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Search term: YDR191W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HST4
SGD link S000002599
Alternative ID YDR191W
Description Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
Synonyms YDR191W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2684 -CDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSINGINFORMATION STORAGE AND PROCESSING Sirtuin 5 and related class III sirtuins (SIR2 family)

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE06302
(WBGene00004800)
GI:17541892 Q21921
Drosophila melanogaster (Dme) 7298007
(FBgn0024291)
GI:17137536 Q9VK34
Homo sapiens (Hsa) Hs13787215 GI:13787215 Q9NXA8
Homo sapiens (Hsa) Hs22045591 GI:22045591
Homo sapiens (Hsa) Hs6912664
(SIRT5)
GI:6912664 Q9NXA8
Homo sapiens (Hsa) Hs7657575
(SIRT1)
GI:7657575 Q96EB6
Saccharomyces cerevisiae (Sce) YDL042c
(S000002200)
GI:6320163 P06700
Saccharomyces cerevisiae (Sce) YDR191w
(S000002599)
GI:6320397 P53688
Saccharomyces cerevisiae (Sce) YOL068c
(S000005429)
GI:6324504 P53685
Saccharomyces cerevisiae (Sce) YOR025w
(S000005551)
GI:6324599 P53687
Schizosaccharomyces pombe (Spo) SPAC1783.04c GI:19114571 Q9UR39
Schizosaccharomyces pombe (Spo) SPBC16D10.07c GI:19113294 O94640
Encephalitozoon cuniculi (Ecu) ECU03g0460 GI:19173006 Q8SSB6


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000775 chromosome, centromeric region C
IDA
SpoSPBC16D10.07c
GO:0000781 chromosome, telomeric region C
IDA
SpoSPBC16D10.07c
GO:0000783 nuclear telomere cap complex C
IDA
SceS000002200
GO:0000790 nuclear chromatin C
IC
SpoSPAC1783.04c
SPBC16D10.07c
GO:0005634 nucleus C
IC
SceS000005551
IDA
CelWBGene00004800
DmeFBgn0024291
HsaSIRT1
SceS000002599
SpoSPAC1783.04c
SPBC16D10.07c
GO:0005635 nuclear envelope C
IDA
HsaSIRT1
GO:0005654 nucleoplasm C
IDA
DmeFBgn0024291
HsaSIRT1
GO:0005677 chromatin silencing complex C
IDA
HsaSIRT1
SceS000002200
GO:0005724 nuclear telomeric heterochromatin C
IDA
SceS000002200
GO:0005730 nucleolus C
IDA
HsaSIRT1
SceS000002200
SpoSPAC1783.04c
GO:0005737 cytoplasm C
IDA
DmeFBgn0024291
HsaSIRT1
SceS000002599
GO:0016585 chromatin remodeling complex C
ISS
SpoSPAC1783.04c
SPBC16D10.07c
GO:0016605 PML body C
IDA
HsaSIRT1
GO:0030869 RENT complex C
IDA
SceS000002200
GO:0031934 mating-type region heterochromatin C
IDA
SpoSPBC16D10.07c
GO:0033553 rDNA heterochromatin C
IDA
HsaSIRT1
GO:0034967 Set3 complex C
IDA
SceS000005429
GO:0002039 p53 binding F
IPI
HsaSIRT1
GO:0003677 DNA binding F
ISS
SceS000002599
S000005551
GO:0003714 transcription corepressor activity F
IEP
SpoSPAC1783.04c
ISS
HsaSIRT1
GO:0004407 histone deacetylase activity F
IDA
DmeFBgn0024291
IMP
SceS000002599
S000005551
GO:0005515 protein binding F
IPI
HsaSIRT1
GO:0008022 protein C-terminus binding F
IPI
HsaSIRT1
GO:0016564 transcription repressor activity F
IDA
HsaSIRT1
GO:0016566 specific transcriptional repressor
activity
F
IEP
SpoSPAC1783.04c
GO:0017136 NAD-dependent histone deacetylase
activity
F
IDA
DmeFBgn0024291
HsaSIRT1
SceS000002200
S000005429
ISS
DmeFBgn0024291
TAS
SpoSPAC1783.04c
GO:0019213 deacetylase activity F
IDA
CelWBGene00004800
HsaSIRT1
GO:0030528 transcription regulator activity F
IC
SpoSPBC16D10.07c
GO:0031491 nucleosome binding F
IDA
SceS000002200
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14
specific)
F
IDA
SceS000002200
ISS
SceS000002200
GO:0032129 histone deacetylase activity (H3-K9
specific)
F
IDA
SpoSPBC16D10.07c
GO:0034979 NAD-dependent protein deacetylase
activity
F
IMP
HsaSIRT1
GO:0042393 histone binding F
IPI
HsaSIRT1
GO:0042802 identical protein binding F
IPI
HsaSIRT1
GO:0045129 NAD-independent histone deacetylase
activity
F
IDA
SceS000005429
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9
specific)
F
IDA
SceS000002200
SpoSPBC16D10.07c
ISS
SceS000002200
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16
specific)
F
IDA
SceS000002200
SpoSPBC16D10.07c
ISS
SceS000002200
GO:0070403 NAD binding F
IDA
SpoSPBC16D10.07c
GO:0000070 mitotic sister chromatid segregation P
IMP
SpoSPAC1783.04c
GO:0000077 DNA damage checkpoint P
IMP
SpoSPAC1783.04c
GO:0000183 chromatin silencing at rDNA P
IDA
HsaSIRT1
IMP
SceS000002200
GO:0001300 chronological cell aging P
IMP
SceS000002200
GO:0001302 replicative cell aging P
IMP
SceS000002200
ISS
SpoSPBC16D10.07c
GO:0001308 loss of chromatin silencing involved in
replicative cell aging
P
TAS
SceS000002200
GO:0006260 DNA replication P
TAS
HsaSIRT1
GO:0006281 DNA repair P
TAS
HsaSIRT1
GO:0006303 double-strand break repair via nonhomologous end
joining
P
IDA
SceS000002200
GO:0006333 chromatin assembly or disassembly P
IDA
SceS000002200
GO:0006338 chromatin remodeling P
ISS
SpoSPAC1783.04c
SPBC16D10.07c
GO:0006342 chromatin silencing P
IGI
SceS000005429
IMP
DmeFBgn0024291
SceS000005429
TAS
HsaSIRT1
GO:0006343 establishment of chromatin silencing P
IDA
HsaSIRT1
GO:0006344 maintenance of chromatin silencing P
IMP
HsaSIRT1
GO:0006348 chromatin silencing at telomere P
IGI
SceS000002599
S000005551
IMP
SceS000002200
SpoSPAC1783.04c
SPBC16D10.07c
IPI
SceS000002200
GO:0006357 regulation of transcription from RNA polymerase II
promoter
P
IEP
SpoSPBC16D10.07c
GO:0006476 protein amino acid deacetylation P
IDA
CelWBGene00004800
HsaSIRT1
IMP
HsaSIRT1
GO:0006642 triglyceride mobilization P
ISS
HsaSIRT1
GO:0006974 response to DNA damage stimulus P
IDA
HsaSIRT1
IMP
SpoSPAC1783.04c
GO:0007059 chromosome segregation P
IMP
SpoSPBC16D10.07c
GO:0007568 aging P
RCA
SceS000002200
GO:0007569 cell aging P
TAS
HsaSIRT1
GO:0007584 response to nutrient P
IMP
DmeFBgn0024291
GO:0008156 negative regulation of DNA replication P
IMP
SceS000002200
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004800
DmeFBgn0024291
GO:0009267 cellular response to starvation P
ISS
HsaSIRT1
GO:0009890 negative regulation of biosynthetic
process
P
RCA
SceS000002200
GO:0010553 negative regulation of gene-specific transcription
from RNA polymerase II promoter
P
IEP
SpoSPAC1783.04c
SPBC16D10.07c
GO:0016458 gene silencing P
RCA
SceS000002200
GO:0016481 negative regulation of transcription P
IDA
HsaSIRT1
RCA
SceS000002200
GO:0016575 histone deacetylation P
IDA
DmeFBgn0024291
HsaSIRT1
SceS000005429
SpoSPBC16D10.07c
IMP
SceS000002599
S000005551
SpoSPAC1783.04c
GO:0030466 chromatin silencing at silent mating-type
cassette
P
IGI
SpoSPBC16D10.07c
IMP
SceS000002200
SpoSPBC16D10.07c
GO:0030702 chromatin silencing at centromere P
IMP
SpoSPAC1783.04c
SPBC16D10.07c
GO:0031937 positive regulation of chromatin
silencing
P
IMP
HsaSIRT1
GO:0033158 regulation of protein import into nucleus,
translocation
P
IMP
HsaSIRT1
GO:0034339 regulation of transcription from RNA polymerase II
promoter by nuclear hormone receptor
P
ISS
HsaSIRT1
GO:0034983 peptidyl-lysine deacetylation P
IDA
HsaSIRT1
GO:0035065 regulation of histone acetylation P
IMP
DmeFBgn0024291
GO:0040024 dauer larval development P
IGI
CelWBGene00004800
GO:0040029 regulation of gene expression,
epigenetic
P
RCA
SceS000002200
GO:0042127 regulation of cell proliferation P
IMP
HsaSIRT1
GO:0042981 regulation of apoptosis P
IMP
DmeFBgn0024291
ISS
HsaSIRT1
GO:0043433 negative regulation of transcription factor
activity
P
IDA
HsaSIRT1
GO:0043518 negative regulation of DNA damage response, signal
transduction by p53 class mediator
P
IDA
HsaSIRT1
GO:0045449 regulation of transcription P
IDA
DmeFBgn0024291
GO:0045599 negative regulation of fat cell
differentiation
P
ISS
HsaSIRT1
GO:0045768 positive regulation of anti-apoptosis P
TAS
HsaSIRT1
GO:0045910 negative regulation of DNA recombination P
IGI
SceS000002200
GO:0045950 negative regulation of mitotic
recombination
P
IMP
SceS000005429
GO:0046459 short-chain fatty acid metabolic
process
P
IMP
SceS000002599
S000005551
GO:0050872 white fat cell differentiation P
ISS
HsaSIRT1
GO:0051097 negative regulation of helicase
activity
P
IDA
HsaSIRT1
GO:0051570 regulation of histone H3-K9 methylation P
IMP
SpoSPBC16D10.07c
GO:0060303 regulation of nucleosome density P
IEP
SpoSPAC1783.04c
SPBC16D10.07c
GO:0070198 protein localization to chromosome, telomeric
region
P
IGI
SpoSPBC16D10.07c
GO:0070932 histone H3 deacetylation P
IMP
SpoSPAC1783.04c
GO:0071572 histone H3-K56 deacetylation P
IMP
SpoSPAC1783.04c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
30493

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) hst4
(SPAC1783.04c)
GI:19114571 Q9UR39
Saccharomyces cerevisiae (Sce) HST4
(S000002599)
GI:6320397 P53688
Kluyveromyces lactis (Kla) KLLA0D18535g GI:50307777
Eremothecium gossypii (Ego) AGOS_AGL118W GI:45200979
Magnaporthe grisea (Mgr) MGG_04588 GI:145614556
Neurospora crassa (Ncr) NCU03059.1 GI:32420103