Bahler Lab

Search term: YDR244W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name PEX5

SGD link S000002652

Alternative ID YDR244W

Description Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions

Synonyms YDR244W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG1125 ACDHYP-

KOGs classification KOGs description

POORLY CHARACTERIZED TPR repeat-containing protein

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce YMR018w

GO:0005737 cytoplasm C
IDA
Spo SPBC725.07

GO:0005777 peroxisome C
IDA
Sce S000002652
Spo SPBC725.07

GO:0005778 peroxisomal membrane C
IDA
Sce S000002652
IPI
Sce S000002652
NAS
Spo SPBC725.07

GO:0005829 cytosol C
IDA
Sce S000002652
Spo SPBC725.07
ISS
Spo SPBC725.07

GO:0000268 peroxisome targeting sequence binding F
IDA
Cel WBGene00004194
ISS
Spo SPBC725.07

GO:0003674 molecular_function F
ND
Sce YMR018w

GO:0005052 peroxisome matrix targeting signal-1
binding F
IDA
Sce S000002652
IMP
Sce S000002652
ISS
Ath At5g56290

GO:0005515 protein binding F
IPI
Ath At5g56290

GO:0030674 protein binding, bridging F
IPI
Sce S000002652

GO:0002119 nematode larval development P
IMP
Cel WBGene00004194

GO:0006625 protein targeting to peroxisome P
IGI
Ath At5g56290
ISS
Ath At5g56290
Spo SPBC725.07

GO:0007031 peroxisome organization P
ISS
Spo SPBC725.07

GO:0008150 biological_process P
ND
Sce YMR018w

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00004194

GO:0009733 response to auxin stimulus P
IMP
Ath At5g56290

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00004194

GO:0016558 protein import into peroxisome
matrix P
IMP
Cel WBGene00004194

GO:0016560 protein import into peroxisome matrix,
docking P
IMP
Sce S000002652
IPI
Sce S000002652

GO:0019915 lipid storage P
IMP
Cel WBGene00004194

GO:0040007 growth P
IMP
Cel WBGene00004194

GO:0040010 positive regulation of growth rate P
IMP
Cel WBGene00004194

GO:0043949 regulation of cAMP-mediated signaling P
ISS
Hsa PEX5L

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

270

Species Gene ID NCBI link UniProt link

Homo sapiens (Hsa) PEX5 GI:196259776

Pan troglodytes (Ptr) PEX5 GI:114643172

Canis familiaris (Cfa) PEX5 GI:73997250

Mus musculus (Mmu) Pex5
(MGI:1098808) GI:113930737 O09012

Gallus gallus (Gga) PEX5 GI:61098308

Drosophila melanogaster (Dme) CG14815
(FBgn0023516) GI:24639189

Anopheles gambiae (Aga) AgaP_AGAP006820 GI:158286791

Caenorhabditis elegans (Cel) prx-5
(CE03054;
WBGene00004194) GI:71983707

Saccharomyces cerevisiae (Sce) PEX5
(S000002652) GI:6320450 P35056

Kluyveromyces lactis (Kla) KLLA0C15455g GI:50305861

Eremothecium gossypii (Ego) AGOS_AFR453W GI:54299408

Magnaporthe grisea (Mgr) MGG_10840 GI:39941982

Neurospora crassa (Ncr) NCU02960.1 GI:32419409

Arabidopsis thaliana (Ath) PEX5 GI:15241175

Oryza sativa (Osa) Os08g0500100 GI:115477114

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005777 peroxisome C
IDA
Hsa PEX5
Sce S000002652

GO:0005778 peroxisomal membrane C
IDA
Sce S000002652
IPI
Sce S000002652

GO:0005782 peroxisomal matrix C
IDA
Hsa PEX5

GO:0005829 cytosol C
IDA
Hsa PEX5
Sce S000002652

GO:0000268 peroxisome targeting sequence binding F
IDA
Cel WBGene00004194
ISS
Dme FBgn0023516
TAS
Mmu MGI:1098808

GO:0005052 peroxisome matrix targeting signal-1
binding F
IDA
Hsa PEX5
Sce S000002652
IMP
Hsa PEX5
Sce S000002652
ISS
Mmu MGI:1098808

GO:0005515 protein binding F
IPI
Hsa PEX5
Mmu MGI:1098808

GO:0008022 protein C-terminus binding F
IPI
Hsa PEX5
ISS
Mmu MGI:1098808

GO:0030674 protein binding, bridging F
IPI
Sce S000002652

GO:0047485 protein N-terminus binding F
IPI
Hsa PEX5

GO:0000038 very long-chain fatty acid metabolic
process P
IMP
Mmu MGI:1098808

GO:0001764 neuron migration P
IMP
Mmu MGI:1098808

GO:0002119 nematode larval development P
IMP
Cel WBGene00004194

GO:0006625 protein targeting to peroxisome P
IMP
Hsa PEX5
ISS
Mmu MGI:1098808
TAS
Mmu MGI:1098808

GO:0006635 fatty acid beta-oxidation P
IMP
Mmu MGI:1098808

GO:0007005 mitochondrion organization P
IMP
Mmu MGI:1098808

GO:0007006 mitochondrial membrane organization P
IMP
Mmu MGI:1098808

GO:0007029 endoplasmic reticulum organization P
IMP
Mmu MGI:1098808

GO:0007031 peroxisome organization P
IDA
Mmu MGI:1098808
IMP
Mmu MGI:1098808

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00004194

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00004194

GO:0016558 protein import into peroxisome
matrix P
IMP
Cel WBGene00004194

GO:0016560 protein import into peroxisome matrix,
docking P
IMP
Sce S000002652
IPI
Sce S000002652

GO:0016561 protein import into peroxisome matrix,
translocation P
IDA
Hsa PEX5

GO:0019915 lipid storage P
IMP
Cel WBGene00004194

GO:0021795 cerebral cortex cell migration P
IMP
Mmu MGI:1098808

GO:0021895 cerebral cortex neuron differentiation P
IMP
Mmu MGI:1098808

GO:0040007 growth P
IMP
Cel WBGene00004194

GO:0040010 positive regulation of growth rate P
IMP
Cel WBGene00004194

GO:0040018 positive regulation of multicellular organism
growth P
IMP
Mmu MGI:1098808

GO:0042221 response to chemical stimulus P
IMP
Dme FBgn0023516

GO:0044255 cellular lipid metabolic process P
IMP
Mmu MGI:1098808

GO:0048468 cell development P
IMP
Mmu MGI:1098808

GO:0050905 neuromuscular process P
IMP
Mmu MGI:1098808

GO:0051262 protein tetramerization P
IDA
Hsa PEX5

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_2041

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga2278 ENSANGP00000013156

Ashbya gossypii (Ago) ago3645 AFR453W

Arabidopsis thaliana (Ath) ath27638 At5g56290.1

Caenorhabditis elegans (Cel) cel3386 C34C6.6a
(CE03054;
WBGene00004194)

Caenorhabditis elegans (Cel) cel3387 C34C6.6b
(CE36377)

Candida glabrata (Cgl) cgl3999 CAGL0K11209g

Cryptococcus neoformans (Cne) cne3665 176.m02549

Cryptococcus neoformans (Cne) cne4783 186.m03656

Dictyostelium discoideum (Ddi) ddi8572 DDB0186780

Debaryomyces hansenii (Dha) dha4827 DEHA0F10021g

Drosophila melanogaster (Dme) dme16120 CG14815-PA
(FBgn0023516)

Drosophila melanogaster (Dme) dme16121 CG14815-PB
(FBgn0023516)

Danio rerio (Dre) dre6244 ENSDARP00000002582

Danio rerio (Dre) dre6874 ENSDARP00000004328

Takifugu rubripes (Fru) fru10780 SINFRUP00000156192

Takifugu rubripes (Fru) fru10781 SINFRUP00000167167

Gallus gallus (Gga) gga1605 ENSGALP00000023614

Gallus gallus (Gga) gga1606 ENSGALP00000023615
(PEX5) Q5ZMQ9

Homo sapiens (Hsa) hsa7015 ENSP00000266563
(PEX5) P50542-2

Homo sapiens (Hsa) hsa7014 ENSP00000266564
(PEX5) P50542-3

Kluyveromyces lactis (Kla) kla1890 KLLA0C15455g

Mus musculus (Mmu) mmu22702 ENSMUSP00000049132
(MGI:1098808) O09012-1

Mus musculus (Mmu) mmu16487 ENSMUSP00000077353
(MGI:1916672) Q8C437-3

Mus musculus (Mmu) mmu22701 ENSMUSP00000079398
(MGI:1098808) O09012-2

Neurospora crassa (Ncr) ncr2865 NCU02960.2

Oryza sativa (Osa) osa15457 3036.m00105

Rattus norvegicus (Rno) rno22186 ENSRNOP00000014028
(RGD:1307612)

Rattus norvegicus (Rno) rno22187 ENSRNOP00000014030
(RGD:1307612) Q2M2R8

Saccharomyces cerevisiae (Sce) sce1292 YDR244W
(S000002652)

Schizosaccharomyces pombe (Spo) spo377 SPBC725.07 O94325

Yarrowia lipolytica (Yli) yli6532 YALI0F28457g

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005624 membrane fraction C
ISO
Mmu MGI:1916672

GO:0005625 soluble fraction C
ISO
Mmu MGI:1916672

GO:0005626 insoluble fraction C
ISO
Mmu MGI:1916672

GO:0005737 cytoplasm C
IDA
Spo SPBC725.07

GO:0005777 peroxisome C
IDA
Sce S000002652
Spo SPBC725.07

GO:0005778 peroxisomal membrane C
IDA
Sce S000002652
IPI
Sce S000002652
NAS
Spo SPBC725.07

GO:0005829 cytosol C
IDA
Sce S000002652
Spo SPBC725.07
ISS
Spo SPBC725.07

GO:0017071 intracellular cyclic nucleotide activated cation
channel complex C
ISO
Mmu MGI:1916672

GO:0030425 dendrite C
IDA
Mmu MGI:1916672

GO:0000268 peroxisome targeting sequence binding F
IDA
Cel WBGene00004194
ISS
Dme FBgn0023516
Spo SPBC725.07
TAS
Mmu MGI:1098808

GO:0005052 peroxisome matrix targeting signal-1
binding F
IDA
Sce S000002652
IMP
Sce S000002652
ISS
Ath At5g56290
Mmu MGI:1098808

GO:0005221 intracellular cyclic nucleotide activated cation
channel activity F
ISO
Mmu MGI:1916672

GO:0005515 protein binding F
IPI
Ath At5g56290
Mmu MGI:1098808
MGI:1916672

GO:0008022 protein C-terminus binding F
ISS
Mmu MGI:1098808

GO:0017137 Rab GTPase binding F
ISO
Mmu MGI:1916672

GO:0030674 protein binding, bridging F
IPI
Sce S000002652

GO:0000038 very long-chain fatty acid metabolic
process P
IMP
Mmu MGI:1098808

GO:0001764 neuron migration P
IMP
Mmu MGI:1098808

GO:0002119 nematode larval development P
IMP
Cel WBGene00004194

GO:0006625 protein targeting to peroxisome P
IGI
Ath At5g56290
ISS
Ath At5g56290
Mmu MGI:1098808
Spo SPBC725.07
TAS
Mmu MGI:1098808

GO:0006635 fatty acid beta-oxidation P
IMP
Mmu MGI:1098808

GO:0007005 mitochondrion organization P
IMP
Mmu MGI:1098808

GO:0007006 mitochondrial membrane organization P
IMP
Mmu MGI:1098808

GO:0007029 endoplasmic reticulum organization P
IMP
Mmu MGI:1098808

GO:0007031 peroxisome organization P
IDA
Mmu MGI:1098808
IMP
Mmu MGI:1098808
ISS
Spo SPBC725.07

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00004194

GO:0009733 response to auxin stimulus P
IMP
Ath At5g56290

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00004194

GO:0016558 protein import into peroxisome
matrix P
IMP
Cel WBGene00004194

GO:0016560 protein import into peroxisome matrix,
docking P
IMP
Sce S000002652
IPI
Sce S000002652

GO:0019915 lipid storage P
IMP
Cel WBGene00004194

GO:0021795 cerebral cortex cell migration P
IMP
Mmu MGI:1098808

GO:0021895 cerebral cortex neuron differentiation P
IMP
Mmu MGI:1098808

GO:0040007 growth P
IMP
Cel WBGene00004194

GO:0040010 positive regulation of growth rate P
IMP
Cel WBGene00004194

GO:0040018 positive regulation of multicellular organism
growth P
IMP
Mmu MGI:1098808

GO:0042221 response to chemical stimulus P
IMP
Dme FBgn0023516

GO:0042391 regulation of membrane potential P
IDA
Mmu MGI:1916672
IGI
Mmu MGI:1916672

GO:0043949 regulation of cAMP-mediated signaling P
ISO
Mmu MGI:1916672

GO:0044255 cellular lipid metabolic process P
IMP
Mmu MGI:1098808

GO:0045055 regulated secretory pathway P
ISO
Mmu MGI:1916672

GO:0045185 maintenance of protein location P
IDA
Mmu MGI:1916672

GO:0048468 cell development P
IMP
Mmu MGI:1098808

GO:0050905 neuromuscular process P
IMP
Mmu MGI:1098808

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPBC725.07
(O94325) YDR244W
(S000002652)

GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005737 cytoplasm C
IDA
Spo SPBC725.07

GO:0005777 peroxisome C
IDA
Sce S000002652
Spo SPBC725.07

GO:0005778 peroxisomal membrane C
IDA
Sce S000002652
IPI
Sce S000002652
NAS
Spo SPBC725.07

GO:0005829 cytosol C
IDA
Sce S000002652
Spo SPBC725.07
ISS
Spo SPBC725.07

GO:0000268 peroxisome targeting sequence binding F
ISS
Spo SPBC725.07

GO:0005052 peroxisome matrix targeting signal-1
binding F
IDA
Sce S000002652
IMP
Sce S000002652

GO:0030674 protein binding, bridging F
IPI
Sce S000002652

GO:0006625 protein targeting to peroxisome P
ISS
Spo SPBC725.07

GO:0007031 peroxisome organization P
ISS
Spo SPBC725.07

GO:0016560 protein import into peroxisome matrix,
docking P
IMP
Sce S000002652
IPI
Sce S000002652

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1125	ACDHYP-

KOGs classification	KOGs description
POORLY CHARACTERIZED	TPR repeat-containing protein

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At5g56290	GI:15241175
Caenorhabditis elegans (Cel)	CE03054 (WBGene00004194)	GI:17532305
Drosophila melanogaster (Dme)	7290214	GI:20128889
Homo sapiens (Hsa)	Hs21361204	GI:14714929	Q13335
Homo sapiens (Hsa)	Hs22042700	GI:22042700
Homo sapiens (Hsa)	Hs7706671 (PEX5L)	GI:7706671	Q8IYB4
Homo sapiens (Hsa)	HsM4506347	GI:4506347
Saccharomyces cerevisiae (Sce)	YDR244w (S000002652)	GI:6320450	P35056
Saccharomyces cerevisiae (Sce)	YMR018w	GI:6323660	Q04364
Schizosaccharomyces pombe (Spo)	SPBC725.07	GI:19112279	O94325
Arabidopsis thaliana (Ath)	At5g56290	GI:15241175
Caenorhabditis elegans (Cel)	CE03054 (WBGene00004194)	GI:17532305
Drosophila melanogaster (Dme)	7290214	GI:20128889
Homo sapiens (Hsa)	Hs21361204	GI:14714929	Q13335
Homo sapiens (Hsa)	Hs22042700	GI:22042700
Homo sapiens (Hsa)	Hs7706671 (PEX5L)	GI:7706671	Q8IYB4
Homo sapiens (Hsa)	HsM4506347	GI:4506347
Saccharomyces cerevisiae (Sce)	YDR244w (S000002652)	GI:6320450	P35056
Saccharomyces cerevisiae (Sce)	YMR018w	GI:6323660	Q04364
Schizosaccharomyces pombe (Spo)	SPBC725.07	GI:19112279	O94325

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	PEX5	GI:196259776
Pan troglodytes (Ptr)	PEX5	GI:114643172
Canis familiaris (Cfa)	PEX5	GI:73997250
Mus musculus (Mmu)	Pex5 (MGI:1098808)	GI:113930737	O09012
Gallus gallus (Gga)	PEX5	GI:61098308
Drosophila melanogaster (Dme)	CG14815 (FBgn0023516)	GI:24639189
Anopheles gambiae (Aga)	AgaP_AGAP006820	GI:158286791
Caenorhabditis elegans (Cel)	prx-5 (CE03054; WBGene00004194)	GI:71983707
Saccharomyces cerevisiae (Sce)	PEX5 (S000002652)	GI:6320450	P35056
Kluyveromyces lactis (Kla)	KLLA0C15455g	GI:50305861
Eremothecium gossypii (Ego)	AGOS_AFR453W	GI:54299408
Magnaporthe grisea (Mgr)	MGG_10840	GI:39941982
Neurospora crassa (Ncr)	NCU02960.1	GI:32419409
Arabidopsis thaliana (Ath)	PEX5	GI:15241175
Oryza sativa (Osa)	Os08g0500100	GI:115477114

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga2278	ENSANGP00000013156
Ashbya gossypii (Ago)	ago3645	AFR453W
Arabidopsis thaliana (Ath)	ath27638	At5g56290.1
Caenorhabditis elegans (Cel)	cel3386	C34C6.6a (CE03054; WBGene00004194)
Caenorhabditis elegans (Cel)	cel3387	C34C6.6b (CE36377)
Candida glabrata (Cgl)	cgl3999	CAGL0K11209g
Cryptococcus neoformans (Cne)	cne3665	176.m02549
Cryptococcus neoformans (Cne)	cne4783	186.m03656
Dictyostelium discoideum (Ddi)	ddi8572	DDB0186780
Debaryomyces hansenii (Dha)	dha4827	DEHA0F10021g
Drosophila melanogaster (Dme)	dme16120	CG14815-PA (FBgn0023516)
Drosophila melanogaster (Dme)	dme16121	CG14815-PB (FBgn0023516)
Danio rerio (Dre)	dre6244	ENSDARP00000002582
Danio rerio (Dre)	dre6874	ENSDARP00000004328
Takifugu rubripes (Fru)	fru10780	SINFRUP00000156192
Takifugu rubripes (Fru)	fru10781	SINFRUP00000167167
Gallus gallus (Gga)	gga1605	ENSGALP00000023614
Gallus gallus (Gga)	gga1606	ENSGALP00000023615 (PEX5)	Q5ZMQ9
Homo sapiens (Hsa)	hsa7015	ENSP00000266563 (PEX5)	P50542-2
Homo sapiens (Hsa)	hsa7014	ENSP00000266564 (PEX5)	P50542-3
Kluyveromyces lactis (Kla)	kla1890	KLLA0C15455g
Mus musculus (Mmu)	mmu22702	ENSMUSP00000049132 (MGI:1098808)	O09012-1
Mus musculus (Mmu)	mmu16487	ENSMUSP00000077353 (MGI:1916672)	Q8C437-3
Mus musculus (Mmu)	mmu22701	ENSMUSP00000079398 (MGI:1098808)	O09012-2
Neurospora crassa (Ncr)	ncr2865	NCU02960.2
Oryza sativa (Osa)	osa15457	3036.m00105
Rattus norvegicus (Rno)	rno22186	ENSRNOP00000014028 (RGD:1307612)
Rattus norvegicus (Rno)	rno22187	ENSRNOP00000014030 (RGD:1307612)	Q2M2R8
Saccharomyces cerevisiae (Sce)	sce1292	YDR244W (S000002652)
Schizosaccharomyces pombe (Spo)	spo377	SPBC725.07	O94325
Yarrowia lipolytica (Yli)	yli6532	YALI0F28457g

S. pombe systematic ID	S. cerevisiae systematic ID
SPBC725.07 (O94325)	YDR244W (S000002652)