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Search term: YDR227W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SIR4
SGD link S000002635
Alternative ID YDR227W
Description Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan
Synonyms YDR227W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_59999

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Candida glabrata (Cgl) cgl4008 CAGL0K11396g
Saccharomyces cerevisiae (Sce) sce1275 YDR227W
(S000002635)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000783 nuclear telomere cap complex C
IDA
SceS000002635
GO:0005635 nuclear envelope C
RCA
SceS000002635
GO:0005677 chromatin silencing complex C
IDA
SceS000002635
GO:0005724 nuclear telomeric heterochromatin C
IDA
SceS000002635
GO:0003690 double-stranded DNA binding F
IDA
SceS000002635
GO:0030527 structural constituent of chromatin F
TAS
SceS000002635
GO:0031491 nucleosome binding F
IDA
SceS000002635
GO:0042393 histone binding F
TAS
SceS000002635
GO:0001308 loss of chromatin silencing involved in
replicative cell aging
P
IDA
SceS000002635
GO:0006303 double-strand break repair via nonhomologous end
joining
P
IDA
SceS000002635
GO:0006342 chromatin silencing P
TAS
SceS000002635
GO:0006414 translational elongation P
RCA
SceS000002635
GO:0007568 aging P
RCA
SceS000002635
GO:0009890 negative regulation of biosynthetic
process
P
RCA
SceS000002635
GO:0016458 gene silencing P
RCA
SceS000002635
GO:0016481 negative regulation of transcription P
RCA
SceS000002635
GO:0040029 regulation of gene expression,
epigenetic
P
RCA
SceS000002635
GO:0045184 establishment of protein localization P
RCA
SceS000002635

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s.khadayate@ucl.ac.uk