2A5R2
Rattus norvegicus (Rno) Arfgef2
(RGD:631430)		 GI:31342051
Gallus gallus (Gga) ARFGEF2 GI:118100582
Schizosaccharomyces pombe (Spo) SPAP8A3.15c GI:19115866
Saccharomyces cerevisiae (Sce) SEC7
(S000002577)		 GI:6320374 P11075
Kluyveromyces lactis (Kla) KLLA0D17358g GI:50307697
Eremothecium gossypii (Ego) AGOS_AGL147C GI:45200950
Magnaporthe grisea (Mgr) MGG_14173 GI:145602795
Neurospora crassa (Ncr) NCU07658.1 GI:32415772
Arabidopsis thaliana (Ath) AT4G38200 GI:15233734
Arabidopsis thaliana (Ath) AT4G35380 GI:42567412


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000139 Golgi membrane C
IDA
HsaARFGEF2
ISO
MmuMGI:2139354
GO:0005737 cytoplasm C
ISO
MmuMGI:2139354
GO:0005770 late endosome C
IDA
SceS000002577
GO:0005798 Golgi-associated vesicle C
IDA
SceS000002577
GO:0005802 trans-Golgi network C
IDA
SceS000002577
ISO
MmuMGI:2139354
GO:0005829 cytosol C
IDA
HsaARFGEF2
SceS000002577
ISO
MmuMGI:2139354
GO:0009507 chloroplast C
IDA
AthAt4g38200
GO:0016020 membrane C
IDA
HsaARFGEF2
ISO
MmuMGI:2139354
GO:0030135 coated vesicle C
RCA
SceS000002577
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
HsaARFGEF2
ISO
MmuMGI:2139354
ISS
AthAt4g35380
At4g38200
GO:0005086 ARF guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000002577
GO:0017022 myosin binding F
ISO
MmuMGI:2139354
GO:0050811 GABA receptor binding F
ISO
MmuMGI:2139354
GO:0000045 autophagic vacuole assembly P
IMP
SceS000002577
GO:0006887 exocytosis P
ISO
MmuMGI:2139354
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SceS000002577
GO:0006891 intra-Golgi vesicle-mediated transport P
IMP
SceS000002577
GO:0023034 intracellular signaling pathway P
IDA
HsaARFGEF2
ISO
MmuMGI:2139354
GO:0050790 regulation of catalytic activity P
ISO
MmuMGI:2139354

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_432

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga10977 ENSANGP00000006433
Ashbya gossypii (Ago) ago4165 AGL147C
Arabidopsis thaliana (Ath) ath104 At1g01960.1
Arabidopsis thaliana (Ath) ath15602 At3g43300.1
Arabidopsis thaliana (Ath) ath17520 At3g60860.1
Arabidopsis thaliana (Ath) ath21690 At4g35380.1
Arabidopsis thaliana (Ath) ath22007 At4g38200.1
Caenorhabditis elegans (Cel) cel20472 Y6B3A.1a
(CE42203;
WBGene00012386)
Candida glabrata (Cgl) cgl977 CAGL0E00847g
Cryptococcus neoformans (Cne) cne619 163.m06184
Dictyostelium discoideum (Ddi) ddi1186 DDB0168059
Dictyostelium discoideum (Ddi) ddi2979 DDB0217329
Dictyostelium discoideum (Ddi) ddi8246 DDB0219551
Debaryomyces hansenii (Dha) dha1120 DEHA0B10230g
Drosophila melanogaster (Dme) dme2317 CG7578-PA
(FBgn0028538)
Drosophila melanogaster (Dme) dme2318 CG7578-PB
(FBgn0028538)
Danio rerio (Dre) dre15290 ENSDARP00000008695
Danio rerio (Dre) dre15291 ENSDARP00000039839
Danio rerio (Dre) dre16105 ENSDARP00000045205
Danio rerio (Dre) dre15292 ENSDARP00000049854
Takifugu rubripes (Fru) fru13622 SINFRUP00000155190
Takifugu rubripes (Fru) fru13624 SINFRUP00000168179
Takifugu rubripes (Fru) fru13626 SINFRUP00000169536
Takifugu rubripes (Fru) fru13625 SINFRUP00000176236
Gallus gallus (Gga) gga11918 ENSGALP00000007416
(ARFGEF2)
Gallus gallus (Gga) gga11919 ENSGALP00000007417
Gallus gallus (Gga) gga11920 ENSGALP00000007418
Gallus gallus (Gga) gga11208 ENSGALP00000025028
Gallus gallus (Gga) gga11205 ENSGALP00000025029
(ARFGEF1)
Gallus gallus (Gga) gga11206 ENSGALP00000025030
Gallus gallus (Gga) gga11207 ENSGALP00000025031
Homo sapiens (Hsa) hsa30384 ENSP00000262215
(ARFGEF1)		 Q9Y6D6
Homo sapiens (Hsa) hsa20386 ENSP00000262983
Kluyveromyces lactis (Kla) kla2827 KLLA0D17358g
Mus musculus (Mmu) mmu16047 ENSMUSP00000018281
Mus musculus (Mmu) mmu16048 ENSMUSP00000072210
Mus musculus (Mmu) mmu16049 ENSMUSP00000073586
Mus musculus (Mmu) mmu16050 ENSMUSP00000079492
Mus musculus (Mmu) mmu16051 ENSMUSP00000080818
Neurospora crassa (Ncr) ncr7456 NCU07658.2
Oryza sativa (Osa) osa1034 1917.m00158
Oryza sativa (Osa) osa4308 1989.m00195
Oryza sativa (Osa) osa13503 2942.m00111
Oryza sativa (Osa) osa20299 3528.m00164
Oryza sativa (Osa) osa21070 3638.m00187
Oryza sativa (Osa) osa38160 5035.m00157
Oryza sativa (Osa) osa46582 5713.m00071
Oryza sativa (Osa) osa68060 6900.m00122
Rattus norvegicus (Rno) rno22630 ENSRNOP00000007766
(RGD:1560793)
Rattus norvegicus (Rno) rno20305 ENSRNOP00000010054
(RGD:631430)		 Q7TSU1
Saccharomyces cerevisiae (Sce) sce1209 YDR170C
(S000002577)
Schizosaccharomyces pombe (Spo) spo3098 SPAC30.01c Q9P7V5
Schizosaccharomyces pombe (Spo) spo984 SPAC4D7.01c Q9UT02
Yarrowia lipolytica (Yli) yli3688 YALI0D23463g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000137 Golgi cis cisterna C
IDA
SpoSPAC30.01c
GO:0000138 Golgi trans cisterna C
IDA
SpoSPAC30.01c
GO:0005634 nucleus C
IDA
AthAt1g01960
GO:0005635 nuclear envelope C
IDA
SpoSPAC30.01c
GO:0005737 cytoplasm C
IDA
SpoSPAC30.01c
GO:0005769 early endosome C
IDA
AthAt3g43300
GO:0005770 late endosome C
IDA
SceS000002577
GO:0005794 Golgi apparatus C
IDA
SpoSPAC4D7.01c
ISS
DmeFBgn0028538
GO:0005798 Golgi-associated vesicle C
IDA
SceS000002577
ISS
SpoSPAC30.01c
SPAC4D7.01c
GO:0005802 trans-Golgi network C
IDA
AthAt3g43300
SceS000002577
GO:0005829 cytosol C
IDA
AthAt1g01960
SceS000002577
GO:0005938 cell cortex C
IDA
SpoSPAC30.01c
GO:0009507 chloroplast C
IDA
AthAt4g38200
GO:0030135 coated vesicle C
RCA
SceS000002577
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
ISS
AthAt3g43300
At3g60860
At4g35380
At1g01960
At4g38200
GO:0005086 ARF guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000002577
ISS
DmeFBgn0028538
SpoSPAC30.01c
SPAC4D7.01c
GO:0005515 protein binding F
IPI
AthAt3g43300
GO:0000003 reproduction P
IMP
CelWBGene00012386
GO:0000045 autophagic vacuole assembly P
IMP
SceS000002577
GO:0002119 nematode larval development P
IMP
CelWBGene00012386
GO:0006886 intracellular protein transport P
ISS
SpoSPAC4D7.01c
SPAC30.01c
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SceS000002577
ISS
DmeFBgn0028538
SpoSPAC4D7.01c
SPAC30.01c
GO:0006891 intra-Golgi vesicle-mediated transport P
IMP
SceS000002577
ISS
DmeFBgn0028538
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00012386
GO:0009561 megagametogenesis P
IMP
AthAt1g01960
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012386
GO:0016192 vesicle-mediated transport P
IMP
AthAt3g43300
GO:0040007 growth P
IMP
AthAt3g43300
CelWBGene00012386
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00012386
GO:0040011 locomotion P
IMP
CelWBGene00012386
GO:0042742 defense response to bacterium P
IMP
AthAt3g43300

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC30.01c
(Q9P7V5)		 YDR170C
(S000002577)
SPAC4D7.01c
(Q9UT02)		 YDR170C
(S000002577)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000137 Golgi cis cisterna C
IDA
SpoSPAC30.01c
GO:0000138 Golgi trans cisterna C
IDA
SpoSPAC30.01c
GO:0005635 nuclear envelope C
IDA
SpoSPAC30.01c
GO:0005737 cytoplasm C
IDA
SpoSPAC30.01c
GO:0005770 late endosome C
IDA
SceS000002577
GO:0005794 Golgi apparatus C
IDA
SpoSPAC4D7.01c
GO:0005798 Golgi-associated vesicle C
IDA
SceS000002577
ISS
SpoSPAC30.01c
SPAC4D7.01c
GO:0005802 trans-Golgi network C
IDA
SceS000002577
GO:0005829 cytosol C
IDA
SceS000002577
GO:0005938 cell cortex C
IDA
SpoSPAC30.01c
GO:0030135 coated vesicle C
RCA
SceS000002577
GO:0005086 ARF guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000002577
ISS
SpoSPAC30.01c
SPAC4D7.01c
GO:0000045 autophagic vacuole assembly P
IMP
SceS000002577
GO:0006886 intracellular protein transport P
ISS
SpoSPAC4D7.01c
SPAC30.01c
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SceS000002577
ISS
SpoSPAC4D7.01c
SPAC30.01c
GO:0006891 intra-Golgi vesicle-mediated transport P
IMP
SceS000002577

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