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Search term: YDR234W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LYS4
SGD link S000002642
Alternative ID YDR234W
Description Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
Synonyms YDR234W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0453 -CDHYP-

KOGs classification KOGs description
METABOLISMMETABOLISM Aconitase/homoaconitase (aconitase superfamily)

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE25005
(WBGene00000041)		 GI:17553624
Drosophila melanogaster (Dme) 7298762 GI:7298762
Drosophila melanogaster (Dme) 7299398 GI:7299398
Homo sapiens (Hsa) Hs17450976 GI:17450976
Homo sapiens (Hsa) Hs17489116 GI:17489116
Homo sapiens (Hsa) Hs22051976 GI:22051976
Homo sapiens (Hsa) Hs22068703 GI:22068703
Homo sapiens (Hsa) Hs4501867
(ACO2)		 GI:4501867 Q71UF1
Saccharomyces cerevisiae (Sce) YDR234w
(S000002642)		 GI:6320440 P49367
Saccharomyces cerevisiae (Sce) YJL200c
(S000003736)		 GI:6322261 P39533
Saccharomyces cerevisiae (Sce) YLR304c
(S000004295)		 GI:6323335 P19414
Schizosaccharomyces pombe (Spo) SPAC24C9.06c GI:19114943 O13966
Schizosaccharomyces pombe (Spo) SPAC343.16 GI:19114349 Q9UT74
Schizosaccharomyces pombe (Spo) SPBP4H10.15 GI:19112981 Q9P7D4
Caenorhabditis elegans (Cel) CE25005
(WBGene00000041)		 GI:17553624
Drosophila melanogaster (Dme) 7298762 GI:7298762
Drosophila melanogaster (Dme) 7299398 GI:7299398
Homo sapiens (Hsa) Hs17450976 GI:17450976
Homo sapiens (Hsa) Hs17489116 GI:17489116
Homo sapiens (Hsa) Hs22051976 GI:22051976
Homo sapiens (Hsa) Hs22068703 GI:22068703
Homo sapiens (Hsa) Hs4501867
(ACO2)		 GI:4501867 Q71UF1
Saccharomyces cerevisiae (Sce) YDR234w
(S000002642)		 GI:6320440 P49367
Saccharomyces cerevisiae (Sce) YJL200c
(S000003736)		 GI:6322261 P39533
Saccharomyces cerevisiae (Sce) YLR304c
(S000004295)		 GI:6323335 P19414
Schizosaccharomyces pombe (Spo) SPAC24C9.06c GI:19114943 O13966
Schizosaccharomyces pombe (Spo) SPAC343.16 GI:19114349 Q9UT74
Schizosaccharomyces pombe (Spo) SPBP4H10.15 GI:19112981 Q9P7D4
Caenorhabditis elegans (Cel) CE25005
(WBGene00000041)		 GI:17553624
Drosophila melanogaster (Dme) 7298762 GI:7298762
Drosophila melanogaster (Dme) 7299398 GI:7299398
Homo sapiens (Hsa) Hs17450976 GI:17450976
Homo sapiens (Hsa) Hs17489116 GI:17489116
Homo sapiens (Hsa) Hs22051976 GI:22051976
Homo sapiens (Hsa) Hs22068703 GI:22068703
Homo sapiens (Hsa) Hs4501867
(ACO2)		 GI:4501867 Q71UF1
Saccharomyces cerevisiae (Sce) YDR234w
(S000002642)		 GI:6320440 P49367
Saccharomyces cerevisiae (Sce) YJL200c
(S000003736)		 GI:6322261 P39533
Saccharomyces cerevisiae (Sce) YLR304c
(S000004295)		 GI:6323335 P19414
Schizosaccharomyces pombe (Spo) SPAC24C9.06c GI:19114943 O13966
Schizosaccharomyces pombe (Spo) SPAC343.16 GI:19114349 Q9UT74
Schizosaccharomyces pombe (Spo) SPBP4H10.15 GI:19112981 Q9P7D4


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
HsaACO2
GO:0005739 mitochondrion C
IC
SpoSPBP4H10.15
IDA
HsaACO2
SceS000004295
S000003736
S000002642
SpoSPAC343.16
SPAC24C9.06c
SPBP4H10.15
IMP
SpoSPAC343.16
TAS
SceS000002642
GO:0005759 mitochondrial matrix C
ISS
SpoSPAC24C9.06c
TAS
SceS000004295
GO:0005762 mitochondrial large ribosomal subunit C
ISS
SpoSPBP4H10.15
GO:0005829 cytosol C
ISS
SpoSPAC24C9.06c
TAS
SceS000004295
GO:0042645 mitochondrial nucleoid C
IDA
SceS000004295
GO:0003690 double-stranded DNA binding F
IDA
SceS000004295
GO:0003697 single-stranded DNA binding F
IDA
SceS000004295
GO:0003735 structural constituent of ribosome F
ISS
SpoSPBP4H10.15
GO:0003994 aconitate hydratase activity F
ISS
SceS000003736
SpoSPBP4H10.15
SPAC24C9.06c
TAS
SceS000004295
GO:0004409 homoaconitate hydratase activity F
IMP
SpoSPAC343.16
TAS
SceS000002642
GO:0005506 iron ion binding F
IDA
HsaACO2
GO:0000002 mitochondrial genome maintenance P
IMP
SceS000004295
GO:0000003 reproduction P
IMP
CelWBGene00000041
GO:0002119 nematode larval development P
IMP
CelWBGene00000041
GO:0006082 organic acid metabolic process P
RCA
SceS000003736
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPAC343.16
TAS
HsaACO2
GO:0006099 tricarboxylic acid cycle P
IDA
HsaACO2
ISS
SpoSPBP4H10.15
SPAC24C9.06c
TAS
SceS000004295
GO:0006101 citrate metabolic process P
IC
SpoSPBP4H10.15
IDA
HsaACO2
ISS
SpoSPAC24C9.06c
TAS
SceS000004295
GO:0006412 translation P
ISS
SpoSPBP4H10.15
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000003736
GO:0006536 glutamate metabolic process P
ISS
SpoSPAC24C9.06c
NAS
SpoSPAC343.16
SPBP4H10.15
GO:0006537 glutamate biosynthetic process P
TAS
SceS000004295
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000003736
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003736
GO:0008150 biological_process P
ND
SceS000003736
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00000041
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000041
GO:0016246 RNA interference P
IMP
CelWBGene00000041
GO:0019541 propionate metabolic process P
IEP
SceS000004295
ISS
SpoSPAC24C9.06c
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IMP
SpoSPAC343.16
NAS
SceS000002642
GO:0032543 mitochondrial translation P
NAS
SpoSPBP4H10.15
GO:0040007 growth P
IMP
CelWBGene00000041
GO:0040011 locomotion P
IMP
CelWBGene00000041
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00000041

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5661

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) lys2
(SPAC343.16)		 GI:19114349 Q9UT74
Saccharomyces cerevisiae (Sce) LYS4
(S000002642)		 GI:6320440 P49367
Kluyveromyces lactis (Kla) KLLA0C15125g GI:50305835
Magnaporthe grisea (Mgr) MGG_04842 GI:145602518
Neurospora crassa (Ncr) NCU08898.1 GI:32421693


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000002642
SpoSPAC343.16
IMP
SpoSPAC343.16
TAS
SceS000002642
GO:0004409 homoaconitate hydratase activity F
IMP
SpoSPAC343.16
TAS
SceS000002642
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPAC343.16
GO:0006536 glutamate metabolic process P
NAS
SpoSPAC343.16
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IMP
SpoSPAC343.16
NAS
SceS000002642

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_11579

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago486 ABL106C
Candida glabrata (Cgl) cgl3990 CAGL0K10978g
Cryptococcus neoformans (Cne) cne3476 176.m02199
Debaryomyces hansenii (Dha) dha4736 DEHA0F08019g
Kluyveromyces lactis (Kla) kla1877 KLLA0C15125g
Neurospora crassa (Ncr) ncr8671 NCU08898.2
Saccharomyces cerevisiae (Sce) sce1282 YDR234W
(S000002642)
Schizosaccharomyces pombe (Spo) spo1210 SPAC343.16 Q9UT74
Yarrowia lipolytica (Yli) yli3973 YALI0E02728g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000002642
SpoSPAC343.16
IMP
SpoSPAC343.16
TAS
SceS000002642
GO:0004409 homoaconitate hydratase activity F
IMP
SpoSPAC343.16
TAS
SceS000002642
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPAC343.16
GO:0006536 glutamate metabolic process P
NAS
SpoSPAC343.16
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IMP
SpoSPAC343.16
NAS
SceS000002642

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC343.16
(Q9UT74)		 YDR234W
(S000002642)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000002642
SpoSPAC343.16
IMP
SpoSPAC343.16
TAS
SceS000002642
GO:0004409 homoaconitate hydratase activity F
IMP
SpoSPAC343.16
TAS
SceS000002642
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPAC343.16
GO:0006536 glutamate metabolic process P
NAS
SpoSPAC343.16
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IMP
SpoSPAC343.16
NAS
SceS000002642

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s.khadayate@ucl.ac.uk