YOGY Home YOGY Help

Search term: YDR211W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GCD6
SGD link S000002619
Alternative ID YDR211W
Description Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
Synonyms YDR211W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1461 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g34970 GI:15226869
Arabidopsis thaliana (Ath) At3g02270 GI:15232869
Arabidopsis thaliana (Ath) At4g18300 GI:15236830
Caenorhabditis elegans (Cel) CE03107
(WBGene00008428)		 GI:17532703 Q18994
Drosophila melanogaster (Dme) 7290233 GI:7290233
Homo sapiens (Hsa) Hs18554439 GI:18554439
Saccharomyces cerevisiae (Sce) YDR211w
(S000002619)		 GI:6320417 P32501
Schizosaccharomyces pombe (Spo) SPAC8C9.15c GI:19115197 P56287
Encephalitozoon cuniculi (Ecu) ECU10g0700 GI:19074679 Q8SR48


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005829 cytosol C
IDA
SpoSPAC8C9.15c
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
SceS000002619
IGI
SceS000002619
IMP
SceS000002619
IPI
SceS000002619
ISS
SpoSPAC8C9.15c
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000002619
IPI
SceS000002619
GO:0003743 translation initiation factor activity F
IGI
SceS000002619
IPI
SceS000002619
ISS
AthAt3g02270
At4g18300
At2g34970
SpoSPAC8C9.15c
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000002619
IMP
SceS000002619
ISS
SpoSPAC8C9.15c
GO:0000003 reproduction P
IMP
CelWBGene00008428
GO:0002119 nematode larval development P
IMP
CelWBGene00008428
GO:0006413 translational initiation P
ISS
SpoSPAC8C9.15c
GO:0006446 regulation of translational initiation P
IDA
SceS000002619
IGI
SceS000002619
IPI
SceS000002619
ISS
AthAt4g18300
At2g34970
At3g02270
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00008428
GO:0010171 body morphogenesis P
IMP
CelWBGene00008428
GO:0040007 growth P
IMP
CelWBGene00008428
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00008428
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00008428
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00008428
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC8C9.15c

Back to the top

HomoloGene results:

HomoloGene cluster Phylogenetic pattern
2903

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) EIF2B5 GI:83267879
Pan troglodytes (Ptr) EIF2B5 GI:114590669
Canis familiaris (Cfa) EIF2B5 GI:74003272
Mus musculus (Mmu) Eif2b5
(MGI:2446176)		 GI:26986557 Q8CHW4
Rattus norvegicus (Rno) Eif2b5
(RGD:708380)		 GI:55741628
Gallus gallus (Gga) EIF2B5 GI:118095207
Drosophila melanogaster (Dme) eIF2B-epsilon GI:45553941
Anopheles gambiae (Aga) AgaP_AGAP000082 GI:158289318
Schizosaccharomyces pombe (Spo) tif225
(SPAC8C9.15c)		 GI:19115197 P56287
Saccharomyces cerevisiae (Sce) GCD6
(S000002619)		 GI:6320417 P32501
Kluyveromyces lactis (Kla) KLLA0A04235g GI:50302505
Eremothecium gossypii (Ego) AGOS_AGL094W GI:45201002
Arabidopsis thaliana (Ath) AT2G34970 GI:15226869
Arabidopsis thaliana (Ath) AT4G18300 GI:15236830
Arabidopsis thaliana (Ath) AT3G02270 GI:15232869
Oryza sativa (Osa) Os02g0812400 GI:115449487


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
MmuMGI:2446176
ISS
HsaEIF2B5
GO:0005737 cytoplasm C
IDA
HsaEIF2B5
MmuMGI:2446176
GO:0005829 cytosol C
IDA
SpoSPAC8C9.15c
ISS
DmeeIF2B-epsilon
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
HsaEIF2B5
SceS000002619
IGI
SceS000002619
IMP
SceS000002619
IPI
SceS000002619
ISO
MmuMGI:2446176
ISS
DmeeIF2B-epsilon
SpoSPAC8C9.15c
TAS
DmeeIF2B-epsilon
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000002619
IPI
SceS000002619
GO:0003743 translation initiation factor activity F
IDA
HsaEIF2B5
IGI
SceS000002619
IPI
SceS000002619
ISS
AthAt3g02270
At4g18300
At2g34970
DmeeIF2B-epsilon
SpoSPAC8C9.15c
NAS
HsaEIF2B5
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
DmeeIF2B-epsilon
HsaEIF2B5
SceS000002619
IMP
HsaEIF2B5
SceS000002619
ISO
MmuMGI:2446176
ISS
DmeeIF2B-epsilon
HsaEIF2B5
SpoSPAC8C9.15c
GO:0005515 protein binding F
IPI
HsaEIF2B5
GO:0031369 translation initiation factor binding F
ISO
MmuMGI:2446176
ISS
HsaEIF2B5
GO:0001541 ovarian follicle development P
IMP
HsaEIF2B5
GO:0006413 translational initiation P
IDA
HsaEIF2B5
ISS
DmeeIF2B-epsilon
SpoSPAC8C9.15c
GO:0006417 regulation of translation P
ISO
MmuMGI:2446176
GO:0006446 regulation of translational initiation P
IDA
SceS000002619
IGI
SceS000002619
IPI
SceS000002619
ISS
AthAt4g18300
At2g34970
At3g02270
GO:0006950 response to stress P
IMP
HsaEIF2B5
GO:0009408 response to heat P
IMP
HsaEIF2B5
ISO
MmuMGI:2446176
ISS
HsaEIF2B5
TAS
HsaEIF2B5
GO:0009749 response to glucose stimulus P
ISO
MmuMGI:2446176
ISS
HsaEIF2B5
GO:0014002 astrocyte development P
IMP
HsaEIF2B5
GO:0014003 oligodendrocyte development P
IMP
HsaEIF2B5
GO:0032057 negative regulation of translational initiation in
response to stress		 P
ISO
MmuMGI:2446176
ISS
HsaEIF2B5
GO:0042552 myelination P
IMP
HsaEIF2B5
GO:0043434 response to peptide hormone stimulus P
ISO
MmuMGI:2446176
ISS
HsaEIF2B5
GO:0045948 positive regulation of translational
initiation		 P
ISS
HsaEIF2B5
SpoSPAC8C9.15c
GO:0048708 astrocyte differentiation P
IMP
HsaEIF2B5
GO:0050790 regulation of catalytic activity P
ISO
MmuMGI:2446176
GO:0051716 cellular response to stimulus P
IDA
HsaEIF2B5

Back to the top

OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1743

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga14643 ENSANGP00000019857
Ashbya gossypii (Ago) ago4217 AGL094W
Arabidopsis thaliana (Ath) ath10547 At2g34970.1
Arabidopsis thaliana (Ath) ath12240 At3g02270.1
Arabidopsis thaliana (Ath) ath19699 At4g18300.1
Caenorhabditis elegans (Cel) cel5121 D2085.3
(CE03107;
WBGene00008428)
Candida glabrata (Cgl) cgl467 CAGL0C01221g
Cryptococcus neoformans (Cne) cne2245 181.m08267
Dictyostelium discoideum (Ddi) ddi6837 DDB0185388
Debaryomyces hansenii (Dha) dha6378 DEHA0G15224g
Drosophila melanogaster (Dme) dme16145 CG3806-PA
(FBgn0023512)
Drosophila melanogaster (Dme) dme16144 CG3806-PB
(FBgn0023512)
Danio rerio (Dre) dre21313 ENSDARP00000011251
Encephalitozoon cuniculi (Ecu) ecu595 19074679
Takifugu rubripes (Fru) fru8783 SINFRUP00000137932
Gallus gallus (Gga) gga23589 ENSGALP00000013630
(EIF2B5)
Homo sapiens (Hsa) hsa23534 ENSP00000273783
(EIF2B5)		 Q13144
Kluyveromyces lactis (Kla) kla184 KLLA0A04235g
Mus musculus (Mmu) mmu10076 ENSMUSP00000003320
(MGI:2446176)		 Q8CHW4
Neurospora crassa (Ncr) ncr2347 NCU02414.2
Oryza sativa (Osa) osa38579 4897.m00130
Oryza sativa (Osa) osa51964 5930.m00032
Plasmodium falciparum (Pfa) pfa4921 PFL0675c
Rattus norvegicus (Rno) rno7605 ENSRNOP00000002321
(RGD:708380)		 Q64350
Saccharomyces cerevisiae (Sce) sce1259 YDR211W
(S000002619)
Schizosaccharomyces pombe (Spo) spo1084 SPAC8C9.15c P56287
Yarrowia lipolytica (Yli) yli1396 YALI0B15708g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
MmuMGI:2446176
GO:0005737 cytoplasm C
IDA
MmuMGI:2446176
GO:0005829 cytosol C
IDA
SpoSPAC8C9.15c
ISS
DmeFBgn0023512
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
SceS000002619
IGI
SceS000002619
IMP
SceS000002619
IPI
SceS000002619
ISO
MmuMGI:2446176
ISS
DmeFBgn0023512
SpoSPAC8C9.15c
TAS
DmeFBgn0023512
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000002619
IPI
SceS000002619
GO:0003743 translation initiation factor activity F
IGI
SceS000002619
IPI
SceS000002619
ISS
AthAt3g02270
At4g18300
At2g34970
DmeFBgn0023512
SpoSPAC8C9.15c
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
DmeFBgn0023512
SceS000002619
IMP
SceS000002619
ISO
MmuMGI:2446176
ISS
DmeFBgn0023512
SpoSPAC8C9.15c
GO:0031369 translation initiation factor binding F
ISO
MmuMGI:2446176
GO:0000003 reproduction P
IMP
CelWBGene00008428
GO:0002119 nematode larval development P
IMP
CelWBGene00008428
GO:0006413 translational initiation P
ISS
DmeFBgn0023512
SpoSPAC8C9.15c
GO:0006417 regulation of translation P
ISO
MmuMGI:2446176
GO:0006446 regulation of translational initiation P
IDA
SceS000002619
IGI
SceS000002619
IPI
SceS000002619
ISS
AthAt4g18300
At2g34970
At3g02270
GO:0009408 response to heat P
ISO
MmuMGI:2446176
GO:0009749 response to glucose stimulus P
ISO
MmuMGI:2446176
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00008428
GO:0010171 body morphogenesis P
IMP
CelWBGene00008428
GO:0032057 negative regulation of translational initiation in
response to stress		 P
ISO
MmuMGI:2446176
GO:0040007 growth P
IMP
CelWBGene00008428
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00008428
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00008428
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00008428
GO:0043434 response to peptide hormone stimulus P
ISO
MmuMGI:2446176
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC8C9.15c
GO:0050790 regulation of catalytic activity P
ISO
MmuMGI:2446176

Back to the top

Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC8C9.15c
(P56287)		 YDR211W
(S000002619)